CYTH2 (cytohesin 2)
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Gene
Gene information from NCBI Gene database.
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| Entrez ID | 9266 |
| Gene name | Cytohesin 2 |
| Gene symbol | CYTH2 |
| Synonyms (NCBI Gene) |
ARNOCTS18CTS18.1PSCD2PSCD2LSEC7LSec7p-LSec7p-likecytohesin-2
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| Chromosome | 19 |
| Chromosome location | 19q13.33 |
| Summary | The protein encoded by this gene is a member of the PSCD family. Members of this family have identical structural organization that consists of an N-terminal coiled-coil motif, a central Sec7 domain, and a C-terminal pleckstrin homology (PH) domain. The c |
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miRNA
miRNA information provided by mirtarbase database.
374
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Gene ontology (GO)
Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
25
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Other IDs
Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
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Protein
Protein information from UniProt database.
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UniProt ID
Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
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Q99418 | |||||||||||||||
| Protein name | Cytohesin-2 (ARF exchange factor) (ARF nucleotide-binding site opener) (Protein ARNO) (PH, SEC7 and coiled-coil domain-containing protein 2) | |||||||||||||||
| Protein function | Acts as a guanine-nucleotide exchange factor (GEF). Promotes guanine-nucleotide exchange on ARF1, ARF3 and ARF6. Activates ARF factors through replacement of GDP with GTP (By similarity). The cell membrane form, in association with ARL4 proteins | |||||||||||||||
| PDB | 1PBV , 1R8M , 1R8Q , 1R8S , 1S9D , 4JMI , 4JMO , 4JWL , 4JXH , 4L5M , 4Z21 | |||||||||||||||
| Family and domains |
Pfam
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| Tissue specificity | TISSUE SPECIFICITY: Widely expressed. {ECO:0000305|PubMed:9417041}. | |||||||||||||||
| Sequence |
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| Sequence length | 400 | |||||||||||||||
| Interactions | View interactions | |||||||||||||||
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Pathways
Pathway information has different metabolic/signaling pathways associated with genes.
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Associated diseases
Disease associations from ClinVar (causal & non-causal) and other databases (OMIM, Orphanet, GWAS, etc.).
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Evidence Score:
★☆☆☆☆ Gene-disease association found in Text Mining only
★★☆☆☆ Found in Text Mining and Unknown/Other Associations
★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources
★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
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