Gene Gene information from NCBI Gene database.
Entrez ID 9221
Gene name Nucleolar and coiled-body phosphoprotein 1
Gene symbol NOLC1
Synonyms (NCBI Gene)
NOPP130NOPP140NS5ATP13P130Srp40
Chromosome 10
Chromosome location 10q24.32
miRNA miRNA information provided by mirtarbase database.
528
miRTarBase ID miRNA Experiments Reference
MIRT019859 hsa-miR-375 Microarray 20215506
MIRT020682 hsa-miR-155-5p Proteomics 18668040
MIRT027538 hsa-miR-98-5p Microarray 19088304
MIRT032259 hsa-let-7b-5p Proteomics 18668040
MIRT052391 hsa-let-7a-5p CLASH 23622248
Transcription factors Transcription factors information provided by TRRUST V2 database.
3
Transcription factor Regulation Reference
CREB1 Activation 21266110
NFKB1 Activation 21266110
RELA Activation 21266110
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
24
GO ID Ontology Definition Evidence Reference
GO:0000166 Function Nucleotide binding IEA
GO:0000278 Process Mitotic cell cycle TAS 7657714
GO:0001650 Component Fibrillar center IDA
GO:0003723 Function RNA binding HDA 22658674, 22681889
GO:0005515 Function Protein binding IPI 17620599, 22190034, 26399832, 33961781
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
602394 15608 ENSG00000166197
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
Q14978
Protein name Nucleolar and coiled-body phosphoprotein 1 (140 kDa nucleolar phosphoprotein) (Nopp140) (Hepatitis C virus NS5A-transactivated protein 13) (HCV NS5A-transactivated protein 13) (Nucleolar 130 kDa protein) (Nucleolar phosphoprotein p130)
Protein function Nucleolar protein that acts as a regulator of RNA polymerase I by connecting RNA polymerase I with enzymes responsible for ribosomal processing and modification (PubMed:10567578, PubMed:26399832). Required for neural crest specification: followi
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF05022 SRP40_C 624 696 SRP40, C-terminal domain Domain
Sequence
MADAGIRRVVPSDLYPLVLGFLRDNQLSEVANKFAKATGATQQDANASSLLDIYSFWLKS
AKVPERKLQANGPVAKKAKKKASSSDSEDSSEEEEEVQGPPAKKAAVPAKRVGLPPGKAA
AKASESSSSEESSDDDDEEDQKKQPVQKGVKPQAKAAKAPPKKAKSSDSDSDSSSEDEPP
KNQKPKITPVTVKAQTKAPPKPARAAPKIANGKAASSSSSSSSSSSSDDSEEEKAAATPK
KTVPKKQVVAKAPVKAATTPTRKSSSSEDSSSDEEEEQKKPMKNKPGPYSSVPPPSAPPP
KKSLGTQPPKKAVEKQQPVESSEDSSDESDSSSEEEKKPPTKAVVSKATTKPPPAKKAAE
SSSDSSDSDSSEDDEAPSKPAGTTKNSSNKPAVTTKSPAVKPAAAPKQPVGGGQKLLTRK
ADSSSSEEESSSSEEEKTKKMVATTKPKATAKAALSLPAKQAPQGSRDSSSDSDSSSSEE
EEEKTSKSAVKKKPQKVAGGAAPSKPASAKKGKAESSNSSSSDDSSEEEEEKLKGKGSPR
PQAPKANGTSALTAQNGKAAKNSEEEEEEKKKAAVVVSKSGSLKKRKQNEAAKEAETPQA
KKIKLQTPNTFPKRKKGEKRASSPFRRVREEEIEVDSRVADNSFDAKRGAAGDWGERANQ
VLKFTKGKSFRHEKTKKKRGSYRGGSISVQVNSIKF
DSE
Sequence length 699
Interactions View interactions
Associated diseases Disease associations from ClinVar (causal & non-causal) and other databases (OMIM, Orphanet, GWAS, etc.).
7
Evidence Score: ★☆☆☆☆  Gene-disease association found in Text Mining only ★★☆☆☆  Found in Text Mining and Unknown/Other Associations ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Phenotype Name Clinical Significance Source Evidence Score
Acute myeloid leukemia Benign ClinVar
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
ALZHEIMER DISEASE GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
ATTENTION DEFICIT HYPERACTIVITY DISORDER GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Sarcoma Benign ClinVar
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Associations from Text MiningDisease associations identified through Pubtator
Disease Name Relationship Type References Evidence Score
Acute erythroleukemia Associate 9074408
★☆☆☆☆
Found in Text Mining only
Anodontia Associate 16868967
★☆☆☆☆
Found in Text Mining only
Breast Cancer 3 Associate 17616674
★☆☆☆☆
Found in Text Mining only
Breast Neoplasms Associate 16537896, 17616674, 19330798, 22431919
★☆☆☆☆
Found in Text Mining only
Carcinoma Hepatocellular Associate 29725012
★☆☆☆☆
Found in Text Mining only
Carcinoma Non Small Cell Lung Associate 30505321
★☆☆☆☆
Found in Text Mining only
Colorectal Neoplasms Associate 37604903
★☆☆☆☆
Found in Text Mining only
Colorectal Neoplasms Stimulate 37670166
★☆☆☆☆
Found in Text Mining only
Drug Related Side Effects and Adverse Reactions Associate 20133863
★☆☆☆☆
Found in Text Mining only
Glioma Associate 21245381
★☆☆☆☆
Found in Text Mining only