Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene miRNA Gene ontology Other IDs Protein Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	9228
Gene name Gene Name - the full gene name approved by the HGNC.	DLG associated protein 2
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	DLGAP2
Synonyms (NCBI Gene) Gene synonyms aliases	C8orf68, DAP2, ERICH1-AS1, SAPAP2
Chromosome Chromosome number	8
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	8p23.3
Summary Summary of gene provided in NCBI Entrez Gene.	The product of this gene is a membrane-associated protein that may play a role in synapse organization and signalling in neuronal cells. This gene is biallelically expressed in the brain, however, only the paternal allele is expressed in the testis (PMID:

Show/Hide all(197)

miRTarBase ID	miRNA	Experiments	Reference
MIRT716570	hsa-miR-4635	HITS-CLIP	19536157
MIRT716569	hsa-miR-627-3p	HITS-CLIP	19536157
MIRT716568	hsa-miR-4764-5p	HITS-CLIP	19536157
MIRT716567	hsa-miR-526b-5p	HITS-CLIP	19536157
MIRT716566	hsa-miR-578	HITS-CLIP	19536157
MIRT716570	hsa-miR-4635	HITS-CLIP	19536157
MIRT716569	hsa-miR-627-3p	HITS-CLIP	19536157
MIRT716568	hsa-miR-4764-5p	HITS-CLIP	19536157
MIRT716567	hsa-miR-526b-5p	HITS-CLIP	19536157
MIRT716566	hsa-miR-578	HITS-CLIP	19536157
MIRT658992	hsa-miR-20a-3p	HITS-CLIP	23824327
MIRT658991	hsa-miR-544a	HITS-CLIP	23824327
MIRT658990	hsa-miR-6738-3p	HITS-CLIP	23824327
MIRT716570	hsa-miR-4635	HITS-CLIP	19536157
MIRT716569	hsa-miR-627-3p	HITS-CLIP	19536157
MIRT716568	hsa-miR-4764-5p	HITS-CLIP	19536157
MIRT716567	hsa-miR-526b-5p	HITS-CLIP	19536157
MIRT716566	hsa-miR-578	HITS-CLIP	19536157
MIRT716570	hsa-miR-4635	HITS-CLIP	19536157
MIRT716569	hsa-miR-627-3p	HITS-CLIP	19536157
MIRT716568	hsa-miR-4764-5p	HITS-CLIP	19536157
MIRT716567	hsa-miR-526b-5p	HITS-CLIP	19536157
MIRT716566	hsa-miR-578	HITS-CLIP	19536157
MIRT658992	hsa-miR-20a-3p	HITS-CLIP	23824327
MIRT658991	hsa-miR-544a	HITS-CLIP	23824327
MIRT658990	hsa-miR-6738-3p	HITS-CLIP	23824327
MIRT938504	hsa-miR-1197	CLIP-seq
MIRT938505	hsa-miR-1207-3p	CLIP-seq
MIRT938506	hsa-miR-1253	CLIP-seq
MIRT938507	hsa-miR-1258	CLIP-seq
MIRT938508	hsa-miR-1290	CLIP-seq
MIRT938509	hsa-miR-1291	CLIP-seq
MIRT938510	hsa-miR-129-5p	CLIP-seq
MIRT938511	hsa-miR-1305	CLIP-seq
MIRT740097	hsa-miR-132	CLIP-seq
MIRT938512	hsa-miR-134	CLIP-seq
MIRT938513	hsa-miR-138	CLIP-seq
MIRT938514	hsa-miR-146a	CLIP-seq
MIRT938515	hsa-miR-146b-5p	CLIP-seq
MIRT938516	hsa-miR-1470	CLIP-seq
MIRT938517	hsa-miR-153	CLIP-seq
MIRT938518	hsa-miR-1912	CLIP-seq
MIRT938519	hsa-miR-194	CLIP-seq
MIRT938520	hsa-miR-196a	CLIP-seq
MIRT938521	hsa-miR-196b	CLIP-seq
MIRT938522	hsa-miR-2110	CLIP-seq
MIRT938523	hsa-miR-2115	CLIP-seq
MIRT740096	hsa-miR-212	CLIP-seq
MIRT938524	hsa-miR-25	CLIP-seq
MIRT938525	hsa-miR-299-3p	CLIP-seq
MIRT938526	hsa-miR-3074-3p	CLIP-seq
MIRT938527	hsa-miR-3117-3p	CLIP-seq
MIRT938528	hsa-miR-3118	CLIP-seq
MIRT938529	hsa-miR-3120-3p	CLIP-seq
MIRT938530	hsa-miR-3123	CLIP-seq
MIRT938531	hsa-miR-3130-5p	CLIP-seq
MIRT740095	hsa-miR-3140-3p	CLIP-seq
MIRT938532	hsa-miR-3151	CLIP-seq
MIRT938533	hsa-miR-3153	CLIP-seq
MIRT938534	hsa-miR-3163	CLIP-seq
MIRT938535	hsa-miR-3173-5p	CLIP-seq
MIRT938536	hsa-miR-3185	CLIP-seq
MIRT938537	hsa-miR-3194-3p	CLIP-seq
MIRT938538	hsa-miR-32	CLIP-seq
MIRT938539	hsa-miR-33a	CLIP-seq
MIRT938540	hsa-miR-33b	CLIP-seq
MIRT938541	hsa-miR-3622a-3p	CLIP-seq
MIRT938542	hsa-miR-3622b-3p	CLIP-seq
MIRT938543	hsa-miR-363	CLIP-seq
MIRT938544	hsa-miR-3655	CLIP-seq
MIRT938545	hsa-miR-367	CLIP-seq
MIRT938546	hsa-miR-370	CLIP-seq
MIRT938547	hsa-miR-371-5p	CLIP-seq
MIRT938548	hsa-miR-371b-5p	CLIP-seq
MIRT938549	hsa-miR-380	CLIP-seq
MIRT938550	hsa-miR-3924	CLIP-seq
MIRT938551	hsa-miR-3927	CLIP-seq
MIRT938552	hsa-miR-3936	CLIP-seq
MIRT938553	hsa-miR-4271	CLIP-seq
MIRT938554	hsa-miR-4290	CLIP-seq
MIRT938555	hsa-miR-4293	CLIP-seq
MIRT938556	hsa-miR-4299	CLIP-seq
MIRT938557	hsa-miR-4312	CLIP-seq
MIRT938558	hsa-miR-4325	CLIP-seq
MIRT938559	hsa-miR-4328	CLIP-seq
MIRT938560	hsa-miR-4418	CLIP-seq
MIRT938561	hsa-miR-4444	CLIP-seq
MIRT938562	hsa-miR-4446-3p	CLIP-seq
MIRT938563	hsa-miR-4447	CLIP-seq
MIRT938564	hsa-miR-4452	CLIP-seq
MIRT938565	hsa-miR-4472	CLIP-seq
MIRT938566	hsa-miR-4477a	CLIP-seq
MIRT938567	hsa-miR-4477b	CLIP-seq
MIRT938568	hsa-miR-448	CLIP-seq
MIRT938569	hsa-miR-4482	CLIP-seq
MIRT938570	hsa-miR-4490	CLIP-seq
MIRT938571	hsa-miR-4492	CLIP-seq
MIRT938572	hsa-miR-4495	CLIP-seq
MIRT938573	hsa-miR-4498	CLIP-seq
MIRT938574	hsa-miR-4503	CLIP-seq
MIRT938575	hsa-miR-4505	CLIP-seq
MIRT938576	hsa-miR-450b-5p	CLIP-seq
MIRT938577	hsa-miR-4646-5p	CLIP-seq
MIRT938578	hsa-miR-4650-3p	CLIP-seq
MIRT938579	hsa-miR-4654	CLIP-seq
MIRT938580	hsa-miR-4668-5p	CLIP-seq
MIRT938581	hsa-miR-4686	CLIP-seq
MIRT938582	hsa-miR-4687-3p	CLIP-seq
MIRT938583	hsa-miR-4687-5p	CLIP-seq
MIRT938584	hsa-miR-4714-3p	CLIP-seq
MIRT938585	hsa-miR-4721	CLIP-seq
MIRT938586	hsa-miR-4725-3p	CLIP-seq
MIRT938587	hsa-miR-4731-3p	CLIP-seq
MIRT938588	hsa-miR-4760-3p	CLIP-seq
MIRT938589	hsa-miR-4769-5p	CLIP-seq
MIRT938590	hsa-miR-4774-5p	CLIP-seq
MIRT938591	hsa-miR-4795-5p	CLIP-seq
MIRT938592	hsa-miR-4801	CLIP-seq
MIRT938593	hsa-miR-4803	CLIP-seq
MIRT938594	hsa-miR-491-5p	CLIP-seq
MIRT938595	hsa-miR-496	CLIP-seq
MIRT938596	hsa-miR-498	CLIP-seq
MIRT938597	hsa-miR-507	CLIP-seq
MIRT938598	hsa-miR-509-3-5p	CLIP-seq
MIRT938599	hsa-miR-5095	CLIP-seq
MIRT938600	hsa-miR-509-5p	CLIP-seq
MIRT938601	hsa-miR-513c	CLIP-seq
MIRT938602	hsa-miR-514b-5p	CLIP-seq
MIRT938603	hsa-miR-532-5p	CLIP-seq
MIRT938604	hsa-miR-543	CLIP-seq
MIRT938605	hsa-miR-548a-3p	CLIP-seq
MIRT938606	hsa-miR-548an	CLIP-seq
MIRT938607	hsa-miR-548c-3p	CLIP-seq
MIRT938608	hsa-miR-548e	CLIP-seq
MIRT938609	hsa-miR-548f	CLIP-seq
MIRT938610	hsa-miR-557	CLIP-seq
MIRT938611	hsa-miR-580	CLIP-seq
MIRT938612	hsa-miR-582-5p	CLIP-seq
MIRT938613	hsa-miR-589	CLIP-seq
MIRT938614	hsa-miR-596	CLIP-seq
MIRT938615	hsa-miR-600	CLIP-seq
MIRT938616	hsa-miR-671-5p	CLIP-seq
MIRT938617	hsa-miR-762	CLIP-seq
MIRT938618	hsa-miR-767-3p	CLIP-seq
MIRT938619	hsa-miR-889	CLIP-seq
MIRT938620	hsa-miR-92a	CLIP-seq
MIRT938621	hsa-miR-92b	CLIP-seq
MIRT938587	hsa-miR-4731-3p	CLIP-seq
MIRT938592	hsa-miR-4801	CLIP-seq
MIRT1556227	hsa-miR-1909	CLIP-seq
MIRT938504	hsa-miR-1197	CLIP-seq
MIRT938510	hsa-miR-129-5p	CLIP-seq
MIRT938511	hsa-miR-1305	CLIP-seq
MIRT1977687	hsa-miR-181a	CLIP-seq
MIRT1977688	hsa-miR-181b	CLIP-seq
MIRT1977689	hsa-miR-181c	CLIP-seq
MIRT1977690	hsa-miR-181d	CLIP-seq
MIRT1977691	hsa-miR-205	CLIP-seq
MIRT938522	hsa-miR-2110	CLIP-seq
MIRT938534	hsa-miR-3163	CLIP-seq
MIRT938539	hsa-miR-33a	CLIP-seq
MIRT938540	hsa-miR-33b	CLIP-seq
MIRT1977692	hsa-miR-4262	CLIP-seq
MIRT1977693	hsa-miR-4428	CLIP-seq
MIRT1977694	hsa-miR-4481	CLIP-seq
MIRT938571	hsa-miR-4492	CLIP-seq
MIRT938573	hsa-miR-4498	CLIP-seq
MIRT938575	hsa-miR-4505	CLIP-seq
MIRT938576	hsa-miR-450b-5p	CLIP-seq
MIRT1977695	hsa-miR-4745-5p	CLIP-seq
MIRT938596	hsa-miR-498	CLIP-seq
MIRT938597	hsa-miR-507	CLIP-seq
MIRT1977696	hsa-miR-520a-5p	CLIP-seq
MIRT1977697	hsa-miR-525-5p	CLIP-seq
MIRT938610	hsa-miR-557	CLIP-seq
MIRT938617	hsa-miR-762	CLIP-seq
MIRT1977698	hsa-miR-873	CLIP-seq
MIRT938511	hsa-miR-1305	CLIP-seq
MIRT2213005	hsa-miR-1915	CLIP-seq
MIRT2213006	hsa-miR-28-5p	CLIP-seq
MIRT2213007	hsa-miR-3139	CLIP-seq
MIRT2213008	hsa-miR-3159	CLIP-seq
MIRT938539	hsa-miR-33a	CLIP-seq
MIRT938540	hsa-miR-33b	CLIP-seq
MIRT2213009	hsa-miR-3670	CLIP-seq
MIRT2213010	hsa-miR-3689d	CLIP-seq
MIRT2213011	hsa-miR-4726-3p	CLIP-seq
MIRT2213012	hsa-miR-665	CLIP-seq
MIRT2213013	hsa-miR-708	CLIP-seq
MIRT1977698	hsa-miR-873	CLIP-seq
MIRT938576	hsa-miR-450b-5p	CLIP-seq
MIRT938597	hsa-miR-507	CLIP-seq
MIRT938604	hsa-miR-543	CLIP-seq
MIRT938610	hsa-miR-557	CLIP-seq
MIRT2386938	hsa-miR-7	CLIP-seq
MIRT2436864	hsa-miR-4453	CLIP-seq
MIRT2436865	hsa-miR-4538	CLIP-seq

Show/Hide all(9)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005515	Function	Protein binding	IPI	17474147, 25416956, 29892012
GO:0005883	Component	Neurofilament	NAS	10759891
GO:0005886	Component	Plasma membrane	TAS
GO:0007270	Process	Neuron-neuron synaptic transmission	NAS
GO:0014069	Component	Postsynaptic density	IEA
GO:0060090	Function	Molecular adaptor activity	IBA	21873635
GO:0098962	Process	Regulation of postsynaptic neurotransmitter receptor activity	IBA	21873635
GO:0098978	Component	Glutamatergic synapse	IBA	21873635
GO:0099572	Component	Postsynaptic specialization	IBA	21873635

MIM	HGNC	e!Ensembl
605438	2906	ENSG00000198010

Protein

UniProt ID

Q9P1A6

Protein name

Disks large-associated protein 2 (DAP-2) (PSD-95/SAP90-binding protein 2) (SAP90/PSD-95-associated protein 2) (SAPAP2)

Protein function

May play a role in the molecular organization of synapses and neuronal cell signaling. Could be an adapter protein linking ion channel to the subsynaptic cytoskeleton. May induce enrichment of PSD-95/SAP90 at the plasma membrane.

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF03359	GKAP	709 → 1054	Guanylate-kinase-associated protein (GKAP) protein	Family

Tissue specificity

TISSUE SPECIFICITY: Expressed in brain and kidney.

Sequence

MGTAQVLPGILQKHCCILPDRNTESQCTLCGEPEEEEAGDLVQPGISFPGPAEEDLDPQY
SWSPTQHFNEERYSPAPRSMKGLSGSRTQPPLCSGHTCGLAPPEDCEHLHHGPDARPPYL
LSPADSCPGGRHRCSPRSSVHSECVMMPVVLGDHVSSSTFPRMHYSSHYDTRDDCAVAHA
GAKINRIPANLLDQFEKQLPLHRDGFHTLQYQRTSAAAEQRSESPGRIRHLVHSVQKLFT
KSHSLEGSSKSNANGTKADGRADDHHHAHHAKHSKRSKSKERKPEGKPRPGMSSWWSSDD
NLDSDSTYRTPSVLNRHHLGPVAHCYPDALQSPFGDLSLKTSKSNNDVKCSACEGLALTP
DAKYLKRSSWSTLTVSQAKEAYRKSSLNLDKPLLHQDAKPALRPCHYLQVPQDEWGGYPT
GGKDEEIPCRRMRSGSYIKAMGDEESGESDSSPKTSPKSAILPEPLLKSIGQRPLGEHQT
QTYLQAASDVPVGHSLDPAANYNSPKFRSRNQSYMRAVSTLSQASCVSQVSEAEINGQFE
SVCESVFSEVESQAMDALDLPGCFRTRSHSYLRAIQAGYSQDDECIPMMTPSDITSTIRS
TAAVSYTNYKKTPPPVPPRTTSKPLISVTAQSSTESTQDAYQDSRAQRMSPWPQDSRGLY
NSTDSLDSNKAMNLALETAAAQRHLPESQSSSVRTSDKAILVSKAEELLKSRCSSIGIQD
SEFPEHQPYPRSDVETATDSDTESRGLREYHSVGVQVEDEKRHGRFKRSNSVTAAVQADL
ELEGFPGHITTEDKGLQFGSSFQRHSEPSTPTQYSAVRTVRTQGLFSYREDYRTQVDTST
LPPPDPWLEPAIDTVETGRMSPCRRDGSWFLKLLHAETKRMEGWCKEMEREAEENDLSEE
ILGKIRSAVGSAQLLMSQKFQQFYWLCQQNMDPSAMPRPTSQDLAGYWDMLQLSIEDVSM
KFDELQRLRLNDWKMMESPERKEERKVPPPIPKKPPKGKFPITREKSLDLPDRQRQEARR
RLMAAKRAASFRQNSASERADSIEIYIPEAQTRL

Sequence length

1054

Interactions

View interactions

Show/Hide Causal Diseases (6)

Disease term	Disease name	dbSNP ID	References
Causal
Autism	Autistic Disorder	rs121964908, rs62643608, rs181327458, rs797046134, rs869312704, rs1555013332, rs876657679, rs1057518999, rs1057518658, rs771827120, rs1555187899, rs773080572, rs753871454, rs1684130791, rs1684180699 View all (8 more)	20531469
Kidney disease	Chronic Kidney Diseases	rs74315342, rs749740335, rs757649673, rs112417755, rs35138315	29885931
Leukemia	Leukemia, Myelocytic, Acute	rs121909646, rs121913488, rs587776834, rs752746786, rs869312821, rs767454740, rs1554564297	27903959
Narcolepsy	Narcolepsy	rs104894574, rs387906655	19629137
Prostate cancer	Prostate carcinoma	rs121909139, rs121909140, rs121909141, rs121909142, rs121909143, rs606231169, rs606231170, rs137852584, rs137852578, rs137852580, rs137852581, rs137852582	31095341
Schizophrenia	Schizophrenia	rs13447324, rs387906932, rs387906933, rs863223354, rs863223355, rs776061422, rs863223349, rs748809996, rs759748655, rs863223353, rs863223350, rs863223356, rs781821239, rs863223348, rs863223346 View all (12 more)	24416398

Show/Hide Unknown Diseases (11)

Disease term	Disease name	Evidence	Source
Unknown
Neurodevelopmental Disorders	complex neurodevelopmental disorder		GenCC
Bipolar Disorder	Bipolar Disorder		GWAS
Neuroticism	Neuroticism		GWAS
Melanoma	Melanoma	SMAD3 and SLC9A5 gain?of?function increases invasion capability of melanoma cells.	GWAS, CBGDA
Alzheimer disease	Alzheimer disease		GWAS
Ischemic Stroke	Ischemic Stroke		GWAS
Rheumatoid arthritis	Rheumatoid arthritis		GWAS
Insomnia	Insomnia		GWAS
Takayasu Arteritis	Takayasu Arteritis		GWAS
Leprosy	Leprosy		GWAS
Breast Cancer	Breast Cancer	Importantly, breast cancer patients bearing PRC2 LOF mutations displayed significantly worse prognosis compared with PRC2 wild-type patients	GWAS, CBGDA

Show/Hide Text Mining Associations (21)

Disease Name	Relationship Type	References
Associations from Text Mining
Aging Premature	Associate	32877673
Alzheimer Disease	Associate	25391383, 32877673
Autism Spectrum Disorder	Associate	27271353, 30392976
Autistic Disorder	Associate	20531469, 28407363
Breast Neoplasms	Associate	37628841, 38003265
Cognition Disorders	Associate	32877673
Developmental Disabilities	Associate	28901431
Diabetes Gestational	Associate	34116986
Diabetes Mellitus	Associate	29518789
Diffuse Neurofibrillary Tangles with Calcification	Inhibit	32877673
Dyskinesia Drug Induced	Associate	30504779
Insulin Resistance	Associate	34116986
Machado Joseph Disease	Associate	34871736
Memory Disorders	Associate	32877673
Microcephaly	Associate	28901431
Neurobehavioral Manifestations	Associate	28901431
Neurologic Manifestations	Associate	33139705
Obsessive Compulsive Disorder	Associate	23154099
Renal Insufficiency	Associate	32123936
Schizophrenia	Associate	27271353, 30504779
Urinary Bladder Neoplasms	Inhibit	18055845

DLGAP2 (DLG associated protein 2)