Gene Gene information from NCBI Gene database.
Entrez ID 91947
Gene name Arrestin domain containing 4
Gene symbol ARRDC4
Synonyms (NCBI Gene)
-
Chromosome 15
Chromosome location 15q26.2
miRNA miRNA information provided by mirtarbase database.
586
miRTarBase ID miRNA Experiments Reference
MIRT028347 hsa-miR-32-5p Sequencing 20371350
MIRT032160 hsa-let-7d-5p Sequencing 20371350
MIRT042875 hsa-miR-324-3p CLASH 23622248
MIRT739747 hsa-miR-4307 HITS-CLIP 33718276
MIRT739748 hsa-miR-4528 HITS-CLIP 33718276
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
29
GO ID Ontology Definition Evidence Reference
GO:0005515 Function Protein binding IPI 23236378
GO:0005737 Component Cytoplasm IBA
GO:0005737 Component Cytoplasm IC 28594402
GO:0005768 Component Endosome IDA 23236378
GO:0005768 Component Endosome IEA
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
619788 28087 ENSG00000140450
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
Q8NCT1
Protein name Arrestin domain-containing protein 4
Protein function Functions as an adapter recruiting ubiquitin-protein ligases to their specific substrates (By similarity). Plays a role in endocytosis of activated G protein-coupled receptors (GPCRs) (Probable). Through an ubiquitination-dependent mechanism als
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00339 Arrestin_N 21 169 Arrestin (or S-antigen), N-terminal domain Domain
PF02752 Arrestin_C 191 318 Arrestin (or S-antigen), C-terminal domain Domain
Sequence
Sequence length 418
Interactions View interactions
Associated diseases Disease associations from ClinVar (causal & non-causal) and other databases (OMIM, Orphanet, GWAS, etc.).
6
Evidence Score: ★☆☆☆☆  Gene-disease association found in Text Mining only ★★☆☆☆  Found in Text Mining and Unknown/Other Associations ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Phenotype Name Clinical Significance Source Evidence Score
COLORECTAL CANCER GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
EYE DISEASE GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
MAJOR DEPRESSIVE DISORDER GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
NEUROTIC DISORDER GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Associations from Text MiningDisease associations identified through Pubtator
Disease Name Relationship Type References Evidence Score
Acidosis Associate 30717828
★☆☆☆☆
Found in Text Mining only
Inflammation Associate 28594402
★☆☆☆☆
Found in Text Mining only