NEURL3 (neuralized E3 ubiquitin protein ligase 3)

Gene
Gene miRNA Gene ontology Other IDs Protein Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
93082
Gene name Gene Name - the full gene name approved by the HGNC.
Neuralized E3 ubiquitin protein ligase 3
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
NEURL3
Synonyms (NCBI Gene) Gene synonyms aliases
LINCR, RNF132
Chromosome Chromosome number
2
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
2q11.2
miRNA miRNA information provided by mirtarbase database.
Gene miRNA Gene ontology Other IDs Protein Associated diseases
Show/Hide all(1)
miRTarBase ID miRNA Experiments Reference
MIRT018320 hsa-miR-335-5p Microarray 18185580
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
Gene miRNA Gene ontology Other IDs Protein Associated diseases
Show/Hide all(3)
GO ID Ontology Definition Evidence Reference
GO:0016567 Process Protein ubiquitination IEA
GO:0046872 Function Metal ion binding IEA
GO:0061630 Function Ubiquitin protein ligase activity IBA 21873635
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
Gene miRNA Gene ontology Other IDs Protein Associated diseases
MIM HGNC e!Ensembl
617206 25162 ENSG00000163121
Protein
Gene miRNA Gene ontology Other IDs Protein Associated diseases
UniProt ID Q96EH8
Protein name E3 ubiquitin-protein ligase NEURL3 (EC 2.3.2.27) (Lung-inducible neuralized-related C3CH4 RING domain protein) (Neuralized-like protein 3) (RING-type E3 ubiquitin transferase NEURL3)
Protein function E3 ubiquitin-protein ligase that plays a role in various biological processes such as lung development or innate immunity (PubMed:30111563). Seems to utilize UBE2E1. Promotes innate antiviral response by catalyzing 'Lys-63'-linked ubiquitination
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF07177 Neuralized 20 → 172 Neuralized Domain
PF13920 zf-C3HC4_3 199 → 247 Domain
Sequence
Sequence length 262
Interactions View interactions
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Gene miRNA Gene ontology Other IDs Protein Associated diseases
Show/Hide Causal Diseases (1)
Causal
Disease term Disease name dbSNP ID References
Leukemia Leukemia, Myelocytic, Acute rs121909646, rs121913488, rs587776834, rs752746786, rs869312821, rs767454740, rs1554564297 27903959
Show/Hide Text Mining Associations (6)
Associations from Text Mining
Disease Name Relationship Type References
Hepatitis C Inhibit 30111563
Nasopharyngeal Carcinoma Inhibit 38191501
Neoplasm Metastasis Inhibit 38191501
Neoplasms Inhibit 38191501
Pain Associate 39674387
Pancreatic Neoplasms Associate 39674387