Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	9246
Gene name	Ubiquitin conjugating enzyme E2 L6
Gene symbol	UBE2L6
Synonyms (NCBI Gene)	RIG-BUBCH8
Chromosome	11
Chromosome location	11q12.1
Summary	The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes (E1s), ubiquitin-conjuga

273

Show/Hide all (273)

miRTarBase ID	miRNA	Experiments
MIRT1468298	hsa-miR-1470	CLIP-seq
MIRT1468299	hsa-miR-4287	CLIP-seq
MIRT1468300	hsa-miR-4667-3p	CLIP-seq
MIRT1468301	hsa-miR-4685-3p	CLIP-seq
MIRT1468302	hsa-miR-642a	CLIP-seq
MIRT1468303	hsa-miR-1269	CLIP-seq
MIRT1468304	hsa-miR-1269b	CLIP-seq
MIRT1468305	hsa-miR-1287	CLIP-seq
MIRT1468306	hsa-miR-1288	CLIP-seq
MIRT1468307	hsa-miR-3135b	CLIP-seq
MIRT1468308	hsa-miR-331-3p	CLIP-seq
MIRT1468309	hsa-miR-3690	CLIP-seq
MIRT1468310	hsa-miR-378	CLIP-seq
MIRT1468311	hsa-miR-378b	CLIP-seq
MIRT1468312	hsa-miR-378c	CLIP-seq
MIRT1468313	hsa-miR-378d	CLIP-seq
MIRT1468314	hsa-miR-378e	CLIP-seq
MIRT1468315	hsa-miR-378f	CLIP-seq
MIRT1468316	hsa-miR-378h	CLIP-seq
MIRT1468317	hsa-miR-378i	CLIP-seq
MIRT1468318	hsa-miR-422a	CLIP-seq
MIRT1468319	hsa-miR-4308	CLIP-seq
MIRT1468320	hsa-miR-4515	CLIP-seq
MIRT1468321	hsa-miR-4740-5p	CLIP-seq
MIRT2361695	hsa-miR-2355-5p	CLIP-seq
MIRT2655456	hsa-miR-1	CLIP-seq
MIRT2655457	hsa-miR-103b	CLIP-seq
MIRT2655458	hsa-miR-1224-3p	CLIP-seq
MIRT2655459	hsa-miR-1225-3p	CLIP-seq
MIRT2655460	hsa-miR-1233	CLIP-seq
MIRT2655461	hsa-miR-125a-3p	CLIP-seq
MIRT2655462	hsa-miR-1260	CLIP-seq
MIRT2655463	hsa-miR-1260b	CLIP-seq
MIRT2655464	hsa-miR-1280	CLIP-seq
MIRT1468305	hsa-miR-1287	CLIP-seq
MIRT2655465	hsa-miR-134	CLIP-seq
MIRT2655466	hsa-miR-140-5p	CLIP-seq
MIRT2655467	hsa-miR-146a	CLIP-seq
MIRT2655468	hsa-miR-146b-5p	CLIP-seq
MIRT1468298	hsa-miR-1470	CLIP-seq
MIRT2655469	hsa-miR-148a	CLIP-seq
MIRT2655470	hsa-miR-148b	CLIP-seq
MIRT2655471	hsa-miR-150	CLIP-seq
MIRT2655472	hsa-miR-152	CLIP-seq
MIRT2655473	hsa-miR-1825	CLIP-seq
MIRT2655474	hsa-miR-185	CLIP-seq
MIRT2655475	hsa-miR-1910	CLIP-seq
MIRT2655476	hsa-miR-193a-3p	CLIP-seq
MIRT2655477	hsa-miR-193b	CLIP-seq
MIRT2655478	hsa-miR-199a-5p	CLIP-seq
MIRT2655479	hsa-miR-199b-5p	CLIP-seq
MIRT2655480	hsa-miR-2052	CLIP-seq
MIRT2655481	hsa-miR-206	CLIP-seq
MIRT2655482	hsa-miR-2110	CLIP-seq
MIRT2655483	hsa-miR-2276	CLIP-seq
MIRT2361695	hsa-miR-2355-5p	CLIP-seq
MIRT2655484	hsa-miR-2392	CLIP-seq
MIRT2655485	hsa-miR-3074-5p	CLIP-seq
MIRT2655486	hsa-miR-31	CLIP-seq
MIRT2655487	hsa-miR-3118	CLIP-seq
MIRT2655488	hsa-miR-3120-5p	CLIP-seq
MIRT2655489	hsa-miR-3121-3p	CLIP-seq
MIRT2655490	hsa-miR-3129-3p	CLIP-seq
MIRT1468307	hsa-miR-3135b	CLIP-seq
MIRT2655491	hsa-miR-3148	CLIP-seq
MIRT2655492	hsa-miR-3154	CLIP-seq
MIRT2655493	hsa-miR-3164	CLIP-seq
MIRT2655494	hsa-miR-3174	CLIP-seq
MIRT2655495	hsa-miR-3176	CLIP-seq
MIRT2655496	hsa-miR-3192	CLIP-seq
MIRT2655497	hsa-miR-3202	CLIP-seq
MIRT2655498	hsa-miR-326	CLIP-seq
MIRT2655499	hsa-miR-330-5p	CLIP-seq
MIRT2655500	hsa-miR-3646	CLIP-seq
MIRT2655501	hsa-miR-3650	CLIP-seq
MIRT2655502	hsa-miR-3653	CLIP-seq
MIRT2655503	hsa-miR-3657	CLIP-seq
MIRT2655504	hsa-miR-3661	CLIP-seq
MIRT2655505	hsa-miR-3662	CLIP-seq
MIRT2655506	hsa-miR-3922-3p	CLIP-seq
MIRT2655507	hsa-miR-3942-3p	CLIP-seq
MIRT2655508	hsa-miR-4264	CLIP-seq
MIRT2655509	hsa-miR-4271	CLIP-seq
MIRT2655510	hsa-miR-4278	CLIP-seq
MIRT2655511	hsa-miR-4283	CLIP-seq
MIRT1468299	hsa-miR-4287	CLIP-seq
MIRT2655512	hsa-miR-4306	CLIP-seq
MIRT2655513	hsa-miR-4320	CLIP-seq
MIRT2655514	hsa-miR-4421	CLIP-seq
MIRT2655515	hsa-miR-4426	CLIP-seq
MIRT2655516	hsa-miR-4434	CLIP-seq
MIRT2655517	hsa-miR-4435	CLIP-seq
MIRT2655518	hsa-miR-4444	CLIP-seq
MIRT2655519	hsa-miR-4450	CLIP-seq
MIRT2655520	hsa-miR-4455	CLIP-seq
MIRT2655521	hsa-miR-4487	CLIP-seq
MIRT2655522	hsa-miR-4495	CLIP-seq
MIRT2655523	hsa-miR-4516	CLIP-seq
MIRT2655524	hsa-miR-4525	CLIP-seq
MIRT2655525	hsa-miR-4531	CLIP-seq
MIRT2655526	hsa-miR-4534	CLIP-seq
MIRT2655527	hsa-miR-455-3p	CLIP-seq
MIRT2655528	hsa-miR-4640-5p	CLIP-seq
MIRT2655529	hsa-miR-4644	CLIP-seq
MIRT2655530	hsa-miR-4647	CLIP-seq
MIRT2655531	hsa-miR-4648	CLIP-seq
MIRT2655532	hsa-miR-4650-5p	CLIP-seq
MIRT2655533	hsa-miR-4654	CLIP-seq
MIRT2655534	hsa-miR-4661-3p	CLIP-seq
MIRT2655535	hsa-miR-4662b	CLIP-seq
MIRT1468300	hsa-miR-4667-3p	CLIP-seq
MIRT2655536	hsa-miR-4667-5p	CLIP-seq
MIRT2655537	hsa-miR-4668-5p	CLIP-seq
MIRT2655538	hsa-miR-4669	CLIP-seq
MIRT1468301	hsa-miR-4685-3p	CLIP-seq
MIRT2655539	hsa-miR-4690-5p	CLIP-seq
MIRT2655540	hsa-miR-4700-5p	CLIP-seq
MIRT2655541	hsa-miR-4708-3p	CLIP-seq
MIRT2655542	hsa-miR-4713-5p	CLIP-seq
MIRT2655543	hsa-miR-4714-3p	CLIP-seq
MIRT2655544	hsa-miR-4715-5p	CLIP-seq
MIRT2655545	hsa-miR-4716-3p	CLIP-seq
MIRT2655546	hsa-miR-4725-3p	CLIP-seq
MIRT2655547	hsa-miR-4726-5p	CLIP-seq
MIRT2655548	hsa-miR-4731-3p	CLIP-seq
MIRT2655549	hsa-miR-4747-5p	CLIP-seq
MIRT2655550	hsa-miR-4757-5p	CLIP-seq
MIRT2655551	hsa-miR-4761-5p	CLIP-seq
MIRT2655552	hsa-miR-4769-5p	CLIP-seq
MIRT2655553	hsa-miR-4780	CLIP-seq
MIRT2655554	hsa-miR-4790-3p	CLIP-seq
MIRT2655555	hsa-miR-4801	CLIP-seq
MIRT2655556	hsa-miR-490-3p	CLIP-seq
MIRT2655557	hsa-miR-494	CLIP-seq
MIRT2655558	hsa-miR-515-3p	CLIP-seq
MIRT2655559	hsa-miR-519e	CLIP-seq
MIRT2655560	hsa-miR-532-3p	CLIP-seq
MIRT2655561	hsa-miR-550a	CLIP-seq
MIRT2655562	hsa-miR-571	CLIP-seq
MIRT2655563	hsa-miR-579	CLIP-seq
MIRT2655564	hsa-miR-593	CLIP-seq
MIRT2655565	hsa-miR-603	CLIP-seq
MIRT2655566	hsa-miR-604	CLIP-seq
MIRT2655567	hsa-miR-613	CLIP-seq
MIRT2655568	hsa-miR-623	CLIP-seq
MIRT2655569	hsa-miR-631	CLIP-seq
MIRT2655570	hsa-miR-637	CLIP-seq
MIRT1468302	hsa-miR-642a	CLIP-seq
MIRT2655571	hsa-miR-647	CLIP-seq
MIRT2655572	hsa-miR-663b	CLIP-seq
MIRT2655573	hsa-miR-664	CLIP-seq
MIRT2655574	hsa-miR-758	CLIP-seq
MIRT2655575	hsa-miR-760	CLIP-seq
MIRT2655456	hsa-miR-1	CLIP-seq
MIRT2655458	hsa-miR-1224-3p	CLIP-seq
MIRT2655459	hsa-miR-1225-3p	CLIP-seq
MIRT2655460	hsa-miR-1233	CLIP-seq
MIRT2655461	hsa-miR-125a-3p	CLIP-seq
MIRT2655462	hsa-miR-1260	CLIP-seq
MIRT2655463	hsa-miR-1260b	CLIP-seq
MIRT2655464	hsa-miR-1280	CLIP-seq
MIRT1468305	hsa-miR-1287	CLIP-seq
MIRT2655465	hsa-miR-134	CLIP-seq
MIRT2655466	hsa-miR-140-5p	CLIP-seq
MIRT2655467	hsa-miR-146a	CLIP-seq
MIRT2655468	hsa-miR-146b-5p	CLIP-seq
MIRT2655469	hsa-miR-148a	CLIP-seq
MIRT2655470	hsa-miR-148b	CLIP-seq
MIRT2655471	hsa-miR-150	CLIP-seq
MIRT2655472	hsa-miR-152	CLIP-seq
MIRT2655473	hsa-miR-1825	CLIP-seq
MIRT2655474	hsa-miR-185	CLIP-seq
MIRT2655475	hsa-miR-1910	CLIP-seq
MIRT2655476	hsa-miR-193a-3p	CLIP-seq
MIRT2655477	hsa-miR-193b	CLIP-seq
MIRT2655478	hsa-miR-199a-5p	CLIP-seq
MIRT2655479	hsa-miR-199b-5p	CLIP-seq
MIRT2655480	hsa-miR-2052	CLIP-seq
MIRT2655481	hsa-miR-206	CLIP-seq
MIRT2655482	hsa-miR-2110	CLIP-seq
MIRT2655483	hsa-miR-2276	CLIP-seq
MIRT2361695	hsa-miR-2355-5p	CLIP-seq
MIRT2655484	hsa-miR-2392	CLIP-seq
MIRT2655485	hsa-miR-3074-5p	CLIP-seq
MIRT2655486	hsa-miR-31	CLIP-seq
MIRT2655487	hsa-miR-3118	CLIP-seq
MIRT2655488	hsa-miR-3120-5p	CLIP-seq
MIRT2655489	hsa-miR-3121-3p	CLIP-seq
MIRT1468307	hsa-miR-3135b	CLIP-seq
MIRT2655491	hsa-miR-3148	CLIP-seq
MIRT2655492	hsa-miR-3154	CLIP-seq
MIRT2655493	hsa-miR-3164	CLIP-seq
MIRT2655494	hsa-miR-3174	CLIP-seq
MIRT2655495	hsa-miR-3176	CLIP-seq
MIRT2655496	hsa-miR-3192	CLIP-seq
MIRT2655497	hsa-miR-3202	CLIP-seq
MIRT2655498	hsa-miR-326	CLIP-seq
MIRT2655499	hsa-miR-330-5p	CLIP-seq
MIRT2655500	hsa-miR-3646	CLIP-seq
MIRT2655501	hsa-miR-3650	CLIP-seq
MIRT2655502	hsa-miR-3653	CLIP-seq
MIRT2655503	hsa-miR-3657	CLIP-seq
MIRT2655504	hsa-miR-3661	CLIP-seq
MIRT2655505	hsa-miR-3662	CLIP-seq
MIRT2655506	hsa-miR-3922-3p	CLIP-seq
MIRT2655507	hsa-miR-3942-3p	CLIP-seq
MIRT2655508	hsa-miR-4264	CLIP-seq
MIRT2655509	hsa-miR-4271	CLIP-seq
MIRT2655510	hsa-miR-4278	CLIP-seq
MIRT2655511	hsa-miR-4283	CLIP-seq
MIRT1468299	hsa-miR-4287	CLIP-seq
MIRT2655512	hsa-miR-4306	CLIP-seq
MIRT2655513	hsa-miR-4320	CLIP-seq
MIRT2655514	hsa-miR-4421	CLIP-seq
MIRT2655515	hsa-miR-4426	CLIP-seq
MIRT2655516	hsa-miR-4434	CLIP-seq
MIRT2655517	hsa-miR-4435	CLIP-seq
MIRT2655518	hsa-miR-4444	CLIP-seq
MIRT2655519	hsa-miR-4450	CLIP-seq
MIRT2655520	hsa-miR-4455	CLIP-seq
MIRT2655521	hsa-miR-4487	CLIP-seq
MIRT2655522	hsa-miR-4495	CLIP-seq
MIRT2655523	hsa-miR-4516	CLIP-seq
MIRT2655524	hsa-miR-4525	CLIP-seq
MIRT2655525	hsa-miR-4531	CLIP-seq
MIRT2655526	hsa-miR-4534	CLIP-seq
MIRT2655527	hsa-miR-455-3p	CLIP-seq
MIRT2655528	hsa-miR-4640-5p	CLIP-seq
MIRT2655529	hsa-miR-4644	CLIP-seq
MIRT2655530	hsa-miR-4647	CLIP-seq
MIRT2655531	hsa-miR-4648	CLIP-seq
MIRT2655532	hsa-miR-4650-5p	CLIP-seq
MIRT2655533	hsa-miR-4654	CLIP-seq
MIRT2655534	hsa-miR-4661-3p	CLIP-seq
MIRT2655535	hsa-miR-4662b	CLIP-seq
MIRT2655536	hsa-miR-4667-5p	CLIP-seq
MIRT2655537	hsa-miR-4668-5p	CLIP-seq
MIRT2655538	hsa-miR-4669	CLIP-seq
MIRT1468301	hsa-miR-4685-3p	CLIP-seq
MIRT2655539	hsa-miR-4690-5p	CLIP-seq
MIRT2655540	hsa-miR-4700-5p	CLIP-seq
MIRT2655541	hsa-miR-4708-3p	CLIP-seq
MIRT2655542	hsa-miR-4713-5p	CLIP-seq
MIRT2655543	hsa-miR-4714-3p	CLIP-seq
MIRT2655544	hsa-miR-4715-5p	CLIP-seq
MIRT2655545	hsa-miR-4716-3p	CLIP-seq
MIRT2655546	hsa-miR-4725-3p	CLIP-seq
MIRT2655547	hsa-miR-4726-5p	CLIP-seq
MIRT2655549	hsa-miR-4747-5p	CLIP-seq
MIRT2655550	hsa-miR-4757-5p	CLIP-seq
MIRT2655551	hsa-miR-4761-5p	CLIP-seq
MIRT2655552	hsa-miR-4769-5p	CLIP-seq
MIRT2655553	hsa-miR-4780	CLIP-seq
MIRT2655554	hsa-miR-4790-3p	CLIP-seq
MIRT2655556	hsa-miR-490-3p	CLIP-seq
MIRT2655557	hsa-miR-494	CLIP-seq
MIRT2655558	hsa-miR-515-3p	CLIP-seq
MIRT2655559	hsa-miR-519e	CLIP-seq
MIRT2655560	hsa-miR-532-3p	CLIP-seq
MIRT2655561	hsa-miR-550a	CLIP-seq
MIRT2655562	hsa-miR-571	CLIP-seq
MIRT2655563	hsa-miR-579	CLIP-seq
MIRT2655564	hsa-miR-593	CLIP-seq
MIRT2655566	hsa-miR-604	CLIP-seq
MIRT2655567	hsa-miR-613	CLIP-seq
MIRT2655568	hsa-miR-623	CLIP-seq
MIRT2655569	hsa-miR-631	CLIP-seq
MIRT2655570	hsa-miR-637	CLIP-seq
MIRT2655571	hsa-miR-647	CLIP-seq
MIRT2655572	hsa-miR-663b	CLIP-seq
MIRT2655573	hsa-miR-664	CLIP-seq
MIRT2655574	hsa-miR-758	CLIP-seq
MIRT2655575	hsa-miR-760	CLIP-seq

Show/Hide all (26)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000209	Process	Protein polyubiquitination	IBA
GO:0004842	Function	Ubiquitin-protein transferase activity	TAS	9153201
GO:0005515	Function	Protein binding	IPI	10085091, 12121982, 16427630, 16709802, 19549727, 19690564, 24446487, 25416956, 31515488, 32296183, 32814053, 33961781
GO:0005634	Component	Nucleus	IBA
GO:0005654	Component	Nucleoplasm	TAS
GO:0005737	Component	Cytoplasm	IC	16009940
GO:0005829	Component	Cytosol	TAS
GO:0006511	Process	Ubiquitin-dependent protein catabolic process	IBA
GO:0016567	Process	Protein ubiquitination	IEA
GO:0016740	Function	Transferase activity	IEA
GO:0019787	Function	Ubiquitin-like protein transferase activity	IEA
GO:0019941	Process	Modification-dependent protein catabolic process	IEA
GO:0032020	Process	ISG15-protein conjugation	IBA
GO:0032020	Process	ISG15-protein conjugation	IDA	16407192
GO:0032020	Process	ISG15-protein conjugation	IDA	15131269
GO:0032020	Process	ISG15-protein conjugation	IEA
GO:0032446	Process	Protein modification by small protein conjugation	IEA
GO:0036211	Process	Protein modification process	TAS	9153201
GO:0042296	Function	ISG15 transferase activity	IBA
GO:0042296	Function	ISG15 transferase activity	IDA	15131269
GO:0042296	Function	ISG15 transferase activity	IEA
GO:0043130	Function	Ubiquitin binding	EXP	15485925
GO:0045087	Process	Innate immune response	IDA	28724761
GO:0045087	Process	Innate immune response	IDA	28724761
GO:0061631	Function	Ubiquitin conjugating enzyme activity	IBA
GO:0061631	Function	Ubiquitin conjugating enzyme activity	IEA

MIM	HGNC	e!Ensembl
603890	12490	ENSG00000156587

O14933

Protein name

Ubiquitin/ISG15-conjugating enzyme E2 L6 (EC 2.3.2.23) (E2 ubiquitin-conjugating enzyme L6) (Retinoic acid-induced gene B protein) (RIG-B) (UbcH8) (Ubiquitin carrier protein L6) (Ubiquitin-protein ligase L6)

Protein function

Catalyzes the covalent attachment of ubiquitin or ISG15 to other proteins. Functions in the E6/E6-AP-induced ubiquitination of p53/TP53. Promotes ubiquitination and subsequent proteasomal degradation of FLT3. {ECO:0000269|PubMed:15131269, ECO:00

PDB

1WZV , 1WZW , 2KJH , 8OIF , 8SE9 , 8SEA , 8SEB , 8SV8

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00179	UQ_con	6 → 144	Ubiquitin-conjugating enzyme	Domain

Tissue specificity

TISSUE SPECIFICITY: Present in natural killer cells (at protein level). {ECO:0000269|PubMed:16709802}.

Sequence

MMASMRVVKELEDLQKKPPPYLRNLSSDDANVLVWHALLLPDQPPYHLKAFNLRISFPPE
YPFKPPMIKFTTKIYHPNVDENGQICLPIISSENWKPCTKTCQVLEALNVLVNRPNIREP
LRMDLADLLTQNPELFRKNAEEFTLRFGVDRPS

Sequence length

153

Interactions

View interactions

	KEGG		Reactome
	Ubiquitin mediated proteolysis Parkinson disease Pathways of neurodegeneration - multiple diseases		ISG15 antiviral mechanism DDX58/IFIH1-mediated induction of interferon-alpha/beta Termination of translesion DNA synthesis Negative regulators of DDX58/IFIH1 signaling Amyloid fiber formation Antigen processing: Ubiquitination & Proteasome degradation

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (1)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
NEUROTIC DISORDER	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (12)

Disease Name	Relationship Type	References	Evidence Score
Associations from Text MiningDisease associations identified through Pubtator
Breast Neoplasms	Associate	18566215, 22185919	★★★★★ ★☆☆☆☆ Found in Text Mining only
COVID 19	Associate	33242255	★★★★★ ★☆☆☆☆ Found in Text Mining only
Esophageal Neoplasms	Associate	28186990	★★★★★ ★☆☆☆☆ Found in Text Mining only
HIV Infections	Associate	37227817	★★★★★ ★☆☆☆☆ Found in Text Mining only
Inflammatory Bowel Diseases	Associate	22710419	★★★★★ ★☆☆☆☆ Found in Text Mining only
Leukemia	Associate	31820845	★★★★★ ★☆☆☆☆ Found in Text Mining only
Leukemia Myeloid Acute	Inhibit	31820845	★★★★★ ★☆☆☆☆ Found in Text Mining only
Leukemia Promyelocytic Acute	Associate	31820845	★★★★★ ★☆☆☆☆ Found in Text Mining only
Melanoma Cutaneous Malignant	Associate	32902917	★★★★★ ★☆☆☆☆ Found in Text Mining only
Migraine Disorders	Associate	39261750	★★★★★ ★☆☆☆☆ Found in Text Mining only
Nasopharyngeal Carcinoma	Associate	26506425	★★★★★ ★☆☆☆☆ Found in Text Mining only
Uterine Cervical Neoplasms	Associate	29157076	★★★★★ ★☆☆☆☆ Found in Text Mining only

UBE2L6 (ubiquitin conjugating enzyme E2 L6)