Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	9282
Gene name	Mediator complex subunit 14
Gene symbol	MED14
Synonyms (NCBI Gene)	CRSP150CRSP2CSRPCXorf4DRIP150EXLM1RGR1TRAP170
Chromosome	X
Chromosome location	Xp11.4
Summary	The activation of gene transcription is a multistep process that is triggered by factors that recognize transcriptional enhancer sites in DNA. These factors work with co-activators to direct transcriptional initiation by the RNA polymerase II apparatus. T

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Show/Hide all (219)

miRTarBase ID	miRNA	Experiments	Reference
MIRT052118	hsa-let-7b-5p	CLASH	23622248
MIRT047245	hsa-miR-181b-5p	CLASH	23622248
MIRT037921	hsa-miR-532-3p	CLASH	23622248
MIRT623274	hsa-miR-6507-3p	HITS-CLIP	23824327
MIRT623274	hsa-miR-6507-3p	HITS-CLIP	23824327
MIRT623274	hsa-miR-6507-3p	HITS-CLIP	23824327
MIRT446737	hsa-miR-7844-5p	PAR-CLIP	22100165
MIRT446736	hsa-miR-4738-3p	PAR-CLIP	22100165
MIRT446735	hsa-miR-510-3p	PAR-CLIP	22100165
MIRT727219	hsa-miR-27a-3p	HITS-CLIP	22473208
MIRT727218	hsa-miR-27b-3p	HITS-CLIP	22473208
MIRT623274	hsa-miR-6507-3p	HITS-CLIP	23824327
MIRT623274	hsa-miR-6507-3p	HITS-CLIP	23824327
MIRT623274	hsa-miR-6507-3p	HITS-CLIP	23824327
MIRT446737	hsa-miR-7844-5p	PAR-CLIP	22100165
MIRT446736	hsa-miR-4738-3p	PAR-CLIP	22100165
MIRT446735	hsa-miR-510-3p	PAR-CLIP	22100165
MIRT1140984	hsa-miR-1202	CLIP-seq
MIRT1140985	hsa-miR-1208	CLIP-seq
MIRT1140986	hsa-miR-1256	CLIP-seq
MIRT1140987	hsa-miR-1271	CLIP-seq
MIRT1140988	hsa-miR-129-5p	CLIP-seq
MIRT1140989	hsa-miR-182	CLIP-seq
MIRT1140990	hsa-miR-186	CLIP-seq
MIRT1140991	hsa-miR-192	CLIP-seq
MIRT1140992	hsa-miR-2052	CLIP-seq
MIRT1140993	hsa-miR-215	CLIP-seq
MIRT1140994	hsa-miR-299-5p	CLIP-seq
MIRT1140995	hsa-miR-3133	CLIP-seq
MIRT1140996	hsa-miR-3170	CLIP-seq
MIRT1140997	hsa-miR-3189-3p	CLIP-seq
MIRT1140998	hsa-miR-342-5p	CLIP-seq
MIRT1140999	hsa-miR-3620	CLIP-seq
MIRT1141000	hsa-miR-3647-3p	CLIP-seq
MIRT1141001	hsa-miR-3650	CLIP-seq
MIRT1141002	hsa-miR-3691-3p	CLIP-seq
MIRT1141003	hsa-miR-3972	CLIP-seq
MIRT1141004	hsa-miR-4282	CLIP-seq
MIRT1141005	hsa-miR-4307	CLIP-seq
MIRT1141006	hsa-miR-4455	CLIP-seq
MIRT1141007	hsa-miR-450a	CLIP-seq
MIRT1141008	hsa-miR-452	CLIP-seq
MIRT1141009	hsa-miR-4642	CLIP-seq
MIRT1141010	hsa-miR-4651	CLIP-seq
MIRT1141011	hsa-miR-4664-5p	CLIP-seq
MIRT1141012	hsa-miR-4668-5p	CLIP-seq
MIRT1141013	hsa-miR-4676-3p	CLIP-seq
MIRT1141014	hsa-miR-4776-3p	CLIP-seq
MIRT1141015	hsa-miR-489	CLIP-seq
MIRT1141016	hsa-miR-502-5p	CLIP-seq
MIRT1141017	hsa-miR-519a	CLIP-seq
MIRT1141018	hsa-miR-519b-3p	CLIP-seq
MIRT1141019	hsa-miR-519c-3p	CLIP-seq
MIRT1141020	hsa-miR-597	CLIP-seq
MIRT1141021	hsa-miR-608	CLIP-seq
MIRT1141022	hsa-miR-629	CLIP-seq
MIRT1141023	hsa-miR-668	CLIP-seq
MIRT1141024	hsa-miR-96	CLIP-seq
MIRT2039983	hsa-miR-101	CLIP-seq
MIRT2039984	hsa-miR-128	CLIP-seq
MIRT1140988	hsa-miR-129-5p	CLIP-seq
MIRT2039985	hsa-miR-137	CLIP-seq
MIRT2039986	hsa-miR-142-5p	CLIP-seq
MIRT2039987	hsa-miR-144	CLIP-seq
MIRT2039988	hsa-miR-203	CLIP-seq
MIRT2039989	hsa-miR-2115	CLIP-seq
MIRT2039990	hsa-miR-27a	CLIP-seq
MIRT2039991	hsa-miR-27b	CLIP-seq
MIRT2039992	hsa-miR-3121-5p	CLIP-seq
MIRT1140996	hsa-miR-3170	CLIP-seq
MIRT1140997	hsa-miR-3189-3p	CLIP-seq
MIRT2039993	hsa-miR-340	CLIP-seq
MIRT1140998	hsa-miR-342-5p	CLIP-seq
MIRT1141001	hsa-miR-3650	CLIP-seq
MIRT2039994	hsa-miR-3977	CLIP-seq
MIRT2039995	hsa-miR-412	CLIP-seq
MIRT2039996	hsa-miR-4272	CLIP-seq
MIRT1141004	hsa-miR-4282	CLIP-seq
MIRT2039997	hsa-miR-4320	CLIP-seq
MIRT2039998	hsa-miR-4328	CLIP-seq
MIRT1141006	hsa-miR-4455	CLIP-seq
MIRT2039999	hsa-miR-4477a	CLIP-seq
MIRT1141010	hsa-miR-4651	CLIP-seq
MIRT1141011	hsa-miR-4664-5p	CLIP-seq
MIRT1141016	hsa-miR-502-5p	CLIP-seq
MIRT2040000	hsa-miR-513b	CLIP-seq
MIRT2040001	hsa-miR-516a-3p	CLIP-seq
MIRT2040002	hsa-miR-582-5p	CLIP-seq
MIRT1141021	hsa-miR-608	CLIP-seq
MIRT1140985	hsa-miR-1208	CLIP-seq
MIRT2269788	hsa-miR-1253	CLIP-seq
MIRT2269789	hsa-miR-1262	CLIP-seq
MIRT2269790	hsa-miR-1305	CLIP-seq
MIRT2269791	hsa-miR-1323	CLIP-seq
MIRT2039985	hsa-miR-137	CLIP-seq
MIRT2269792	hsa-miR-143	CLIP-seq
MIRT1140991	hsa-miR-192	CLIP-seq
MIRT1140992	hsa-miR-2052	CLIP-seq
MIRT2039989	hsa-miR-2115	CLIP-seq
MIRT1140993	hsa-miR-215	CLIP-seq
MIRT2269793	hsa-miR-3074-3p	CLIP-seq
MIRT2269794	hsa-miR-3128	CLIP-seq
MIRT2269795	hsa-miR-3143	CLIP-seq
MIRT2269796	hsa-miR-3158-5p	CLIP-seq
MIRT2269797	hsa-miR-3163	CLIP-seq
MIRT1140996	hsa-miR-3170	CLIP-seq
MIRT1140997	hsa-miR-3189-3p	CLIP-seq
MIRT2269798	hsa-miR-338-5p	CLIP-seq
MIRT1140998	hsa-miR-342-5p	CLIP-seq
MIRT2269799	hsa-miR-3619-3p	CLIP-seq
MIRT1141001	hsa-miR-3650	CLIP-seq
MIRT2269800	hsa-miR-3671	CLIP-seq
MIRT1141002	hsa-miR-3691-3p	CLIP-seq
MIRT2039994	hsa-miR-3977	CLIP-seq
MIRT2269801	hsa-miR-4259	CLIP-seq
MIRT1141005	hsa-miR-4307	CLIP-seq
MIRT1141006	hsa-miR-4455	CLIP-seq
MIRT2269802	hsa-miR-4470	CLIP-seq
MIRT1141007	hsa-miR-450a	CLIP-seq
MIRT1141008	hsa-miR-452	CLIP-seq
MIRT1141010	hsa-miR-4651	CLIP-seq
MIRT1141011	hsa-miR-4664-5p	CLIP-seq
MIRT1141013	hsa-miR-4676-3p	CLIP-seq
MIRT2269803	hsa-miR-4701-3p	CLIP-seq
MIRT2269804	hsa-miR-4770	CLIP-seq
MIRT2269805	hsa-miR-4776-5p	CLIP-seq
MIRT2269806	hsa-miR-4795-5p	CLIP-seq
MIRT2269807	hsa-miR-498	CLIP-seq
MIRT1141016	hsa-miR-502-5p	CLIP-seq
MIRT2040001	hsa-miR-516a-3p	CLIP-seq
MIRT2269808	hsa-miR-543	CLIP-seq
MIRT2269809	hsa-miR-548aa	CLIP-seq
MIRT2269810	hsa-miR-548c-3p	CLIP-seq
MIRT2269811	hsa-miR-548o	CLIP-seq
MIRT2269812	hsa-miR-561	CLIP-seq
MIRT2269813	hsa-miR-568	CLIP-seq
MIRT2269814	hsa-miR-571	CLIP-seq
MIRT2269815	hsa-miR-577	CLIP-seq
MIRT2269816	hsa-miR-578	CLIP-seq
MIRT2269817	hsa-miR-607	CLIP-seq
MIRT1141021	hsa-miR-608	CLIP-seq
MIRT2269818	hsa-miR-643	CLIP-seq
MIRT2269819	hsa-miR-656	CLIP-seq
MIRT1141023	hsa-miR-668	CLIP-seq
MIRT2039983	hsa-miR-101	CLIP-seq
MIRT1140984	hsa-miR-1202	CLIP-seq
MIRT2039984	hsa-miR-128	CLIP-seq
MIRT1140988	hsa-miR-129-5p	CLIP-seq
MIRT2039987	hsa-miR-144	CLIP-seq
MIRT2039990	hsa-miR-27a	CLIP-seq
MIRT2039991	hsa-miR-27b	CLIP-seq
MIRT2390778	hsa-miR-3613-3p	CLIP-seq
MIRT1141000	hsa-miR-3647-3p	CLIP-seq
MIRT1141003	hsa-miR-3972	CLIP-seq
MIRT2039996	hsa-miR-4272	CLIP-seq
MIRT1141004	hsa-miR-4282	CLIP-seq
MIRT2039998	hsa-miR-4328	CLIP-seq
MIRT1141014	hsa-miR-4776-3p	CLIP-seq
MIRT2269812	hsa-miR-561	CLIP-seq
MIRT2040002	hsa-miR-582-5p	CLIP-seq
MIRT2269792	hsa-miR-143	CLIP-seq
MIRT2438546	hsa-miR-3919	CLIP-seq
MIRT2438547	hsa-miR-4424	CLIP-seq
MIRT2438548	hsa-miR-4756-3p	CLIP-seq
MIRT2269804	hsa-miR-4770	CLIP-seq
MIRT2438549	hsa-miR-586	CLIP-seq
MIRT2568913	hsa-miR-1260	CLIP-seq
MIRT2568914	hsa-miR-1260b	CLIP-seq
MIRT2568915	hsa-miR-1284	CLIP-seq
MIRT2269792	hsa-miR-143	CLIP-seq
MIRT2568916	hsa-miR-188-3p	CLIP-seq
MIRT2039988	hsa-miR-203	CLIP-seq
MIRT2568917	hsa-miR-300	CLIP-seq
MIRT2039992	hsa-miR-3121-5p	CLIP-seq
MIRT2568918	hsa-miR-3148	CLIP-seq
MIRT2568919	hsa-miR-3156-3p	CLIP-seq
MIRT2568920	hsa-miR-3607-5p	CLIP-seq
MIRT2568921	hsa-miR-3657	CLIP-seq
MIRT2568922	hsa-miR-374a	CLIP-seq
MIRT2568923	hsa-miR-374b	CLIP-seq
MIRT2568924	hsa-miR-381	CLIP-seq
MIRT2438546	hsa-miR-3919	CLIP-seq
MIRT2568925	hsa-miR-421	CLIP-seq
MIRT2438547	hsa-miR-4424	CLIP-seq
MIRT2568926	hsa-miR-4496	CLIP-seq
MIRT2568927	hsa-miR-4528	CLIP-seq
MIRT2568928	hsa-miR-4666-3p	CLIP-seq
MIRT2568929	hsa-miR-4669	CLIP-seq
MIRT2568930	hsa-miR-4709-5p	CLIP-seq
MIRT2568931	hsa-miR-4711-5p	CLIP-seq
MIRT2438548	hsa-miR-4756-3p	CLIP-seq
MIRT2269804	hsa-miR-4770	CLIP-seq
MIRT2568932	hsa-miR-4789-5p	CLIP-seq
MIRT2269810	hsa-miR-548c-3p	CLIP-seq
MIRT2269812	hsa-miR-561	CLIP-seq
MIRT2568933	hsa-miR-570	CLIP-seq
MIRT2438549	hsa-miR-586	CLIP-seq
MIRT2568934	hsa-miR-603	CLIP-seq
MIRT2684787	hsa-miR-1255a	CLIP-seq
MIRT2684788	hsa-miR-1255b	CLIP-seq
MIRT2269792	hsa-miR-143	CLIP-seq
MIRT2039988	hsa-miR-203	CLIP-seq
MIRT2039992	hsa-miR-3121-5p	CLIP-seq
MIRT2684789	hsa-miR-3134	CLIP-seq
MIRT2568918	hsa-miR-3148	CLIP-seq
MIRT2568920	hsa-miR-3607-5p	CLIP-seq
MIRT2568921	hsa-miR-3657	CLIP-seq
MIRT2568922	hsa-miR-374a	CLIP-seq
MIRT2568923	hsa-miR-374b	CLIP-seq
MIRT2438546	hsa-miR-3919	CLIP-seq
MIRT2438547	hsa-miR-4424	CLIP-seq
MIRT2568926	hsa-miR-4496	CLIP-seq
MIRT2568929	hsa-miR-4669	CLIP-seq
MIRT2568931	hsa-miR-4711-5p	CLIP-seq
MIRT2438548	hsa-miR-4756-3p	CLIP-seq
MIRT2269804	hsa-miR-4770	CLIP-seq
MIRT2269810	hsa-miR-548c-3p	CLIP-seq
MIRT2438549	hsa-miR-586	CLIP-seq
MIRT2568934	hsa-miR-603	CLIP-seq

Show/Hide all (27)

GO ID	Ontology	Definition	Evidence	Reference
GO:0003712	Function	Transcription coregulator activity	IBA
GO:0003712	Function	Transcription coregulator activity	IDA	10198638
GO:0003712	Function	Transcription coregulator activity	IEA
GO:0003713	Function	Transcription coactivator activity	IDA	12037571, 12218053
GO:0003713	Function	Transcription coactivator activity	NAS	10235266
GO:0003713	Function	Transcription coactivator activity	TAS	9989412
GO:0005515	Function	Protein binding	IPI	24882805, 25281560, 25792360, 33961781, 35271311
GO:0005634	Component	Nucleus	IDA	10235267, 24882805
GO:0005634	Component	Nucleus	IEA
GO:0005654	Component	Nucleoplasm	TAS
GO:0006357	Process	Regulation of transcription by RNA polymerase II	IBA
GO:0006357	Process	Regulation of transcription by RNA polymerase II	IEA
GO:0006357	Process	Regulation of transcription by RNA polymerase II	TAS	9989412
GO:0016020	Component	Membrane	HDA	19946888
GO:0016592	Component	Mediator complex	IBA
GO:0016592	Component	Mediator complex	IDA	10198638, 12037571
GO:0016592	Component	Mediator complex	IEA
GO:0032968	Process	Positive regulation of transcription elongation by RNA polymerase II	NAS	11559591
GO:0035019	Process	Somatic stem cell population maintenance	IEA
GO:0042809	Function	Nuclear vitamin D receptor binding	NAS	10235266
GO:0045893	Process	Positive regulation of DNA-templated transcription	IDA	10198638
GO:0045944	Process	Positive regulation of transcription by RNA polymerase II	IDA	12037571
GO:0051123	Process	RNA polymerase II preinitiation complex assembly	NAS	11559591
GO:0060261	Process	Positive regulation of transcription initiation by RNA polymerase II	IDA	12218053
GO:0060261	Process	Positive regulation of transcription initiation by RNA polymerase II	NAS	11559591
GO:0070847	Component	Core mediator complex	IBA
GO:0070847	Component	Core mediator complex	IPI	24882805

MIM	HGNC	e!Ensembl
300182	2370	ENSG00000180182

O60244

Protein name

Mediator of RNA polymerase II transcription subunit 14 (Activator-recruited cofactor 150 kDa component) (ARC150) (Cofactor required for Sp1 transcriptional activation subunit 2) (CRSP complex subunit 2) (Mediator complex subunit 14) (RGR1 homolog) (hRGR1)

Protein function

Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RN

PDB

7EMF , 7ENA , 7ENC , 7ENJ , 7LBM , 7NVR , 8GXQ , 8GXS , 8T9D , 8TQW , 8TRH

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF08638	Med14	49 → 238	Mediator complex subunit MED14	Family

Tissue specificity

TISSUE SPECIFICITY: Ubiquitous.

Sequence

MAPVQLENHQLVPPGGGGGGSGGPPSAPAPPPPGAAVAAAAAAAASPGYRLSTLIEFLLH
RAYSELMVLTDLLPRKSDVERKIEIVQFASRTRQLFVRLLALVKWANNAGKVEKCAMISS
FLDQQAILFVDTADRLASLARDALVHARLPSFAIPYAIDVLTTGSYPRLPTCIRDKIIPP
DPITKIEKQATLHQLNQILRHRLVTTDLPPQLANLTVANGRVKFRVEGEFEATLTVMGDD
PDVPWRLLKLEILVEDKETGDGRALVHSMQISFIHQLVQSRLFADEKPLQDMYNCLHSFC
LSLQLEVLHSQTLMLIRERWGDLVQVERYHAGKCLSLSVWNQQVLGRKTGTASVHKVTIK
IDENDVSKPLQIFHDPPLPASDSKLVERAMKIDHLSIEKLLIDSVHARAHQKLQELKAIL
RGFNANENSSIETALPALVVPILEPCGNSECLHIFVDLHSGMFQLMLYGLDQATLDDMEK
SVNDDMKRIIPWIQQLKFWLGQQRCKQSIKHLPTISSETLQLSNYSTHPIGNLSKNKLFI
KLTRLPQYYIVVEMLEVPNKPTQLSYKYYFMSVNAADREDSPAMALLLQQFKENIQDLVF
RTKTGKQTRTNAKRKLSDDPCPVESKKTKRAGEMCAFNKVLAHFVAMCDTNMPFVGLRLE
LSNLEIPHQGVQVEGDGFSHAIRLLKIPPCKGITEETQKALDRSLLDCTFRLQGRNNRTW
VAELVFANCPLNGTSTREQGPSRHVYLTYENLLSEPVGGRKVVEMFLNDWNSIARLYECV
LEFARSLPDIPAHLNIFSEVRVYNYRKLILCYGTTKGSSISIQWNSIHQKFHISLGTVGP
NSGCSNCHNTILHQLQEMFNKTPNVVQLLQVLFDTQAPLNAINKLPTVPMLGLTQRTNTA
YQCFSILPQSSTHIRLAFRNMYCIDIYCRSRGVVAIRDGAYSLFDNSKLVEGFYPAPGLK
TFLNMFVDSNQDARRRSVNEDDNPPSPIGGDMMDSLISQLQPPPQQQPFPKQPGTSGAYP
LTSPPTSYHSTVNQSPSMMHTQSPGNLHAASSPSGALRAPSPASFVPTPPPSSHGISIGP
GASFASPHGTLDPSSPYTMVSPSGRAGNWPGSPQVSGPSPAARMPGMSPANPSLHSPVPD
ASHSPRAGTSSQTMPTNMPPPRKLPQRSWAASIPTILTHSALNILLLPSPTPGLVPGLAG
SYLCSPLERFLGSVIMRRHLQRIIQQETLQLINSNEPGVIMFKTDALKCRVALSPKTNQT
LQLKVTPENAGQWKPDELQVLEKFFETRVAGPPFKANTLIAFTKLLGAPTHILRDCVHIM
KLELFPDQATQLKWNVQFCLTIPPSAPPIAPPGTPAVVLKSKMLFFLQLTQKTSVPPQEP
VSIIVPIIYDMASGTTQQADIPRQQNSSVAAPMMVSNILKRFAEMNPPRQGECTIFAAVR
DLMANLTLPPGGRP

Sequence length

1454

Interactions

View interactions

	KEGG		Reactome
	Thyroid hormone signaling pathway		PPARA activates gene expression Generic Transcription Pathway Transcriptional regulation of white adipocyte differentiation

Show/Hide Unknown Diseases (4)

Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession
Unknown Diseases with uncertain, conflicting, or no pathogenic evidence in ClinVar
EBV-positive nodal T- and NK-cell lymphoma	Likely benign	rs2519084219	RCV004557795
Intellectual disability	Likely benign; Uncertain significance; Conflicting classifications of pathogenicity	rs755442697, rs149954074, rs145739870	RCV001252066 RCV001252065 RCV001252067
Neurodevelopmental disorder	Uncertain significance	rs2146606969	RCV001375022
Thyroid cancer, nonmedullary, 1	Uncertain significance	rs200941559	RCV005939029

Show/Hide Text Mining Associations (7)

Disease Name	Relationship Type	References
Associations from Text MiningDisease associations identified through Pubtator
Breast Neoplasms	Associate	15625066, 17306756
Carcinogenesis	Associate	31695025
Immunologic Deficiency Syndromes	Associate	35597241
Lupus Erythematosus Systemic	Associate	19793680
Neoplasms	Inhibit	31695025
Prostatic Neoplasms	Associate	31501863
Ventricular Remodeling	Inhibit	39302489

MED14 (mediator complex subunit 14)