BUB3 (BUB3 mitotic checkpoint protein)

Gene

• Entrez ID: 9184
• Gene name: BUB3 mitotic checkpoint protein
• Gene symbol: BUB3
• Synonyms (NCBI Gene): BUB3L, hBUB3
• Chromosome: 10
• Chromosome location: 10q26.13
• Summary: This gene encodes a protein involved in spindle checkpoint function. The encoded protein contains four WD repeat domains and has sequence similarity with the yeast BUB3 protein. Alternate transcriptional splice variants, encoding different isoforms, have

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT032111	hsa-let-7d-5p	Sequencing	20371350
MIRT039843	hsa-miR-615-3p	CLASH	23622248
MIRT039843	hsa-miR-615-3p	CLASH	23622248
MIRT037378	hsa-miR-744-3p	CLASH	23622248
MIRT055863	hsa-miR-548ac	HITS-CLIP	19536157
MIRT055866	hsa-miR-548bb-3p	HITS-CLIP	19536157
MIRT055857	hsa-miR-548d-3p	HITS-CLIP	19536157
MIRT055858	hsa-miR-548h-3p	HITS-CLIP	19536157
MIRT055862	hsa-miR-548z	HITS-CLIP	19536157
MIRT722422	hsa-miR-3613-3p	HITS-CLIP	19536157
MIRT722421	hsa-miR-885-5p	HITS-CLIP	19536157
MIRT722420	hsa-miR-627-3p	HITS-CLIP	19536157
MIRT722419	hsa-miR-587	HITS-CLIP	19536157
MIRT560494	hsa-miR-605-5p	PAR-CLIP	20371350
MIRT560493	hsa-miR-302b-5p	PAR-CLIP	20371350
MIRT560492	hsa-miR-302d-5p	PAR-CLIP	20371350
MIRT560491	hsa-miR-633	PAR-CLIP	20371350
MIRT560490	hsa-miR-29b-2-5p	PAR-CLIP	20371350
MIRT261814	hsa-miR-651-3p	PAR-CLIP	20371350
MIRT509219	hsa-miR-4476	PAR-CLIP	20371350
MIRT509218	hsa-miR-6876-5p	PAR-CLIP	20371350
MIRT509217	hsa-miR-188-5p	PAR-CLIP	20371350
MIRT509216	hsa-miR-6866-3p	PAR-CLIP	20371350
MIRT330039	hsa-miR-6828-5p	PAR-CLIP	20371350
MIRT261817	hsa-miR-8065	PAR-CLIP	20371350
MIRT509215	hsa-miR-135b-3p	PAR-CLIP	20371350
MIRT330018	hsa-miR-3674	PAR-CLIP	20371350
MIRT560494	hsa-miR-605-5p	PAR-CLIP	20371350
MIRT560493	hsa-miR-302b-5p	PAR-CLIP	20371350
MIRT560492	hsa-miR-302d-5p	PAR-CLIP	20371350
MIRT560491	hsa-miR-633	PAR-CLIP	20371350
MIRT560490	hsa-miR-29b-2-5p	PAR-CLIP	20371350
MIRT261814	hsa-miR-651-3p	PAR-CLIP	23446348
MIRT509219	hsa-miR-4476	PAR-CLIP	23446348
MIRT509218	hsa-miR-6876-5p	PAR-CLIP	23446348
MIRT509217	hsa-miR-188-5p	PAR-CLIP	23446348
MIRT509216	hsa-miR-6866-3p	PAR-CLIP	23446348
MIRT330039	hsa-miR-6828-5p	PAR-CLIP	23446348
MIRT261817	hsa-miR-8065	PAR-CLIP	23446348
MIRT509215	hsa-miR-135b-3p	PAR-CLIP	23446348
MIRT261814	hsa-miR-651-3p	PAR-CLIP	23446348
MIRT509219	hsa-miR-4476	PAR-CLIP	23446348
MIRT509218	hsa-miR-6876-5p	PAR-CLIP	23446348
MIRT509217	hsa-miR-188-5p	PAR-CLIP	23446348
MIRT509216	hsa-miR-6866-3p	PAR-CLIP	23446348
MIRT330039	hsa-miR-6828-5p	PAR-CLIP	23446348
MIRT261817	hsa-miR-8065	PAR-CLIP	23446348
MIRT509215	hsa-miR-135b-3p	PAR-CLIP	23446348
MIRT261815	hsa-miR-4477b	PAR-CLIP	23446348
MIRT330018	hsa-miR-3674	PAR-CLIP	23446348
MIRT480592	hsa-miR-497-3p	PAR-CLIP	23592263
MIRT480591	hsa-miR-1255b-2-3p	PAR-CLIP	23592263
MIRT480590	hsa-miR-6815-5p	PAR-CLIP	23592263
MIRT480589	hsa-miR-6865-5p	PAR-CLIP	23592263
MIRT480588	hsa-miR-3185	PAR-CLIP	23592263
MIRT480587	hsa-miR-6861-3p	PAR-CLIP	23592263
MIRT261800	hsa-miR-492	PAR-CLIP	23592263
MIRT480586	hsa-miR-659-5p	PAR-CLIP	23592263
MIRT261813	hsa-miR-8071	PAR-CLIP	23592263
MIRT261810	hsa-miR-4800-5p	PAR-CLIP	23592263
MIRT480585	hsa-miR-6800-5p	PAR-CLIP	23592263
MIRT261812	hsa-miR-6802-5p	PAR-CLIP	23592263
MIRT261801	hsa-miR-513a-5p	PAR-CLIP	23592263
MIRT480584	hsa-miR-27a-3p	PAR-CLIP	23592263
MIRT480583	hsa-miR-27b-3p	PAR-CLIP	23592263
MIRT261799	hsa-miR-106a-3p	PAR-CLIP	23592263
MIRT261806	hsa-miR-4535	PAR-CLIP	23592263
MIRT330080	hsa-miR-1276	PAR-CLIP	23592263
MIRT480582	hsa-miR-656-3p	PAR-CLIP	23592263
MIRT261787	hsa-miR-6504-3p	PAR-CLIP	23592263
MIRT480581	hsa-miR-3670	PAR-CLIP	23592263
MIRT480580	hsa-miR-520d-5p	PAR-CLIP	23592263
MIRT480579	hsa-miR-524-5p	PAR-CLIP	23592263
MIRT261820	hsa-miR-1303	PAR-CLIP	23592263
MIRT739756	hsa-miR-3653	HITS-CLIP	33718276
MIRT739757	hsa-miR-3658	HITS-CLIP	33718276
MIRT055863	hsa-miR-548ac	HITS-CLIP	19536157
MIRT055866	hsa-miR-548bb-3p	HITS-CLIP	19536157
MIRT055857	hsa-miR-548d-3p	HITS-CLIP	19536157
MIRT055858	hsa-miR-548h-3p	HITS-CLIP	19536157
MIRT055862	hsa-miR-548z	HITS-CLIP	19536157
MIRT722422	hsa-miR-3613-3p	HITS-CLIP	19536157
MIRT722421	hsa-miR-885-5p	HITS-CLIP	19536157
MIRT722420	hsa-miR-627-3p	HITS-CLIP	19536157
MIRT722419	hsa-miR-587	HITS-CLIP	19536157
MIRT560494	hsa-miR-605-5p	PAR-CLIP	20371350
MIRT560493	hsa-miR-302b-5p	PAR-CLIP	20371350
MIRT560492	hsa-miR-302d-5p	PAR-CLIP	20371350
MIRT560491	hsa-miR-633	PAR-CLIP	20371350
MIRT560490	hsa-miR-29b-2-5p	PAR-CLIP	20371350
MIRT261814	hsa-miR-651-3p	PAR-CLIP	20371350
MIRT509219	hsa-miR-4476	PAR-CLIP	20371350
MIRT509218	hsa-miR-6876-5p	PAR-CLIP	20371350
MIRT509217	hsa-miR-188-5p	PAR-CLIP	20371350
MIRT509216	hsa-miR-6866-3p	PAR-CLIP	20371350
MIRT330039	hsa-miR-6828-5p	PAR-CLIP	20371350
MIRT261817	hsa-miR-8065	PAR-CLIP	20371350
MIRT509215	hsa-miR-135b-3p	PAR-CLIP	20371350
MIRT330018	hsa-miR-3674	PAR-CLIP	20371350
MIRT560494	hsa-miR-605-5p	PAR-CLIP	20371350
MIRT560493	hsa-miR-302b-5p	PAR-CLIP	20371350
MIRT560492	hsa-miR-302d-5p	PAR-CLIP	20371350
MIRT560491	hsa-miR-633	PAR-CLIP	20371350
MIRT560490	hsa-miR-29b-2-5p	PAR-CLIP	20371350
MIRT261814	hsa-miR-651-3p	PAR-CLIP	23446348
MIRT509219	hsa-miR-4476	PAR-CLIP	23446348
MIRT509218	hsa-miR-6876-5p	PAR-CLIP	23446348
MIRT509217	hsa-miR-188-5p	PAR-CLIP	23446348
MIRT509216	hsa-miR-6866-3p	PAR-CLIP	23446348
MIRT330039	hsa-miR-6828-5p	PAR-CLIP	23446348
MIRT261817	hsa-miR-8065	PAR-CLIP	23446348
MIRT509215	hsa-miR-135b-3p	PAR-CLIP	23446348
MIRT261814	hsa-miR-651-3p	PAR-CLIP	23446348
MIRT509219	hsa-miR-4476	PAR-CLIP	23446348
MIRT509218	hsa-miR-6876-5p	PAR-CLIP	23446348
MIRT509217	hsa-miR-188-5p	PAR-CLIP	23446348
MIRT509216	hsa-miR-6866-3p	PAR-CLIP	23446348
MIRT330039	hsa-miR-6828-5p	PAR-CLIP	23446348
MIRT261817	hsa-miR-8065	PAR-CLIP	23446348
MIRT509215	hsa-miR-135b-3p	PAR-CLIP	23446348
MIRT261815	hsa-miR-4477b	PAR-CLIP	23446348
MIRT330018	hsa-miR-3674	PAR-CLIP	23446348
MIRT480592	hsa-miR-497-3p	PAR-CLIP	23592263
MIRT480591	hsa-miR-1255b-2-3p	PAR-CLIP	23592263
MIRT480590	hsa-miR-6815-5p	PAR-CLIP	23592263
MIRT480589	hsa-miR-6865-5p	PAR-CLIP	23592263
MIRT480588	hsa-miR-3185	PAR-CLIP	23592263
MIRT480587	hsa-miR-6861-3p	PAR-CLIP	23592263
MIRT261800	hsa-miR-492	PAR-CLIP	23592263
MIRT480586	hsa-miR-659-5p	PAR-CLIP	23592263
MIRT261813	hsa-miR-8071	PAR-CLIP	23592263
MIRT261810	hsa-miR-4800-5p	PAR-CLIP	23592263
MIRT480585	hsa-miR-6800-5p	PAR-CLIP	23592263
MIRT261812	hsa-miR-6802-5p	PAR-CLIP	23592263
MIRT261801	hsa-miR-513a-5p	PAR-CLIP	23592263
MIRT480584	hsa-miR-27a-3p	PAR-CLIP	23592263
MIRT480583	hsa-miR-27b-3p	PAR-CLIP	23592263
MIRT261799	hsa-miR-106a-3p	PAR-CLIP	23592263
MIRT261806	hsa-miR-4535	PAR-CLIP	23592263
MIRT330080	hsa-miR-1276	PAR-CLIP	23592263
MIRT480582	hsa-miR-656-3p	PAR-CLIP	23592263
MIRT261787	hsa-miR-6504-3p	PAR-CLIP	23592263
MIRT480581	hsa-miR-3670	PAR-CLIP	23592263
MIRT480580	hsa-miR-520d-5p	PAR-CLIP	23592263
MIRT480579	hsa-miR-524-5p	PAR-CLIP	23592263
MIRT261820	hsa-miR-1303	PAR-CLIP	23592263
MIRT827665	hsa-miR-1229	CLIP-seq
MIRT827666	hsa-miR-1237	CLIP-seq
MIRT827667	hsa-miR-1238	CLIP-seq
MIRT827668	hsa-miR-186	CLIP-seq
MIRT827669	hsa-miR-198	CLIP-seq
MIRT827670	hsa-miR-203	CLIP-seq
MIRT827671	hsa-miR-216a	CLIP-seq
MIRT827672	hsa-miR-24	CLIP-seq
MIRT827673	hsa-miR-3065-5p	CLIP-seq
MIRT827674	hsa-miR-3157-3p	CLIP-seq
MIRT827675	hsa-miR-3192	CLIP-seq
MIRT827676	hsa-miR-3646	CLIP-seq
MIRT827677	hsa-miR-369-3p	CLIP-seq
MIRT827678	hsa-miR-374a	CLIP-seq
MIRT827679	hsa-miR-374b	CLIP-seq
MIRT827680	hsa-miR-3973	CLIP-seq
MIRT827681	hsa-miR-3974	CLIP-seq
MIRT827682	hsa-miR-4274	CLIP-seq
MIRT827683	hsa-miR-4284	CLIP-seq
MIRT827684	hsa-miR-4314	CLIP-seq
MIRT827685	hsa-miR-4420	CLIP-seq
MIRT827686	hsa-miR-4432	CLIP-seq
MIRT827687	hsa-miR-450b-3p	CLIP-seq
MIRT827688	hsa-miR-4639-5p	CLIP-seq
MIRT827689	hsa-miR-4646-5p	CLIP-seq
MIRT827690	hsa-miR-4713-3p	CLIP-seq
MIRT827691	hsa-miR-4717-5p	CLIP-seq
MIRT827692	hsa-miR-4793-5p	CLIP-seq
MIRT827693	hsa-miR-5096	CLIP-seq
MIRT827694	hsa-miR-514	CLIP-seq
MIRT827695	hsa-miR-514b-3p	CLIP-seq
MIRT827696	hsa-miR-518a-5p	CLIP-seq
MIRT827697	hsa-miR-527	CLIP-seq
MIRT827698	hsa-miR-548l	CLIP-seq
MIRT827699	hsa-miR-548u	CLIP-seq
MIRT827700	hsa-miR-549	CLIP-seq
MIRT827701	hsa-miR-561	CLIP-seq
MIRT827702	hsa-miR-622	CLIP-seq
MIRT827703	hsa-miR-638	CLIP-seq
MIRT827704	hsa-miR-646	CLIP-seq
MIRT827705	hsa-miR-769-3p	CLIP-seq
MIRT827706	hsa-miR-874	CLIP-seq
MIRT827707	hsa-miR-938	CLIP-seq
MIRT827666	hsa-miR-1237	CLIP-seq
MIRT1944905	hsa-miR-1248	CLIP-seq
MIRT1944906	hsa-miR-3130-3p	CLIP-seq
MIRT827674	hsa-miR-3157-3p	CLIP-seq
MIRT1944907	hsa-miR-3664-3p	CLIP-seq
MIRT1944908	hsa-miR-3691-3p	CLIP-seq
MIRT1944909	hsa-miR-3919	CLIP-seq
MIRT1944910	hsa-miR-4686	CLIP-seq
MIRT1944911	hsa-miR-4704-3p	CLIP-seq
MIRT1944912	hsa-miR-4756-3p	CLIP-seq
MIRT1944913	hsa-miR-4793-3p	CLIP-seq
MIRT1944914	hsa-miR-510	CLIP-seq
MIRT1944915	hsa-miR-512-5p	CLIP-seq
MIRT827696	hsa-miR-518a-5p	CLIP-seq
MIRT827697	hsa-miR-527	CLIP-seq
MIRT1944916	hsa-miR-544	CLIP-seq
MIRT1944917	hsa-miR-590-3p	CLIP-seq
MIRT1944918	hsa-miR-873	CLIP-seq
MIRT827706	hsa-miR-874	CLIP-seq
MIRT2183428	hsa-miR-1183	CLIP-seq
MIRT2183429	hsa-miR-2110	CLIP-seq
MIRT2183430	hsa-miR-219-2-3p	CLIP-seq
MIRT827672	hsa-miR-24	CLIP-seq
MIRT2183431	hsa-miR-3120-5p	CLIP-seq
MIRT2183432	hsa-miR-3150a-3p	CLIP-seq
MIRT2183433	hsa-miR-3154	CLIP-seq
MIRT2183434	hsa-miR-3175	CLIP-seq
MIRT2183435	hsa-miR-3179	CLIP-seq
MIRT2183436	hsa-miR-3194-3p	CLIP-seq
MIRT2183437	hsa-miR-3662	CLIP-seq
MIRT2183438	hsa-miR-371-5p	CLIP-seq
MIRT2183439	hsa-miR-378g	CLIP-seq
MIRT827681	hsa-miR-3974	CLIP-seq
MIRT827683	hsa-miR-4284	CLIP-seq
MIRT2183440	hsa-miR-4494	CLIP-seq
MIRT2183441	hsa-miR-4698	CLIP-seq
MIRT2183442	hsa-miR-4699-3p	CLIP-seq
MIRT1944911	hsa-miR-4704-3p	CLIP-seq
MIRT2183443	hsa-miR-4719	CLIP-seq
MIRT2183444	hsa-miR-4766-3p	CLIP-seq
MIRT2183445	hsa-miR-4795-3p	CLIP-seq
MIRT2183446	hsa-miR-499a-5p	CLIP-seq
MIRT2183447	hsa-miR-511	CLIP-seq
MIRT2183448	hsa-miR-545	CLIP-seq
MIRT2183449	hsa-miR-548g	CLIP-seq
MIRT2183450	hsa-miR-548p	CLIP-seq
MIRT2183451	hsa-miR-582-5p	CLIP-seq
MIRT2183452	hsa-miR-598	CLIP-seq
MIRT2183453	hsa-miR-605	CLIP-seq
MIRT2183454	hsa-miR-634	CLIP-seq
MIRT2183455	hsa-miR-939	CLIP-seq
MIRT827666	hsa-miR-1237	CLIP-seq
MIRT1944905	hsa-miR-1248	CLIP-seq
MIRT2487067	hsa-miR-1266	CLIP-seq
MIRT827668	hsa-miR-186	CLIP-seq
MIRT827670	hsa-miR-203	CLIP-seq
MIRT827671	hsa-miR-216a	CLIP-seq
MIRT2487068	hsa-miR-27a	CLIP-seq
MIRT2487069	hsa-miR-27b	CLIP-seq
MIRT827673	hsa-miR-3065-5p	CLIP-seq
MIRT2487070	hsa-miR-30a	CLIP-seq
MIRT2487071	hsa-miR-30b	CLIP-seq
MIRT2487072	hsa-miR-30c	CLIP-seq
MIRT2487073	hsa-miR-30d	CLIP-seq
MIRT2487074	hsa-miR-30e	CLIP-seq
MIRT2487075	hsa-miR-3123	CLIP-seq
MIRT1944906	hsa-miR-3130-3p	CLIP-seq
MIRT2487076	hsa-miR-3145-3p	CLIP-seq
MIRT827674	hsa-miR-3157-3p	CLIP-seq
MIRT2487077	hsa-miR-3163	CLIP-seq
MIRT827675	hsa-miR-3192	CLIP-seq
MIRT2487078	hsa-miR-3614-5p	CLIP-seq
MIRT2183437	hsa-miR-3662	CLIP-seq
MIRT1944907	hsa-miR-3664-3p	CLIP-seq
MIRT2487079	hsa-miR-3667-5p	CLIP-seq
MIRT1944908	hsa-miR-3691-3p	CLIP-seq
MIRT2487080	hsa-miR-380	CLIP-seq
MIRT1944909	hsa-miR-3919	CLIP-seq
MIRT2487081	hsa-miR-3925-5p	CLIP-seq
MIRT2487082	hsa-miR-3976	CLIP-seq
MIRT2487083	hsa-miR-409-3p	CLIP-seq
MIRT2487084	hsa-miR-410	CLIP-seq
MIRT2487085	hsa-miR-4266	CLIP-seq
MIRT827684	hsa-miR-4314	CLIP-seq
MIRT2487086	hsa-miR-4418	CLIP-seq
MIRT827685	hsa-miR-4420	CLIP-seq
MIRT2487087	hsa-miR-4495	CLIP-seq
MIRT827687	hsa-miR-450b-3p	CLIP-seq
MIRT2487088	hsa-miR-4511	CLIP-seq
MIRT2487089	hsa-miR-4518	CLIP-seq
MIRT827688	hsa-miR-4639-5p	CLIP-seq
MIRT827689	hsa-miR-4646-5p	CLIP-seq
MIRT2487090	hsa-miR-4661-5p	CLIP-seq
MIRT2487091	hsa-miR-4694-3p	CLIP-seq
MIRT2487092	hsa-miR-4695-5p	CLIP-seq
MIRT2183441	hsa-miR-4698	CLIP-seq
MIRT1944911	hsa-miR-4704-3p	CLIP-seq
MIRT827690	hsa-miR-4713-3p	CLIP-seq
MIRT827691	hsa-miR-4717-5p	CLIP-seq
MIRT2183443	hsa-miR-4719	CLIP-seq
MIRT2487093	hsa-miR-4742-3p	CLIP-seq
MIRT1944912	hsa-miR-4756-3p	CLIP-seq
MIRT2487094	hsa-miR-4779	CLIP-seq
MIRT1944913	hsa-miR-4793-3p	CLIP-seq
MIRT2487095	hsa-miR-499-3p	CLIP-seq
MIRT2487096	hsa-miR-499a-3p	CLIP-seq
MIRT2487097	hsa-miR-509-3-5p	CLIP-seq
MIRT2487098	hsa-miR-509-5p	CLIP-seq
MIRT827693	hsa-miR-5096	CLIP-seq
MIRT2487099	hsa-miR-539	CLIP-seq
MIRT1944916	hsa-miR-544	CLIP-seq
MIRT2487100	hsa-miR-548b-3p	CLIP-seq
MIRT827700	hsa-miR-549	CLIP-seq
MIRT2487101	hsa-miR-570	CLIP-seq
MIRT2183451	hsa-miR-582-5p	CLIP-seq
MIRT827703	hsa-miR-638	CLIP-seq
MIRT827705	hsa-miR-769-3p	CLIP-seq
MIRT1944918	hsa-miR-873	CLIP-seq
MIRT827706	hsa-miR-874	CLIP-seq
MIRT827707	hsa-miR-938	CLIP-seq
MIRT2487102	hsa-miR-942	CLIP-seq
MIRT827665	hsa-miR-1229	CLIP-seq
MIRT827666	hsa-miR-1237	CLIP-seq
MIRT1944905	hsa-miR-1248	CLIP-seq
MIRT827668	hsa-miR-186	CLIP-seq
MIRT827670	hsa-miR-203	CLIP-seq
MIRT827671	hsa-miR-216a	CLIP-seq
MIRT2487068	hsa-miR-27a	CLIP-seq
MIRT2487069	hsa-miR-27b	CLIP-seq
MIRT2487070	hsa-miR-30a	CLIP-seq
MIRT2487071	hsa-miR-30b	CLIP-seq
MIRT2487072	hsa-miR-30c	CLIP-seq
MIRT2487073	hsa-miR-30d	CLIP-seq
MIRT2487074	hsa-miR-30e	CLIP-seq
MIRT2487075	hsa-miR-3123	CLIP-seq
MIRT1944906	hsa-miR-3130-3p	CLIP-seq
MIRT2487076	hsa-miR-3145-3p	CLIP-seq
MIRT827674	hsa-miR-3157-3p	CLIP-seq
MIRT827675	hsa-miR-3192	CLIP-seq
MIRT2183437	hsa-miR-3662	CLIP-seq
MIRT2487079	hsa-miR-3667-5p	CLIP-seq
MIRT2487080	hsa-miR-380	CLIP-seq
MIRT1944909	hsa-miR-3919	CLIP-seq
MIRT2487081	hsa-miR-3925-5p	CLIP-seq
MIRT2487082	hsa-miR-3976	CLIP-seq
MIRT2487083	hsa-miR-409-3p	CLIP-seq
MIRT2487084	hsa-miR-410	CLIP-seq
MIRT2487085	hsa-miR-4266	CLIP-seq
MIRT827684	hsa-miR-4314	CLIP-seq
MIRT827685	hsa-miR-4420	CLIP-seq
MIRT2487087	hsa-miR-4495	CLIP-seq
MIRT827687	hsa-miR-450b-3p	CLIP-seq
MIRT2487088	hsa-miR-4511	CLIP-seq
MIRT827688	hsa-miR-4639-5p	CLIP-seq
MIRT827689	hsa-miR-4646-5p	CLIP-seq
MIRT2487090	hsa-miR-4661-5p	CLIP-seq
MIRT2487091	hsa-miR-4694-3p	CLIP-seq
MIRT2487092	hsa-miR-4695-5p	CLIP-seq
MIRT2183441	hsa-miR-4698	CLIP-seq
MIRT1944911	hsa-miR-4704-3p	CLIP-seq
MIRT827690	hsa-miR-4713-3p	CLIP-seq
MIRT2183443	hsa-miR-4719	CLIP-seq
MIRT2487093	hsa-miR-4742-3p	CLIP-seq
MIRT1944912	hsa-miR-4756-3p	CLIP-seq
MIRT2676237	hsa-miR-4760-3p	CLIP-seq
MIRT2676238	hsa-miR-4775	CLIP-seq
MIRT2487094	hsa-miR-4779	CLIP-seq
MIRT1944913	hsa-miR-4793-3p	CLIP-seq
MIRT2487095	hsa-miR-499-3p	CLIP-seq
MIRT2487096	hsa-miR-499a-3p	CLIP-seq
MIRT827693	hsa-miR-5096	CLIP-seq
MIRT2487099	hsa-miR-539	CLIP-seq
MIRT1944916	hsa-miR-544	CLIP-seq
MIRT2487100	hsa-miR-548b-3p	CLIP-seq
MIRT2487101	hsa-miR-570	CLIP-seq
MIRT2183451	hsa-miR-582-5p	CLIP-seq
MIRT1944917	hsa-miR-590-3p	CLIP-seq
MIRT827703	hsa-miR-638	CLIP-seq
MIRT2676239	hsa-miR-664	CLIP-seq
MIRT827705	hsa-miR-769-3p	CLIP-seq
MIRT827706	hsa-miR-874	CLIP-seq
MIRT827707	hsa-miR-938	CLIP-seq
MIRT2487102	hsa-miR-942	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000775	Component	Chromosome, centromeric region	IEA
GO:0000776	Component	Kinetochore	IBA
GO:0000776	Component	Kinetochore	IDA	9660858
GO:0000776	Component	Kinetochore	IEA
GO:0005515	Function	Protein binding	IPI	9660858, 10198256, 11283619, 12762840, 15525512, 17289665, 19407811, 21566117, 21988832, 22000412, 22365833, 24462186, 24462187, 25383541, 25416956, 25852190, 25959826, 26496610, 32707033, 32814053, 33961781, 35271311
GO:0005634	Component	Nucleus	IEA
GO:0005654	Component	Nucleoplasm	IBA
GO:0005654	Component	Nucleoplasm	IDA
GO:0005694	Component	Chromosome	IEA
GO:0005829	Component	Cytosol	TAS
GO:0007059	Process	Chromosome segregation	IEA
GO:0007094	Process	Mitotic spindle assembly checkpoint signaling	IBA
GO:0007094	Process	Mitotic spindle assembly checkpoint signaling	NAS	11535616
GO:0008608	Process	Attachment of spindle microtubules to kinetochore	IDA	18199686
GO:0033597	Component	Mitotic checkpoint complex	IBA
GO:0033597	Component	Mitotic checkpoint complex	IPI	27509861
GO:0034501	Process	Protein localization to kinetochore	IPI	9660858
GO:0043130	Function	Ubiquitin binding	IBA
GO:0051301	Process	Cell division	IEA
GO:0051321	Process	Meiotic cell cycle	IEA
GO:0051983	Process	Regulation of chromosome segregation	IEA
GO:1990298	Component	Bub1-bub3 complex	IBA

Other IDs

• MIM: 603719
• HGNC: 1151
• e!Ensembl: ENSG00000154473

Protein

• UniProt ID: O43684
• Protein name: Mitotic checkpoint protein BUB3
• Protein function: Has a dual function in spindle-assembly checkpoint signaling and in promoting the establishment of correct kinetochore-microtubule (K-MT) attachments. Promotes the formation of stable end-on bipolar attachments. Necessary for kinetochore localiz
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00400	WD40	4 → 43	WD domain, G-beta repeat	Repeat
  PF00400	WD40	88 → 124	WD domain, G-beta repeat	Repeat
  PF00400	WD40	215 → 262	WD domain, G-beta repeat	Repeat

• Sequence:

  MTGSNEFKLNQPPEDGISSVKFSPNTSQFLLVSSWDTSVRLYDVPANSMRLKYQHTGAVL
  DCAFYDPTHAWSGGLDHQLKMHDLNTDQENLVGTHDAPIRCVEYCPEVNVMVTGSWDQTV
  KLWDPRTPCNAGTFSQPEKVYTLSVSGDRLIVGTAGRRVLVWDLRNMGYVQQRRESSLKY
  QTRCIRAFPNKQGYVLSSIEGRVAVEYLDPSPEVQKKKYAFKCHRLKENNIEQIYPVNAI
  SFHNIHNTFATGGSDGFVNIWDPFNKKRLCQFHRYPTSIASLAFSNDGTTLAIASSYMYE
  MDDTEHPEDGIFIRQVTDAETKPKSPCT

• Sequence length: 328

Pathways

KEGG:

Cell cycle
Human T-cell leukemia virus 1 infection

Reactome:

Inactivation of APC/C via direct inhibition of the APC/C complex
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
Cdc20:Phospho-APC/C mediated degradation of Cyclin A
APC/C:Cdc20 mediated degradation of mitotic proteins
APC-Cdc20 mediated degradation of Nek2A
Separation of Sister Chromatids
Resolution of Sister Chromatid Cohesion
RHO GTPases Activate Formins
Mitotic Prometaphase
EML4 and NUDC in mitotic spindle formation

Associated diseases

Unknown
Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession
BUB3-related disorder	Likely benign; Benign	rs777836898, rs762924864, rs2304550	RCV004758230 RCV003906710 RCV003974773

Associations from Text Mining
Disease Name	Relationship Type	References
Adenocarcinoma of Lung	Associate	36787437, 37228122
Adrenocortical Carcinoma	Associate	30413320
Aneuploidy	Associate	29448935, 33564066
Breast Neoplasms	Associate	35186236, 35493295
Carcinoma Hepatocellular	Associate	32596342, 35493295, 37301543
Carcinoma in Situ	Associate	26398519
Carcinoma Non Small Cell Lung	Associate	36551208
Colorectal Neoplasms	Associate	29448935, 35156516
Elliptocytosis 1	Associate	29448935
Glioblastoma	Associate	18694480
Glioma	Associate	22022424
Leukemia	Associate	37535603
Lichen Planus Oral	Associate	26398519
Melanoma	Associate	24743044
Mosaic variegated aneuploidy syndrome	Associate	29448935
Neoplasm Metastasis	Associate	37228122
Neoplasms	Associate	31801961, 35493295, 37228122
Pancreatic Neoplasms	Associate	28767289
Prostatic Neoplasms	Associate	31801961
Rectal Neoplasms	Associate	37895091
Sarcoma	Associate	33872216, 35493295
Triple Negative Breast Neoplasms	Associate	35056723