Gene Gene information from NCBI Gene database.
Entrez ID 92140
Gene name Metadherin
Gene symbol MTDH
Synonyms (NCBI Gene)
3D3AEG-1AEG1LYRICLYRIC/3D3
Chromosome 8
Chromosome location 8q22.1
miRNA miRNA information provided by mirtarbase database.
1438
miRTarBase ID miRNA Experiments Reference
MIRT005920 hsa-miR-26a-5p ImmunohistochemistryLuciferase reporter assayqRT-PCRWestern blot 20952513
MIRT006207 hsa-miR-375 ImmunofluorescenceLuciferase reporter assayqRT-PCRWestern blot 22508479
MIRT006207 hsa-miR-375 ImmunofluorescenceLuciferase reporter assayqRT-PCRWestern blot 22508479
MIRT006207 hsa-miR-375 ImmunofluorescenceLuciferase reporter assayqRT-PCRWestern blot 22508479
MIRT006867 hsa-miR-136-5p Luciferase reporter assay 22967897
Transcription factors Transcription factors information provided by TRRUST V2 database.
1
Transcription factor Regulation Reference
MYC Unknown 17088530
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
42
GO ID Ontology Definition Evidence Reference
GO:0000122 Process Negative regulation of transcription by RNA polymerase II IDA 15927426
GO:0001650 Component Fibrillar center IDA
GO:0003712 Function Transcription coregulator activity IBA
GO:0003713 Function Transcription coactivator activity IMP 18316612
GO:0003723 Function RNA binding HDA 22658674, 22681889
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
610323 29608 ENSG00000147649
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
Q86UE4
Protein name Protein LYRIC (3D3/LYRIC) (Astrocyte elevated gene-1 protein) (AEG-1) (Lysine-rich CEACAM1 co-isolated protein) (Metadherin) (Metastasis adhesion protein)
Protein function Down-regulates SLC1A2/EAAT2 promoter activity when expressed ectopically. Activates the nuclear factor kappa-B (NF-kappa-B) transcription factor. Promotes anchorage-independent growth of immortalized melanocytes and astrocytes which is a key com
PDB 4QMG
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF15686 LYRIC 6 424 Lysine-rich CEACAM1 co-isolated protein family Family
Tissue specificity TISSUE SPECIFICITY: Widely expressed with highest levels in muscle-dominating organs such as skeletal muscle, heart, tongue and small intestine and in endocrine glands such as thyroid and adrenal gland. Overexpressed in various cancers including breast, b
Sequence
Sequence length 582
Interactions View interactions