SPSB4 (splA/ryanodine receptor domain and SOCS box containing 4)

Gene

• Entrez ID: 92369
• Gene name: SplA/ryanodine receptor domain and SOCS box containing 4
• Gene symbol: SPSB4
• Synonyms (NCBI Gene): SSB-4, SSB4
• Chromosome: 3
• Chromosome location: 3q23

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT1386591	hsa-miR-145	CLIP-seq
MIRT1386592	hsa-miR-146a	CLIP-seq
MIRT1386593	hsa-miR-146b-5p	CLIP-seq
MIRT1386594	hsa-miR-15a	CLIP-seq
MIRT1386595	hsa-miR-15b	CLIP-seq
MIRT1386596	hsa-miR-16	CLIP-seq
MIRT1386597	hsa-miR-195	CLIP-seq
MIRT1386598	hsa-miR-2277-3p	CLIP-seq
MIRT1386599	hsa-miR-3133	CLIP-seq
MIRT1386600	hsa-miR-3140-5p	CLIP-seq
MIRT1386601	hsa-miR-3620	CLIP-seq
MIRT1386602	hsa-miR-3663-5p	CLIP-seq
MIRT1386603	hsa-miR-3919	CLIP-seq
MIRT1386604	hsa-miR-3925-5p	CLIP-seq
MIRT1386605	hsa-miR-424	CLIP-seq
MIRT1386606	hsa-miR-4457	CLIP-seq
MIRT1386607	hsa-miR-4467	CLIP-seq
MIRT1386608	hsa-miR-4504	CLIP-seq
MIRT1386609	hsa-miR-4511	CLIP-seq
MIRT1386610	hsa-miR-4519	CLIP-seq
MIRT1386611	hsa-miR-4677-3p	CLIP-seq
MIRT1386612	hsa-miR-4697-3p	CLIP-seq
MIRT1386613	hsa-miR-4704-3p	CLIP-seq
MIRT1386614	hsa-miR-4793-5p	CLIP-seq
MIRT1386615	hsa-miR-488	CLIP-seq
MIRT1386616	hsa-miR-497	CLIP-seq
MIRT1386617	hsa-miR-513b	CLIP-seq
MIRT1386618	hsa-miR-520a-5p	CLIP-seq
MIRT1386619	hsa-miR-525-5p	CLIP-seq
MIRT1386620	hsa-miR-542-3p	CLIP-seq
MIRT1386621	hsa-miR-758	CLIP-seq
MIRT1386622	hsa-miR-885-3p	CLIP-seq
MIRT2115705	hsa-miR-1231	CLIP-seq
MIRT2115706	hsa-miR-1298	CLIP-seq
MIRT1386594	hsa-miR-15a	CLIP-seq
MIRT1386595	hsa-miR-15b	CLIP-seq
MIRT1386596	hsa-miR-16	CLIP-seq
MIRT2115707	hsa-miR-1827	CLIP-seq
MIRT2115708	hsa-miR-18a	CLIP-seq
MIRT2115709	hsa-miR-18b	CLIP-seq
MIRT1386597	hsa-miR-195	CLIP-seq
MIRT2115710	hsa-miR-2682	CLIP-seq
MIRT2115711	hsa-miR-3120-5p	CLIP-seq
MIRT2115712	hsa-miR-3123	CLIP-seq
MIRT2115713	hsa-miR-3150a-3p	CLIP-seq
MIRT2115714	hsa-miR-3155	CLIP-seq
MIRT2115715	hsa-miR-3155b	CLIP-seq
MIRT2115716	hsa-miR-3175	CLIP-seq
MIRT2115717	hsa-miR-3180-5p	CLIP-seq
MIRT2115718	hsa-miR-342-5p	CLIP-seq
MIRT2115719	hsa-miR-34a	CLIP-seq
MIRT2115720	hsa-miR-34c-5p	CLIP-seq
MIRT2115721	hsa-miR-371-5p	CLIP-seq
MIRT2115722	hsa-miR-371b-5p	CLIP-seq
MIRT1386604	hsa-miR-3925-5p	CLIP-seq
MIRT2115723	hsa-miR-3927	CLIP-seq
MIRT2115724	hsa-miR-3960	CLIP-seq
MIRT2115725	hsa-miR-3973	CLIP-seq
MIRT1386605	hsa-miR-424	CLIP-seq
MIRT2115726	hsa-miR-4283	CLIP-seq
MIRT2115727	hsa-miR-4447	CLIP-seq
MIRT2115728	hsa-miR-4451	CLIP-seq
MIRT1386607	hsa-miR-4467	CLIP-seq
MIRT2115729	hsa-miR-4472	CLIP-seq
MIRT2115730	hsa-miR-4488	CLIP-seq
MIRT2115731	hsa-miR-4489	CLIP-seq
MIRT2115732	hsa-miR-4494	CLIP-seq
MIRT2115733	hsa-miR-449a	CLIP-seq
MIRT2115734	hsa-miR-449b	CLIP-seq
MIRT2115735	hsa-miR-449c	CLIP-seq
MIRT1386610	hsa-miR-4519	CLIP-seq
MIRT2115736	hsa-miR-4651	CLIP-seq
MIRT2115737	hsa-miR-4664-5p	CLIP-seq
MIRT2115738	hsa-miR-4667-5p	CLIP-seq
MIRT2115739	hsa-miR-4697-5p	CLIP-seq
MIRT2115740	hsa-miR-4700-5p	CLIP-seq
MIRT2115741	hsa-miR-4732-3p	CLIP-seq
MIRT2115742	hsa-miR-4735-3p	CLIP-seq
MIRT2115743	hsa-miR-4751	CLIP-seq
MIRT2115744	hsa-miR-4796-3p	CLIP-seq
MIRT2115745	hsa-miR-4797-5p	CLIP-seq
MIRT2115746	hsa-miR-484	CLIP-seq
MIRT2115747	hsa-miR-486-3p	CLIP-seq
MIRT2115748	hsa-miR-491-5p	CLIP-seq
MIRT1386616	hsa-miR-497	CLIP-seq
MIRT2115749	hsa-miR-499a-5p	CLIP-seq
MIRT2115750	hsa-miR-512-3p	CLIP-seq
MIRT2115751	hsa-miR-520g	CLIP-seq
MIRT2115752	hsa-miR-520h	CLIP-seq
MIRT2115753	hsa-miR-608	CLIP-seq
MIRT2115754	hsa-miR-626	CLIP-seq
MIRT2115755	hsa-miR-637	CLIP-seq
MIRT2115756	hsa-miR-664	CLIP-seq
MIRT2115757	hsa-miR-665	CLIP-seq
MIRT2115758	hsa-miR-670	CLIP-seq
MIRT2115759	hsa-miR-760	CLIP-seq
MIRT1386622	hsa-miR-885-3p	CLIP-seq
MIRT2115760	hsa-miR-939	CLIP-seq
MIRT2338346	hsa-miR-103a	CLIP-seq
MIRT2338347	hsa-miR-107	CLIP-seq
MIRT2338348	hsa-miR-1179	CLIP-seq
MIRT2338349	hsa-miR-1197	CLIP-seq
MIRT2115705	hsa-miR-1231	CLIP-seq
MIRT2115706	hsa-miR-1298	CLIP-seq
MIRT2338350	hsa-miR-1539	CLIP-seq
MIRT1386594	hsa-miR-15a	CLIP-seq
MIRT1386595	hsa-miR-15b	CLIP-seq
MIRT1386596	hsa-miR-16	CLIP-seq
MIRT2115707	hsa-miR-1827	CLIP-seq
MIRT2115708	hsa-miR-18a	CLIP-seq
MIRT2115709	hsa-miR-18b	CLIP-seq
MIRT1386597	hsa-miR-195	CLIP-seq
MIRT2338351	hsa-miR-23a	CLIP-seq
MIRT2338352	hsa-miR-23b	CLIP-seq
MIRT2338353	hsa-miR-23c	CLIP-seq
MIRT2115710	hsa-miR-2682	CLIP-seq
MIRT2338354	hsa-miR-3074-5p	CLIP-seq
MIRT2338355	hsa-miR-3117-5p	CLIP-seq
MIRT2115711	hsa-miR-3120-5p	CLIP-seq
MIRT2115713	hsa-miR-3150a-3p	CLIP-seq
MIRT2115716	hsa-miR-3175	CLIP-seq
MIRT2338356	hsa-miR-3179	CLIP-seq
MIRT2338357	hsa-miR-3193	CLIP-seq
MIRT2338358	hsa-miR-3202	CLIP-seq
MIRT2115718	hsa-miR-342-5p	CLIP-seq
MIRT2115719	hsa-miR-34a	CLIP-seq
MIRT2115720	hsa-miR-34c-5p	CLIP-seq
MIRT2338359	hsa-miR-3978	CLIP-seq
MIRT1386605	hsa-miR-424	CLIP-seq
MIRT2115726	hsa-miR-4283	CLIP-seq
MIRT2338360	hsa-miR-4310	CLIP-seq
MIRT2338361	hsa-miR-4436a	CLIP-seq
MIRT2115727	hsa-miR-4447	CLIP-seq
MIRT2115729	hsa-miR-4472	CLIP-seq
MIRT2338362	hsa-miR-4476	CLIP-seq
MIRT2115730	hsa-miR-4488	CLIP-seq
MIRT2115731	hsa-miR-4489	CLIP-seq
MIRT2338363	hsa-miR-4493	CLIP-seq
MIRT2115733	hsa-miR-449a	CLIP-seq
MIRT2115734	hsa-miR-449b	CLIP-seq
MIRT2115735	hsa-miR-449c	CLIP-seq
MIRT2338364	hsa-miR-4505	CLIP-seq
MIRT2338365	hsa-miR-4646-5p	CLIP-seq
MIRT2115736	hsa-miR-4651	CLIP-seq
MIRT2115737	hsa-miR-4664-5p	CLIP-seq
MIRT2115738	hsa-miR-4667-5p	CLIP-seq
MIRT2115739	hsa-miR-4697-5p	CLIP-seq
MIRT2115740	hsa-miR-4700-5p	CLIP-seq
MIRT1386613	hsa-miR-4704-3p	CLIP-seq
MIRT2115741	hsa-miR-4732-3p	CLIP-seq
MIRT2338366	hsa-miR-4733-5p	CLIP-seq
MIRT2115742	hsa-miR-4735-3p	CLIP-seq
MIRT2338367	hsa-miR-4747-5p	CLIP-seq
MIRT2115743	hsa-miR-4751	CLIP-seq
MIRT2115747	hsa-miR-486-3p	CLIP-seq
MIRT2115748	hsa-miR-491-5p	CLIP-seq
MIRT1386616	hsa-miR-497	CLIP-seq
MIRT2338368	hsa-miR-508-5p	CLIP-seq
MIRT2115750	hsa-miR-512-3p	CLIP-seq
MIRT2115753	hsa-miR-608	CLIP-seq
MIRT2115754	hsa-miR-626	CLIP-seq
MIRT2115755	hsa-miR-637	CLIP-seq
MIRT2338369	hsa-miR-642b	CLIP-seq
MIRT2115757	hsa-miR-665	CLIP-seq
MIRT2115759	hsa-miR-760	CLIP-seq
MIRT2115760	hsa-miR-939	CLIP-seq
MIRT2395114	hsa-miR-1291	CLIP-seq
MIRT2395115	hsa-miR-146b-3p	CLIP-seq
MIRT2395116	hsa-miR-2276	CLIP-seq
MIRT2115711	hsa-miR-3120-5p	CLIP-seq
MIRT2115714	hsa-miR-3155	CLIP-seq
MIRT2115715	hsa-miR-3155b	CLIP-seq
MIRT2395117	hsa-miR-328	CLIP-seq
MIRT2395118	hsa-miR-339-5p	CLIP-seq
MIRT2395119	hsa-miR-346	CLIP-seq
MIRT2395120	hsa-miR-4288	CLIP-seq
MIRT2395121	hsa-miR-4421	CLIP-seq
MIRT2115743	hsa-miR-4751	CLIP-seq
MIRT2395122	hsa-miR-4772-3p	CLIP-seq
MIRT2115746	hsa-miR-484	CLIP-seq
MIRT2395123	hsa-miR-632	CLIP-seq
MIRT2395124	hsa-miR-891a	CLIP-seq
MIRT2115713	hsa-miR-3150a-3p	CLIP-seq
MIRT2115716	hsa-miR-3175	CLIP-seq
MIRT2115718	hsa-miR-342-5p	CLIP-seq
MIRT2115719	hsa-miR-34a	CLIP-seq
MIRT2115720	hsa-miR-34c-5p	CLIP-seq
MIRT2115727	hsa-miR-4447	CLIP-seq
MIRT2115729	hsa-miR-4472	CLIP-seq
MIRT2115730	hsa-miR-4488	CLIP-seq
MIRT2115733	hsa-miR-449a	CLIP-seq
MIRT2115734	hsa-miR-449b	CLIP-seq
MIRT2115736	hsa-miR-4651	CLIP-seq
MIRT2115737	hsa-miR-4664-5p	CLIP-seq
MIRT2115739	hsa-miR-4697-5p	CLIP-seq
MIRT2115747	hsa-miR-486-3p	CLIP-seq
MIRT2115748	hsa-miR-491-5p	CLIP-seq
MIRT2115753	hsa-miR-608	CLIP-seq
MIRT2115760	hsa-miR-939	CLIP-seq
MIRT2115713	hsa-miR-3150a-3p	CLIP-seq
MIRT2115716	hsa-miR-3175	CLIP-seq
MIRT2115718	hsa-miR-342-5p	CLIP-seq
MIRT2115719	hsa-miR-34a	CLIP-seq
MIRT2115720	hsa-miR-34c-5p	CLIP-seq
MIRT2115727	hsa-miR-4447	CLIP-seq
MIRT2115729	hsa-miR-4472	CLIP-seq
MIRT2115730	hsa-miR-4488	CLIP-seq
MIRT2115733	hsa-miR-449a	CLIP-seq
MIRT2115734	hsa-miR-449b	CLIP-seq
MIRT2115736	hsa-miR-4651	CLIP-seq
MIRT2115737	hsa-miR-4664-5p	CLIP-seq
MIRT2115739	hsa-miR-4697-5p	CLIP-seq
MIRT2115747	hsa-miR-486-3p	CLIP-seq
MIRT2115748	hsa-miR-491-5p	CLIP-seq
MIRT2115753	hsa-miR-608	CLIP-seq
MIRT2115760	hsa-miR-939	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005515	Function	Protein binding	IPI	15601820, 19159283, 20561531, 21199876, 28931592, 32814053, 33961781
GO:0005737	Component	Cytoplasm	IEA
GO:0005829	Component	Cytosol	IDA	21199876
GO:0005829	Component	Cytosol	IEA
GO:0005829	Component	Cytosol	TAS
GO:0006511	Process	Ubiquitin-dependent protein catabolic process	IDA	21199876
GO:0006511	Process	Ubiquitin-dependent protein catabolic process	IEA
GO:0006511	Process	Ubiquitin-dependent protein catabolic process	IMP	26392558
GO:0016567	Process	Protein ubiquitination	IDA	21199876
GO:0016567	Process	Protein ubiquitination	IEA
GO:0019005	Component	SCF ubiquitin ligase complex	IBA
GO:0035556	Process	Intracellular signal transduction	IEA
GO:0042752	Process	Regulation of circadian rhythm	IMP	26392558
GO:0043161	Process	Proteasome-mediated ubiquitin-dependent protein catabolic process	IBA
GO:0048511	Process	Rhythmic process	IEA
GO:1902916	Process	Positive regulation of protein polyubiquitination	IDA	28931592
GO:1990756	Function	Ubiquitin-like ligase-substrate adaptor activity	IEA
GO:1990756	Function	Ubiquitin-like ligase-substrate adaptor activity	IPI	21199876

Other IDs

• MIM: 611660
• HGNC: 30630
• e!Ensembl: ENSG00000175093

Protein

• UniProt ID: Q96A44
• Protein name: SPRY domain-containing SOCS box protein 4 (SSB-4)
• Protein function: Substrate recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (PubMed:15601820, PubMed:21199
• PDB: 2V24, 6DN7, 6DN8
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00622	SPRY	97 → 228	SPRY domain	Family
  PF07525	SOCS_box	234 → 272	SOCS box	Domain

• Sequence:

  MGQKLSGSLKSVEVREPALRPAKRELRGAEPGRPARLDQLLDMPAAGLAVQLRHAWNPED
  RSLNVFVKDDDRLTFHRHPVAQSTDGIRGKVGHARGLHAWQINWPARQRGTHAVVGVATA
  RAPLHSVGYTALVGSDAESWGWDLGRSRLYHDGKNQPGVAYPAFLGPDEAFALPDSLLVV
  LDMDEGTLSFIVDGQYLGVAFRGLKGKKLYPVVSAVWGHCEVTMRYINGLDPEPLPLMDL
  CRRSIRSALGRQRLQDISSLPLPQSLKNYLQYQ

• Sequence length: 273

Pathways

Reactome:

Neddylation
Antigen processing: Ubiquitination & Proteasome degradation