Gene Gene information from NCBI Gene database.
Entrez ID 9180
Gene name Oncostatin M receptor
Gene symbol OSMR
Synonyms (NCBI Gene)
IL-31R-betaIL-31RBOSMRBOSMRbetaPLCA1
Chromosome 5
Chromosome location 5p13.1
Summary This gene encodes a member of the type I cytokine receptor family. The encoded protein heterodimerizes with interleukin 6 signal transducer to form the type II oncostatin M receptor and with interleukin 31 receptor A to form the interleukin 31 receptor, a
SNPs SNP information provided by dbSNP.
5
SNP ID Visualize variation Clinical significance Consequence
rs63750560 G>C Pathogenic Genic downstream transcript variant, coding sequence variant, missense variant, non coding transcript variant
rs63750567 T>C Pathogenic Genic downstream transcript variant, coding sequence variant, missense variant, non coding transcript variant
rs387906821 A>T Pathogenic Non coding transcript variant, genic downstream transcript variant, coding sequence variant, missense variant
rs387906822 C>T Likely-pathogenic, pathogenic Non coding transcript variant, genic downstream transcript variant, coding sequence variant, missense variant
rs387906823 A>C,G Pathogenic Non coding transcript variant, genic downstream transcript variant, coding sequence variant, missense variant
miRNA miRNA information provided by mirtarbase database.
1076
miRTarBase ID miRNA Experiments Reference
MIRT016997 hsa-miR-335-5p Microarray 18185580
MIRT027517 hsa-miR-98-5p Microarray 19088304
MIRT724297 hsa-miR-25-3p HITS-CLIP 19536157
MIRT724296 hsa-miR-32-5p HITS-CLIP 19536157
MIRT724295 hsa-miR-363-3p HITS-CLIP 19536157
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
22
GO ID Ontology Definition Evidence Reference
GO:0002675 Process Positive regulation of acute inflammatory response IC 8999038
GO:0004896 Function Cytokine receptor activity IBA
GO:0004896 Function Cytokine receptor activity IEA
GO:0004924 Function Oncostatin-M receptor activity IBA
GO:0004924 Function Oncostatin-M receptor activity IDA 8999038
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
601743 8507 ENSG00000145623
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
Q99650
Protein name Oncostatin-M-specific receptor subunit beta (Interleukin-31 receptor subunit beta) (IL-31 receptor subunit beta) (IL-31R subunit beta) (IL-31R-beta) (IL-31RB)
Protein function Associates with IL31RA to form the IL31 receptor. Binds IL31 to activate STAT3 and possibly STAT1 and STAT5. Capable of transducing OSM-specific signaling events.
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF17971 LIFR_D2 28 138 Leukemia inhibitory factor receptor D2 domain Domain
PF00041 fn3 525 609 Fibronectin type III domain Domain
Tissue specificity TISSUE SPECIFICITY: Expressed in keratinocytes (at protein level) (PubMed:21261663). Expressed at relatively high levels in all neural cells as well as fibroblast and epithelial cells (PubMed:8999038). {ECO:0000269|PubMed:21261663, ECO:0000269|PubMed:8999
Sequence
MALFAVFQTTFFLTLLSLRTYQSEVLAERLPLTPVSLKVSTNSTRQSLHLQWTVHNLPYH
QELKMVFQIQISRIETSNVIWVGNYSTTVKWNQVLHWSWESELPLECATHFVRIKSLVDD
AKFPEPNFWSNWSSWEEV
SVQDSTGQDILFVFPKDKLVEEGTNVTICYVSRNIQNNVSCY
LEGKQIHGEQLDPHVTAFNLNSVPFIRNKGTNIYCEASQGNVSEGMKGIVLFVSKVLEEP
KDFSCETEDFKTLHCTWDPGTDTALGWSKQPSQSYTLFESFSGEKKLCTHKNWCNWQITQ
DSQETYNFTLIAENYLRKRSVNILFNLTHRVYLMNPFSVNFENVNATNAIMTWKVHSIRN
NFTYLCQIELHGEGKMMQYNVSIKVNGEYFLSELEPATEYMARVRCADASHFWKWSEWSG
QNFTTLEAAPSEAPDVWRIVSLEPGNHTVTLFWKPLSKLHANGKILFYNVVVENLDKPSS
SELHSIPAPANSTKLILDRCSYQICVIANNSVGASPASVIVISADPENKEVEEERIAGTE
GGFSLSWKPQPGDVIGYVVDWCDHTQDVLGDFQWKNVGPNTTSTVISTDAFRPGVRYDFR
IYGLSTKRI
ACLLEKKTGYSQELAPSDNPHVLVDTLTSHSFTLSWKDYSTESQPGFIQGY
HVYLKSKARQCHPRFEKAVLSDGSECCKYKIDNPEEKALIVDNLKPESFYEFFITPFTSA
GEGPSATFTKVTTPDEHSSMLIHILLPMVFCVLLIMVMCYLKSQWIKETCYPDIPDPYKS
SILSLIKFKENPHLIIMNVSDCIPDAIEVVSKPEGTKIQFLGTRKSLTETELTKPNYLYL
LPTEKNHSGPGPCICFENLTYNQAASDSGSCGHVPVSPKAPSMLGLMTSPENVLKALEKN
YMNSLGEIPAGETSLNYVSQLASPMFGDKDSLPTNPVEAPHCSEYKMQMAVSLRLALPPP
TENSSLSSITLLDPGEHYC
Sequence length 979
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG  Reactome
  Cytokine-cytokine receptor interaction
PI3K-Akt signaling pathway
JAK-STAT signaling pathway
  IL-6-type cytokine receptor ligand interactions
Associated diseases Disease associations from ClinVar categorized as Causal (Pathogenic/Likely Pathogenic) or Unknown.
23
Causal Diseases associated with Pathogenic or Likely Pathogenic variants in ClinVar
Phenotype Name Clinical Significance dbSNP ID RCV Accession
Amyloidosis, primary localized cutaneous, 1 Likely pathogenic; Pathogenic rs63750567, rs63750560, rs387906821, rs387906822, rs387906823 RCV000008251
RCV000008252
RCV000023143
RCV000023144
RCV000023145
Unknown Diseases with uncertain, conflicting, or no pathogenic evidence in ClinVar
Phenotype Name Clinical Significance dbSNP ID RCV Accession
OSMR-related disorder Uncertain significance; Benign; Likely benign; Conflicting classifications of pathogenicity rs747403471, rs375673847, rs34675408, rs190725368, rs142334998, rs367714483, rs756379833, rs764796970, rs754064150, rs10941412, rs142927792, rs16867807, rs34324145, rs142014556, rs113413897 RCV003963759
RCV003392755
RCV003919705
RCV003916775
RCV003909706
RCV003941798
RCV003942070
RCV003964157
RCV003926951
RCV003982126
RCV003969119
RCV003926043
RCV003910619
RCV003910549
RCV003902858
Sarcoma Uncertain significance rs146348743 RCV005927244
Associations from Text MiningDisease associations identified through Pubtator
Disease Name Relationship Type References
Adenocarcinoma of Lung Associate 28729401
Amyloidosis Primary Cutaneous Associate 18179886, 19690585, 25054142, 35714449
Arthritis Associate 24219225
Arthritis Rheumatoid Associate 24219225
Asthma Associate 26956917
Breast Neoplasms Associate 30755233
Carcinogenesis Associate 20187983
Carcinoma Hepatocellular Associate 17028186, 30945699
Carcinoma Pancreatic Ductal Associate 32615164
Carcinoma Squamous Cell Associate 23765377, 28025425, 35289095