ZNF300 (zinc finger protein 300)

Gene

• Entrez ID: 91975
• Gene name: Zinc finger protein 300
• Gene symbol: ZNF300
• Synonyms (NCBI Gene): -
• Chromosome: 5
• Chromosome location: 5q33.1
• Summary: The protein encoded by this gene is a C2H2-type zinc finger DNA binding protein and likely transcriptional regulator. The function of this protein is not yet known. Three transcript variants encoding different isoforms have been found for this gene.[provi

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT439210	hsa-miR-155-5p	HITS-CLIP	22473208
MIRT439210	hsa-miR-155-5p	HITS-CLIP	22473208
MIRT1521597	hsa-miR-198	CLIP-seq
MIRT1521598	hsa-miR-338-5p	CLIP-seq
MIRT1521599	hsa-miR-3686	CLIP-seq
MIRT1521600	hsa-miR-4668-5p	CLIP-seq
MIRT1521601	hsa-miR-4742-3p	CLIP-seq
MIRT1521602	hsa-miR-4778-5p	CLIP-seq
MIRT1521603	hsa-miR-520a-5p	CLIP-seq
MIRT1521604	hsa-miR-525-5p	CLIP-seq
MIRT1521605	hsa-miR-759	CLIP-seq
MIRT1521606	hsa-miR-891b	CLIP-seq
MIRT1521607	hsa-miR-1294	CLIP-seq
MIRT1521608	hsa-miR-148a	CLIP-seq
MIRT1521609	hsa-miR-148b	CLIP-seq
MIRT1521610	hsa-miR-152	CLIP-seq
MIRT1521611	hsa-miR-1827	CLIP-seq
MIRT1521612	hsa-miR-3126-3p	CLIP-seq
MIRT1521613	hsa-miR-3159	CLIP-seq
MIRT1521614	hsa-miR-3176	CLIP-seq
MIRT1521615	hsa-miR-3922-3p	CLIP-seq
MIRT1521616	hsa-miR-4307	CLIP-seq
MIRT1521617	hsa-miR-4316	CLIP-seq
MIRT1521618	hsa-miR-4677-3p	CLIP-seq
MIRT1521619	hsa-miR-4679	CLIP-seq
MIRT1521620	hsa-miR-4757-5p	CLIP-seq
MIRT2157438	hsa-miR-3691-3p	CLIP-seq
MIRT1521597	hsa-miR-198	CLIP-seq
MIRT1521600	hsa-miR-4668-5p	CLIP-seq
MIRT2377037	hsa-miR-4724-5p	CLIP-seq
MIRT1521603	hsa-miR-520a-5p	CLIP-seq
MIRT1521604	hsa-miR-525-5p	CLIP-seq
MIRT1521605	hsa-miR-759	CLIP-seq
MIRT2669328	hsa-miR-129-5p	CLIP-seq
MIRT2669329	hsa-miR-4274	CLIP-seq
MIRT2669330	hsa-miR-4519	CLIP-seq
MIRT2669331	hsa-miR-4524	CLIP-seq
MIRT2669332	hsa-miR-4714-3p	CLIP-seq
MIRT2669333	hsa-miR-513b	CLIP-seq

Transcription factors

Transcription factor	Regulation	Reference
SPI1	Unknown	20471086

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000978	Function	RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA
GO:0000981	Function	DNA-binding transcription factor activity, RNA polymerase II-specific	IBA
GO:0001228	Function	DNA-binding transcription activator activity, RNA polymerase II-specific	IDA	20585888
GO:0001228	Function	DNA-binding transcription activator activity, RNA polymerase II-specific	IEA
GO:0003677	Function	DNA binding	IEA
GO:0005515	Function	Protein binding	IPI	23665872, 32296183
GO:0005634	Component	Nucleus	IBA
GO:0005634	Component	Nucleus	IDA	23665872
GO:0005634	Component	Nucleus	IEA
GO:0005654	Component	Nucleoplasm	IDA
GO:0005730	Component	Nucleolus	IDA
GO:0005730	Component	Nucleolus	IEA
GO:0006355	Process	Regulation of DNA-templated transcription	IEA
GO:0006357	Process	Regulation of transcription by RNA polymerase II	IBA
GO:0008270	Function	Zinc ion binding	IEA
GO:0016604	Component	Nuclear body	IDA
GO:0043565	Function	Sequence-specific DNA binding	IDA	20585888
GO:0043565	Function	Sequence-specific DNA binding	IEA
GO:0045944	Process	Positive regulation of transcription by RNA polymerase II	IDA	20585888
GO:0046872	Function	Metal ion binding	IEA

Other IDs

• MIM: 612429
• HGNC: 13091
• e!Ensembl: ENSG00000145908

Protein

• UniProt ID: Q96RE9
• Protein name: Zinc finger protein 300
• Protein function: Has a transcriptional repressor activity.
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF01352	KRAB	7 → 48	KRAB box	Family
  PF00096	zf-C2H2	269 → 291	Zinc finger, C2H2 type	Domain
  PF00096	zf-C2H2	297 → 319	Zinc finger, C2H2 type	Domain
  PF00096	zf-C2H2	325 → 347	Zinc finger, C2H2 type	Domain
  PF00096	zf-C2H2	353 → 375	Zinc finger, C2H2 type	Domain
  PF00096	zf-C2H2	381 → 403	Zinc finger, C2H2 type	Domain
  PF00096	zf-C2H2	409 → 431	Zinc finger, C2H2 type	Domain
  PF00096	zf-C2H2	437 → 459	Zinc finger, C2H2 type	Domain
  PF00096	zf-C2H2	465 → 487	Zinc finger, C2H2 type	Domain
  PF00096	zf-C2H2	493 → 515	Zinc finger, C2H2 type	Domain
  PF00096	zf-C2H2	521 → 543	Zinc finger, C2H2 type	Domain
  PF00096	zf-C2H2	549 → 571	Zinc finger, C2H2 type	Domain
  PF00096	zf-C2H2	577 → 599	Zinc finger, C2H2 type	Domain

• Tissue specificity: TISSUE SPECIFICITY: Expressed mostly in heart, skeletal muscle and brain. Isoform 1 and isoform 2 are highly expressed in testis. {ECO:0000269|PubMed:14746915, ECO:0000269|PubMed:17541838}.
• Sequence:

  MMKSQGLVSFKDVAVDFTQEEWQQLDPSQRTLYRDVMLENYSHLVSMGYPVSKPDVISKL
  EQGEEPWIIKGDISNWIYPDEYQADGRQDRKSNLHNSQSCILGTVSFHHKILKGVTRDGS
  LCSILKVCQGDGQLQRFLENQDKLFRQVTFVNSKTVTEASGHKYNPLGKIFQECIETDIS
  IQRFHKYDAFKKNLKPNIDLPSCYKSNSRKKPDQSFGGGKSSSQSEPNSNLEKIHNGVIP
  FDDNQCGNVFRNTQSLIQYQNVETKEKSCVCVTCGKAFAKKSQLIVHQRIHTGKKPYDCG
  ACGKAFSEKFHLVVHQRTHTGEKPYDCSECGKAFSQKSSLIIHQRVHTGEKPYECSECGK
  AFSQKSPLIIHQRIHTGEKPYECRECGKAFSQKSQLIIHHRAHTGEKPYECTECGKAFCE
  KSHLIIHKRIHTGEKPYKCAQCEEAFSRKTELITHQLVHTGEKPYECTECGKTFSRKSQL
  IIHQRTHTGEKPYKCSECGKAFCQKSHLIGHQRIHTGEKPYICTECGKAFSQKSHLPGHQ
  RIHTGEKPYICAECGKAFSQKSDLVLHQRIHTGERPYQCAICGKAFIQKSQLTVHQRIHT
  VVKS

• Sequence length: 604

Pathways

Reactome:

Generic Transcription Pathway