Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
92140
Gene name Gene Name - the full gene name approved by the HGNC.
Metadherin
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
MTDH
Synonyms (NCBI Gene) Gene synonyms aliases
3D3, AEG-1, AEG1, LYRIC, LYRIC/3D3
Chromosome Chromosome number
8
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
8q22.1
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT005920 hsa-miR-26a-5p Immunohistochemistry, Luciferase reporter assay, qRT-PCR, Western blot 20952513
MIRT006207 hsa-miR-375 Immunofluorescence, Luciferase reporter assay, qRT-PCR, Western blot 22508479
MIRT006207 hsa-miR-375 Immunofluorescence, Luciferase reporter assay, qRT-PCR, Western blot 22508479
MIRT006207 hsa-miR-375 Immunofluorescence, Luciferase reporter assay, qRT-PCR, Western blot 22508479
MIRT006867 hsa-miR-136-5p Luciferase reporter assay 22967897
Transcription factors
Transcription factor Regulation Reference
MYC Unknown 17088530
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0000122 Process Negative regulation of transcription by RNA polymerase II IDA 15927426
GO:0001085 Function RNA polymerase II transcription factor binding IPI 18316612
GO:0001650 Component Fibrillar center IDA
GO:0003712 Function Transcription coregulator activity IBA 21873635
GO:0003713 Function Transcription coactivator activity IMP 18316612
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
610323 29608 ENSG00000147649
Protein
UniProt ID Q86UE4
Protein name Protein LYRIC (3D3/LYRIC) (Astrocyte elevated gene-1 protein) (AEG-1) (Lysine-rich CEACAM1 co-isolated protein) (Metadherin) (Metastasis adhesion protein)
Protein function Down-regulates SLC1A2/EAAT2 promoter activity when expressed ectopically. Activates the nuclear factor kappa-B (NF-kappa-B) transcription factor. Promotes anchorage-independent growth of immortalized melanocytes and astrocytes which is a key com
PDB 4QMG
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF15686 LYRIC 6 424 Lysine-rich CEACAM1 co-isolated protein family Family
Tissue specificity TISSUE SPECIFICITY: Widely expressed with highest levels in muscle-dominating organs such as skeletal muscle, heart, tongue and small intestine and in endocrine glands such as thyroid and adrenal gland. Overexpressed in various cancers including breast, b
Sequence
Sequence length 582
Interactions View interactions
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Causal
Disease term Disease name dbSNP ID References
Breast cancer Malignant neoplasm of breast rs587776547, rs1137887, rs137853007, rs587776650, rs80359351, rs80359714, rs121917783, rs104886456, rs121964878, rs80359874, rs80357868, rs80357508, rs387906843, rs80357569, rs80358158
View all (309 more)
19111877
Breast carcinoma Breast Carcinoma rs80359671, rs11540652, rs28934575, rs28897672, rs137886232, rs193922376, rs80357783, rs80359306, rs80359405, rs80359507, rs80359598, rs80358429, rs397507683, rs397515636, rs80359451
View all (71 more)
19111877
Colorectal cancer Colorectal Carcinoma rs137854568, rs137854573, rs137854575, rs387906234, rs121908380, rs121908702, rs267606674, rs794729661, rs121909055, rs281865417, rs267606884, rs28934575, rs587776769, rs104893815, rs587776800
View all (467 more)
29315995
Colorectal neoplasms Colorectal Neoplasms rs28929483, rs63751108, rs28929484, rs63749831, rs63750047, rs63751207, rs63749811, rs1553350126, rs63750875, rs63750955, rs587776706, rs63750871, rs587776715, rs63751466, rs63750049
View all (1682 more)
29315995
Unknown
Disease term Disease name Evidence References Source
Dementia Dementia GWAS
Alzheimer disease Alzheimer disease GWAS
Associations from Text Mining
Disease Name Relationship Type References
Adenocarcinoma Stimulate 23595222
Aortic Dissection Associate 28415624
Astrocytoma Associate 25197376
Atypical Squamous Cells of the Cervix Stimulate 23595222
Brain Neoplasms Stimulate 28952213
Breast Neoplasms Associate 20565850, 21408129, 22195048, 22336587, 22938464, 23011158, 23240043, 25993398, 26236947, 28952213, 30464390, 30969950, 31490377, 31779025, 32993809
View all (3 more)
Breast Neoplasms Stimulate 21687633
Breast Neoplasms Male Associate 22527098
Calcinosis Cutis Associate 24375254
Carcinogenesis Associate 17088530, 21750404, 22133054, 24136747, 24375254, 24462870, 24829520, 24989027, 25652471, 27903708, 28627585, 37838281