CABLES1 (Cdk5 and Abl enzyme substrate 1)
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Gene
Gene information from NCBI Gene database.
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| Entrez ID | 91768 |
| Gene name | Cdk5 and Abl enzyme substrate 1 |
| Gene symbol | CABLES1 |
| Synonyms (NCBI Gene) |
CABL1CABLESHsT2563IK3-1
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| Chromosome | 18 |
| Chromosome location | 18q11.2 |
| Summary | This gene encodes a protein involved in regulation of the cell cycle through interactions with several cyclin-dependent kinases. One study (PMID: 16177568) reported aberrant splicing of transcripts from this gene which results in removal of the cyclin bin |
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miRNA
miRNA information provided by mirtarbase database.
436
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Transcription factors
Transcription factors information provided by TRRUST V2 database.
2
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Gene ontology (GO)
Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
9
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Other IDs
Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
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Protein
Protein information from UniProt database.
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UniProt ID
Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
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Q8TDN4 | ||||||||||
| Protein name | CDK5 and ABL1 enzyme substrate 1 (Interactor with CDK3 1) (Ik3-1) | ||||||||||
| Protein function | Cyclin-dependent kinase binding protein. Enhances cyclin-dependent kinase tyrosine phosphorylation by nonreceptor tyrosine kinases, such as that of CDK5 by activated ABL1, which leads to increased CDK5 activity and is critical for neuronal devel | ||||||||||
| Family and domains |
Pfam
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| Tissue specificity | TISSUE SPECIFICITY: Expressed in breast, pancreas, colon, head and neck (at protein level). Strongly decreased in more than half of cases of atypical endometrial hyperplasia and in more than 90% of endometrial cancers. {ECO:0000269|PubMed:11585773, ECO:00 | ||||||||||
| Sequence |
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| Sequence length | 633 | ||||||||||
| Interactions | View interactions | ||||||||||
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Pathways
Pathway information has different metabolic/signaling pathways associated with genes.
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