IL32 (interleukin 32)

Gene

• Entrez ID: 9235
• Gene name: Interleukin 32
• Gene symbol: IL32
• Synonyms (NCBI Gene): IL-32alpha, IL-32beta, IL-32delta, IL-32gamma, NK4, TAIF, TAIFa, TAIFb, TAIFc, TAIFd
• Chromosome: 16
• Chromosome location: 16p13.3
• Summary: This gene encodes a member of the cytokine family. The protein contains a tyrosine sulfation site, 3 potential N-myristoylation sites, multiple putative phosphorylation sites, and an RGD cell-attachment sequence. Expression of this protein is increased af

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT005564	hsa-miR-205-5p	Luciferase reporter assay, qRT-PCR, Western blot	20737563
MIRT005564	hsa-miR-205-5p	Luciferase reporter assay, qRT-PCR, Western blot	20737563
MIRT027524	hsa-miR-98-5p	Microarray	19088304
MIRT437870	hsa-miR-29b-3p	Luciferase reporter assay	23729669
MIRT437870	hsa-miR-29b-3p	Luciferase reporter assay	23729669
MIRT1064849	hsa-miR-146b-3p	CLIP-seq
MIRT1064850	hsa-miR-3153	CLIP-seq
MIRT1064851	hsa-miR-3157-3p	CLIP-seq
MIRT1064852	hsa-miR-3173-5p	CLIP-seq
MIRT1064853	hsa-miR-4292	CLIP-seq
MIRT1064854	hsa-miR-4646-5p	CLIP-seq
MIRT1064855	hsa-miR-4668-5p	CLIP-seq
MIRT1064856	hsa-miR-874	CLIP-seq
MIRT1064857	hsa-miR-1224-3p	CLIP-seq
MIRT1064849	hsa-miR-146b-3p	CLIP-seq
MIRT1064858	hsa-miR-2681	CLIP-seq
MIRT1064850	hsa-miR-3153	CLIP-seq
MIRT1064851	hsa-miR-3157-3p	CLIP-seq
MIRT1064852	hsa-miR-3173-5p	CLIP-seq
MIRT1064859	hsa-miR-331-3p	CLIP-seq
MIRT1064853	hsa-miR-4292	CLIP-seq
MIRT1064854	hsa-miR-4646-5p	CLIP-seq
MIRT1064855	hsa-miR-4668-5p	CLIP-seq
MIRT1064860	hsa-miR-4722-3p	CLIP-seq
MIRT1064861	hsa-miR-4755-3p	CLIP-seq
MIRT1064856	hsa-miR-874	CLIP-seq
MIRT1064858	hsa-miR-2681	CLIP-seq
MIRT1064859	hsa-miR-331-3p	CLIP-seq
MIRT1064860	hsa-miR-4722-3p	CLIP-seq
MIRT1064861	hsa-miR-4755-3p	CLIP-seq
MIRT1064858	hsa-miR-2681	CLIP-seq
MIRT1064859	hsa-miR-331-3p	CLIP-seq
MIRT1064860	hsa-miR-4722-3p	CLIP-seq
MIRT1064861	hsa-miR-4755-3p	CLIP-seq
MIRT1064858	hsa-miR-2681	CLIP-seq
MIRT1064859	hsa-miR-331-3p	CLIP-seq
MIRT1064860	hsa-miR-4722-3p	CLIP-seq
MIRT1064861	hsa-miR-4755-3p	CLIP-seq
MIRT1064849	hsa-miR-146b-3p	CLIP-seq
MIRT1064858	hsa-miR-2681	CLIP-seq
MIRT1064850	hsa-miR-3153	CLIP-seq
MIRT1064851	hsa-miR-3157-3p	CLIP-seq
MIRT1064852	hsa-miR-3173-5p	CLIP-seq
MIRT1064859	hsa-miR-331-3p	CLIP-seq
MIRT1064853	hsa-miR-4292	CLIP-seq
MIRT1064854	hsa-miR-4646-5p	CLIP-seq
MIRT1064855	hsa-miR-4668-5p	CLIP-seq
MIRT1064860	hsa-miR-4722-3p	CLIP-seq
MIRT1064861	hsa-miR-4755-3p	CLIP-seq
MIRT1064856	hsa-miR-874	CLIP-seq
MIRT2389392	hsa-miR-2277-5p	CLIP-seq
MIRT2389393	hsa-miR-4479	CLIP-seq
MIRT2389394	hsa-miR-4728-5p	CLIP-seq

Transcription factors

Transcription factor	Regulation	Reference
DNMT1	Repression	20889550

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005125	Function	Cytokine activity	IEA
GO:0005515	Function	Protein binding	IPI	16488976, 23814099, 24396867, 32296183
GO:0005576	Component	Extracellular region	IEA
GO:0005615	Component	Extracellular space	IEA
GO:0005615	Component	Extracellular space	TAS	1729377
GO:0005829	Component	Cytosol	TAS
GO:0006952	Process	Defense response	TAS	1729377
GO:0006955	Process	Immune response	IEA
GO:0006955	Process	Immune response	TAS	1729377
GO:0007155	Process	Cell adhesion	TAS	1729377
GO:0007165	Process	Signal transduction	IEA
GO:0010628	Process	Positive regulation of gene expression	IDA	23729669
GO:0016020	Component	Membrane	HDA	19946888
GO:0034346	Process	Positive regulation of type III interferon production	IDA	23729669
GO:1903901	Process	Negative regulation of viral life cycle	IDA	23729669

Other IDs

• MIM: 606001
• HGNC: 16830
• e!Ensembl: ENSG00000008517

Protein

• UniProt ID: P24001
• Protein name: Interleukin-32 (IL-32) (Natural killer cells protein 4) (Tumor necrosis factor alpha-inducing factor)
• Protein function: Cytokine that may play a role in innate and adaptive immune responses. It induces various cytokines such as TNFA/TNF-alpha and IL8. It activates typical cytokine signal pathways of NF-kappa-B and p38 MAPK.
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF15225	IL32	114 → 210	Interleukin 32	Family

• Tissue specificity: TISSUE SPECIFICITY: Selectively expressed in lymphocytes. Expression is more prominent in immune cells than in non-immune cells. {ECO:0000269|PubMed:15664165}.
• Sequence:

  MCFPKVLSDDMKKLKARMVMLLPTSAQGLGAWVSACDTEDTVGHLGPWRDKDPALWCQLC
  LSSQHQAIERFYDKMQNAESGRGQVMSSLAELEDDFKEGYLETVAAYYEEQHPELTPLLE
  KERDGLRCRGNRSPVPDVEDPATEEPGESFCDKVMRWFQAMLQRLQTWWHGVLAWVKEKV
  VALVHAVQALWKQFQSFCCSLSELFMSSFQSYGAPRGDKEELTPQKCSEPQSSK

• Sequence length: 234

Pathways

KEGG:

Cytokine-cytokine receptor interaction

Reactome:

Other interleukin signaling