CD5 (CD5 molecule)

Gene

• Entrez ID: 921
• Gene name: CD5 molecule
• Gene symbol: CD5
• Synonyms (NCBI Gene): LEU1, T1
• Chromosome: 11
• Chromosome location: 11q12.2
• Summary: This gene encodes a member of the scavenger receptor cysteine-rich (SRCR) superfamily. Members of this family are secreted or membrane-anchored proteins mainly found in cells associated with the immune system. This protein is a type-I transmembrane glycop

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT875792	hsa-miR-1913	CLIP-seq
MIRT875793	hsa-miR-3064-5p	CLIP-seq
MIRT875794	hsa-miR-324-3p	CLIP-seq
MIRT875795	hsa-miR-3613-3p	CLIP-seq
MIRT875796	hsa-miR-4272	CLIP-seq
MIRT875797	hsa-miR-4313	CLIP-seq
MIRT875798	hsa-miR-4677-3p	CLIP-seq
MIRT875799	hsa-miR-4698	CLIP-seq
MIRT875800	hsa-miR-483-3p	CLIP-seq
MIRT875801	hsa-miR-502-5p	CLIP-seq
MIRT875802	hsa-miR-516a-3p	CLIP-seq
MIRT875803	hsa-miR-520d-5p	CLIP-seq
MIRT875804	hsa-miR-524-5p	CLIP-seq
MIRT875805	hsa-miR-548ae	CLIP-seq
MIRT875806	hsa-miR-548aj	CLIP-seq
MIRT875807	hsa-miR-548am	CLIP-seq
MIRT875808	hsa-miR-548x	CLIP-seq
MIRT875809	hsa-miR-604	CLIP-seq
MIRT875810	hsa-miR-647	CLIP-seq
MIRT875811	hsa-miR-668	CLIP-seq
MIRT875812	hsa-miR-892b	CLIP-seq
MIRT2196550	hsa-miR-3184	CLIP-seq
MIRT2196551	hsa-miR-423-5p	CLIP-seq
MIRT2446604	hsa-miR-1291	CLIP-seq
MIRT2446605	hsa-miR-2113	CLIP-seq
MIRT2446606	hsa-miR-4292	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005515	Function	Protein binding	IPI	1711157
GO:0005886	Component	Plasma membrane	IBA
GO:0005886	Component	Plasma membrane	IDA	11390434
GO:0005886	Component	Plasma membrane	IEA
GO:0005886	Component	Plasma membrane	NAS	1711157
GO:0008037	Process	Cell recognition	NAS	1711157
GO:0009897	Component	External side of plasma membrane	IEA
GO:0016020	Component	Membrane	IEA
GO:0031295	Process	T cell costimulation	IBA
GO:0031295	Process	T cell costimulation	IEA
GO:0038023	Function	Signaling receptor activity	NAS	1711157
GO:0097190	Process	Apoptotic signaling pathway	IEA

Other IDs

• MIM: 153340
• HGNC: 1685
• e!Ensembl: ENSG00000110448

Protein

• UniProt ID: P06127
• Protein name: T-cell surface glycoprotein CD5 (Lymphocyte antigen T1/Leu-1) (CD antigen CD5)
• Protein function: Lymphoid-specific receptor expressed by all T-cells and in a subset of B-cells known as B1a cells. Plays a role in the regulation of TCR and BCR signaling, thymocyte selection, T-cell effector differentiation and immune tolerance. Acts by intera
• PDB: 2JA4, 2JOP, 2JP0, 2OTT
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00530	SRCR	38 → 133	Scavenger receptor cysteine-rich domain	Domain

• Sequence:

  MPMGSLQPLATLYLLGMLVASCLGRLSWYDPDFQARLTRSNSKCQGQLEVYLKDGWHMVC
  SQSWGRSSKQWEDPSQASKVCQRLNCGVPLSLGPFLVTYTPQSSIICYGQLGSFSNCSHS
  RNDMCHSLGLTCLEPQKTTPPTTRPPPTTTPEPTAPPRLQLVAQSGGQHCAGVVEFYSGS
  LGGTISYEAQDKTQDLENFLCNNLQCGSFLKHLPETEAGRAQDPGEPREHQPLPIQWKIQ
  NSSCTSLEHCFRKIKPQKSGRVLALLCSGFQPKVQSRLVGGSSICEGTVEVRQGAQWAAL
  CDSSSARSSLRWEEVCREQQCGSVNSYRVLDAGDPTSRGLFCPHQKLSQCHELWERNSYC
  KKVFVTCQDPNPAGLAAGTVASIILALVLLVVLLVVCGPLAYKKLVKKFRQKKQRQWIGP
  TGMNQNMSFHRNHTATVRSHAENPTASHVDNEYSQPPRNSHLSAYPALEGALHRSSMQPD
  NSSDSDYDLHGAQRL

• Sequence length: 495

Pathways

KEGG:

Hematopoietic cell lineage