STK17A (serine/threonine kinase 17a)

Gene

• Entrez ID: 9263
• Gene name: Serine/threonine kinase 17a
• Gene symbol: STK17A
• Synonyms (NCBI Gene): DRAK1
• Chromosome: 7
• Chromosome location: 7p13
• Summary: This gene is a member of the DAP kinase-related apoptosis-inducing protein kinase family and encodes an autophosphorylated nuclear protein with a protein kinase domain. The protein has apoptosis-inducing activity. [provided by RefSeq, Jul 2008]

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT647688	hsa-miR-6783-5p	HITS-CLIP	23824327
MIRT647687	hsa-miR-4639-3p	HITS-CLIP	23824327
MIRT647686	hsa-miR-8060	HITS-CLIP	23824327
MIRT629759	hsa-miR-7110-3p	HITS-CLIP	23824327
MIRT629758	hsa-miR-6817-3p	HITS-CLIP	23824327
MIRT629757	hsa-miR-6728-3p	HITS-CLIP	23824327
MIRT629756	hsa-miR-767-3p	HITS-CLIP	23824327
MIRT629755	hsa-miR-1301-5p	HITS-CLIP	23824327
MIRT629754	hsa-miR-6502-5p	HITS-CLIP	23824327
MIRT647685	hsa-miR-6824-5p	HITS-CLIP	23824327
MIRT629753	hsa-miR-6873-3p	HITS-CLIP	23824327
MIRT629752	hsa-miR-6828-3p	HITS-CLIP	23824327
MIRT629759	hsa-miR-7110-3p	HITS-CLIP	23824327
MIRT629758	hsa-miR-6817-3p	HITS-CLIP	23824327
MIRT629757	hsa-miR-6728-3p	HITS-CLIP	23824327
MIRT629756	hsa-miR-767-3p	HITS-CLIP	23824327
MIRT629755	hsa-miR-1301-5p	HITS-CLIP	23824327
MIRT629754	hsa-miR-6502-5p	HITS-CLIP	23824327
MIRT629753	hsa-miR-6873-3p	HITS-CLIP	23824327
MIRT629752	hsa-miR-6828-3p	HITS-CLIP	23824327
MIRT446838	hsa-miR-148a-5p	PAR-CLIP	22100165
MIRT446837	hsa-miR-5680	PAR-CLIP	22100165
MIRT446836	hsa-miR-3668	PAR-CLIP	22100165
MIRT450061	hsa-miR-1250-3p	PAR-CLIP	22100165
MIRT446835	hsa-miR-4635	PAR-CLIP	22100165
MIRT446834	hsa-miR-4670-3p	PAR-CLIP	22100165
MIRT446833	hsa-miR-3616-5p	PAR-CLIP	22100165
MIRT446832	hsa-miR-573	PAR-CLIP	22100165
MIRT446831	hsa-miR-1305	PAR-CLIP	22100165
MIRT446838	hsa-miR-148a-5p	PAR-CLIP	22100165
MIRT446837	hsa-miR-5680	PAR-CLIP	22100165
MIRT446836	hsa-miR-3668	PAR-CLIP	22100165
MIRT446835	hsa-miR-4635	PAR-CLIP	22100165
MIRT446834	hsa-miR-4670-3p	PAR-CLIP	22100165
MIRT446833	hsa-miR-3616-5p	PAR-CLIP	22100165
MIRT446832	hsa-miR-573	PAR-CLIP	22100165
MIRT446831	hsa-miR-1305	PAR-CLIP	22100165
MIRT446830	hsa-miR-548a-3p	PAR-CLIP	22100165
MIRT446829	hsa-miR-548ar-3p	PAR-CLIP	22100165
MIRT446828	hsa-miR-548az-3p	PAR-CLIP	22100165
MIRT446827	hsa-miR-548e-3p	PAR-CLIP	22100165
MIRT446826	hsa-miR-548f-3p	PAR-CLIP	22100165
MIRT446825	hsa-miR-5582-3p	PAR-CLIP	22100165
MIRT446824	hsa-miR-3920	PAR-CLIP	22100165
MIRT446823	hsa-miR-29a-5p	PAR-CLIP	22100165
MIRT446822	hsa-miR-3192-3p	PAR-CLIP	22100165
MIRT446820	hsa-miR-4762-3p	PAR-CLIP	22100165
MIRT735374	hsa-miR-411-5p	Luciferase reporter assay, Western blotting, qRT-PCR, Flow cytometry	31746360
MIRT647688	hsa-miR-6783-5p	HITS-CLIP	23824327
MIRT647687	hsa-miR-4639-3p	HITS-CLIP	23824327
MIRT647686	hsa-miR-8060	HITS-CLIP	23824327
MIRT629759	hsa-miR-7110-3p	HITS-CLIP	23824327
MIRT629758	hsa-miR-6817-3p	HITS-CLIP	23824327
MIRT629757	hsa-miR-6728-3p	HITS-CLIP	23824327
MIRT629756	hsa-miR-767-3p	HITS-CLIP	23824327
MIRT629755	hsa-miR-1301-5p	HITS-CLIP	23824327
MIRT629754	hsa-miR-6502-5p	HITS-CLIP	23824327
MIRT647685	hsa-miR-6824-5p	HITS-CLIP	23824327
MIRT629753	hsa-miR-6873-3p	HITS-CLIP	23824327
MIRT629752	hsa-miR-6828-3p	HITS-CLIP	23824327
MIRT629759	hsa-miR-7110-3p	HITS-CLIP	23824327
MIRT629758	hsa-miR-6817-3p	HITS-CLIP	23824327
MIRT629757	hsa-miR-6728-3p	HITS-CLIP	23824327
MIRT629756	hsa-miR-767-3p	HITS-CLIP	23824327
MIRT629755	hsa-miR-1301-5p	HITS-CLIP	23824327
MIRT629754	hsa-miR-6502-5p	HITS-CLIP	23824327
MIRT629753	hsa-miR-6873-3p	HITS-CLIP	23824327
MIRT629752	hsa-miR-6828-3p	HITS-CLIP	23824327
MIRT446838	hsa-miR-148a-5p	PAR-CLIP	22100165
MIRT446837	hsa-miR-5680	PAR-CLIP	22100165
MIRT446836	hsa-miR-3668	PAR-CLIP	22100165
MIRT450061	hsa-miR-1250-3p	PAR-CLIP	22100165
MIRT446835	hsa-miR-4635	PAR-CLIP	22100165
MIRT446834	hsa-miR-4670-3p	PAR-CLIP	22100165
MIRT446833	hsa-miR-3616-5p	PAR-CLIP	22100165
MIRT446832	hsa-miR-573	PAR-CLIP	22100165
MIRT446831	hsa-miR-1305	PAR-CLIP	22100165
MIRT446838	hsa-miR-148a-5p	PAR-CLIP	22100165
MIRT446837	hsa-miR-5680	PAR-CLIP	22100165
MIRT446836	hsa-miR-3668	PAR-CLIP	22100165
MIRT446835	hsa-miR-4635	PAR-CLIP	22100165
MIRT446834	hsa-miR-4670-3p	PAR-CLIP	22100165
MIRT446833	hsa-miR-3616-5p	PAR-CLIP	22100165
MIRT446832	hsa-miR-573	PAR-CLIP	22100165
MIRT446831	hsa-miR-1305	PAR-CLIP	22100165
MIRT446830	hsa-miR-548a-3p	PAR-CLIP	22100165
MIRT446829	hsa-miR-548ar-3p	PAR-CLIP	22100165
MIRT446828	hsa-miR-548az-3p	PAR-CLIP	22100165
MIRT446827	hsa-miR-548e-3p	PAR-CLIP	22100165
MIRT446826	hsa-miR-548f-3p	PAR-CLIP	22100165
MIRT446825	hsa-miR-5582-3p	PAR-CLIP	22100165
MIRT446824	hsa-miR-3920	PAR-CLIP	22100165
MIRT446823	hsa-miR-29a-5p	PAR-CLIP	22100165
MIRT446822	hsa-miR-3192-3p	PAR-CLIP	22100165
MIRT446820	hsa-miR-4762-3p	PAR-CLIP	22100165
MIRT1397277	hsa-miR-1208	CLIP-seq
MIRT1397278	hsa-miR-125a-3p	CLIP-seq
MIRT1397279	hsa-miR-1262	CLIP-seq
MIRT1397280	hsa-miR-1286	CLIP-seq
MIRT1397281	hsa-miR-1302	CLIP-seq
MIRT1397282	hsa-miR-18a	CLIP-seq
MIRT1397283	hsa-miR-18b	CLIP-seq
MIRT1397284	hsa-miR-214	CLIP-seq
MIRT1397285	hsa-miR-3120-3p	CLIP-seq
MIRT1397286	hsa-miR-3122	CLIP-seq
MIRT1397287	hsa-miR-3143	CLIP-seq
MIRT1397288	hsa-miR-3151	CLIP-seq
MIRT1397289	hsa-miR-3169	CLIP-seq
MIRT1397290	hsa-miR-3187-3p	CLIP-seq
MIRT1397291	hsa-miR-34c-3p	CLIP-seq
MIRT1397292	hsa-miR-3619-5p	CLIP-seq
MIRT1397293	hsa-miR-3688-5p	CLIP-seq
MIRT1397294	hsa-miR-377	CLIP-seq
MIRT1397295	hsa-miR-3913-5p	CLIP-seq
MIRT1397296	hsa-miR-3942-5p	CLIP-seq
MIRT1397297	hsa-miR-3945	CLIP-seq
MIRT1397298	hsa-miR-4257	CLIP-seq
MIRT1397299	hsa-miR-4298	CLIP-seq
MIRT1397300	hsa-miR-4318	CLIP-seq
MIRT1397301	hsa-miR-4435	CLIP-seq
MIRT1397302	hsa-miR-4447	CLIP-seq
MIRT1397303	hsa-miR-4472	CLIP-seq
MIRT1397304	hsa-miR-4515	CLIP-seq
MIRT1397305	hsa-miR-4539	CLIP-seq
MIRT1397306	hsa-miR-4672	CLIP-seq
MIRT1397307	hsa-miR-4701-3p	CLIP-seq
MIRT1397308	hsa-miR-4701-5p	CLIP-seq
MIRT1397309	hsa-miR-4703-5p	CLIP-seq
MIRT1397310	hsa-miR-4724-5p	CLIP-seq
MIRT1397311	hsa-miR-4735-3p	CLIP-seq
MIRT1397312	hsa-miR-486-3p	CLIP-seq
MIRT1397313	hsa-miR-491-5p	CLIP-seq
MIRT1397314	hsa-miR-543	CLIP-seq
MIRT1397315	hsa-miR-548ac	CLIP-seq
MIRT1397316	hsa-miR-548ae	CLIP-seq
MIRT1397317	hsa-miR-548aj	CLIP-seq
MIRT1397318	hsa-miR-548am	CLIP-seq
MIRT1397319	hsa-miR-548d-3p	CLIP-seq
MIRT1397320	hsa-miR-548s	CLIP-seq
MIRT1397321	hsa-miR-548x	CLIP-seq
MIRT1397322	hsa-miR-548z	CLIP-seq
MIRT1397323	hsa-miR-552	CLIP-seq
MIRT1397324	hsa-miR-588	CLIP-seq
MIRT1397325	hsa-miR-618	CLIP-seq
MIRT1397326	hsa-miR-656	CLIP-seq
MIRT1397327	hsa-miR-761	CLIP-seq
MIRT2118981	hsa-miR-1297	CLIP-seq
MIRT2118982	hsa-miR-26a	CLIP-seq
MIRT2118983	hsa-miR-26b	CLIP-seq
MIRT2118984	hsa-miR-4465	CLIP-seq
MIRT2118985	hsa-miR-466	CLIP-seq
MIRT2118986	hsa-miR-4719	CLIP-seq
MIRT2118981	hsa-miR-1297	CLIP-seq
MIRT2341289	hsa-miR-145	CLIP-seq
MIRT2118982	hsa-miR-26a	CLIP-seq
MIRT2118983	hsa-miR-26b	CLIP-seq
MIRT1397290	hsa-miR-3187-3p	CLIP-seq
MIRT1397298	hsa-miR-4257	CLIP-seq
MIRT1397301	hsa-miR-4435	CLIP-seq
MIRT2341290	hsa-miR-4436b-5p	CLIP-seq
MIRT2118984	hsa-miR-4465	CLIP-seq
MIRT2341291	hsa-miR-4666-5p	CLIP-seq
MIRT1397308	hsa-miR-4701-5p	CLIP-seq
MIRT2341292	hsa-miR-4712-5p	CLIP-seq
MIRT2341293	hsa-miR-4755-3p	CLIP-seq
MIRT2341294	hsa-miR-4795-5p	CLIP-seq
MIRT1397320	hsa-miR-548s	CLIP-seq
MIRT1397324	hsa-miR-588	CLIP-seq
MIRT2341295	hsa-miR-770-5p	CLIP-seq
MIRT2440858	hsa-miR-514	CLIP-seq
MIRT2440859	hsa-miR-514b-3p	CLIP-seq
MIRT2440860	hsa-miR-599	CLIP-seq
MIRT2635198	hsa-miR-1207-5p	CLIP-seq
MIRT2635199	hsa-miR-1909	CLIP-seq
MIRT2635200	hsa-miR-1912	CLIP-seq
MIRT2635201	hsa-miR-3126-5p	CLIP-seq
MIRT2635202	hsa-miR-3607-5p	CLIP-seq
MIRT2635203	hsa-miR-3646	CLIP-seq
MIRT2635204	hsa-miR-3650	CLIP-seq
MIRT2635205	hsa-miR-3659	CLIP-seq
MIRT2635206	hsa-miR-3677-5p	CLIP-seq
MIRT2635207	hsa-miR-3689d	CLIP-seq
MIRT2635208	hsa-miR-3925-5p	CLIP-seq
MIRT2635209	hsa-miR-3926	CLIP-seq
MIRT2635210	hsa-miR-3942-3p	CLIP-seq
MIRT2635211	hsa-miR-3976	CLIP-seq
MIRT1397298	hsa-miR-4257	CLIP-seq
MIRT2635212	hsa-miR-4419a	CLIP-seq
MIRT2635213	hsa-miR-4510	CLIP-seq
MIRT2635214	hsa-miR-4658	CLIP-seq
MIRT2635215	hsa-miR-4696	CLIP-seq
MIRT2635216	hsa-miR-4723-5p	CLIP-seq
MIRT2635217	hsa-miR-4736	CLIP-seq
MIRT2341293	hsa-miR-4755-3p	CLIP-seq
MIRT2635218	hsa-miR-4763-3p	CLIP-seq
MIRT2635219	hsa-miR-4773	CLIP-seq
MIRT2341294	hsa-miR-4795-5p	CLIP-seq
MIRT1397320	hsa-miR-548s	CLIP-seq
MIRT2635220	hsa-miR-574-5p	CLIP-seq
MIRT2635221	hsa-miR-646	CLIP-seq
MIRT2692233	hsa-miR-1206	CLIP-seq
MIRT2692234	hsa-miR-130a	CLIP-seq
MIRT2692235	hsa-miR-130b	CLIP-seq
MIRT2692236	hsa-miR-219-1-3p	CLIP-seq
MIRT2692237	hsa-miR-2467-3p	CLIP-seq
MIRT2692238	hsa-miR-301a	CLIP-seq
MIRT2692239	hsa-miR-301b	CLIP-seq
MIRT2635201	hsa-miR-3126-5p	CLIP-seq
MIRT2692240	hsa-miR-3179	CLIP-seq
MIRT2635203	hsa-miR-3646	CLIP-seq
MIRT2635204	hsa-miR-3650	CLIP-seq
MIRT2635205	hsa-miR-3659	CLIP-seq
MIRT2692241	hsa-miR-3666	CLIP-seq
MIRT2635206	hsa-miR-3677-5p	CLIP-seq
MIRT2692242	hsa-miR-3678-3p	CLIP-seq
MIRT2635207	hsa-miR-3689d	CLIP-seq
MIRT2692243	hsa-miR-376a	CLIP-seq
MIRT2692244	hsa-miR-376b	CLIP-seq
MIRT2635209	hsa-miR-3926	CLIP-seq
MIRT2692245	hsa-miR-4295	CLIP-seq
MIRT2635212	hsa-miR-4419a	CLIP-seq
MIRT2692246	hsa-miR-4475	CLIP-seq
MIRT2635213	hsa-miR-4510	CLIP-seq
MIRT2692247	hsa-miR-454	CLIP-seq
MIRT2635214	hsa-miR-4658	CLIP-seq
MIRT2692248	hsa-miR-4671-3p	CLIP-seq
MIRT2692249	hsa-miR-4682	CLIP-seq
MIRT2635216	hsa-miR-4723-5p	CLIP-seq
MIRT2341293	hsa-miR-4755-3p	CLIP-seq
MIRT2341294	hsa-miR-4795-5p	CLIP-seq
MIRT1397320	hsa-miR-548s	CLIP-seq
MIRT2692250	hsa-miR-571	CLIP-seq
MIRT2635220	hsa-miR-574-5p	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000166	Function	Nucleotide binding	IEA
GO:0004672	Function	Protein kinase activity	IEA
GO:0004674	Function	Protein serine/threonine kinase activity	IBA
GO:0004674	Function	Protein serine/threonine kinase activity	IDA	9786912
GO:0004674	Function	Protein serine/threonine kinase activity	IEA
GO:0005524	Function	ATP binding	IDA	9786912
GO:0005524	Function	ATP binding	IEA
GO:0005634	Component	Nucleus	IBA
GO:0005634	Component	Nucleus	IDA	9786912
GO:0005634	Component	Nucleus	IEA
GO:0005886	Component	Plasma membrane	IDA
GO:0006468	Process	Protein phosphorylation	IDA	9786912
GO:0006915	Process	Apoptotic process	IEA
GO:0016301	Function	Kinase activity	IEA
GO:0016607	Component	Nuclear speck	IDA
GO:0016740	Function	Transferase activity	IEA
GO:0035556	Process	Intracellular signal transduction	IBA
GO:0035556	Process	Intracellular signal transduction	IDA	9786912
GO:0035556	Process	Intracellular signal transduction	IEA
GO:0043065	Process	Positive regulation of apoptotic process	IBA
GO:0043065	Process	Positive regulation of apoptotic process	IMP	21489989
GO:0106310	Function	Protein serine kinase activity	IEA
GO:2000271	Process	Positive regulation of fibroblast apoptotic process	IEA
GO:2000271	Process	Positive regulation of fibroblast apoptotic process	IMP	9786912
GO:2000377	Process	Regulation of reactive oxygen species metabolic process	IMP	21489989

Other IDs

• MIM: 604726
• HGNC: 11395
• e!Ensembl: ENSG00000164543

Protein

• UniProt ID: Q9UEE5
• Protein name: Serine/threonine-protein kinase 17A (EC 2.7.11.1) (DAP kinase-related apoptosis-inducing protein kinase 1)
• Protein function: Acts as a positive regulator of apoptosis. Also acts as a regulator of cellular reactive oxygen species.
• PDB: 7QUE, 7QUF
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00069	Pkinase	62 → 321	Protein kinase domain	Domain

• Tissue specificity: TISSUE SPECIFICITY: Highly expressed in placenta. Lower levels in heart, lung, skeletal muscle, kidney and pancreas. {ECO:0000269|PubMed:9786912}.
• Sequence:

  MIPLEKPGSGGSSPGATSGSGRAGRGLSGPCRPPPPPQARGLLTEIRAVVRTEPFQDGYS
  LCPGRELGRGKFAVVRKCIKKDSGKEFAAKFMRKRRKGQDCRMEIIHEIAVLELAQDNPW
  VINLHEVYETASEMILVLEYAAGGEIFDQCVADREEAFKEKDVQRLMRQILEGVHFLHTR
  DVVHLDLKPQNILLTSESPLGDIKIVDFGLSRILKNSEELREIMGTPEYVAPEILSYDPI
  SMATDMWSIGVLTYVMLTGISPFLGNDKQETFLNISQMNLSYSEEEFDVLSESAVDFIRT
  LLVKKPEDRATAEECLKHPWLTQSSIQEPSFRMEKALEEANALQEGHSVPEINSDTDKSE
  TKESIVTEELIVVTSYTLGQCRQSEKEKMEQKAISKRFKFEEPLLQEIPGEFIY

• Sequence length: 414

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Unknown / Other Associations
Phenotype Name	Clinical Significance	Source	Evidence Score
IRRITABLE BOWEL SYNDROME	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
PATELLAR TENDINITIS	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Associations from Text Mining
Disease Name	Relationship Type	References	Evidence Score
Arthritis Rheumatoid	Stimulate	18302252	★☆☆☆☆ Found in Text Mining only
Calcinosis Cutis	Inhibit	30655319	★☆☆☆☆ Found in Text Mining only
Colorectal Neoplasms	Associate	30655319	★☆☆☆☆ Found in Text Mining only
Glioblastoma	Associate	24312360	★☆☆☆☆ Found in Text Mining only
Glioma	Stimulate	24312360	★☆☆☆☆ Found in Text Mining only
Leukemia	Associate	37370186	★☆☆☆☆ Found in Text Mining only
Lymphatic Metastasis	Stimulate	33955523	★☆☆☆☆ Found in Text Mining only
Memory Disorders	Associate	18302252	★☆☆☆☆ Found in Text Mining only
Neoplasm Metastasis	Associate	30655319	★☆☆☆☆ Found in Text Mining only
Neoplasms	Stimulate	33955523	★☆☆☆☆ Found in Text Mining only
Neoplasms	Associate	35194034	★☆☆☆☆ Found in Text Mining only
Stomach Neoplasms	Associate	33955523	★☆☆☆☆ Found in Text Mining only
Uterine Cervical Neoplasms	Associate	24403257, 31746360, 35194034	★☆☆☆☆ Found in Text Mining only