Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
91807
Gene name Gene Name - the full gene name approved by the HGNC.
Myosin light chain kinase 3
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
MYLK3
Synonyms (NCBI Gene) Gene synonyms aliases
MLCK, MLCK2, caMLCK
Chromosome Chromosome number
16
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
16q11.2
Summary Summary of gene provided in NCBI Entrez Gene.
Phosphorylation of cardiac myosin heavy chains (see MYH7B, MIM 609928) and light chains (see MYL2, MIM 160781) by a kinase, such as MYLK3, potentiates the force and rate of cross-bridge recruitment in cardiac myocytes (Chan et al., 2008 [PubMed 18202317])
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT027564 hsa-miR-98-5p Microarray 19088304
MIRT721641 hsa-miR-5003-3p HITS-CLIP 19536157
MIRT721640 hsa-miR-4705 HITS-CLIP 19536157
MIRT721639 hsa-miR-500b-3p HITS-CLIP 19536157
MIRT721638 hsa-miR-6892-3p HITS-CLIP 19536157
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0002528 Process Regulation of vascular permeability involved in acute inflammatory response IMP 18390750
GO:0004683 Function Calmodulin-dependent protein kinase activity ISS
GO:0004687 Function Myosin light chain kinase activity IBA 21873635
GO:0004687 Function Myosin light chain kinase activity ISS
GO:0005524 Function ATP binding IEA
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
612147 29826 ENSG00000140795
Protein
UniProt ID Q32MK0
Protein name Myosin light chain kinase 3 (EC 2.7.11.18) (Cardiac-MyBP-C-associated Ca/CaM kinase) (Cardiac-MLCK)
Protein function Kinase that phosphorylates MYL2 in vitro. Promotes sarcomere formation in cardiomyocytes and increases cardiomyocyte contractility (By similarity).
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00069 Pkinase 515 770 Protein kinase domain Domain
Tissue specificity TISSUE SPECIFICITY: Restricted to heart. {ECO:0000269|PubMed:17885681}.
Sequence
MSGTSKESLGHGGLPGLGKTCLTTMDTKLNMLNEKVDQLLHFQEDVTEKLQSMCRDMGHL
ERGLHRLEASRAPGPGGADGVPHIDTQAGWPEVLELVRAMQQDAAQHGARLEALFRMVAA
VDRAIALVGATFQKSKVADFLMQGRVPWRRGSPGDSPEENKERVEEEGGKPKHVLSTSGV
QSDAREPGEESQKADVLEGTAERLPPIRASGLGADPAQAVVSPGQGDGVPGPAQAFPGHL
PLPTKVEAKAPETPSENLRTGLELAPAPGRVNVVSPSLEVAPGAGQGASSSRPDPEPLEE
GTRLTPGPGPQCPGPPGLPAQARATHSGGETPPRISIHIQEMDTPGEMLMTGRGSLGPTL
TTEAPAAAQPGKQGPPGTGRCLQAPGTEPGEQTPEGARELSPLQESSSPGGVKAEEEQRA
GAEPGTRPSLARSDDNDHEVGALGLQQGKSPGAGNPEPEQDCAARAPVRAEAVRRMPPGA
EAGSVVLDDSPAPPAPFEHRVVSVKETSISAGYEVCQHEVLGGGRFGQVHRCTEKSTGLP
LAAKIIKVKSAKDREDVKNEINIMNQLSHVNLIQLYDAFESKHSCTLVMEYVDGGELFDR
ITDEKYHLTELDVVLFTRQICEGVHYLHQHYILHLDLKPENILCVNQTGHQIKIIDFGLA
RRYKPREKLKVNFGTPEFLAPEVVNYEFVSFPTDMWSVGVITYMLLSGLSPFLGETDAET
MNFIVNCSWDFDADTFEGLSEEAKDFVSRLLVKEKSCRMSATQCLKHEWL
NNLPAKASRS
KTRLKSQLLLQKYIAQRKWKKHFYVVTAANRLRKFPTSP
Sequence length 819
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG  
  Calcium signaling pathway
cGMP-PKG signaling pathway
Vascular smooth muscle contraction
Apelin signaling pathway
Focal adhesion
Platelet activation
Regulation of actin cytoskeleton
Oxytocin signaling pathway
Gastric acid secretion
 
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Causal
Disease term Disease name dbSNP ID References
Colorectal cancer Colorectal Carcinoma rs137854568, rs137854573, rs137854575, rs387906234, rs121908380, rs121908702, rs267606674, rs794729661, rs121909055, rs281865417, rs267606884, rs28934575, rs587776769, rs104893815, rs587776800
View all (467 more)
Unknown
Disease term Disease name Evidence References Source
Myopathy dilated cardiomyopathy GenCC
Associations from Text Mining
Disease Name Relationship Type References
Breast Neoplasms Stimulate 35886011
Cardiomyopathy Dilated Associate 29235529
Colorectal Neoplasms Associate 38092774
familial dilated cardiomyopathy Associate 29235529
Glut1 Deficiency Syndrome Associate 23671580, 34539242
Microcystic adnexal carcinoma Stimulate 35509066
Neoplasm Residual Associate 28350786
Neoplasms Associate 24670416
Ovarian Neoplasms Associate 28350786
Pancreatic Neoplasms Associate 24670416