Gene Gene information from NCBI Gene database.
Entrez ID 9262
Gene name Serine/threonine kinase 17b
Gene symbol STK17B
Synonyms (NCBI Gene)
DRAK2
Chromosome 2
Chromosome location 2q32.3
miRNA miRNA information provided by mirtarbase database.
663
miRTarBase ID miRNA Experiments Reference
MIRT026577 hsa-miR-192-5p Microarray 19074876
MIRT027654 hsa-miR-98-5p Microarray 19088304
MIRT622021 hsa-miR-183-5p HITS-CLIP 23824327
MIRT622020 hsa-miR-96-5p HITS-CLIP 23824327
MIRT622019 hsa-miR-1271-5p HITS-CLIP 23824327
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
30
GO ID Ontology Definition Evidence Reference
GO:0000166 Function Nucleotide binding IEA
GO:0004672 Function Protein kinase activity IEA
GO:0004672 Function Protein kinase activity ISS
GO:0004674 Function Protein serine/threonine kinase activity IBA
GO:0004674 Function Protein serine/threonine kinase activity IDA 9786912
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
604727 11396 ENSG00000081320
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
O94768
Protein name Serine/threonine-protein kinase 17B (EC 2.7.11.1) (DAP kinase-related apoptosis-inducing protein kinase 2)
Protein function Phosphorylates myosin light chains (By similarity). Acts as a positive regulator of apoptosis.
PDB 3LM0 , 3LM5 , 6QF4 , 6Y6F , 6Y6H , 6ZJF , 7AKG , 7Q7C , 7Q7D , 7Q7E
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00069 Pkinase 33 293 Protein kinase domain Domain
Tissue specificity TISSUE SPECIFICITY: Highly expressed in placenta, lung, pancreas. Lower levels in heart, brain, liver, skeletal muscle and kidney. {ECO:0000269|PubMed:9786912}.
Sequence
Sequence length 372
Interactions View interactions
Associated diseases Disease associations from ClinVar (causal & non-causal) and other databases (OMIM, Orphanet, GWAS, etc.).
2
Evidence Score: ★☆☆☆☆  Gene-disease association found in Text Mining only ★★☆☆☆  Found in Text Mining and Unknown/Other Associations ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Phenotype Name Clinical Significance Source Evidence Score
MAJOR DEPRESSIVE DISORDER GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
TYPE 2 DIABETES MELLITUS GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Associations from Text MiningDisease associations identified through Pubtator
Disease Name Relationship Type References Evidence Score
Adenoma Stimulate 35260162
★☆☆☆☆
Found in Text Mining only
Carcinoma Hepatocellular Associate 23651211
★☆☆☆☆
Found in Text Mining only
Colorectal Neoplasms Inhibit 19638987
★☆☆☆☆
Found in Text Mining only
Idiopathic Pulmonary Fibrosis Associate 22506007
★☆☆☆☆
Found in Text Mining only
Leukemia Lymphocytic Chronic B Cell Associate 33081245
★☆☆☆☆
Found in Text Mining only
Melanoma Associate 35171924
★☆☆☆☆
Found in Text Mining only
Melanoma Cutaneous Malignant Inhibit 35171924
★☆☆☆☆
Found in Text Mining only
Neoplasms Associate 19638987, 23651211
★☆☆☆☆
Found in Text Mining only
Osteoporosis Associate 39778696
★☆☆☆☆
Found in Text Mining only
Thyroid Cancer Papillary Associate 24086368
★☆☆☆☆
Found in Text Mining only