LDHAL6B (lactate dehydrogenase A like 6B)

Gene

• Entrez ID: 92483
• Gene name: Lactate dehydrogenase A like 6B
• Gene symbol: LDHAL6B
• Synonyms (NCBI Gene): LDH6B, LDHAL6, LDHL
• Chromosome: 15
• Chromosome location: 15q22.2

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT1106391	hsa-miR-302a	CLIP-seq
MIRT1106392	hsa-miR-302b	CLIP-seq
MIRT1106393	hsa-miR-302c	CLIP-seq
MIRT1106394	hsa-miR-302d	CLIP-seq
MIRT1106395	hsa-miR-302e	CLIP-seq
MIRT1106396	hsa-miR-31	CLIP-seq
MIRT1106397	hsa-miR-372	CLIP-seq
MIRT1106398	hsa-miR-373	CLIP-seq
MIRT1106399	hsa-miR-410	CLIP-seq
MIRT1106400	hsa-miR-512-3p	CLIP-seq
MIRT1106401	hsa-miR-520a-3p	CLIP-seq
MIRT1106402	hsa-miR-520b	CLIP-seq
MIRT1106403	hsa-miR-520c-3p	CLIP-seq
MIRT1106404	hsa-miR-520d-3p	CLIP-seq
MIRT1106405	hsa-miR-520e	CLIP-seq
MIRT1921259	hsa-miR-1276	CLIP-seq
MIRT1921260	hsa-miR-3135b	CLIP-seq
MIRT1921261	hsa-miR-4487	CLIP-seq
MIRT1921262	hsa-miR-4759	CLIP-seq
MIRT1921263	hsa-miR-765	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0003824	Function	Catalytic activity	IEA
GO:0004459	Function	L-lactate dehydrogenase (NAD+) activity	IBA
GO:0004459	Function	L-lactate dehydrogenase (NAD+) activity	IEA
GO:0004459	Function	L-lactate dehydrogenase (NAD+) activity	TAS
GO:0005515	Function	Protein binding	IPI	12107167, 32814053
GO:0005634	Component	Nucleus	HDA	21630459
GO:0005737	Component	Cytoplasm	IDA	18351441
GO:0005737	Component	Cytoplasm	IEA
GO:0005739	Component	Mitochondrion	IBA
GO:0005759	Component	Mitochondrial matrix	TAS
GO:0006089	Process	Lactate metabolic process	IBA
GO:0006089	Process	Lactate metabolic process	IDA	18351441
GO:0016491	Function	Oxidoreductase activity	IEA
GO:0016616	Function	Oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	IEA
GO:0019752	Process	Carboxylic acid metabolic process	IEA
GO:0042867	Process	Pyruvate catabolic process	IBA
GO:1990204	Component	Oxidoreductase complex	NAS	18351441

Other IDs

• MIM: HGNC
• HGNC: N/A
• e!Ensembl: HGNC

Protein

• UniProt ID: Q9BYZ2
• Protein name: L-lactate dehydrogenase A-like 6B (EC 1.1.1.27)
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00056	Ldh_1_N	70 → 209	lactate/malate dehydrogenase, NAD binding domain	Family
  PF02866	Ldh_1_C	212 → 380	lactate/malate dehydrogenase, alpha/beta C-terminal domain	Domain

• Tissue specificity: TISSUE SPECIFICITY: Testis specific.
• Sequence:

  MSWTVPVVRASQRVSSVGANFLCLGMALCPRQATRIPLNGTWLFTPVSKMATVKSELIER
  FTSEKPVHHSKVSIIGTGSVGMACAISILLKGLSDELALVDLDEDKLKGETMDLQHGSPF
  TKMPNIVCSKDYFVTANSNLVIITAGARQEKGETRLNLVQRNVAIFKLMISSIVQYSPHC
  KLIIVSNPVDILTYVAWKLSAFPKNRIIGSGCNLDTARFRFLIGQKLGIHSESCHGWILG
  EHGDSSVPVWSGVNIAGVPLKDLNSDIGTDKDPEQWKNVHKEVTATAYEIIKMKGYTSWA
  IGLSVADLTESILKNLRRIHPVSTIIKGLYGIDEEVFLSIPCILGENGITNLIKIKLTPE
  EEAHLKKSAKTLWEIQNKLKL

• Sequence length: 381

Pathways

KEGG:

Glycolysis / Gluconeogenesis
Cysteine and methionine metabolism
Pyruvate metabolism
Propanoate metabolism
Metabolic pathways
HIF-1 signaling pathway
Glucagon signaling pathway
Central carbon metabolism in cancer

Reactome:

Pyruvate metabolism