GLYATL1 (glycine-N-acyltransferase like 1)

Gene

• Entrez ID: 92292
• Gene name: Glycine-N-acyltransferase like 1
• Gene symbol: GLYATL1
• Synonyms (NCBI Gene): GATF-C, GNAT
• Chromosome: 11
• Chromosome location: 11q12.1

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT1022119	hsa-miR-1261	CLIP-seq
MIRT1022120	hsa-miR-3155	CLIP-seq
MIRT1022121	hsa-miR-3155b	CLIP-seq
MIRT1022122	hsa-miR-412	CLIP-seq
MIRT1022123	hsa-miR-484	CLIP-seq
MIRT1022124	hsa-miR-944	CLIP-seq
MIRT1022125	hsa-miR-1258	CLIP-seq
MIRT1022119	hsa-miR-1261	CLIP-seq
MIRT1022126	hsa-miR-2116	CLIP-seq
MIRT1022127	hsa-miR-219-2-3p	CLIP-seq
MIRT1022120	hsa-miR-3155	CLIP-seq
MIRT1022121	hsa-miR-3155b	CLIP-seq
MIRT1022128	hsa-miR-3156-5p	CLIP-seq
MIRT1022129	hsa-miR-335	CLIP-seq
MIRT1022122	hsa-miR-412	CLIP-seq
MIRT1022130	hsa-miR-4255	CLIP-seq
MIRT1022131	hsa-miR-4268	CLIP-seq
MIRT1022132	hsa-miR-4270	CLIP-seq
MIRT1022133	hsa-miR-4302	CLIP-seq
MIRT1022134	hsa-miR-4441	CLIP-seq
MIRT1022135	hsa-miR-4476	CLIP-seq
MIRT1022136	hsa-miR-4772-5p	CLIP-seq
MIRT1022123	hsa-miR-484	CLIP-seq
MIRT1022137	hsa-miR-508-3p	CLIP-seq
MIRT1022138	hsa-miR-935	CLIP-seq
MIRT1022119	hsa-miR-1261	CLIP-seq
MIRT1549287	hsa-miR-128	CLIP-seq
MIRT1549288	hsa-miR-27a	CLIP-seq
MIRT1549289	hsa-miR-27b	CLIP-seq
MIRT1549290	hsa-miR-3691-3p	CLIP-seq
MIRT1022122	hsa-miR-412	CLIP-seq
MIRT1549291	hsa-miR-513a-5p	CLIP-seq
MIRT1920460	hsa-miR-587	CLIP-seq
MIRT1920460	hsa-miR-587	CLIP-seq
MIRT1022129	hsa-miR-335	CLIP-seq
MIRT1022131	hsa-miR-4268	CLIP-seq
MIRT1022137	hsa-miR-508-3p	CLIP-seq
MIRT1022119	hsa-miR-1261	CLIP-seq
MIRT1022120	hsa-miR-3155	CLIP-seq
MIRT1022121	hsa-miR-3155b	CLIP-seq
MIRT1022122	hsa-miR-412	CLIP-seq
MIRT1022123	hsa-miR-484	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005739	Component	Mitochondrion	IEA
GO:0006541	Process	Glutamine metabolic process	IBA
GO:0006541	Process	Glutamine metabolic process	IDA	22475485
GO:0016740	Function	Transferase activity	IEA
GO:0016746	Function	Acyltransferase activity	IEA
GO:0047946	Function	Glutamine N-acyltransferase activity	IBA
GO:0047946	Function	Glutamine N-acyltransferase activity	IDA	22475485
GO:0047946	Function	Glutamine N-acyltransferase activity	IEA
GO:0047961	Function	Glycine N-acyltransferase activity	IEA

Other IDs

• MIM: 614761
• HGNC: 30519
• e!Ensembl: ENSG00000166840

Protein

• UniProt ID: Q969I3
• Protein name: Glycine N-acyltransferase-like protein 1 (EC 2.3.1.68) (Acyl-CoA:glycine N-acyltransferase-like protein 1) (Glutamine N-acyltransferase)
• Protein function: Acyltransferase which transfers an acyl group to the N-terminus of glutamine. Can use phenylacetyl-CoA as an acyl donor.
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF06021	Gly_acyl_tr_N	1 → 207	Aralkyl acyl-CoA:amino acid N-acyltransferase	Family
  PF08444	Gly_acyl_tr_C	208 → 296	Aralkyl acyl-CoA:amino acid N-acyltransferase, C-terminal region	Family

• Tissue specificity: TISSUE SPECIFICITY: Expressed in liver and kidney and, at lower levels, in pancreas, testis, ovary and stomach. {ECO:0000269|Ref.1}.
• Sequence:

  MILLNNSHKLLALYKSLARSIPESLKVYGSVYHINHGNPFNMEVLVDSWPEYQMVIIRPQ
  KQEMTDDMDSYTNVYRMFSKEPQKSEEVLKNCEIVNWKQRLQIQGLQESLGEGIRVATFS
  KSVKVEHSRALLLVTEDILKLNASSKSKLGSWAETGHPDDEFESETPNFKYAQLDVSYSG
  LVNDNWKRGKNERSLHYIKRCIEDLPAACMLGPEGVPVSWVTMDPSCEVGMAYSMEKYRR
  TGNMARVMVRYMKYLRQKNIPFYISVLEENEDSRRFVGQFGFFEASCEWHQWTCYPQNLV
  PF

• Sequence length: 302

Pathways

Reactome:

Conjugation of salicylate with glycine
Conjugation of benzoate with glycine

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Unknown / Other Associations
Phenotype Name	Clinical Significance	Source	Evidence Score
TIETZE SYNDROME	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Associations from Text Mining
Disease Name	Relationship Type	References	Evidence Score
Aortic Aneurysm Abdominal	Associate	26767057	★☆☆☆☆ Found in Text Mining only
Carcinoma Hepatocellular	Associate	36308411	★☆☆☆☆ Found in Text Mining only
Prostatic Neoplasms	Associate	31376196	★☆☆☆☆ Found in Text Mining only