Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways
Entrez ID	9260
Gene name	PDZ and LIM domain 7
Gene symbol	PDLIM7
Synonyms (NCBI Gene)	LMP1LMP3
Chromosome	5
Chromosome location	5q35.3
Summary	The protein encoded by this gene is representative of a family of proteins composed of conserved PDZ and LIM domains. LIM domains are proposed to function in protein-protein recognition in a variety of contexts including gene transcription and development

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miRTarBase ID	miRNA	Experiments	Reference
MIRT001351	hsa-miR-1-3p	pSILAC	18668040
MIRT006185	ebv-miR-BHRF1-2-3p	ImmunoprecipitaionqRT-PCRWestern blot	21379335
MIRT006185	ebv-miR-BHRF1-2-3p	ImmunoprecipitaionqRT-PCRWestern blot	21379335
MIRT006185	ebv-miR-BHRF1-2-3p	ImmunoprecipitaionqRT-PCRWestern blot	21379335
MIRT002914	hsa-miR-124-3p	Proteomics;Microarray	18668037
MIRT001351	hsa-miR-1-3p	Proteomics;Microarray	18668037
MIRT001351	hsa-miR-1-3p	Proteomics	18668040
MIRT028432	hsa-miR-30a-5p	Proteomics	18668040
MIRT030427	hsa-miR-24-3p	Microarray	19748357
MIRT045848	hsa-miR-132-3p	CLASH	23622248
MIRT054644	hsa-miR-17-5p	Luciferase reporter assayqRT-PCRWestern blot	24257599
MIRT440011	hsa-miR-218-5p	HITS-CLIP	23212916
MIRT440011	hsa-miR-218-5p	HITS-CLIP	23212916
MIRT1222313	hsa-miR-1225-3p	CLIP-seq
MIRT1222314	hsa-miR-1915	CLIP-seq
MIRT1222315	hsa-miR-3065-3p	CLIP-seq
MIRT1222316	hsa-miR-3155	CLIP-seq
MIRT1222317	hsa-miR-3155b	CLIP-seq
MIRT1222318	hsa-miR-3165	CLIP-seq
MIRT1222319	hsa-miR-3181	CLIP-seq
MIRT1222320	hsa-miR-323-5p	CLIP-seq
MIRT1222321	hsa-miR-4270	CLIP-seq
MIRT1222322	hsa-miR-4323	CLIP-seq
MIRT1222323	hsa-miR-4441	CLIP-seq
MIRT1222324	hsa-miR-4640-5p	CLIP-seq
MIRT1222325	hsa-miR-4726-5p	CLIP-seq
MIRT1222326	hsa-miR-484	CLIP-seq
MIRT1222327	hsa-miR-876-3p	CLIP-seq
MIRT1222328	hsa-let-7a	CLIP-seq
MIRT1222329	hsa-let-7b	CLIP-seq
MIRT1222330	hsa-let-7c	CLIP-seq
MIRT1222331	hsa-let-7d	CLIP-seq
MIRT1222332	hsa-let-7e	CLIP-seq
MIRT1222333	hsa-let-7f	CLIP-seq
MIRT1222334	hsa-let-7g	CLIP-seq
MIRT1222335	hsa-let-7i	CLIP-seq
MIRT1222336	hsa-miR-1294	CLIP-seq
MIRT1222337	hsa-miR-202	CLIP-seq
MIRT1222338	hsa-miR-2682	CLIP-seq
MIRT1222339	hsa-miR-298	CLIP-seq
MIRT1222340	hsa-miR-4458	CLIP-seq
MIRT1222341	hsa-miR-449c	CLIP-seq
MIRT1222342	hsa-miR-4500	CLIP-seq
MIRT1222343	hsa-miR-4710	CLIP-seq
MIRT1222344	hsa-miR-940	CLIP-seq
MIRT1222345	hsa-miR-98	CLIP-seq
MIRT2064421	hsa-miR-124	CLIP-seq
MIRT1222319	hsa-miR-3181	CLIP-seq
MIRT2064422	hsa-miR-3714	CLIP-seq
MIRT2064423	hsa-miR-3910	CLIP-seq
MIRT1222324	hsa-miR-4640-5p	CLIP-seq
MIRT1222325	hsa-miR-4726-5p	CLIP-seq
MIRT2064424	hsa-miR-506	CLIP-seq
MIRT2064425	hsa-miR-665	CLIP-seq
MIRT2292754	hsa-miR-583	CLIP-seq
MIRT2392335	hsa-miR-138	CLIP-seq
MIRT1222315	hsa-miR-3065-3p	CLIP-seq
MIRT1222318	hsa-miR-3165	CLIP-seq
MIRT1222320	hsa-miR-323-5p	CLIP-seq
MIRT2392336	hsa-miR-3650	CLIP-seq
MIRT2392337	hsa-miR-3689d	CLIP-seq
MIRT2392338	hsa-miR-4435	CLIP-seq
MIRT2392339	hsa-miR-4492	CLIP-seq
MIRT2392340	hsa-miR-4498	CLIP-seq
MIRT2392341	hsa-miR-488	CLIP-seq
MIRT2392342	hsa-miR-644	CLIP-seq
MIRT2392343	hsa-miR-663b	CLIP-seq
MIRT2392344	hsa-miR-762	CLIP-seq
MIRT1222327	hsa-miR-876-3p	CLIP-seq
MIRT2590757	hsa-miR-3688-5p	CLIP-seq
MIRT2392337	hsa-miR-3689d	CLIP-seq
MIRT2590758	hsa-miR-4474-3p	CLIP-seq
MIRT2590757	hsa-miR-3688-5p	CLIP-seq
MIRT2392337	hsa-miR-3689d	CLIP-seq
MIRT2590758	hsa-miR-4474-3p	CLIP-seq

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Transcription factor	Regulation	Reference
IRF5	Repression	16140744

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GO ID	Ontology	Definition	Evidence	Reference
GO:0001503	Process	Ossification	IEA
GO:0001725	Component	Stress fiber	IBA
GO:0001725	Component	Stress fiber	IEA
GO:0001726	Component	Ruffle	IEA
GO:0003779	Function	Actin binding	IBA
GO:0005515	Function	Protein binding	IPI	16189514, 16713569, 23088713, 25036637, 25416956, 28514442, 29892012, 31515488, 32296183, 33961781
GO:0005654	Component	Nucleoplasm	IDA
GO:0005737	Component	Cytoplasm	IEA
GO:0005829	Component	Cytosol	TAS
GO:0005856	Component	Cytoskeleton	IEA
GO:0005912	Component	Adherens junction	IBA
GO:0005912	Component	Adherens junction	IDA	25468996
GO:0005925	Component	Focal adhesion	IDA
GO:0006898	Process	Receptor-mediated endocytosis	TAS	7929196
GO:0007507	Process	Heart development	IBA
GO:0015629	Component	Actin cytoskeleton	IDA
GO:0030018	Component	Z disc	IBA
GO:0030036	Process	Actin cytoskeleton organization	IBA
GO:0030036	Process	Actin cytoskeleton organization	IEA
GO:0030154	Process	Cell differentiation	IEA
GO:0031941	Component	Filamentous actin	IBA
GO:0046872	Function	Metal ion binding	IEA
GO:0051371	Function	Muscle alpha-actinin binding	IBA
GO:0061061	Process	Muscle structure development	IBA

MIM	HGNC	e!Ensembl
605903	22958	ENSG00000196923

Q9NR12

Protein name

PDZ and LIM domain protein 7 (LIM mineralization protein) (LMP) (Protein enigma)

Protein function

May function as a scaffold on which the coordinated assembly of proteins can occur. May play a role as an adapter that, via its PDZ domain, localizes LIM-binding proteins to actin filaments of both skeletal muscle and nonmuscle tissues. Involved

PDB

2Q3G , 7RM8

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00595	PDZ	3 → 82	PDZ domain	Domain
PF00412	LIM	282 → 337	LIM domain	Domain
PF00412	LIM	341 → 396	LIM domain	Domain
PF00412	LIM	400 → 457	LIM domain	Domain

Tissue specificity

TISSUE SPECIFICITY: Isoform 1 and isoform 2 are expressed ubiquitously, however, isoform 2 predominates in skeletal muscle, isoform 1 is more abundant in lung, spleen, leukocytes and fetal liver. {ECO:0000269|PubMed:11874232}.

Sequence

MDSFKVVLEGPAPWGFRLQGGKDFNVPLSISRLTPGGKAAQAGVAVGDWVLSIDGENAGS
LTHIEAQNKIRACGERLSLGLSRAQPVQSKPQKASAPAADPPRYTFAPSVSLNKTARPFG
APPPADSAPQQNGQPLRPLVPDASKQRLMENTEDWRPRPGTGQSRSFRILAHLTGTEFMQ
DPDEEHLKKSSQVPRTEAPAPASSTPQEPWPGPTAPSPTSRPPWAVDPAFAERYAPDKTS
TVLTRHSQPATPTPLQSRTSIVQAAAGGVPGGGSNNGKTPVCHQCHKVIRGRYLVALGHA
YHPEEFVCSQCGKVLEEGGFFEEKGAIFCPPCYDVRYAPSCAKCKKKITGEIMHALKMTW
HVHCFTCAACKTPIRNRAFYMEEGVPYCERDYEKMFGTKCHGCDFKIDAGDRFLEALGFS
WHDTCFVCAICQINLEGKTFYSKKDRPLCKSHAFSHV

Sequence length

457

Interactions

View interactions

	KEGG		Reactome
	Cytoskeleton in muscle cells		RET signaling

PDLIM7 (PDZ and LIM domain 7)