Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
92369
Gene name Gene Name - the full gene name approved by the HGNC.
SplA/ryanodine receptor domain and SOCS box containing 4
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
SPSB4
Synonyms (NCBI Gene) Gene synonyms aliases
SSB-4, SSB4
Chromosome Chromosome number
3
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
3q23
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT1386591 hsa-miR-145 CLIP-seq
MIRT1386592 hsa-miR-146a CLIP-seq
MIRT1386593 hsa-miR-146b-5p CLIP-seq
MIRT1386594 hsa-miR-15a CLIP-seq
MIRT1386595 hsa-miR-15b CLIP-seq
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0005515 Function Protein binding IPI 15601820, 19159283, 21199876, 28931592, 32814053
GO:0005829 Component Cytosol IDA 21199876
GO:0005829 Component Cytosol TAS
GO:0006511 Process Ubiquitin-dependent protein catabolic process IDA 21199876
GO:0006511 Process Ubiquitin-dependent protein catabolic process IMP 26392558
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
611660 30630 ENSG00000175093
Protein
UniProt ID Q96A44
Protein name SPRY domain-containing SOCS box protein 4 (SSB-4)
Protein function Substrate recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (PubMed:15601820, PubMed:21199
PDB 2V24 , 6DN7 , 6DN8
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00622 SPRY 97 228 SPRY domain Family
PF07525 SOCS_box 234 272 SOCS box Domain
Sequence
Sequence length 273
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  Reactome
    Neddylation
Antigen processing: Ubiquitination & Proteasome degradation
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Unknown
Disease term Disease name Evidence References Source
Mental depression Unipolar Depression, Major Depressive Disorder 27622933 ClinVar
Ischemic Stroke Ischemic Stroke GWAS
Cleft Lip With Or Without Cleft Palate Cleft Lip With Or Without Cleft Palate GWAS