Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene miRNA Gene ontology Other IDs Protein Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	9201
Gene name Gene Name - the full gene name approved by the HGNC.	Doublecortin like kinase 1
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	DCLK1
Synonyms (NCBI Gene) Gene synonyms aliases	CL1, CLICK1, DCAMKL1, DCDC3A, DCLK
Chromosome Chromosome number	13
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	13q13.3
Summary Summary of gene provided in NCBI Entrez Gene.	This gene encodes a member of the protein kinase superfamily and the doublecortin family. The protein encoded by this gene contains two N-terminal doublecortin domains, which bind microtubules and regulate microtubule polymerization, a C-terminal serine/t

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miRTarBase ID	miRNA	Experiments
MIRT926104	hsa-miR-1205	CLIP-seq
MIRT926105	hsa-miR-1276	CLIP-seq
MIRT926106	hsa-miR-143	CLIP-seq
MIRT926107	hsa-miR-217	CLIP-seq
MIRT926108	hsa-miR-3123	CLIP-seq
MIRT926109	hsa-miR-3136-5p	CLIP-seq
MIRT926110	hsa-miR-3158-5p	CLIP-seq
MIRT926111	hsa-miR-3662	CLIP-seq
MIRT926112	hsa-miR-3665	CLIP-seq
MIRT926113	hsa-miR-3925-5p	CLIP-seq
MIRT926114	hsa-miR-4418	CLIP-seq
MIRT926115	hsa-miR-4439	CLIP-seq
MIRT926116	hsa-miR-4453	CLIP-seq
MIRT926117	hsa-miR-4495	CLIP-seq
MIRT926118	hsa-miR-4538	CLIP-seq
MIRT926119	hsa-miR-455-3p	CLIP-seq
MIRT926120	hsa-miR-4645-3p	CLIP-seq
MIRT926121	hsa-miR-4756-3p	CLIP-seq
MIRT926122	hsa-miR-4770	CLIP-seq
MIRT926123	hsa-miR-4777-5p	CLIP-seq
MIRT926124	hsa-miR-509-3-5p	CLIP-seq
MIRT926125	hsa-miR-509-5p	CLIP-seq
MIRT926126	hsa-miR-518d-5p	CLIP-seq
MIRT926127	hsa-miR-519b-5p	CLIP-seq
MIRT926128	hsa-miR-519c-5p	CLIP-seq
MIRT926129	hsa-miR-520c-5p	CLIP-seq
MIRT926130	hsa-miR-526a	CLIP-seq
MIRT926131	hsa-miR-657	CLIP-seq
MIRT926132	hsa-miR-943	CLIP-seq
MIRT926133	hsa-miR-1207-3p	CLIP-seq
MIRT926134	hsa-miR-1237	CLIP-seq
MIRT926135	hsa-miR-1248	CLIP-seq
MIRT926136	hsa-miR-1299	CLIP-seq
MIRT926137	hsa-miR-2909	CLIP-seq
MIRT926138	hsa-miR-3162-5p	CLIP-seq
MIRT926139	hsa-miR-3646	CLIP-seq
MIRT926111	hsa-miR-3662	CLIP-seq
MIRT926140	hsa-miR-378	CLIP-seq
MIRT926141	hsa-miR-378b	CLIP-seq
MIRT926142	hsa-miR-378c	CLIP-seq
MIRT926143	hsa-miR-378d	CLIP-seq
MIRT926144	hsa-miR-378e	CLIP-seq
MIRT926145	hsa-miR-378f	CLIP-seq
MIRT926146	hsa-miR-378g	CLIP-seq
MIRT926147	hsa-miR-378h	CLIP-seq
MIRT926148	hsa-miR-378i	CLIP-seq
MIRT926149	hsa-miR-422a	CLIP-seq
MIRT926150	hsa-miR-4291	CLIP-seq
MIRT926151	hsa-miR-4310	CLIP-seq
MIRT926152	hsa-miR-4473	CLIP-seq
MIRT926153	hsa-miR-4511	CLIP-seq
MIRT926154	hsa-miR-4638-3p	CLIP-seq
MIRT926155	hsa-miR-4698	CLIP-seq
MIRT926156	hsa-miR-4738-3p	CLIP-seq
MIRT926157	hsa-miR-4782-5p	CLIP-seq
MIRT926158	hsa-miR-512-3p	CLIP-seq
MIRT926159	hsa-miR-516b	CLIP-seq
MIRT926160	hsa-miR-520d-5p	CLIP-seq
MIRT926161	hsa-miR-520f	CLIP-seq
MIRT926162	hsa-miR-524-5p	CLIP-seq
MIRT926163	hsa-miR-548b-3p	CLIP-seq
MIRT926164	hsa-miR-105	CLIP-seq
MIRT926165	hsa-miR-1291	CLIP-seq
MIRT926166	hsa-miR-1305	CLIP-seq
MIRT926167	hsa-miR-146b-3p	CLIP-seq
MIRT926168	hsa-miR-216a	CLIP-seq
MIRT926169	hsa-miR-3121-3p	CLIP-seq
MIRT926170	hsa-miR-3671	CLIP-seq
MIRT926171	hsa-miR-3976	CLIP-seq
MIRT926172	hsa-miR-4719	CLIP-seq
MIRT926173	hsa-miR-4755-3p	CLIP-seq
MIRT926174	hsa-miR-4760-5p	CLIP-seq
MIRT926175	hsa-miR-486-5p	CLIP-seq
MIRT926176	hsa-miR-548c-3p	CLIP-seq
MIRT926177	hsa-miR-607	CLIP-seq
MIRT926178	hsa-miR-668	CLIP-seq
MIRT1974375	hsa-miR-2467-3p	CLIP-seq
MIRT926110	hsa-miR-3158-5p	CLIP-seq
MIRT1974376	hsa-miR-3173-5p	CLIP-seq
MIRT1974377	hsa-miR-3663-3p	CLIP-seq
MIRT1974378	hsa-miR-3678-3p	CLIP-seq
MIRT1974379	hsa-miR-4446-5p	CLIP-seq
MIRT2209818	hsa-miR-1244	CLIP-seq
MIRT2209819	hsa-miR-1252	CLIP-seq
MIRT2209820	hsa-miR-1283	CLIP-seq
MIRT2209821	hsa-miR-140-3p	CLIP-seq
MIRT2209822	hsa-miR-155	CLIP-seq
MIRT2209823	hsa-miR-181a	CLIP-seq
MIRT2209824	hsa-miR-181b	CLIP-seq
MIRT2209825	hsa-miR-181c	CLIP-seq
MIRT2209826	hsa-miR-181d	CLIP-seq
MIRT2209827	hsa-miR-199a-3p	CLIP-seq
MIRT2209828	hsa-miR-199b-3p	CLIP-seq
MIRT2209829	hsa-miR-21	CLIP-seq
MIRT926107	hsa-miR-217	CLIP-seq
MIRT2209830	hsa-miR-23a	CLIP-seq
MIRT2209831	hsa-miR-23b	CLIP-seq
MIRT2209832	hsa-miR-23c	CLIP-seq
MIRT2209833	hsa-miR-3117-5p	CLIP-seq
MIRT2209834	hsa-miR-3129-5p	CLIP-seq
MIRT926109	hsa-miR-3136-5p	CLIP-seq
MIRT2209835	hsa-miR-3157-5p	CLIP-seq
MIRT926110	hsa-miR-3158-5p	CLIP-seq
MIRT2209836	hsa-miR-3159	CLIP-seq
MIRT2209837	hsa-miR-365	CLIP-seq
MIRT2209838	hsa-miR-3660	CLIP-seq
MIRT2209839	hsa-miR-3668	CLIP-seq
MIRT2209840	hsa-miR-3921	CLIP-seq
MIRT2209841	hsa-miR-3924	CLIP-seq
MIRT2209842	hsa-miR-412	CLIP-seq
MIRT2209843	hsa-miR-4262	CLIP-seq
MIRT926114	hsa-miR-4418	CLIP-seq
MIRT2209844	hsa-miR-4436a	CLIP-seq
MIRT926115	hsa-miR-4439	CLIP-seq
MIRT926116	hsa-miR-4453	CLIP-seq
MIRT2209845	hsa-miR-4502	CLIP-seq
MIRT2209846	hsa-miR-4513	CLIP-seq
MIRT2209847	hsa-miR-4526	CLIP-seq
MIRT926118	hsa-miR-4538	CLIP-seq
MIRT926120	hsa-miR-4645-3p	CLIP-seq
MIRT2209848	hsa-miR-4653-5p	CLIP-seq
MIRT2209849	hsa-miR-4666-5p	CLIP-seq
MIRT2209850	hsa-miR-4691-3p	CLIP-seq
MIRT2209851	hsa-miR-485-3p	CLIP-seq
MIRT926124	hsa-miR-509-3-5p	CLIP-seq
MIRT926125	hsa-miR-509-5p	CLIP-seq
MIRT926160	hsa-miR-520d-5p	CLIP-seq
MIRT926162	hsa-miR-524-5p	CLIP-seq
MIRT2209852	hsa-miR-548ac	CLIP-seq
MIRT2209853	hsa-miR-548d-3p	CLIP-seq
MIRT2209854	hsa-miR-548z	CLIP-seq
MIRT2209855	hsa-miR-569	CLIP-seq
MIRT2209856	hsa-miR-570	CLIP-seq
MIRT2209857	hsa-miR-590-5p	CLIP-seq
MIRT2209858	hsa-miR-767-5p	CLIP-seq
MIRT2209859	hsa-miR-936	CLIP-seq
MIRT926132	hsa-miR-943	CLIP-seq
MIRT926133	hsa-miR-1207-3p	CLIP-seq
MIRT926146	hsa-miR-378g	CLIP-seq
MIRT2448084	hsa-miR-1249	CLIP-seq
MIRT2448085	hsa-miR-3187-3p	CLIP-seq
MIRT2448086	hsa-miR-3681	CLIP-seq
MIRT2448087	hsa-miR-4435	CLIP-seq
MIRT2448088	hsa-miR-4701-5p	CLIP-seq
MIRT2448089	hsa-miR-548s	CLIP-seq
MIRT2448090	hsa-miR-588	CLIP-seq
MIRT2513589	hsa-miR-103a	CLIP-seq
MIRT2513590	hsa-miR-107	CLIP-seq
MIRT926104	hsa-miR-1205	CLIP-seq
MIRT2513591	hsa-miR-1206	CLIP-seq
MIRT2513592	hsa-miR-1208	CLIP-seq
MIRT2513593	hsa-miR-1226	CLIP-seq
MIRT2513594	hsa-miR-1231	CLIP-seq
MIRT926134	hsa-miR-1237	CLIP-seq
MIRT926135	hsa-miR-1248	CLIP-seq
MIRT2513595	hsa-miR-125a-5p	CLIP-seq
MIRT2513596	hsa-miR-125b	CLIP-seq
MIRT2513597	hsa-miR-1273d	CLIP-seq
MIRT2513598	hsa-miR-1286	CLIP-seq
MIRT926136	hsa-miR-1299	CLIP-seq
MIRT2513599	hsa-miR-139-5p	CLIP-seq
MIRT926106	hsa-miR-143	CLIP-seq
MIRT2513600	hsa-miR-15a	CLIP-seq
MIRT2513601	hsa-miR-15b	CLIP-seq
MIRT2513602	hsa-miR-16	CLIP-seq
MIRT2209823	hsa-miR-181a	CLIP-seq
MIRT2209824	hsa-miR-181b	CLIP-seq
MIRT2209825	hsa-miR-181c	CLIP-seq
MIRT2209826	hsa-miR-181d	CLIP-seq
MIRT2513603	hsa-miR-190	CLIP-seq
MIRT2513604	hsa-miR-190b	CLIP-seq
MIRT2513605	hsa-miR-1912	CLIP-seq
MIRT2513606	hsa-miR-195	CLIP-seq
MIRT2513607	hsa-miR-1972	CLIP-seq
MIRT2513608	hsa-miR-204	CLIP-seq
MIRT2209829	hsa-miR-21	CLIP-seq
MIRT2513609	hsa-miR-211	CLIP-seq
MIRT2513610	hsa-miR-218	CLIP-seq
MIRT2513611	hsa-miR-221	CLIP-seq
MIRT2513612	hsa-miR-222	CLIP-seq
MIRT2513613	hsa-miR-223	CLIP-seq
MIRT2209830	hsa-miR-23a	CLIP-seq
MIRT2209831	hsa-miR-23b	CLIP-seq
MIRT2209832	hsa-miR-23c	CLIP-seq
MIRT2513614	hsa-miR-3065-3p	CLIP-seq
MIRT2209833	hsa-miR-3117-5p	CLIP-seq
MIRT926109	hsa-miR-3136-5p	CLIP-seq
MIRT2513615	hsa-miR-3150a-3p	CLIP-seq
MIRT2513616	hsa-miR-3154	CLIP-seq
MIRT2513617	hsa-miR-3156-5p	CLIP-seq
MIRT2513618	hsa-miR-3161	CLIP-seq
MIRT2513619	hsa-miR-3163	CLIP-seq
MIRT2513620	hsa-miR-3175	CLIP-seq
MIRT2513621	hsa-miR-33a	CLIP-seq
MIRT2513622	hsa-miR-33b	CLIP-seq
MIRT2513623	hsa-miR-3607-5p	CLIP-seq
MIRT2513624	hsa-miR-3613-3p	CLIP-seq
MIRT2513625	hsa-miR-3618	CLIP-seq
MIRT2513626	hsa-miR-3647-3p	CLIP-seq
MIRT2513627	hsa-miR-3653	CLIP-seq
MIRT2513628	hsa-miR-3658	CLIP-seq
MIRT926111	hsa-miR-3662	CLIP-seq
MIRT2513629	hsa-miR-3688-3p	CLIP-seq
MIRT2513630	hsa-miR-375	CLIP-seq
MIRT926140	hsa-miR-378	CLIP-seq
MIRT926141	hsa-miR-378b	CLIP-seq
MIRT926142	hsa-miR-378c	CLIP-seq
MIRT926143	hsa-miR-378d	CLIP-seq
MIRT926144	hsa-miR-378e	CLIP-seq
MIRT926145	hsa-miR-378f	CLIP-seq
MIRT926147	hsa-miR-378h	CLIP-seq
MIRT926148	hsa-miR-378i	CLIP-seq
MIRT2513631	hsa-miR-3919	CLIP-seq
MIRT2513632	hsa-miR-3920	CLIP-seq
MIRT2513633	hsa-miR-3938	CLIP-seq
MIRT2513634	hsa-miR-409-3p	CLIP-seq
MIRT926149	hsa-miR-422a	CLIP-seq
MIRT2513635	hsa-miR-424	CLIP-seq
MIRT2209843	hsa-miR-4262	CLIP-seq
MIRT2513636	hsa-miR-4273	CLIP-seq
MIRT2513637	hsa-miR-4282	CLIP-seq
MIRT2513638	hsa-miR-4287	CLIP-seq
MIRT2513639	hsa-miR-4288	CLIP-seq
MIRT926150	hsa-miR-4291	CLIP-seq
MIRT926151	hsa-miR-4310	CLIP-seq
MIRT2513640	hsa-miR-4312	CLIP-seq
MIRT2513641	hsa-miR-4319	CLIP-seq
MIRT2513642	hsa-miR-4324	CLIP-seq
MIRT2513643	hsa-miR-4436b-5p	CLIP-seq
MIRT926115	hsa-miR-4439	CLIP-seq
MIRT2513644	hsa-miR-4469	CLIP-seq
MIRT2513645	hsa-miR-4476	CLIP-seq
MIRT2513646	hsa-miR-4477a	CLIP-seq
MIRT2513647	hsa-miR-450b-3p	CLIP-seq
MIRT2513648	hsa-miR-4517	CLIP-seq
MIRT2513649	hsa-miR-452	CLIP-seq
MIRT2513650	hsa-miR-4524	CLIP-seq
MIRT926154	hsa-miR-4638-3p	CLIP-seq
MIRT2513651	hsa-miR-4643	CLIP-seq
MIRT2513652	hsa-miR-4676-3p	CLIP-seq
MIRT2513653	hsa-miR-4677-5p	CLIP-seq
MIRT2513654	hsa-miR-4685-3p	CLIP-seq
MIRT2513655	hsa-miR-4693-3p	CLIP-seq
MIRT2513656	hsa-miR-4697-3p	CLIP-seq
MIRT2513657	hsa-miR-4713-3p	CLIP-seq
MIRT2513658	hsa-miR-4715-3p	CLIP-seq
MIRT2513659	hsa-miR-4717-5p	CLIP-seq
MIRT2513660	hsa-miR-4722-5p	CLIP-seq
MIRT2513661	hsa-miR-4728-3p	CLIP-seq
MIRT2513662	hsa-miR-4731-5p	CLIP-seq
MIRT2513663	hsa-miR-4732-3p	CLIP-seq
MIRT2513664	hsa-miR-4733-3p	CLIP-seq
MIRT2513665	hsa-miR-4746-5p	CLIP-seq
MIRT2513666	hsa-miR-4755-5p	CLIP-seq
MIRT926121	hsa-miR-4756-3p	CLIP-seq
MIRT926122	hsa-miR-4770	CLIP-seq
MIRT2513667	hsa-miR-4773	CLIP-seq
MIRT2513668	hsa-miR-4780	CLIP-seq
MIRT926157	hsa-miR-4782-5p	CLIP-seq
MIRT2513669	hsa-miR-4790-3p	CLIP-seq
MIRT2513670	hsa-miR-4797-5p	CLIP-seq
MIRT2513671	hsa-miR-4799-5p	CLIP-seq
MIRT2513672	hsa-miR-497	CLIP-seq
MIRT2513673	hsa-miR-503	CLIP-seq
MIRT2513674	hsa-miR-509-3p	CLIP-seq
MIRT926159	hsa-miR-516b	CLIP-seq
MIRT2513675	hsa-miR-532-5p	CLIP-seq
MIRT2513676	hsa-miR-539	CLIP-seq
MIRT2513677	hsa-miR-543	CLIP-seq
MIRT2513678	hsa-miR-544	CLIP-seq
MIRT2513679	hsa-miR-548v	CLIP-seq
MIRT2513680	hsa-miR-550b	CLIP-seq
MIRT2209856	hsa-miR-570	CLIP-seq
MIRT2513681	hsa-miR-580	CLIP-seq
MIRT2209857	hsa-miR-590-5p	CLIP-seq
MIRT2513682	hsa-miR-592	CLIP-seq
MIRT2513683	hsa-miR-597	CLIP-seq
MIRT2513684	hsa-miR-621	CLIP-seq
MIRT2513685	hsa-miR-623	CLIP-seq
MIRT2513686	hsa-miR-632	CLIP-seq
MIRT2513687	hsa-miR-636	CLIP-seq
MIRT2513688	hsa-miR-638	CLIP-seq
MIRT2513689	hsa-miR-646	CLIP-seq
MIRT926131	hsa-miR-657	CLIP-seq
MIRT2513690	hsa-miR-659	CLIP-seq
MIRT2513691	hsa-miR-664	CLIP-seq
MIRT2513692	hsa-miR-670	CLIP-seq
MIRT2513693	hsa-miR-671-5p	CLIP-seq
MIRT2513694	hsa-miR-769-3p	CLIP-seq
MIRT2513695	hsa-miR-888	CLIP-seq
MIRT2513696	hsa-miR-889	CLIP-seq
MIRT2513697	hsa-miR-934	CLIP-seq
MIRT2513698	hsa-miR-939	CLIP-seq
MIRT926132	hsa-miR-943	CLIP-seq
MIRT2513591	hsa-miR-1206	CLIP-seq
MIRT2513592	hsa-miR-1208	CLIP-seq
MIRT926134	hsa-miR-1237	CLIP-seq
MIRT926135	hsa-miR-1248	CLIP-seq
MIRT2513595	hsa-miR-125a-5p	CLIP-seq
MIRT2513596	hsa-miR-125b	CLIP-seq
MIRT2209823	hsa-miR-181a	CLIP-seq
MIRT2209824	hsa-miR-181b	CLIP-seq
MIRT2209825	hsa-miR-181c	CLIP-seq
MIRT2209826	hsa-miR-181d	CLIP-seq
MIRT2513608	hsa-miR-204	CLIP-seq
MIRT2209829	hsa-miR-21	CLIP-seq
MIRT2513609	hsa-miR-211	CLIP-seq
MIRT2513611	hsa-miR-221	CLIP-seq
MIRT2513612	hsa-miR-222	CLIP-seq
MIRT2209830	hsa-miR-23a	CLIP-seq
MIRT2209831	hsa-miR-23b	CLIP-seq
MIRT2209832	hsa-miR-23c	CLIP-seq
MIRT2209833	hsa-miR-3117-5p	CLIP-seq
MIRT926109	hsa-miR-3136-5p	CLIP-seq
MIRT2513619	hsa-miR-3163	CLIP-seq
MIRT2513621	hsa-miR-33a	CLIP-seq
MIRT2513622	hsa-miR-33b	CLIP-seq
MIRT2513626	hsa-miR-3647-3p	CLIP-seq
MIRT926111	hsa-miR-3662	CLIP-seq
MIRT2513632	hsa-miR-3920	CLIP-seq
MIRT2513633	hsa-miR-3938	CLIP-seq
MIRT2513634	hsa-miR-409-3p	CLIP-seq
MIRT2209843	hsa-miR-4262	CLIP-seq
MIRT2513637	hsa-miR-4282	CLIP-seq
MIRT926150	hsa-miR-4291	CLIP-seq
MIRT926151	hsa-miR-4310	CLIP-seq
MIRT2513641	hsa-miR-4319	CLIP-seq
MIRT2513643	hsa-miR-4436b-5p	CLIP-seq
MIRT926115	hsa-miR-4439	CLIP-seq
MIRT2513648	hsa-miR-4517	CLIP-seq
MIRT2513649	hsa-miR-452	CLIP-seq
MIRT2513652	hsa-miR-4676-3p	CLIP-seq
MIRT2513663	hsa-miR-4732-3p	CLIP-seq
MIRT2513666	hsa-miR-4755-5p	CLIP-seq
MIRT2513668	hsa-miR-4780	CLIP-seq
MIRT2513674	hsa-miR-509-3p	CLIP-seq
MIRT926159	hsa-miR-516b	CLIP-seq
MIRT2513676	hsa-miR-539	CLIP-seq
MIRT2513678	hsa-miR-544	CLIP-seq
MIRT2513679	hsa-miR-548v	CLIP-seq
MIRT2513680	hsa-miR-550b	CLIP-seq
MIRT2513681	hsa-miR-580	CLIP-seq
MIRT2209857	hsa-miR-590-5p	CLIP-seq
MIRT2513685	hsa-miR-623	CLIP-seq
MIRT2513689	hsa-miR-646	CLIP-seq
MIRT2513691	hsa-miR-664	CLIP-seq
MIRT2513692	hsa-miR-670	CLIP-seq
MIRT2513695	hsa-miR-888	CLIP-seq
MIRT2513696	hsa-miR-889	CLIP-seq
MIRT2513697	hsa-miR-934	CLIP-seq
MIRT926132	hsa-miR-943	CLIP-seq
MIRT2209840	hsa-miR-3921	CLIP-seq
MIRT2209848	hsa-miR-4653-5p	CLIP-seq
MIRT2513689	hsa-miR-646	CLIP-seq

Show/Hide all(23)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000166	Function	Nucleotide binding	IEA
GO:0004672	Function	Protein kinase activity	IEA
GO:0004672	Function	Protein kinase activity	TAS	9747029
GO:0004674	Function	Protein serine/threonine kinase activity	IBA
GO:0004674	Function	Protein serine/threonine kinase activity	IEA
GO:0005515	Function	Protein binding	IPI	32296183, 33199366
GO:0005524	Function	ATP binding	IEA
GO:0005737	Component	Cytoplasm	IBA
GO:0005886	Component	Plasma membrane	TAS	10036192
GO:0006468	Process	Protein phosphorylation	TAS	9747029
GO:0007399	Process	Nervous system development	IEA
GO:0007399	Process	Nervous system development	TAS	10036192
GO:0007417	Process	Central nervous system development	IEA
GO:0007417	Process	Central nervous system development	TAS	10051403
GO:0009615	Process	Response to virus	IEP	16548883
GO:0016197	Process	Endosomal transport	NAS	14613930
GO:0016301	Function	Kinase activity	IEA
GO:0016740	Function	Transferase activity	IEA
GO:0030154	Process	Cell differentiation	IEA
GO:0034504	Process	Protein localization to nucleus	IBA
GO:0035556	Process	Intracellular signal transduction	IEA
GO:0048675	Process	Axon extension	IBA
GO:0106310	Function	Protein serine kinase activity	IEA

MIM	HGNC	e!Ensembl
604742	2700	ENSG00000133083

Protein

UniProt ID

O15075

Protein name

Serine/threonine-protein kinase DCLK1 (EC 2.7.11.1) (Doublecortin domain-containing protein 3A) (Doublecortin-like and CAM kinase-like 1) (Doublecortin-like kinase 1)

Protein function

Probable kinase that may be involved in a calcium-signaling pathway controlling neuronal migration in the developing brain. May also participate in functions of the mature nervous system.

PDB

1MFW , 1MG4 , 1UF0 , 5JZJ , 5JZN , 6KYQ , 6KYR , 7F3G , 7KX6 , 7KX8 , 7KXW

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF03607	DCX	75 → 137	Doublecortin	Family
PF03607	DCX	204 → 263	Doublecortin	Family
PF00069	Pkinase	390 → 647	Protein kinase domain	Domain

Tissue specificity

TISSUE SPECIFICITY: In fetal tissues, highly expressed in brain, detectable in lung and liver, but not in kidney. In adult tissues, expressed ubiquitously in the brain, detectable in the heart, liver, spleen, thymus, prostate, testis, ovary, small intesti

Sequence

MSFGRDMELEHFDERDKAQRYSRGSRVNGLPSPTHSAHCSFYRTRTLQTLSSEKKAKKVR
FYRNGDRYFKGIVYAISPDRFRSFEALLADLTRTLSDNVNLPQGVRTIYTIDGLKKISSL
DQLVEGESYVCGSIEPFKKLEYTKNVNPNWSVNVKTTSASRAVSSLATAKGSPSEVRENK
DFIRPKLVTIIRSGVKPRKAVRILLNKKTAHSFEQVLTDITDAIKLDSGVVKRLYTLDGK
QVMCLQDFFGDDDIFIACGPEKFRYQDDFLLDESECRVVKSTSYTKIASSSRRSTTKSPG
PSRRSKSPASTSSVNGTPGSQLSTPRSGKSPSPSPTSPGSLRKQRSSQHGGSSTSLASTK
VCSSMDENDGPGEEVSEEGFQIPATITERYKVGRTIGDGNFAVVKECVERSTAREYALKI
IKKSKCRGKEHMIQNEVSILRRVKHPNIVLLIEEMDVPTELYLVMELVKGGDLFDAITST
NKYTERDASGMLYNLASAIKYLHSLNIVHRDIKPENLLVYEHQDGSKSLKLGDFGLATIV
DGPLYTVCGTPTYVAPEIIAETGYGLKVDIWAAGVITYILLCGFPPFRGSGDDQEVLFDQ
ILMGQVDFPSPYWDNVSDSAKELITMMLLVDVDQRFSAVQVLEHPWVNDDGLPENEHQLS
VAGKIKKHFNTGPKPNSTAAGVSVIATTALDKERQVFRRRRNQDVRSRYKAQPAPPELNS
ESEDYSPSSSETVRSPNSPF

Sequence length

740

Interactions

View interactions

Show/Hide Unknown Diseases (3)

Disease merge term	Disease name	Evidence	References	Source
Unknown Includes: (1) ClinVar NON-pathogenic variants (Uncertain, Benign, Conflicting, VUS), (2) GenCC associations, (3) GWAS associations, (4) CBGDA evidence-based associations. NOTE: Diseases with pathogenic evidence are excluded to avoid conflicts.
Asthma	Asthma (childhood onset)	N/A	N/A	GWAS
Lung adenocarcinoma	Familial squamous cell lung carcinoma	N/A	N/A	GWAS
Metabolic Syndrome	Metabolic syndrome	N/A	N/A	GWAS

Show/Hide Text Mining Associations (57)

Disease Name	Relationship Type	References
Associations from Text Mining Disease associations identified through Pubtator
13q deletion syndrome	Stimulate	34573300
Adenocarcinoma	Stimulate	21916995
Adenocarcinoma	Associate	25283374
Adenocarcinoma of Lung	Associate	35157971
Adenoma	Stimulate	29475922
Attention Deficit Disorder with Hyperactivity	Associate	22539971
Autistic Disorder	Associate	12826745
Barrett Esophagus	Associate	21916995, 25283374
Bone Diseases Metabolic	Associate	36728938
Breast Neoplasms	Associate	26621833, 31223610, 31773701
Calcinosis Cutis	Stimulate	31223610
Carcinogenesis	Associate	28851816, 31636360, 37762326
Carcinoma Pancreatic Ductal	Associate	22797009, 28883702
Carcinoma Renal Cell	Associate	25605241
Cholangiocarcinoma	Associate	22983262, 24948044, 32978808
Cognition Disorders	Associate	22539971
Colonic Diseases	Associate	28851816
Colonic Neoplasms	Associate	28851816
Colonic Polyps	Associate	29475922
Colorectal Neoplasms	Associate	24384857, 24885928, 24948044, 25599653, 25605241, 25631749, 26383518, 28414327, 28851816, 31636360, 32671503, 33268966, 34958000, 37998393
COVID 19	Associate	35943255
Endometrial Neoplasms	Associate	35404759
Esophagitis	Associate	21916995
Gastrointestinal Neoplasms	Associate	24885928, 26621833, 27287716
Hodgkin Disease	Associate	32572888
Hypotension	Associate	22539971
Idiopathic Pulmonary Fibrosis	Stimulate	35130915
Infections	Associate	16548883, 35943255
Inflammation	Associate	35943255
Intestinal Neoplasms	Associate	24384857
Klatskin Tumor	Associate	32978808
Language Disorders	Associate	12826745
Liver Diseases	Associate	35943255
Lymphatic Metastasis	Stimulate	28621231
Major Affective Disorder 2	Associate	22539971
Mesothelioma	Associate	28560410
Mesothelioma Malignant	Associate	28560410
Neoplasm Metastasis	Associate	25066378, 25605241, 31636360, 32756469, 35404759, 37838282
Neoplasm Metastasis	Stimulate	28621231
Neoplasms	Associate	22797009, 22983262, 24384857, 24885928, 25605241, 25631749, 26785732, 27287716, 28883702, 31223610, 32756469, 33268966, 33515271, 34958000, 35157971, 37069669, 37762326, 37838282 View all (3 more)
Neoplasms	Stimulate	26383518, 29475922
Nervous System Diseases	Associate	34573300
Neuroblastoma	Associate	32495887
Neuroendocrine Tumors	Associate	26621833
Osteogenesis imperfecta type 3	Stimulate	25605241
Ovarian Neoplasms	Associate	37838282
Pancreatic Neoplasms	Associate	22797009, 25283374, 27287716, 28244691, 28883702
Pancreatitis	Associate	28244691
Prostatic Neoplasms	Associate	26990456
Prostatic Neoplasms Castration Resistant	Associate	26990456
Retinal Dysplasia	Stimulate	21916995, 29475922
Schizophrenia	Associate	22539971
Stomach Neoplasms	Associate	28946555, 30702489, 32423385
Triple Negative Breast Neoplasms	Associate	32406563, 37069669
Tuberculosis Multidrug Resistant	Associate	33515271
Urinary Bladder Neoplasms	Associate	28621231
Viremia	Associate	35943255

DCLK1 (doublecortin like kinase 1)