Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
9294
Gene name Gene Name - the full gene name approved by the HGNC.
Sphingosine-1-phosphate receptor 2
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
S1PR2
Synonyms (NCBI Gene) Gene synonyms aliases
AGR16, DFNB68, EDG-5, EDG5, Gpcr13, H218, LPB2, S1P2
Disease Acronyms (UniProt) Disease acronyms from UniProt database
DFNB68
Chromosome Chromosome number
19
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
19p13.2
Summary Summary of gene provided in NCBI Entrez Gene.
This gene encodes a member of the G protein-coupled receptors, as well as the EDG family of proteins. The encoded protein is a receptor for sphingosine 1-phosphate, which participates in cell proliferation, survival, and transcriptional activation. Defect
SNPs SNP information provided by dbSNP.
SNP ID Visualize variation Clinical significance Consequence
rs869312749 C>G Pathogenic Missense variant, coding sequence variant
rs869312750 T>C Pathogenic Missense variant, coding sequence variant
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT632466 hsa-miR-128-3p HITS-CLIP 23824327
MIRT632465 hsa-miR-216a-3p HITS-CLIP 23824327
MIRT632464 hsa-miR-3681-3p HITS-CLIP 23824327
MIRT632463 hsa-miR-5693 HITS-CLIP 23824327
MIRT632462 hsa-miR-3185 HITS-CLIP 23824327
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0000187 Process Activation of MAPK activity TAS 10617617
GO:0001664 Function G protein-coupled receptor binding IPI 24851274
GO:0003376 Process Sphingosine-1-phosphate receptor signaling pathway IBA 21873635
GO:0003376 Process Sphingosine-1-phosphate receptor signaling pathway IMP 23106337
GO:0004930 Function G protein-coupled receptor activity IBA 21873635
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
605111 3169 ENSG00000267534
Protein
UniProt ID O95136
Protein name Sphingosine 1-phosphate receptor 2 (S1P receptor 2) (S1P2) (Endothelial differentiation G-protein coupled receptor 5) (Sphingosine 1-phosphate receptor Edg-5) (S1P receptor Edg-5)
Protein function Receptor for the lysosphingolipid sphingosine 1-phosphate (S1P) (PubMed:10617617, PubMed:25274307). S1P is a bioactive lysophospholipid that elicits diverse physiological effects on most types of cells and tissues (PubMed:10617617). When express
PDB 7T6B
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00001 7tm_1 50 288 7 transmembrane receptor (rhodopsin family) Family
Sequence
Sequence length 353
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG   Reactome
  Sphingolipid signaling pathway
Neuroactive ligand-receptor interaction
  G alpha (i) signalling events
Lysosphingolipid and LPA receptors
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Causal
Disease term Disease name dbSNP ID References
Deafness DEAFNESS, AUTOSOMAL RECESSIVE 68 rs267607135, rs387906219, rs387906220, rs387906221, rs387906222, rs606231120, rs267606855, rs121918370, rs137853185, rs137853186, rs137853187, rs137853188, rs587776522, rs587776523, rs200781822
View all (1019 more)
27383011, 26805784, 24176858, 17284444, 29776397, 17287522, 27080739, 16945494
Hearing loss Sensorineural Hearing Loss (disorder) rs267607135, rs267606855, rs779841884, rs267606854, rs28942097, rs121908073, rs121908076, rs74315289, rs121908144, rs111033313, rs74315437, rs121908348, rs121908349, rs121908350, rs397515359
View all (184 more)
Unknown
Disease term Disease name Evidence References Source
Hypertension Hypertension GWAS
Associations from Text Mining
Disease Name Relationship Type References
Abnormalities Drug Induced Associate 26805784
Adenocarcinoma Associate 29963993
Adenocarcinoma Inhibit 37232164
Adenoma Associate 27079615
Aortic Aneurysm Abdominal Associate 22547907
Aortic Aneurysm Familial Abdominal 1 Associate 22547907
Arthritis Rheumatoid Associate 18658144
Atherosclerosis Associate 18765664, 23770055
Breast Neoplasms Associate 24486401
Carcinoma Hepatocellular Associate 10617617