KCNG4 (potassium voltage-gated channel modifier subfamily G member 4)

Gene

• Entrez ID: 93107
• Gene name: Potassium voltage-gated channel modifier subfamily G member 4
• Gene symbol: KCNG4
• Synonyms (NCBI Gene): KV6.3, KV6.4
• Chromosome: 16
• Chromosome location: 16q24.1
• Summary: Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuro

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT1080982	hsa-miR-1182	CLIP-seq
MIRT1080983	hsa-miR-1237	CLIP-seq
MIRT1080984	hsa-miR-1248	CLIP-seq
MIRT1080985	hsa-miR-193a-5p	CLIP-seq
MIRT1080986	hsa-miR-217	CLIP-seq
MIRT1080987	hsa-miR-3162-5p	CLIP-seq
MIRT1080988	hsa-miR-3173-3p	CLIP-seq
MIRT1080989	hsa-miR-3670	CLIP-seq
MIRT1080990	hsa-miR-4268	CLIP-seq
MIRT1080991	hsa-miR-4418	CLIP-seq
MIRT1080992	hsa-miR-4448	CLIP-seq
MIRT1080993	hsa-miR-4476	CLIP-seq
MIRT1080994	hsa-miR-4533	CLIP-seq
MIRT1080995	hsa-miR-4699-3p	CLIP-seq
MIRT1080996	hsa-miR-4763-5p	CLIP-seq
MIRT1080997	hsa-miR-4779	CLIP-seq
MIRT1080998	hsa-miR-509-3-5p	CLIP-seq
MIRT1080999	hsa-miR-509-5p	CLIP-seq
MIRT1081000	hsa-miR-526b	CLIP-seq
MIRT2020072	hsa-miR-1243	CLIP-seq
MIRT2020073	hsa-miR-1252	CLIP-seq
MIRT2020074	hsa-miR-1261	CLIP-seq
MIRT2020075	hsa-miR-3123	CLIP-seq
MIRT2020076	hsa-miR-3169	CLIP-seq
MIRT2020077	hsa-miR-3591-3p	CLIP-seq
MIRT2020078	hsa-miR-4311	CLIP-seq
MIRT2020079	hsa-miR-4434	CLIP-seq
MIRT2020080	hsa-miR-4437	CLIP-seq
MIRT2020081	hsa-miR-4515	CLIP-seq
MIRT2020082	hsa-miR-4516	CLIP-seq
MIRT2020083	hsa-miR-4531	CLIP-seq
MIRT1080994	hsa-miR-4533	CLIP-seq
MIRT2020084	hsa-miR-4646-5p	CLIP-seq
MIRT2020085	hsa-miR-4731-5p	CLIP-seq
MIRT2020086	hsa-miR-4747-5p	CLIP-seq
MIRT2020087	hsa-miR-582-3p	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005249	Function	Voltage-gated potassium channel activity	IBA	21873635
GO:0005251	Function	Delayed rectifier potassium channel activity	IBA	21873635
GO:0005251	Function	Delayed rectifier potassium channel activity	IDA	19074135
GO:0005886	Component	Plasma membrane	IDA	19074135
GO:0005886	Component	Plasma membrane	TAS
GO:0008076	Component	Voltage-gated potassium channel complex	IBA	21873635
GO:0008076	Component	Voltage-gated potassium channel complex	IDA	19074135
GO:0016021	Component	Integral component of membrane	IBA	21873635
GO:0034765	Process	Regulation of ion transmembrane transport	IEA
GO:0044325	Function	Ion channel binding	IPI	19074135
GO:0051260	Process	Protein homooligomerization	IEA
GO:0071805	Process	Potassium ion transmembrane transport	IBA	21873635
GO:0071805	Process	Potassium ion transmembrane transport	IDA	19074135

Other IDs

• MIM: 607603
• HGNC: 19697
• e!Ensembl: ENSG00000168418

Protein

• UniProt ID: Q8TDN1
• Protein name: Voltage-gated potassium channel regulatory subunit KCNG4 (Potassium voltage-gated channel subfamily G member 4) (Voltage-gated potassium channel subunit Kv6.3) (Voltage-gated potassium channel subunit Kv6.4)
• Protein function: Regulatory subunit of the voltage-gated potassium (Kv) channel which, when coassembled with KCNB1, modulates the kinetics parameters of the heterotetrameric channel namely the time course of activation, deactivation and inactivation and on the v
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF02214	BTB_2	61 → 160	BTB/POZ domain	Domain
  PF00520	Ion_trans	220 → 464	Ion transport protein	Family

• Tissue specificity: TISSUE SPECIFICITY: Highly expressed in brain, and at lower levels in liver, small intestine and colon. {ECO:0000269|PubMed:12060745}.
• Sequence:

  MPMPSRDGGLHPRHHHYGSHSPWSQLLSSPMETPSIKGLYYRRVRKVGALDASPVDLKKE
  ILINVGGRRYLLPWSTLDRFPLSRLSKLRLCRSYEEIVQLCDDYDEDSQEFFFDRSPSAF
  GVIVSFLAAGKLVLLQEMCALSFQEELAYWGIEEAHLERCCLRKLLRKLEELEELAKLHR
  EDVLRQQRETRRPASHSSRWGLCMNRLREMVENPQSGLPGKVFACLSILFVATTAVSLCV
  STMPDLRAEEDQGECSRKCYYIFIVETICVAWFSLEFCLRFVQAQDKCQFFQGPLNIIDI
  LAISPYYVSLAVSEEPPEDGERPSGSSYLEKVGLVLRVLRALRILYVMRLARHSLGLQTL
  GLTVRRCTREFGLLLLFLAVAITLFSPLVYVAEKESGRVLEFTSIPASYWWAIISMTTVG
  YGDMVPRSVPGQMVALSSILSGILIMAFPATSIFHTFSHSYLELKKEQEQLQARLRHLQN
  TGPASECELLDPHVASEHELMNDVNDLILEGPALPIMHM

• Sequence length: 519

Pathways

Reactome:

Voltage gated Potassium channels

Associated diseases

Unknown
Disease term	Disease name	Evidence	References	Source
Chronic obstructive pulmonary disease	Chronic Obstructive Airway Disease		26503814	ClinVar

Associations from Text Mining
Disease Name	Relationship Type	References
Multiple Sclerosis	Associate	31170158
Neurodegenerative Diseases	Associate	31170158