Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein
Entrez ID	92370
Gene name	2-phosphoxylose phosphatase 1
Gene symbol	PXYLP1
Synonyms (NCBI Gene)	ACPL2HEL124XYLP
Chromosome	3
Chromosome location	3q23

Show/Hide all (88)

miRTarBase ID	miRNA	Experiments	Reference
MIRT754165	hsa-miR-3666	PAR-CLIP	21572407
MIRT754166	hsa-miR-301b-3p	PAR-CLIP	21572407
MIRT754167	hsa-miR-454-3p	PAR-CLIP	21572407
MIRT754168	hsa-miR-4295	PAR-CLIP	21572407
MIRT754169	hsa-miR-301a-3p	PAR-CLIP	21572407
MIRT754170	hsa-miR-130a-3p	PAR-CLIP	21572407
MIRT754171	hsa-miR-130b-3p	PAR-CLIP	21572407
MIRT754172	hsa-miR-302a-3p	PAR-CLIP	21572407
MIRT754173	hsa-miR-520c-3p	PAR-CLIP	21572407
MIRT754174	hsa-miR-302c-3p	PAR-CLIP	21572407
MIRT754175	hsa-miR-520e	PAR-CLIP	21572407
MIRT754176	hsa-miR-302b-3p	PAR-CLIP	21572407
MIRT754177	hsa-miR-372-3p	PAR-CLIP	21572407
MIRT754178	hsa-miR-373-3p	PAR-CLIP	21572407
MIRT754179	hsa-miR-520a-3p	PAR-CLIP	21572407
MIRT754180	hsa-miR-520b	PAR-CLIP	21572407
MIRT754181	hsa-miR-302e	PAR-CLIP	21572407
MIRT754182	hsa-miR-520d-3p	PAR-CLIP	21572407
MIRT754183	hsa-miR-302d-3p	PAR-CLIP	21572407
MIRT754184	hsa-miR-106a-5p	PAR-CLIP	21572407
MIRT754185	hsa-miR-20a-5p	PAR-CLIP	21572407
MIRT754186	hsa-miR-93-5p	PAR-CLIP	21572407
MIRT754187	hsa-miR-526b-3p	PAR-CLIP	21572407
MIRT754188	hsa-miR-519d-3p	PAR-CLIP	21572407
MIRT754189	hsa-miR-20b-5p	PAR-CLIP	21572407
MIRT754190	hsa-miR-17-5p	PAR-CLIP	21572407
MIRT754191	hsa-miR-106b-5p	PAR-CLIP	21572407
MIRT754192	hsa-miR-519a-3p	PAR-CLIP	21572407
MIRT754193	hsa-miR-519b-3p	PAR-CLIP	21572407
MIRT754194	hsa-miR-519c-3p	PAR-CLIP	21572407
MIRT754195	hsa-miR-512-3p	PAR-CLIP	21572407
MIRT754196	hsa-miR-3651	PAR-CLIP	21572407
MIRT754197	hsa-miR-3973	PAR-CLIP	21572407
MIRT754198	hsa-miR-520g-3p	PAR-CLIP	21572407
MIRT754199	hsa-miR-520h	PAR-CLIP	21572407
MIRT754200	hsa-miR-371b-5p	PAR-CLIP	21572407
MIRT754201	hsa-miR-373-5p	PAR-CLIP	21572407
MIRT754202	hsa-miR-616-5p	PAR-CLIP	21572407
MIRT754203	hsa-miR-371a-5p	PAR-CLIP	21572407
MIRT754204	hsa-miR-372-5p	PAR-CLIP	21572407
MIRT754205	hsa-miR-3135b	PAR-CLIP	21572407
MIRT754206	hsa-miR-1287-5p	PAR-CLIP	21572407
MIRT754207	hsa-miR-513c-5p	PAR-CLIP	21572407
MIRT754208	hsa-miR-514b-5p	PAR-CLIP	21572407
MIRT754165	hsa-miR-3666	PAR-CLIP	23446348
MIRT754166	hsa-miR-301b-3p	PAR-CLIP	23446348
MIRT754167	hsa-miR-454-3p	PAR-CLIP	23446348
MIRT754168	hsa-miR-4295	PAR-CLIP	23446348
MIRT754169	hsa-miR-301a-3p	PAR-CLIP	23446348
MIRT754170	hsa-miR-130a-3p	PAR-CLIP	23446348
MIRT754171	hsa-miR-130b-3p	PAR-CLIP	23446348
MIRT754172	hsa-miR-302a-3p	PAR-CLIP	23446348
MIRT754173	hsa-miR-520c-3p	PAR-CLIP	23446348
MIRT754174	hsa-miR-302c-3p	PAR-CLIP	23446348
MIRT754175	hsa-miR-520e	PAR-CLIP	23446348
MIRT754176	hsa-miR-302b-3p	PAR-CLIP	23446348
MIRT754177	hsa-miR-372-3p	PAR-CLIP	23446348
MIRT754178	hsa-miR-373-3p	PAR-CLIP	23446348
MIRT754179	hsa-miR-520a-3p	PAR-CLIP	23446348
MIRT754180	hsa-miR-520b	PAR-CLIP	23446348
MIRT754181	hsa-miR-302e	PAR-CLIP	23446348
MIRT754182	hsa-miR-520d-3p	PAR-CLIP	23446348
MIRT754183	hsa-miR-302d-3p	PAR-CLIP	23446348
MIRT754184	hsa-miR-106a-5p	PAR-CLIP	23446348
MIRT754185	hsa-miR-20a-5p	PAR-CLIP	23446348
MIRT754186	hsa-miR-93-5p	PAR-CLIP	23446348
MIRT754187	hsa-miR-526b-3p	PAR-CLIP	23446348
MIRT754188	hsa-miR-519d-3p	PAR-CLIP	23446348
MIRT754189	hsa-miR-20b-5p	PAR-CLIP	23446348
MIRT754190	hsa-miR-17-5p	PAR-CLIP	23446348
MIRT754191	hsa-miR-106b-5p	PAR-CLIP	23446348
MIRT754192	hsa-miR-519a-3p	PAR-CLIP	23446348
MIRT754193	hsa-miR-519b-3p	PAR-CLIP	23446348
MIRT754194	hsa-miR-519c-3p	PAR-CLIP	23446348
MIRT754195	hsa-miR-512-3p	PAR-CLIP	23446348
MIRT754196	hsa-miR-3651	PAR-CLIP	23446348
MIRT754197	hsa-miR-3973	PAR-CLIP	23446348
MIRT754198	hsa-miR-520g-3p	PAR-CLIP	23446348
MIRT754199	hsa-miR-520h	PAR-CLIP	23446348
MIRT754200	hsa-miR-371b-5p	PAR-CLIP	23446348
MIRT754201	hsa-miR-373-5p	PAR-CLIP	23446348
MIRT754202	hsa-miR-616-5p	PAR-CLIP	23446348
MIRT754203	hsa-miR-371a-5p	PAR-CLIP	23446348
MIRT754204	hsa-miR-372-5p	PAR-CLIP	23446348
MIRT754205	hsa-miR-3135b	PAR-CLIP	23446348
MIRT754206	hsa-miR-1287-5p	PAR-CLIP	23446348
MIRT754207	hsa-miR-513c-5p	PAR-CLIP	23446348
MIRT754208	hsa-miR-514b-5p	PAR-CLIP	23446348

Show/Hide all (13)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000139	Component	Golgi membrane	IEA
GO:0005515	Function	Protein binding	IPI	24425863, 33961781
GO:0005794	Component	Golgi apparatus	IBA
GO:0005794	Component	Golgi apparatus	IDA	24425863
GO:0005794	Component	Golgi apparatus	IEA
GO:0006024	Process	Glycosaminoglycan biosynthetic process	IDA	24425863
GO:0010909	Process	Positive regulation of heparan sulfate proteoglycan biosynthetic process	IMP	24425863
GO:0016020	Component	Membrane	IEA
GO:0016787	Function	Hydrolase activity	IEA
GO:0016791	Function	Phosphatase activity	IBA
GO:0016791	Function	Phosphatase activity	IDA	24425863
GO:0050650	Process	Chondroitin sulfate proteoglycan biosynthetic process	IBA
GO:0050650	Process	Chondroitin sulfate proteoglycan biosynthetic process	IMP	24425863

MIM	HGNC	e!Ensembl
619732	26303	ENSG00000155893

Q8TE99

Protein name

2-phosphoxylose phosphatase 1 (EC 3.1.3.-) (Acid phosphatase-like protein 2) (Xylosyl phosphatase) (epididymis luminal protein 124)

Protein function

Responsible for the 2-O-dephosphorylation of xylose in the glycosaminoglycan-protein linkage region of proteoglycans thereby regulating the amount of mature glycosaminoglycan (GAG) chains. Sulfated glycosaminoglycans (GAGs), including heparan su

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00328	His_Phos_2	87 → 424	Histidine phosphatase superfamily (branch 2)	Family

Tissue specificity

TISSUE SPECIFICITY: Widely expressed. Strongly expressed in spleen, fetal liver, moderately in placenta, pancreas, kidney, thymus and colon. {ECO:0000269|PubMed:24425863}.

Sequence

MLFRNRFLLLLALAALLAFVSLSLQFFHLIPVSTPKNGMSSKSRKRIMPDPVTEPPVTDP
VYEALLYCNIPSVAERSMEGHAPHHFKLVSVHVFIRHGDRYPLYVIPKTKRPEIDCTLVA
NRKPYHPKLEAFISHMSKGSGASFESPLNSLPLYPNHPLCEMGELTQTGVVQHLQNGQLL
RDIYLKKHKLLPNDWSADQLYLETTGKSRTLQSGLALLYGFLPDFDWKKIYFRHQPSALF
CSGSCYCPVRNQYLEKEQRRQYLLRLKNSQLEKTYGEMAKIVDVPTKQLRAANPIDSMLC
HFCHNVSFPCTRNGCVDMEHFKVIKTHQIEDERERREKKLYFGYSLLGAHPILNQTIGRM
QRATEGRKEELFALYSAHDVTLSPVLSALGLSEARFPRFAARLIFELWQDREKPSEHSVR
ILYNGVDVTFHTSFCQDHHKRSPKPMCPLENLVRFVKRDMFVALGGSGTNYYDACHREGF

Sequence length

480

Interactions

View interactions

PXYLP1 (2-phosphoxylose phosphatase 1)