Gene Gene information from NCBI Gene database.
Entrez ID 9266
Gene name Cytohesin 2
Gene symbol CYTH2
Synonyms (NCBI Gene)
ARNOCTS18CTS18.1PSCD2PSCD2LSEC7LSec7p-LSec7p-likecytohesin-2
Chromosome 19
Chromosome location 19q13.33
Summary The protein encoded by this gene is a member of the PSCD family. Members of this family have identical structural organization that consists of an N-terminal coiled-coil motif, a central Sec7 domain, and a C-terminal pleckstrin homology (PH) domain. The c
miRNA miRNA information provided by mirtarbase database.
374
miRTarBase ID miRNA Experiments Reference
MIRT030082 hsa-miR-26b-5p Microarray 19088304
MIRT045806 hsa-miR-191-5p CLASH 23622248
MIRT712531 hsa-miR-744-5p HITS-CLIP 19536157
MIRT712530 hsa-miR-500b-3p HITS-CLIP 19536157
MIRT715570 hsa-miR-6736-3p HITS-CLIP 19536157
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
25
GO ID Ontology Definition Evidence Reference
GO:0000139 Component Golgi membrane IEA
GO:0000139 Component Golgi membrane TAS
GO:0005085 Function Guanyl-nucleotide exchange factor activity IBA
GO:0005085 Function Guanyl-nucleotide exchange factor activity IEA
GO:0005085 Function Guanyl-nucleotide exchange factor activity ISS
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
602488 9502 ENSG00000105443
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
Q99418
Protein name Cytohesin-2 (ARF exchange factor) (ARF nucleotide-binding site opener) (Protein ARNO) (PH, SEC7 and coiled-coil domain-containing protein 2)
Protein function Acts as a guanine-nucleotide exchange factor (GEF). Promotes guanine-nucleotide exchange on ARF1, ARF3 and ARF6. Activates ARF factors through replacement of GDP with GTP (By similarity). The cell membrane form, in association with ARL4 proteins
PDB 1PBV , 1R8M , 1R8Q , 1R8S , 1S9D , 4JMI , 4JMO , 4JWL , 4JXH , 4L5M , 4Z21
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF01369 Sec7 61 243 Sec7 domain Domain
PF00169 PH 260 376 PH domain Domain
Tissue specificity TISSUE SPECIFICITY: Widely expressed. {ECO:0000305|PubMed:9417041}.
Sequence
Sequence length 400
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG  Reactome
  Phospholipase D signaling pathway
Endocytosis
Pathogenic Escherichia coli infection
Shigellosis
Salmonella infection
  Intra-Golgi traffic
Associated diseases Disease associations from ClinVar (causal & non-causal) and other databases (OMIM, Orphanet, GWAS, etc.).
1
Evidence Score: ★☆☆☆☆  Gene-disease association found in Text Mining only ★★☆☆☆  Found in Text Mining and Unknown/Other Associations ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Phenotype Name Clinical Significance Source Evidence Score
IGA GLOMERULONEPHRITIS GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Associations from Text MiningDisease associations identified through Pubtator
Disease Name Relationship Type References Evidence Score
Colorectal Neoplasms Associate 37728516
★☆☆☆☆
Found in Text Mining only
Colorectal Neoplasms Hereditary Nonpolyposis Associate 37728516
★☆☆☆☆
Found in Text Mining only
Endometrial Neoplasms Associate 37728516
★☆☆☆☆
Found in Text Mining only
Glucosephosphate Dehydrogenase Deficiency Associate 37728516
★☆☆☆☆
Found in Text Mining only
Inflammation Associate 30355448
★☆☆☆☆
Found in Text Mining only
Inflammatory Bowel Diseases Associate 30355448
★☆☆☆☆
Found in Text Mining only
Influenza Human Associate 35354039
★☆☆☆☆
Found in Text Mining only
Ovarian Neoplasms Associate 37577760
★☆☆☆☆
Found in Text Mining only
Virus Diseases Associate 35354039
★☆☆☆☆
Found in Text Mining only