Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
9261
Gene name Gene Name - the full gene name approved by the HGNC.
MAPK activated protein kinase 2
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
MAPKAPK2
Synonyms (NCBI Gene) Gene synonyms aliases
MAPKAP-K2, MK-2, MK2
Chromosome Chromosome number
1
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
1q32.1
Summary Summary of gene provided in NCBI Entrez Gene.
This gene encodes a member of the Ser/Thr protein kinase family. This kinase is regulated through direct phosphorylation by p38 MAP kinase. In conjunction with p38 MAP kinase, this kinase is known to be involved in many cellular processes including stress
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT022202 hsa-miR-124-3p Microarray 18668037
MIRT043144 hsa-miR-324-5p CLASH 23622248
MIRT043144 hsa-miR-324-5p CLASH 23622248
MIRT041511 hsa-miR-193b-3p CLASH 23622248
MIRT040005 hsa-miR-615-3p CLASH 23622248
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0000165 Process MAPK cascade TAS 8179591
GO:0000187 Process Activation of MAPK activity TAS
GO:0002224 Process Toll-like receptor signaling pathway IBA 21873635
GO:0002224 Process Toll-like receptor signaling pathway ISS
GO:0004672 Function Protein kinase activity TAS 8179591
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
602006 6887 ENSG00000162889
Protein
UniProt ID P49137
Protein name MAP kinase-activated protein kinase 2 (MAPK-activated protein kinase 2) (MAPKAP kinase 2) (MAPKAP-K2) (MAPKAPK-2) (MK-2) (MK2) (EC 2.7.11.1)
Protein function Stress-activated serine/threonine-protein kinase involved in cytokine production, endocytosis, reorganization of the cytoskeleton, cell migration, cell cycle control, chromatin remodeling, DNA damage response and transcriptional regulation. Foll
PDB 1KWP , 1NXK , 1NY3 , 2JBO , 2JBP , 2OKR , 2ONL , 2OZA , 2P3G , 2PZY , 3A2C , 3FPM , 3FYJ , 3FYK , 3GOK , 3KA0 , 3KC3 , 3KGA , 3M2W , 3M42 , 3R2B , 3R2Y , 3R30 , 3WI6 , 4TYH , 6T8X , 6TCA , 7NRY , 8XU4 , 8XX1
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00069 Pkinase 64 325 Protein kinase domain Domain
Tissue specificity TISSUE SPECIFICITY: Expressed in all tissues examined.
Sequence
Sequence length 400
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG   Reactome
  MAPK signaling pathway
Efferocytosis
Cellular senescence
VEGF signaling pathway
C-type lectin receptor signaling pathway
Neurotrophin signaling pathway
Kaposi sarcoma-associated herpesvirus infection
Viral carcinogenesis
  p38MAPK events
CREB phosphorylation
Synthesis of Leukotrienes (LT) and Eoxins (EX)
Oxidative Stress Induced Senescence
Regulation of HSF1-mediated heat shock response
VEGFA-VEGFR2 Pathway
activated TAK1 mediates p38 MAPK activation
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA
Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Unknown
Disease term Disease name Evidence References Source
Crohn Disease Crohn Disease GWAS
Associations from Text Mining
Disease Name Relationship Type References
Acne Vulgaris Associate 37018476
Adenocarcinoma of Lung Associate 36878491
alpha 1 Antitrypsin Deficiency Associate 29238183
Aortic Dissection Associate 37684281
Arthritis Juvenile Associate 23094074
Breast Neoplasms Associate 12377770
Carcinogenesis Associate 22883146
Carcinoma Non Small Cell Lung Inhibit 36878491
Colorectal Neoplasms Associate 27107574, 31575657
Drug Related Side Effects and Adverse Reactions Associate 21470196