NEURL3 (neuralized E3 ubiquitin protein ligase 3)

Gene

• Entrez ID: 93082
• Gene name: Neuralized E3 ubiquitin protein ligase 3
• Gene symbol: NEURL3
• Synonyms (NCBI Gene): LINCR, RNF132
• Chromosome: 2
• Chromosome location: 2q11.2

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT018320	hsa-miR-335-5p	Microarray	18185580

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0002376	Process	Immune system process	IEA
GO:0005737	Component	Cytoplasm	IDA	30111563
GO:0005737	Component	Cytoplasm	IEA
GO:0005769	Component	Early endosome	IBA
GO:0008270	Function	Zinc ion binding	IEA
GO:0016567	Process	Protein ubiquitination	IEA
GO:0016567	Process	Protein ubiquitination	IEA
GO:0016740	Function	Transferase activity	IEA
GO:0043409	Process	Negative regulation of MAPK cascade	ISS
GO:0045087	Process	Innate immune response	IEA
GO:0046872	Function	Metal ion binding	IEA
GO:0061630	Function	Ubiquitin protein ligase activity	IBA
GO:0061630	Function	Ubiquitin protein ligase activity	IDA	38667302
GO:0061630	Function	Ubiquitin protein ligase activity	IEA
GO:0070086	Process	Ubiquitin-dependent endocytosis	IBA
GO:0070371	Process	ERK1 and ERK2 cascade	IDA	16314496
GO:1901800	Process	Positive regulation of proteasomal protein catabolic process	IDA	38667302

Other IDs

• MIM: 617206
• HGNC: 25162
• e!Ensembl: ENSG00000163121

Protein

• UniProt ID: Q96EH8
• Protein name: E3 ubiquitin-protein ligase NEURL3 (EC 2.3.2.27) (Lung-inducible neuralized-related C3CH4 RING domain protein) (Neuralized-like protein 3) (RING-type E3 ubiquitin transferase NEURL3)
• Protein function: E3 ubiquitin-protein ligase that plays a role in various biological processes such as lung development or innate immunity (PubMed:30111563). Seems to utilize UBE2E1. Promotes innate antiviral response by catalyzing 'Lys-63'-linked ubiquitination
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF07177	Neuralized	20 → 172	Neuralized	Domain
  PF13920	zf-C3HC4_3	199 → 247		Domain

• Sequence:

  MGAQLCFEANAKAPREALRFHAEAKGAQVRLDTRGCIAHRRTTFHDGIVFSQRPVRLGER
  VALRVLREESGWCGGLRVGFTRLDPACVSVPSLPPFLCPDLEEQSPTWAAVLPEGCALTG
  DLVRFWVDRRGCLFAKVNAGCRLLLREGVPVGAPLWAVMDVYGTTKAIELLDPTASRLPT
  PMPWDLSNKAVPEPKATPGEECAICFYHAANTRLVPCGHTYFCRYCAWRVFSDTAKCPVC
  RWQIEAVAPAQGPPALRVEEGS

• Sequence length: 262