TIMD4 (T cell immunoglobulin and mucin domain containing 4)

Gene
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
91937
Gene name Gene Name - the full gene name approved by the HGNC.
T cell immunoglobulin and mucin domain containing 4
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
TIMD4
Synonyms (NCBI Gene) Gene synonyms aliases
SMUCKLER, TIM4
Chromosome Chromosome number
5
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
5q33.3
miRNA miRNA information provided by mirtarbase database.
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide all(4)
miRTarBase ID miRNA Experiments Reference
MIRT518703 hsa-miR-4282 PAR-CLIP 20371350
MIRT518703 hsa-miR-4282 PAR-CLIP 23446348
MIRT518703 hsa-miR-4282 PAR-CLIP 20371350
MIRT518703 hsa-miR-4282 PAR-CLIP 23446348
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide all(1)
GO ID Ontology Definition Evidence Reference
GO:0016021 Component Integral component of membrane IEA
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
MIM HGNC e!Ensembl
610096 25132 ENSG00000145850
Protein
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
UniProt ID Q96H15
Protein name T-cell immunoglobulin and mucin domain-containing protein 4 (TIMD-4) (T-cell immunoglobulin mucin receptor 4) (TIM-4) (T-cell membrane protein 4)
Protein function Phosphatidylserine receptor that plays different role in immune response including phagocytosis of apoptotic cells and T-cell regulation. Controls T-cell activation in a bimodal fashion, decreasing the activation of naive T-cells by inducing cel
PDB 5DZN , 5F7F , 5F7H
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF07686 V-set 23 → 130 Immunoglobulin V-set domain Domain
Sequence 
MSKEPLILWLMIEFWWLYLTPVTSETVVTEVLGHRVTLPCLYSSWSHNSNSMCWGKDQCP
YSGCKEALIRTDGMRVTSRKSAKYRLQGTIPRGDVSLTILNPSESDSGVYCCRIEVPGWF
NDVKINVRLNLQRASTTTHRTATTTTRRTTTTSPTTTRQMTTTPAALPTTVVTTPDLTTG
TPLQMTTIAVFTTANTCLSLTPSTLPEEATGLLTPEPSKEGPILTAESETVLPSDSWSSV
ESTSADTVLLTSKESKVWDLPSTSHVSMWKTSDSVSSPQPGASDTAVPEQNKTTKTGQMD
GIPMSMKNEMPISQLLMIIAPSLGFVLFALFVAFLLRGKLMETYCSQKHTRLDYIGDSKN
VLNDVQHGREDEDGLFTL
Sequence length 378
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
  KEGG  
  Efferocytosis  
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide Unknown Diseases (4)
Unknown
Disease term Disease name Evidence References Source
Hyperlipidemia Hyperlipidemia GWAS
Dementia Dementia GWAS
Inflammatory Bowel Disease Inflammatory Bowel Disease GWAS
Crohn Disease Crohn Disease GWAS
Show/Hide Text Mining Associations (16)
Associations from Text Mining
Disease Name Relationship Type References
Arthritis Rheumatoid Associate 24217665
Autoimmune Diseases Associate 34539672
Cerebral Infarction Associate 29208769, 31337960
Coronary Disease Associate 29208769, 31337960
Dyslipidemias Associate 19060906
Frontotemporal Dementia Associate 34539672
Glioblastoma Associate 37853449
Glioma Associate 21896488, 26741116
Heart Failure Systolic Associate 35595781
Inflammation Associate 35595781