Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	9219
Gene name Gene Name - the full gene name approved by the HGNC.	Metastasis associated 1 family member 2
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	MTA2
Synonyms (NCBI Gene) Gene synonyms aliases	MTA1L1, PID
Chromosome Chromosome number	11
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	11q12.3
Summary Summary of gene provided in NCBI Entrez Gene.	This gene encodes a protein that has been identified as a component of NuRD, a nucleosome remodeling deacetylase complex identified in the nucleus of human cells. It shows a very broad expression pattern and is strongly expressed in many tissues. It may r

Show/Hide all(127)

miRTarBase ID	miRNA	Experiments	Reference
MIRT004731	hsa-miR-146a-5p	qRT-PCR, Western blot	20124483
MIRT004117	hsa-miR-661	Western blot	19584269
MIRT004116	hsa-miR-559	Western blot	19584269
MIRT017668	hsa-miR-335-5p	Microarray	18185580
MIRT025233	hsa-miR-34a-5p	Proteomics	21566225
MIRT025233	hsa-miR-34a-5p	Proteomics	21566225
MIRT025233	hsa-miR-34a-5p	Reporter assay;Western blot;Other	20018894
MIRT046730	hsa-miR-222-3p	CLASH	23622248
MIRT044965	hsa-miR-186-5p	CLASH	23622248
MIRT044044	hsa-miR-365a-3p	CLASH	23622248
MIRT042480	hsa-miR-423-3p	CLASH	23622248
MIRT041029	hsa-miR-505-3p	CLASH	23622248
MIRT040512	hsa-miR-548a-3p	CLASH	23622248
MIRT040292	hsa-miR-615-3p	CLASH	23622248
MIRT040292	hsa-miR-615-3p	CLASH	23622248
MIRT038634	hsa-miR-125b-2-3p	CLASH	23622248
MIRT737195	hsa-miR-589-3p	Luciferase reporter assay, Western blotting, RNA-seq, qRT-PCR	31452724
MIRT1162181	hsa-miR-1236	CLIP-seq
MIRT1162182	hsa-miR-146a	CLIP-seq
MIRT1162183	hsa-miR-146b-5p	CLIP-seq
MIRT1162184	hsa-miR-3145-5p	CLIP-seq
MIRT1162185	hsa-miR-3148	CLIP-seq
MIRT1162186	hsa-miR-3156-5p	CLIP-seq
MIRT1162187	hsa-miR-3687	CLIP-seq
MIRT1162188	hsa-miR-371-5p	CLIP-seq
MIRT1162189	hsa-miR-4251	CLIP-seq
MIRT1162190	hsa-miR-4278	CLIP-seq
MIRT1162191	hsa-miR-4303	CLIP-seq
MIRT1162192	hsa-miR-4311	CLIP-seq
MIRT1162193	hsa-miR-4329	CLIP-seq
MIRT1162194	hsa-miR-4442	CLIP-seq
MIRT1162195	hsa-miR-4496	CLIP-seq
MIRT1162196	hsa-miR-4688	CLIP-seq
MIRT1162197	hsa-miR-4762-3p	CLIP-seq
MIRT1162198	hsa-miR-589	CLIP-seq
MIRT1162181	hsa-miR-1236	CLIP-seq
MIRT2046489	hsa-miR-1321	CLIP-seq
MIRT2046490	hsa-miR-3591-3p	CLIP-seq
MIRT2046491	hsa-miR-4287	CLIP-seq
MIRT2046492	hsa-miR-4685-3p	CLIP-seq
MIRT2046493	hsa-miR-4685-5p	CLIP-seq
MIRT2046494	hsa-miR-4719	CLIP-seq
MIRT2046495	hsa-miR-4739	CLIP-seq
MIRT2046496	hsa-miR-4747-5p	CLIP-seq
MIRT2046497	hsa-miR-4756-5p	CLIP-seq
MIRT2046498	hsa-miR-483-3p	CLIP-seq
MIRT2046499	hsa-miR-513b	CLIP-seq
MIRT2046500	hsa-miR-570	CLIP-seq
MIRT2046501	hsa-miR-603	CLIP-seq
MIRT2275598	hsa-miR-1204	CLIP-seq
MIRT2275599	hsa-miR-1252	CLIP-seq
MIRT2275600	hsa-miR-1262	CLIP-seq
MIRT2275601	hsa-miR-1276	CLIP-seq
MIRT2275602	hsa-miR-1285	CLIP-seq
MIRT2046489	hsa-miR-1321	CLIP-seq
MIRT2275603	hsa-miR-146b-3p	CLIP-seq
MIRT2275604	hsa-miR-3170	CLIP-seq
MIRT2275605	hsa-miR-3173-5p	CLIP-seq
MIRT2275606	hsa-miR-3187-5p	CLIP-seq
MIRT2275607	hsa-miR-3945	CLIP-seq
MIRT2275608	hsa-miR-4253	CLIP-seq
MIRT2275609	hsa-miR-4292	CLIP-seq
MIRT2275610	hsa-miR-4533	CLIP-seq
MIRT2275611	hsa-miR-4701-3p	CLIP-seq
MIRT2046495	hsa-miR-4739	CLIP-seq
MIRT2046496	hsa-miR-4747-5p	CLIP-seq
MIRT2046497	hsa-miR-4756-5p	CLIP-seq
MIRT2275612	hsa-miR-612	CLIP-seq
MIRT2275613	hsa-miR-874	CLIP-seq
MIRT1162181	hsa-miR-1236	CLIP-seq
MIRT2438813	hsa-miR-3614-5p	CLIP-seq
MIRT2438814	hsa-miR-3680	CLIP-seq
MIRT2438815	hsa-miR-4760-3p	CLIP-seq
MIRT2046501	hsa-miR-603	CLIP-seq
MIRT1162181	hsa-miR-1236	CLIP-seq
MIRT2275600	hsa-miR-1262	CLIP-seq
MIRT2275602	hsa-miR-1285	CLIP-seq
MIRT2046489	hsa-miR-1321	CLIP-seq
MIRT2275603	hsa-miR-146b-3p	CLIP-seq
MIRT2275605	hsa-miR-3173-5p	CLIP-seq
MIRT2275606	hsa-miR-3187-5p	CLIP-seq
MIRT2574594	hsa-miR-3202	CLIP-seq
MIRT2438813	hsa-miR-3614-5p	CLIP-seq
MIRT2438814	hsa-miR-3680	CLIP-seq
MIRT2275607	hsa-miR-3945	CLIP-seq
MIRT2275608	hsa-miR-4253	CLIP-seq
MIRT2046491	hsa-miR-4287	CLIP-seq
MIRT2275609	hsa-miR-4292	CLIP-seq
MIRT2574595	hsa-miR-4464	CLIP-seq
MIRT2046492	hsa-miR-4685-3p	CLIP-seq
MIRT2574596	hsa-miR-4690-3p	CLIP-seq
MIRT2275611	hsa-miR-4701-3p	CLIP-seq
MIRT2046495	hsa-miR-4739	CLIP-seq
MIRT2046496	hsa-miR-4747-5p	CLIP-seq
MIRT2574597	hsa-miR-4748	CLIP-seq
MIRT2046497	hsa-miR-4756-5p	CLIP-seq
MIRT2438815	hsa-miR-4760-3p	CLIP-seq
MIRT2046498	hsa-miR-483-3p	CLIP-seq
MIRT2046501	hsa-miR-603	CLIP-seq
MIRT2275612	hsa-miR-612	CLIP-seq
MIRT2275613	hsa-miR-874	CLIP-seq
MIRT1162181	hsa-miR-1236	CLIP-seq
MIRT2275600	hsa-miR-1262	CLIP-seq
MIRT2275602	hsa-miR-1285	CLIP-seq
MIRT2046489	hsa-miR-1321	CLIP-seq
MIRT2275603	hsa-miR-146b-3p	CLIP-seq
MIRT2275605	hsa-miR-3173-5p	CLIP-seq
MIRT2275606	hsa-miR-3187-5p	CLIP-seq
MIRT2574594	hsa-miR-3202	CLIP-seq
MIRT2438813	hsa-miR-3614-5p	CLIP-seq
MIRT2438814	hsa-miR-3680	CLIP-seq
MIRT2275607	hsa-miR-3945	CLIP-seq
MIRT2275608	hsa-miR-4253	CLIP-seq
MIRT2046491	hsa-miR-4287	CLIP-seq
MIRT2275609	hsa-miR-4292	CLIP-seq
MIRT2574595	hsa-miR-4464	CLIP-seq
MIRT2046492	hsa-miR-4685-3p	CLIP-seq
MIRT2275611	hsa-miR-4701-3p	CLIP-seq
MIRT2046495	hsa-miR-4739	CLIP-seq
MIRT2046496	hsa-miR-4747-5p	CLIP-seq
MIRT2574597	hsa-miR-4748	CLIP-seq
MIRT2046497	hsa-miR-4756-5p	CLIP-seq
MIRT2438815	hsa-miR-4760-3p	CLIP-seq
MIRT2046498	hsa-miR-483-3p	CLIP-seq
MIRT2046501	hsa-miR-603	CLIP-seq
MIRT2275612	hsa-miR-612	CLIP-seq
MIRT2275613	hsa-miR-874	CLIP-seq

Show/Hide all(29)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000118	Component	Histone deacetylase complex	TAS	10444591
GO:0000122	Process	Negative regulation of transcription by RNA polymerase II	IBA	21873635
GO:0000785	Component	Chromatin	HDA	16217013
GO:0001085	Function	RNA polymerase II transcription factor binding	IPI	15920471
GO:0001103	Function	RNA polymerase II repressing transcription factor binding	IBA	21873635
GO:0001103	Function	RNA polymerase II repressing transcription factor binding	IPI	22926524
GO:0003713	Function	Transcription coactivator activity	IBA	21873635
GO:0003714	Function	Transcription corepressor activity	IBA	21873635
GO:0004407	Function	Histone deacetylase activity	IEA
GO:0005515	Function	Protein binding	IPI	17646674, 17956988, 18451879, 19703393, 20127688, 21258344, 23752268, 24981860, 25150861, 26028330, 26030138, 26496610, 26949739, 27705803, 28179136, 28514442, 31980649
GO:0005654	Component	Nucleoplasm	IBA	21873635
GO:0005654	Component	Nucleoplasm	IDA
GO:0005654	Component	Nucleoplasm	TAS
GO:0005667	Component	Transcription regulator complex	IDA	15920471
GO:0006306	Process	DNA methylation	IEA
GO:0006333	Process	Chromatin assembly or disassembly	TAS	10444591
GO:0008270	Function	Zinc ion binding	IEA
GO:0010762	Process	Regulation of fibroblast migration	IEA
GO:0016020	Component	Membrane	HDA	19946888
GO:0016575	Process	Histone deacetylation	IBA	21873635
GO:0016581	Component	NuRD complex	IBA	21873635
GO:0016581	Component	NuRD complex	IDA	19644445, 22926524
GO:0031492	Function	Nucleosomal DNA binding	HDA	16217013
GO:0032991	Component	Protein-containing complex	HDA	16217013
GO:0042826	Function	Histone deacetylase binding	IBA	21873635
GO:0043044	Process	ATP-dependent chromatin remodeling	HDA	16217013
GO:0043565	Function	Sequence-specific DNA binding	IEA
GO:0045944	Process	Positive regulation of transcription by RNA polymerase II	IEA
GO:1901796	Process	Regulation of signal transduction by p53 class mediator	TAS

MIM	HGNC	e!Ensembl
603947	7411	ENSG00000149480

Protein

UniProt ID

O94776

Protein name

Metastasis-associated protein MTA2 (Metastasis-associated 1-like 1) (MTA1-L1 protein) (p53 target protein in deacetylase complex)

Protein function

May function as a transcriptional coregulator (PubMed:16428440, PubMed:28977666). Acts as a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin (PubMed:16428440, PubMed:28977666). {ECO:0000269|PubM

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF01426	BAH	4 → 144	BAH domain	Domain
PF01448	ELM2	147 → 199	ELM2 domain	Family
PF00320	GATA	367 → 404	GATA zinc finger	Domain
PF17226	MTA_R1	447 → 524	MTA R1 domain	Domain

Tissue specificity

TISSUE SPECIFICITY: Widely expressed.

Sequence

MAANMYRVGDYVYFENSSSNPYLVRRIEELNKTANGNVEAKVVCLFRRRDISSSLNSLAD
SNAREFEEESKQPGVSEQQRHQLKHRELFLSRQFESLPATHIRGKCSVTLLNETDILSQY
LEKEDCFFYSLVFDPVQKTLLADQGEIRVGCKYQAEIPDRLVEGESDNRNQQKMEMKVWD
PDNPLTDRQIDQFLVVARAVGTFARALDCSSSIRQPSLHMSAAAASRDITLFHAMDTLQR
NGYDLAKAMSTLVPQGGPVLCRDEMEEWSASEAMLFEEALEKYGKDFNDIRQDFLPWKSL
ASIVQFYYMWKTTDRYIQQKRLKAAEADSKLKQVYIPTYTKPNPNQIISVGSKPGMNGAG
FQKGLTCESCHTTQSAQWYAWGPPNMQCRLCASCWIYWKKYGGLKTPTQLEGATRGTTEP
HSRGHLSRPEAQSLSPYTTSANRAKLLAKNRQTFLLQTTKLTRLARRMCRDLLQPRRAAR
RPYAPINANAIKAECSIRLPKAAKTPLKIHPLVRLPLATIVKDLVAQAPLKPKTPRGTKT
PINRNQLSQNRGLGGIMVKRAYETMAGAGVPFSANGRPLASGIRSSSQPAAKRQKLNPAD
APNPVVFVATKDTRALRKALTHLEMRRAARRPNLPLKVKPTLIAVRPPVPLPAPSHPAST
NEPIVLED

Sequence length

668

Interactions

View interactions

	KEGG		Reactome
	ATP-dependent chromatin remodeling		HDACs deacetylate histones Regulation of TP53 Activity through Acetylation RNA Polymerase I Transcription Initiation Regulation of PTEN gene transcription

Show/Hide Unknown Diseases (1)

Disease term	Disease name	Evidence	References	Source
Unknown
Endometriosis	Endometriosis		22138541	ClinVar

Show/Hide Text Mining Associations (20)

Disease Name	Relationship Type	References
Associations from Text Mining
Adenoma	Stimulate	26048755
Anemia Hemolytic	Associate	19687298
Breast Neoplasms	Associate	16645043, 30642362, 36913304
Carcinoma Hepatocellular	Associate	26722504, 36575438, 37371463
Carcinoma Pancreatic Ductal	Stimulate	23400716
Colorectal Neoplasms	Associate	26261611
DNA Virus Infections	Associate	37898641
Lymphatic Metastasis	Stimulate	23400716
Melanoma	Associate	24850177
Mesothelioma	Associate	26254420
Mesothelioma Malignant	Associate	26254420
Multiple Myeloma	Associate	36454786
Neoplasm Metastasis	Associate	12920132, 20124483, 25929737, 26722504
Neoplasm Metastasis	Stimulate	30642362
Neoplasms	Associate	16309230, 25929737, 26261611, 36913304, 37371463
Pancreatic Neoplasms	Associate	20124483
Sarcoma	Associate	26254420
Stomach Neoplasms	Associate	25929737, 35484118
Thymoma	Associate	22833212
Thyroid Cancer Papillary	Associate	32940102

MTA2 (metastasis associated 1 family member 2)