DLG5 (discs large MAGUK scaffold protein 5)
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Gene
Gene information from NCBI Gene database.
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| Entrez ID | 9231 |
| Gene name | Discs large MAGUK scaffold protein 5 |
| Gene symbol | DLG5 |
| Synonyms (NCBI Gene) |
LP-DLGP-DLG5PDLGYUVOB
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| Chromosome | 10 |
| Chromosome location | 10q22.3 |
| Summary | This gene encodes a member of the family of discs large (DLG) homologs, a subset of the membrane-associated guanylate kinase (MAGUK) superfamily. The MAGUK proteins are composed of a catalytically inactive guanylate kinase domain, in addition to PDZ and S |
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miRNA
miRNA information provided by mirtarbase database.
1074
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Gene ontology (GO)
Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
60
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Other IDs
Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
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Protein
Protein information from UniProt database.
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UniProt ID
Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
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Q8TDM6 | |||||||||||||||||||||||||||||||||||
| Protein name | Disks large homolog 5 (Discs large protein P-dlg) (Placenta and prostate DLG) | |||||||||||||||||||||||||||||||||||
| Protein function | Acts as a regulator of the Hippo signaling pathway (PubMed:28087714, PubMed:28169360). Negatively regulates the Hippo signaling pathway by mediating the interaction of MARK3 with STK3/4, bringing them together to promote MARK3-dependent hyperpho | |||||||||||||||||||||||||||||||||||
| PDB | 1UIT | |||||||||||||||||||||||||||||||||||
| Family and domains |
Pfam
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| Tissue specificity | TISSUE SPECIFICITY: Highly expressed in normal breast tissues and low-grade breast cancer tissues (at protein level) (PubMed:28169360). Highly expressed in the placenta and prostate. Expressed at a lower level in the thyroid, spinal cord, trachea, adrenal | |||||||||||||||||||||||||||||||||||
| Sequence |
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| Sequence length | 1919 | |||||||||||||||||||||||||||||||||||
| Interactions | View interactions | |||||||||||||||||||||||||||||||||||
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Pathways
Pathway information has different metabolic/signaling pathways associated with genes.
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Associated diseases
Disease associations from ClinVar (causal & non-causal) and other databases (OMIM, Orphanet, GWAS, etc.).
8
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Evidence Score:
★☆☆☆☆ Gene-disease association found in Text Mining only
★★☆☆☆ Found in Text Mining and Unknown/Other Associations
★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources
★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
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