CD5L (CD5 molecule like)

Gene

• Entrez ID: 922
• Gene name: CD5 molecule like
• Gene symbol: CD5L
• Synonyms (NCBI Gene): AIM, API6, CT-2, PRO229, SP-ALPHA, Spalpha, hAIM
• Chromosome: 1
• Chromosome location: 1q23.1

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT017271	hsa-miR-335-5p	Microarray	18185580
MIRT876080	hsa-miR-1298	CLIP-seq
MIRT876081	hsa-miR-1908	CLIP-seq
MIRT876082	hsa-miR-382	CLIP-seq
MIRT876083	hsa-miR-3937	CLIP-seq
MIRT876084	hsa-miR-409-3p	CLIP-seq
MIRT876085	hsa-miR-4289	CLIP-seq
MIRT876086	hsa-miR-4326	CLIP-seq
MIRT876087	hsa-miR-4436b-3p	CLIP-seq
MIRT876088	hsa-miR-4640-5p	CLIP-seq
MIRT876089	hsa-miR-4726-5p	CLIP-seq
MIRT876090	hsa-miR-663	CLIP-seq
MIRT876091	hsa-miR-744	CLIP-seq
MIRT2196663	hsa-miR-1185	CLIP-seq
MIRT2196664	hsa-miR-1224-5p	CLIP-seq
MIRT2196665	hsa-miR-1304	CLIP-seq
MIRT2196666	hsa-miR-2355-5p	CLIP-seq
MIRT2196667	hsa-miR-3605-5p	CLIP-seq
MIRT2196668	hsa-miR-3609	CLIP-seq
MIRT2196669	hsa-miR-3679-5p	CLIP-seq
MIRT2196670	hsa-miR-3915	CLIP-seq
MIRT2196671	hsa-miR-4464	CLIP-seq
MIRT2196672	hsa-miR-451b	CLIP-seq
MIRT2196673	hsa-miR-4689	CLIP-seq
MIRT2196674	hsa-miR-4748	CLIP-seq
MIRT2196675	hsa-miR-520g	CLIP-seq
MIRT2196676	hsa-miR-520h	CLIP-seq
MIRT2196677	hsa-miR-542-3p	CLIP-seq
MIRT2196678	hsa-miR-548ah	CLIP-seq
MIRT2385749	hsa-miR-1207-5p	CLIP-seq
MIRT2385750	hsa-miR-4736	CLIP-seq
MIRT2385751	hsa-miR-4763-3p	CLIP-seq
MIRT2385752	hsa-miR-568	CLIP-seq
MIRT2385753	hsa-miR-657	CLIP-seq
MIRT2499851	hsa-miR-199a-5p	CLIP-seq
MIRT2499852	hsa-miR-199b-5p	CLIP-seq
MIRT2499853	hsa-miR-3714	CLIP-seq
MIRT2499854	hsa-miR-4753-5p	CLIP-seq
MIRT2499855	hsa-miR-548an	CLIP-seq
MIRT2499856	hsa-miR-940	CLIP-seq
MIRT2499851	hsa-miR-199a-5p	CLIP-seq
MIRT2499852	hsa-miR-199b-5p	CLIP-seq
MIRT2499853	hsa-miR-3714	CLIP-seq
MIRT2499854	hsa-miR-4753-5p	CLIP-seq
MIRT2499855	hsa-miR-548an	CLIP-seq
MIRT2499856	hsa-miR-940	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0002376	Process	Immune system process	IEA
GO:0005576	Component	Extracellular region	IEA
GO:0005576	Component	Extracellular region	NAS	14718574
GO:0005615	Component	Extracellular space	TAS	9045627
GO:0005737	Component	Cytoplasm	IEA
GO:0005886	Component	Plasma membrane	IBA
GO:0005886	Component	Plasma membrane	IEA
GO:0006915	Process	Apoptotic process	IEA
GO:0006954	Process	Inflammatory response	IEA
GO:0006968	Process	Cellular defense response	TAS	9045627
GO:0009986	Component	Cell surface	IDA	25284781
GO:0009986	Component	Cell surface	IEA
GO:0016020	Component	Membrane	IEA
GO:0030449	Process	Regulation of complement activation	IEA
GO:0072562	Component	Blood microparticle	HDA	22516433
GO:1903661	Process	Positive regulation of complement-dependent cytotoxicity	IEA

Other IDs

• MIM: 602592
• HGNC: 1690
• e!Ensembl: ENSG00000073754

Protein

• UniProt ID: O43866
• Protein name: CD5 antigen-like (Apoptosis inhibitor expressed by macrophages) (hAIM) (CT-2) (IgM-associated peptide) (SP-alpha)
• Protein function: Secreted protein that acts as a key regulator of lipid synthesis: mainly expressed by macrophages in lymphoid and inflamed tissues and regulates mechanisms in inflammatory responses, such as infection or atherosclerosis. Able to inhibit lipid dr
• PDB: 8R83, 8R84, 8WYR, 8WYS
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00530	SRCR	27 → 125	Scavenger receptor cysteine-rich domain	Domain
  PF00530	SRCR	141 → 239	Scavenger receptor cysteine-rich domain	Domain
  PF00530	SRCR	247 → 346	Scavenger receptor cysteine-rich domain	Domain

• Tissue specificity: TISSUE SPECIFICITY: Expressed in spleen, lymph node, thymus, bone marrow, and fetal liver, but not in non-lymphoid tissues. {ECO:0000269|PubMed:9045627}.
• Sequence:

  MALLFSLILAICTRPGFLASPSGVRLVGGLHRCEGRVEVEQKGQWGTVCDDGWDIKDVAV
  LCRELGCGAASGTPSGILYEPPAEKEQKVLIQSVSCTGTEDTLAQCEQEEVYDCSHDEDA
  GASCENPESSFSPVPEGVRLADGPGHCKGRVEVKHQNQWYTVCQTGWSLRAAKVVCRQLG
  CGRAVLTQKRCNKHAYGRKPIWLSQMSCSGREATLQDCPSGPWGKNTCNHDEDTWVECED
  PFDLRLVGGDNLCSGRLEVLHKGVWGSVCDDNWGEKEDQVVCKQLGCGKSLSPSFRDRKC
  YGPGVGRIWLDNVRCSGEEQSLEQCQHRFWGFHDCTHQEDVAVICSG

• Sequence length: 347