OLFM2 (olfactomedin 2)

Gene

• Entrez ID: 93145
• Gene name: Olfactomedin 2
• Gene symbol: OLFM2
• Synonyms (NCBI Gene): NOE2, NOELIN2, NOELIN2_V1, OlfC
• Chromosome: 19
• Chromosome location: 19p13.2

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT1203090	hsa-miR-1827	CLIP-seq
MIRT1203091	hsa-miR-3126-5p	CLIP-seq
MIRT1203092	hsa-miR-3620	CLIP-seq
MIRT1203093	hsa-miR-4419a	CLIP-seq
MIRT1203094	hsa-miR-4510	CLIP-seq
MIRT1203095	hsa-miR-4514	CLIP-seq
MIRT1203096	hsa-miR-4533	CLIP-seq
MIRT1203097	hsa-miR-4692	CLIP-seq
MIRT1203098	hsa-miR-4756-3p	CLIP-seq
MIRT1203099	hsa-miR-4780	CLIP-seq
MIRT1203090	hsa-miR-1827	CLIP-seq
MIRT1203091	hsa-miR-3126-5p	CLIP-seq
MIRT1203092	hsa-miR-3620	CLIP-seq
MIRT1203093	hsa-miR-4419a	CLIP-seq
MIRT1203094	hsa-miR-4510	CLIP-seq
MIRT1203099	hsa-miR-4780	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005515	Function	Protein binding	IPI	25298399, 32296183
GO:0005576	Component	Extracellular region	IDA	21228389
GO:0005576	Component	Extracellular region	IEA
GO:0005615	Component	Extracellular space	IBA
GO:0005634	Component	Nucleus	IDA	25298399
GO:0005634	Component	Nucleus	IEA
GO:0005654	Component	Nucleoplasm	IDA
GO:0005737	Component	Cytoplasm	IDA	25298399
GO:0005737	Component	Cytoplasm	IEA
GO:0007165	Process	Signal transduction	IBA
GO:0009306	Process	Protein secretion	IDA	21228389
GO:0016020	Component	Membrane	IEA
GO:0032281	Component	AMPA glutamate receptor complex	ISS
GO:0045202	Component	Synapse	IEA
GO:0051152	Process	Positive regulation of smooth muscle cell differentiation	IMP	25298399
GO:1905174	Process	Regulation of vascular associated smooth muscle cell dedifferentiation	IEA
GO:1905174	Process	Regulation of vascular associated smooth muscle cell dedifferentiation	ISS

Other IDs

• MIM: 617492
• HGNC: 17189
• e!Ensembl: ENSG00000105088

Protein

• UniProt ID: O95897
• Protein name: Noelin-2 (Olfactomedin-2)
• Protein function: Involved in transforming growth factor beta (TGF-beta)-induced smooth muscle differentiation. TGF-beta induces expression and translocation of OLFM2 to the nucleus where it binds to SRF, causing its dissociation from the transcriptional represso
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF12308	Noelin-1	25 → 121	Neurogenesis glycoprotein	Family
  PF02191	OLF	198 → 444	Olfactomedin-like domain	Family

• Tissue specificity: TISSUE SPECIFICITY: Expressed in aortic smooth muscle (at protein level) (PubMed:25298399). In the fetus, expressed in the brain and ocular tissues including lens vesicle and optic cup (PubMed:27844144). {ECO:0000269|PubMed:25298399, ECO:0000269|PubMed:27
• Sequence:

  MWPLTVPPPLLLLLCSGLAGQTLFQNPEEGWQLYTSAQAPDGKCICTAVIPAQSTCSRDG
  RSRELRQLMEKVQNVSQSMEVLELRTYRDLQYVRGMETLMRSLDARLRAADGSLSAKSFQ
  ELKDRMTELLPLSSVLEQYKADTRTIVRLREEVRNLSGSLAAIQEEMGAYGYEDLQQRVM
  ALEARLHACAQKLGCGKLTGVSNPITVRAMGSRFGSWMTDTMAPSADSRVWYMDGYYKGR
  RVLEFRTLGDFIKGQNFIQHLLPQPWAGTGHVVYNGSLFYNKYQSNVVVKYHFRSRSVLV
  QRSLPGAGYNNTFPYSWGGFSDMDFMVDESGLWAVYTTNQNAGNIVVSRLDPHTLEVMRS
  WDTGYPKRSAGEAFMICGVLYVTNSHLAGAKVYFAYFTNTSSYEYTDVPFHNQYSHISML
  DYNPRERALYTWNNGHQVLYNVTLFHVISTSGDP

• Sequence length: 454

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