NEK9 (NIMA related kinase 9)

Gene

• Entrez ID: 91754
• Gene name: NIMA related kinase 9
• Gene symbol: NEK9
• Synonyms (NCBI Gene): APUG, LCCS10, NC, NERCC, NERCC1
• Chromosome: 14
• Chromosome location: 14q24.3
• Summary: This gene encodes a member of the NimA (never in mitosis A) family of serine/threonine protein kinases. The encoded protein is activated in mitosis and, in turn, activates other family members during mitosis. This protein also mediates cellular processes

SNPs

SNP ID	Visualize variation	Clinical significance	Consequence
rs142859694	C>A,T	Pathogenic	Coding sequence variant, missense variant
rs757011098	G>A,T	Pathogenic	Stop gained, synonymous variant, coding sequence variant
rs879253775	A>G	Pathogenic	Coding sequence variant, missense variant
rs886037838	C>A	Pathogenic	Splice donor variant
rs886037839	C>A	Pathogenic	Coding sequence variant, missense variant
rs901508820	C>A	Likely-pathogenic	Coding sequence variant, stop gained
rs1057518379	A>G	Likely-pathogenic	Missense variant, coding sequence variant
rs1555352529	A>G	Pathogenic	Coding sequence variant, missense variant

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT002635	hsa-miR-124-3p	Microarray	18668037
MIRT002635	hsa-miR-124-3p	Microarray	15685193
MIRT029337	hsa-miR-26b-5p	Microarray	19088304
MIRT052110	hsa-let-7b-5p	CLASH	23622248
MIRT042950	hsa-miR-324-3p	CLASH	23622248
MIRT040420	hsa-miR-615-3p	CLASH	23622248
MIRT701485	hsa-miR-606	HITS-CLIP	23313552
MIRT701484	hsa-miR-302f	HITS-CLIP	23313552
MIRT701483	hsa-miR-6808-5p	HITS-CLIP	23313552
MIRT701482	hsa-miR-6893-5p	HITS-CLIP	23313552
MIRT701481	hsa-miR-940	HITS-CLIP	23313552
MIRT701480	hsa-miR-3929	HITS-CLIP	23313552
MIRT701479	hsa-miR-4419b	HITS-CLIP	23313552
MIRT701478	hsa-miR-4478	HITS-CLIP	23313552
MIRT701477	hsa-miR-5588-3p	HITS-CLIP	23313552
MIRT701476	hsa-miR-2114-5p	HITS-CLIP	23313552
MIRT701475	hsa-miR-4768-3p	HITS-CLIP	23313552
MIRT701474	hsa-miR-6746-5p	HITS-CLIP	23313552
MIRT701473	hsa-miR-4649-3p	HITS-CLIP	23313552
MIRT701472	hsa-miR-219b-3p	HITS-CLIP	23313552
MIRT701471	hsa-miR-1827	HITS-CLIP	23313552
MIRT701470	hsa-miR-485-5p	HITS-CLIP	23313552
MIRT701469	hsa-miR-6884-5p	HITS-CLIP	23313552
MIRT701468	hsa-miR-4722-5p	HITS-CLIP	23313552
MIRT701467	hsa-miR-7160-5p	HITS-CLIP	23313552
MIRT701466	hsa-miR-6771-5p	HITS-CLIP	23313552
MIRT701465	hsa-miR-1273e	HITS-CLIP	23313552
MIRT701464	hsa-miR-665	HITS-CLIP	23313552
MIRT667259	hsa-miR-3145-5p	HITS-CLIP	23824327
MIRT667257	hsa-miR-6729-3p	HITS-CLIP	23824327
MIRT667258	hsa-miR-508-5p	HITS-CLIP	23824327
MIRT667256	hsa-miR-1273g-3p	HITS-CLIP	23824327
MIRT667255	hsa-miR-6849-3p	HITS-CLIP	23824327
MIRT667254	hsa-miR-1292-3p	HITS-CLIP	23824327
MIRT667253	hsa-miR-766-3p	HITS-CLIP	23824327
MIRT667252	hsa-miR-4793-3p	HITS-CLIP	23824327
MIRT667251	hsa-miR-4299	HITS-CLIP	23824327
MIRT667250	hsa-miR-4252	HITS-CLIP	23824327
MIRT667249	hsa-miR-6512-3p	HITS-CLIP	23824327
MIRT667248	hsa-miR-6720-5p	HITS-CLIP	23824327
MIRT667247	hsa-miR-192-5p	HITS-CLIP	23824327
MIRT667246	hsa-miR-215-5p	HITS-CLIP	23824327
MIRT667245	hsa-miR-7703	HITS-CLIP	23824327
MIRT655914	hsa-miR-3173-3p	HITS-CLIP	23824327
MIRT655913	hsa-miR-6891-5p	HITS-CLIP	23824327
MIRT655912	hsa-miR-877-3p	HITS-CLIP	23824327
MIRT655911	hsa-miR-205-5p	HITS-CLIP	23824327
MIRT655910	hsa-miR-4509	HITS-CLIP	23824327
MIRT655909	hsa-miR-942-5p	HITS-CLIP	23824327
MIRT655908	hsa-miR-6821-3p	HITS-CLIP	23824327
MIRT655907	hsa-miR-4751	HITS-CLIP	23824327
MIRT655906	hsa-miR-6861-3p	HITS-CLIP	23824327
MIRT655905	hsa-miR-7154-3p	HITS-CLIP	23824327
MIRT002635	hsa-miR-124-3p	HITS-CLIP	23824327
MIRT655904	hsa-miR-506-3p	HITS-CLIP	23824327
MIRT655903	hsa-miR-7154-5p	HITS-CLIP	23824327
MIRT655902	hsa-miR-433-3p	HITS-CLIP	23824327
MIRT655901	hsa-miR-4722-3p	HITS-CLIP	23824327
MIRT655900	hsa-miR-6727-3p	HITS-CLIP	23824327
MIRT655899	hsa-miR-6747-3p	HITS-CLIP	23824327
MIRT655898	hsa-miR-939-3p	HITS-CLIP	23824327
MIRT655897	hsa-miR-6852-5p	HITS-CLIP	23824327
MIRT655896	hsa-miR-6742-3p	HITS-CLIP	23824327
MIRT655895	hsa-miR-1976	HITS-CLIP	23824327
MIRT655894	hsa-miR-23a-5p	HITS-CLIP	23824327
MIRT655893	hsa-miR-23b-5p	HITS-CLIP	23824327
MIRT655892	hsa-miR-520a-5p	HITS-CLIP	23824327
MIRT655891	hsa-miR-525-5p	HITS-CLIP	23824327
MIRT655890	hsa-miR-1343-3p	HITS-CLIP	23824327
MIRT655888	hsa-miR-6783-3p	HITS-CLIP	23824327
MIRT655889	hsa-miR-4279	HITS-CLIP	23824327
MIRT701485	hsa-miR-606	HITS-CLIP	23313552
MIRT701484	hsa-miR-302f	HITS-CLIP	23313552
MIRT701483	hsa-miR-6808-5p	HITS-CLIP	23313552
MIRT701482	hsa-miR-6893-5p	HITS-CLIP	23313552
MIRT701481	hsa-miR-940	HITS-CLIP	23313552
MIRT701480	hsa-miR-3929	HITS-CLIP	23313552
MIRT701479	hsa-miR-4419b	HITS-CLIP	23313552
MIRT701478	hsa-miR-4478	HITS-CLIP	23313552
MIRT701477	hsa-miR-5588-3p	HITS-CLIP	23313552
MIRT701476	hsa-miR-2114-5p	HITS-CLIP	23313552
MIRT701475	hsa-miR-4768-3p	HITS-CLIP	23313552
MIRT701474	hsa-miR-6746-5p	HITS-CLIP	23313552
MIRT701473	hsa-miR-4649-3p	HITS-CLIP	23313552
MIRT701472	hsa-miR-219b-3p	HITS-CLIP	23313552
MIRT701471	hsa-miR-1827	HITS-CLIP	23313552
MIRT701470	hsa-miR-485-5p	HITS-CLIP	23313552
MIRT701469	hsa-miR-6884-5p	HITS-CLIP	23313552
MIRT701468	hsa-miR-4722-5p	HITS-CLIP	23313552
MIRT701467	hsa-miR-7160-5p	HITS-CLIP	23313552
MIRT701466	hsa-miR-6771-5p	HITS-CLIP	23313552
MIRT701465	hsa-miR-1273e	HITS-CLIP	23313552
MIRT701464	hsa-miR-665	HITS-CLIP	23313552
MIRT667259	hsa-miR-3145-5p	HITS-CLIP	23824327
MIRT667257	hsa-miR-6729-3p	HITS-CLIP	23824327
MIRT667258	hsa-miR-508-5p	HITS-CLIP	23824327
MIRT667256	hsa-miR-1273g-3p	HITS-CLIP	23824327
MIRT667255	hsa-miR-6849-3p	HITS-CLIP	23824327
MIRT667254	hsa-miR-1292-3p	HITS-CLIP	23824327
MIRT667253	hsa-miR-766-3p	HITS-CLIP	23824327
MIRT667252	hsa-miR-4793-3p	HITS-CLIP	23824327
MIRT667251	hsa-miR-4299	HITS-CLIP	23824327
MIRT667250	hsa-miR-4252	HITS-CLIP	23824327
MIRT667249	hsa-miR-6512-3p	HITS-CLIP	23824327
MIRT667248	hsa-miR-6720-5p	HITS-CLIP	23824327
MIRT667247	hsa-miR-192-5p	HITS-CLIP	23824327
MIRT667246	hsa-miR-215-5p	HITS-CLIP	23824327
MIRT667245	hsa-miR-7703	HITS-CLIP	23824327
MIRT655914	hsa-miR-3173-3p	HITS-CLIP	23824327
MIRT655913	hsa-miR-6891-5p	HITS-CLIP	23824327
MIRT655912	hsa-miR-877-3p	HITS-CLIP	23824327
MIRT655911	hsa-miR-205-5p	HITS-CLIP	23824327
MIRT655910	hsa-miR-4509	HITS-CLIP	23824327
MIRT655909	hsa-miR-942-5p	HITS-CLIP	23824327
MIRT655908	hsa-miR-6821-3p	HITS-CLIP	23824327
MIRT655907	hsa-miR-4751	HITS-CLIP	23824327
MIRT655906	hsa-miR-6861-3p	HITS-CLIP	23824327
MIRT655905	hsa-miR-7154-3p	HITS-CLIP	23824327
MIRT002635	hsa-miR-124-3p	HITS-CLIP	23824327
MIRT655904	hsa-miR-506-3p	HITS-CLIP	23824327
MIRT655903	hsa-miR-7154-5p	HITS-CLIP	23824327
MIRT655902	hsa-miR-433-3p	HITS-CLIP	23824327
MIRT655901	hsa-miR-4722-3p	HITS-CLIP	23824327
MIRT655900	hsa-miR-6727-3p	HITS-CLIP	23824327
MIRT655899	hsa-miR-6747-3p	HITS-CLIP	23824327
MIRT655898	hsa-miR-939-3p	HITS-CLIP	23824327
MIRT655897	hsa-miR-6852-5p	HITS-CLIP	23824327
MIRT655896	hsa-miR-6742-3p	HITS-CLIP	23824327
MIRT655895	hsa-miR-1976	HITS-CLIP	23824327
MIRT655894	hsa-miR-23a-5p	HITS-CLIP	23824327
MIRT655893	hsa-miR-23b-5p	HITS-CLIP	23824327
MIRT655892	hsa-miR-520a-5p	HITS-CLIP	23824327
MIRT655891	hsa-miR-525-5p	HITS-CLIP	23824327
MIRT655890	hsa-miR-1343-3p	HITS-CLIP	23824327
MIRT655888	hsa-miR-6783-3p	HITS-CLIP	23824327
MIRT655889	hsa-miR-4279	HITS-CLIP	23824327
MIRT1180455	hsa-miR-1273g	CLIP-seq
MIRT1180456	hsa-miR-140-5p	CLIP-seq
MIRT1180457	hsa-miR-3611	CLIP-seq
MIRT1180458	hsa-miR-4260	CLIP-seq
MIRT1180459	hsa-miR-4283	CLIP-seq
MIRT1180460	hsa-miR-4489	CLIP-seq
MIRT1180461	hsa-miR-4670-3p	CLIP-seq
MIRT1180462	hsa-miR-4796-3p	CLIP-seq
MIRT1180463	hsa-miR-595	CLIP-seq
MIRT1180464	hsa-miR-648	CLIP-seq
MIRT1180465	hsa-miR-9	CLIP-seq
MIRT2052208	hsa-miR-1270	CLIP-seq
MIRT2052209	hsa-miR-135a	CLIP-seq
MIRT2052210	hsa-miR-135b	CLIP-seq
MIRT2052211	hsa-miR-2276	CLIP-seq
MIRT2052212	hsa-miR-3157-5p	CLIP-seq
MIRT2052213	hsa-miR-3591-3p	CLIP-seq
MIRT2052214	hsa-miR-4328	CLIP-seq
MIRT2052215	hsa-miR-4420	CLIP-seq
MIRT2052216	hsa-miR-4434	CLIP-seq
MIRT2052217	hsa-miR-4516	CLIP-seq
MIRT2052218	hsa-miR-4531	CLIP-seq
MIRT2052219	hsa-miR-4633-5p	CLIP-seq
MIRT2052220	hsa-miR-4691-3p	CLIP-seq
MIRT2052221	hsa-miR-4715-3p	CLIP-seq
MIRT2052222	hsa-miR-4772-3p	CLIP-seq
MIRT2052223	hsa-miR-491-3p	CLIP-seq
MIRT2052224	hsa-miR-544	CLIP-seq
MIRT2052225	hsa-miR-620	CLIP-seq
MIRT2281558	hsa-miR-1183	CLIP-seq
MIRT2281559	hsa-miR-1224-3p	CLIP-seq
MIRT2281560	hsa-miR-124	CLIP-seq
MIRT2281561	hsa-miR-1258	CLIP-seq
MIRT2281562	hsa-miR-1260	CLIP-seq
MIRT2281563	hsa-miR-1260b	CLIP-seq
MIRT2052208	hsa-miR-1270	CLIP-seq
MIRT2281564	hsa-miR-1280	CLIP-seq
MIRT2281565	hsa-miR-1343	CLIP-seq
MIRT2052209	hsa-miR-135a	CLIP-seq
MIRT2052210	hsa-miR-135b	CLIP-seq
MIRT2281566	hsa-miR-140-3p	CLIP-seq
MIRT2281567	hsa-miR-150	CLIP-seq
MIRT2281568	hsa-miR-188-3p	CLIP-seq
MIRT2281569	hsa-miR-1915	CLIP-seq
MIRT2281570	hsa-miR-197	CLIP-seq
MIRT2052211	hsa-miR-2276	CLIP-seq
MIRT2281571	hsa-miR-25	CLIP-seq
MIRT2281572	hsa-miR-3117-5p	CLIP-seq
MIRT2281573	hsa-miR-3135	CLIP-seq
MIRT2281574	hsa-miR-3148	CLIP-seq
MIRT2281575	hsa-miR-3153	CLIP-seq
MIRT2052212	hsa-miR-3157-5p	CLIP-seq
MIRT2281576	hsa-miR-3161	CLIP-seq
MIRT2281577	hsa-miR-32	CLIP-seq
MIRT2281578	hsa-miR-320a	CLIP-seq
MIRT2281579	hsa-miR-320b	CLIP-seq
MIRT2281580	hsa-miR-320c	CLIP-seq
MIRT2281581	hsa-miR-320d	CLIP-seq
MIRT2281582	hsa-miR-320e	CLIP-seq
MIRT2281583	hsa-miR-338-5p	CLIP-seq
MIRT2281584	hsa-miR-33a	CLIP-seq
MIRT2281585	hsa-miR-33b	CLIP-seq
MIRT2281586	hsa-miR-34a	CLIP-seq
MIRT2281587	hsa-miR-34c-5p	CLIP-seq
MIRT2052213	hsa-miR-3591-3p	CLIP-seq
MIRT2281588	hsa-miR-3620	CLIP-seq
MIRT2281589	hsa-miR-363	CLIP-seq
MIRT2281590	hsa-miR-367	CLIP-seq
MIRT2281591	hsa-miR-3671	CLIP-seq
MIRT2281592	hsa-miR-3714	CLIP-seq
MIRT2281593	hsa-miR-383	CLIP-seq
MIRT2281594	hsa-miR-3910	CLIP-seq
MIRT2281595	hsa-miR-3919	CLIP-seq
MIRT2281596	hsa-miR-3973	CLIP-seq
MIRT2281597	hsa-miR-409-3p	CLIP-seq
MIRT2281598	hsa-miR-412	CLIP-seq
MIRT1180458	hsa-miR-4260	CLIP-seq
MIRT2281599	hsa-miR-4269	CLIP-seq
MIRT2281600	hsa-miR-4282	CLIP-seq
MIRT1180459	hsa-miR-4283	CLIP-seq
MIRT2281601	hsa-miR-4305	CLIP-seq
MIRT2052214	hsa-miR-4328	CLIP-seq
MIRT2281602	hsa-miR-4329	CLIP-seq
MIRT2052215	hsa-miR-4420	CLIP-seq
MIRT2281603	hsa-miR-4429	CLIP-seq
MIRT2052216	hsa-miR-4434	CLIP-seq
MIRT2281604	hsa-miR-4453	CLIP-seq
MIRT2281605	hsa-miR-4470	CLIP-seq
MIRT2281606	hsa-miR-4477b	CLIP-seq
MIRT1180460	hsa-miR-4489	CLIP-seq
MIRT2281607	hsa-miR-4493	CLIP-seq
MIRT2281608	hsa-miR-4496	CLIP-seq
MIRT2281609	hsa-miR-449a	CLIP-seq
MIRT2281610	hsa-miR-449b	CLIP-seq
MIRT2052217	hsa-miR-4516	CLIP-seq
MIRT2281611	hsa-miR-4521	CLIP-seq
MIRT2052218	hsa-miR-4531	CLIP-seq
MIRT2281612	hsa-miR-4538	CLIP-seq
MIRT2281613	hsa-miR-4640-5p	CLIP-seq
MIRT2281614	hsa-miR-4645-5p	CLIP-seq
MIRT2281615	hsa-miR-4668-5p	CLIP-seq
MIRT2281616	hsa-miR-4673	CLIP-seq
MIRT2281617	hsa-miR-4687-3p	CLIP-seq
MIRT2052220	hsa-miR-4691-3p	CLIP-seq
MIRT2281618	hsa-miR-4704-3p	CLIP-seq
MIRT2281619	hsa-miR-4711-3p	CLIP-seq
MIRT2281620	hsa-miR-4726-3p	CLIP-seq
MIRT2281621	hsa-miR-4726-5p	CLIP-seq
MIRT2281622	hsa-miR-4738-5p	CLIP-seq
MIRT2281623	hsa-miR-4753-3p	CLIP-seq
MIRT2281624	hsa-miR-4756-3p	CLIP-seq
MIRT2281625	hsa-miR-4760-5p	CLIP-seq
MIRT2281626	hsa-miR-4768-5p	CLIP-seq
MIRT2281627	hsa-miR-4774-3p	CLIP-seq
MIRT2281628	hsa-miR-494	CLIP-seq
MIRT2281629	hsa-miR-506	CLIP-seq
MIRT2281630	hsa-miR-513a-3p	CLIP-seq
MIRT2281631	hsa-miR-520g	CLIP-seq
MIRT2281632	hsa-miR-520h	CLIP-seq
MIRT2281633	hsa-miR-532-3p	CLIP-seq
MIRT2281634	hsa-miR-539	CLIP-seq
MIRT2281635	hsa-miR-541	CLIP-seq
MIRT2281636	hsa-miR-548an	CLIP-seq
MIRT2281637	hsa-miR-548c-3p	CLIP-seq
MIRT2281638	hsa-miR-548g	CLIP-seq
MIRT2281639	hsa-miR-587	CLIP-seq
MIRT2281640	hsa-miR-593	CLIP-seq
MIRT1180463	hsa-miR-595	CLIP-seq
MIRT2281641	hsa-miR-605	CLIP-seq
MIRT2052225	hsa-miR-620	CLIP-seq
MIRT2281642	hsa-miR-633	CLIP-seq
MIRT2281643	hsa-miR-634	CLIP-seq
MIRT1180464	hsa-miR-648	CLIP-seq
MIRT2281644	hsa-miR-654-5p	CLIP-seq
MIRT2281645	hsa-miR-892a	CLIP-seq
MIRT1180465	hsa-miR-9	CLIP-seq
MIRT2281646	hsa-miR-92a	CLIP-seq
MIRT2281647	hsa-miR-92b	CLIP-seq
MIRT2281559	hsa-miR-1224-3p	CLIP-seq
MIRT2391477	hsa-miR-3159	CLIP-seq
MIRT2052213	hsa-miR-3591-3p	CLIP-seq
MIRT2281592	hsa-miR-3714	CLIP-seq
MIRT2391478	hsa-miR-4700-3p	CLIP-seq
MIRT2281619	hsa-miR-4711-3p	CLIP-seq
MIRT2281645	hsa-miR-892a	CLIP-seq
MIRT2438970	hsa-miR-1298	CLIP-seq
MIRT2281566	hsa-miR-140-3p	CLIP-seq
MIRT2052215	hsa-miR-4420	CLIP-seq
MIRT2438971	hsa-miR-664	CLIP-seq
MIRT2579817	hsa-miR-1185	CLIP-seq
MIRT2281559	hsa-miR-1224-3p	CLIP-seq
MIRT2579818	hsa-miR-1226	CLIP-seq
MIRT2579819	hsa-miR-1233	CLIP-seq
MIRT2281561	hsa-miR-1258	CLIP-seq
MIRT2281562	hsa-miR-1260	CLIP-seq
MIRT2281563	hsa-miR-1260b	CLIP-seq
MIRT2579820	hsa-miR-1266	CLIP-seq
MIRT2052208	hsa-miR-1270	CLIP-seq
MIRT2579821	hsa-miR-1272	CLIP-seq
MIRT2579822	hsa-miR-1273f	CLIP-seq
MIRT2579823	hsa-miR-128	CLIP-seq
MIRT2281564	hsa-miR-1280	CLIP-seq
MIRT2579824	hsa-miR-1283	CLIP-seq
MIRT2579825	hsa-miR-133a	CLIP-seq
MIRT2579826	hsa-miR-133b	CLIP-seq
MIRT2281566	hsa-miR-140-3p	CLIP-seq
MIRT2579827	hsa-miR-143	CLIP-seq
MIRT2579828	hsa-miR-153	CLIP-seq
MIRT2281568	hsa-miR-188-3p	CLIP-seq
MIRT2579829	hsa-miR-1911	CLIP-seq
MIRT2579830	hsa-miR-1972	CLIP-seq
MIRT2281571	hsa-miR-25	CLIP-seq
MIRT2281572	hsa-miR-3117-5p	CLIP-seq
MIRT2579831	hsa-miR-3125	CLIP-seq
MIRT2281573	hsa-miR-3135	CLIP-seq
MIRT2579832	hsa-miR-3150b-3p	CLIP-seq
MIRT2052212	hsa-miR-3157-5p	CLIP-seq
MIRT2391477	hsa-miR-3159	CLIP-seq
MIRT2281576	hsa-miR-3161	CLIP-seq
MIRT2579833	hsa-miR-3174	CLIP-seq
MIRT2579834	hsa-miR-3183	CLIP-seq
MIRT2579835	hsa-miR-3185	CLIP-seq
MIRT2579836	hsa-miR-3189-5p	CLIP-seq
MIRT2281577	hsa-miR-32	CLIP-seq
MIRT2281578	hsa-miR-320a	CLIP-seq
MIRT2281579	hsa-miR-320b	CLIP-seq
MIRT2281580	hsa-miR-320c	CLIP-seq
MIRT2281581	hsa-miR-320d	CLIP-seq
MIRT2281584	hsa-miR-33a	CLIP-seq
MIRT2281585	hsa-miR-33b	CLIP-seq
MIRT2579837	hsa-miR-3545-3p	CLIP-seq
MIRT2052213	hsa-miR-3591-3p	CLIP-seq
MIRT2579838	hsa-miR-3605-5p	CLIP-seq
MIRT2281588	hsa-miR-3620	CLIP-seq
MIRT2281589	hsa-miR-363	CLIP-seq
MIRT2579839	hsa-miR-3664-3p	CLIP-seq
MIRT2281590	hsa-miR-367	CLIP-seq
MIRT2579840	hsa-miR-3670	CLIP-seq
MIRT2281591	hsa-miR-3671	CLIP-seq
MIRT2579841	hsa-miR-3679-5p	CLIP-seq
MIRT2579842	hsa-miR-370	CLIP-seq
MIRT2579843	hsa-miR-3916	CLIP-seq
MIRT2281595	hsa-miR-3919	CLIP-seq
MIRT2579844	hsa-miR-3921	CLIP-seq
MIRT2281596	hsa-miR-3973	CLIP-seq
MIRT2281597	hsa-miR-409-3p	CLIP-seq
MIRT2579845	hsa-miR-4251	CLIP-seq
MIRT2579846	hsa-miR-4257	CLIP-seq
MIRT2281600	hsa-miR-4282	CLIP-seq
MIRT2579847	hsa-miR-4293	CLIP-seq
MIRT2052214	hsa-miR-4328	CLIP-seq
MIRT2281602	hsa-miR-4329	CLIP-seq
MIRT2052215	hsa-miR-4420	CLIP-seq
MIRT2281603	hsa-miR-4429	CLIP-seq
MIRT2052216	hsa-miR-4434	CLIP-seq
MIRT2281604	hsa-miR-4453	CLIP-seq
MIRT2281605	hsa-miR-4470	CLIP-seq
MIRT2281606	hsa-miR-4477b	CLIP-seq
MIRT2579848	hsa-miR-448	CLIP-seq
MIRT2281608	hsa-miR-4496	CLIP-seq
MIRT2579849	hsa-miR-450b-5p	CLIP-seq
MIRT2052217	hsa-miR-4516	CLIP-seq
MIRT2579850	hsa-miR-4518	CLIP-seq
MIRT2579851	hsa-miR-4527	CLIP-seq
MIRT2052218	hsa-miR-4531	CLIP-seq
MIRT2281612	hsa-miR-4538	CLIP-seq
MIRT2579852	hsa-miR-4650-5p	CLIP-seq
MIRT2579853	hsa-miR-4652-3p	CLIP-seq
MIRT2579854	hsa-miR-4653-5p	CLIP-seq
MIRT2579855	hsa-miR-4662a-3p	CLIP-seq
MIRT2579856	hsa-miR-4663	CLIP-seq
MIRT2579857	hsa-miR-4666-5p	CLIP-seq
MIRT2579858	hsa-miR-4684-5p	CLIP-seq
MIRT2579859	hsa-miR-4687-5p	CLIP-seq
MIRT2579860	hsa-miR-4689	CLIP-seq
MIRT2052220	hsa-miR-4691-3p	CLIP-seq
MIRT2391478	hsa-miR-4700-3p	CLIP-seq
MIRT2579861	hsa-miR-4705	CLIP-seq
MIRT2579862	hsa-miR-4708-5p	CLIP-seq
MIRT2579863	hsa-miR-4714-3p	CLIP-seq
MIRT2052221	hsa-miR-4715-3p	CLIP-seq
MIRT2579864	hsa-miR-4723-3p	CLIP-seq
MIRT2579865	hsa-miR-4728-3p	CLIP-seq
MIRT2579866	hsa-miR-4746-5p	CLIP-seq
MIRT2281623	hsa-miR-4753-3p	CLIP-seq
MIRT2281624	hsa-miR-4756-3p	CLIP-seq
MIRT2579867	hsa-miR-4758-3p	CLIP-seq
MIRT2281626	hsa-miR-4768-5p	CLIP-seq
MIRT2579868	hsa-miR-4770	CLIP-seq
MIRT2281627	hsa-miR-4774-3p	CLIP-seq
MIRT2579869	hsa-miR-4779	CLIP-seq
MIRT2579870	hsa-miR-4784	CLIP-seq
MIRT2281628	hsa-miR-494	CLIP-seq
MIRT2579871	hsa-miR-507	CLIP-seq
MIRT2281630	hsa-miR-513a-3p	CLIP-seq
MIRT2579872	hsa-miR-520d-5p	CLIP-seq
MIRT2281631	hsa-miR-520g	CLIP-seq
MIRT2281632	hsa-miR-520h	CLIP-seq
MIRT2579873	hsa-miR-524-5p	CLIP-seq
MIRT2281633	hsa-miR-532-3p	CLIP-seq
MIRT2281634	hsa-miR-539	CLIP-seq
MIRT2579874	hsa-miR-557	CLIP-seq
MIRT2579875	hsa-miR-582-3p	CLIP-seq
MIRT2281639	hsa-miR-587	CLIP-seq
MIRT2281641	hsa-miR-605	CLIP-seq
MIRT2052225	hsa-miR-620	CLIP-seq
MIRT2579876	hsa-miR-624	CLIP-seq
MIRT2579877	hsa-miR-642b	CLIP-seq
MIRT2579878	hsa-miR-873	CLIP-seq
MIRT1180465	hsa-miR-9	CLIP-seq
MIRT2281646	hsa-miR-92a	CLIP-seq
MIRT2281647	hsa-miR-92b	CLIP-seq
MIRT2579879	hsa-miR-938	CLIP-seq
MIRT2579880	hsa-miR-942	CLIP-seq
MIRT2579817	hsa-miR-1185	CLIP-seq
MIRT2281559	hsa-miR-1224-3p	CLIP-seq
MIRT2579818	hsa-miR-1226	CLIP-seq
MIRT2579819	hsa-miR-1233	CLIP-seq
MIRT2686190	hsa-miR-1238	CLIP-seq
MIRT2281561	hsa-miR-1258	CLIP-seq
MIRT2281562	hsa-miR-1260	CLIP-seq
MIRT2281563	hsa-miR-1260b	CLIP-seq
MIRT2579820	hsa-miR-1266	CLIP-seq
MIRT2052208	hsa-miR-1270	CLIP-seq
MIRT2579821	hsa-miR-1272	CLIP-seq
MIRT2579822	hsa-miR-1273f	CLIP-seq
MIRT2281564	hsa-miR-1280	CLIP-seq
MIRT2579824	hsa-miR-1283	CLIP-seq
MIRT2686191	hsa-miR-1324	CLIP-seq
MIRT2281565	hsa-miR-1343	CLIP-seq
MIRT2281566	hsa-miR-140-3p	CLIP-seq
MIRT2579827	hsa-miR-143	CLIP-seq
MIRT2281568	hsa-miR-188-3p	CLIP-seq
MIRT2579830	hsa-miR-1972	CLIP-seq
MIRT2281571	hsa-miR-25	CLIP-seq
MIRT2686192	hsa-miR-3074-5p	CLIP-seq
MIRT2281572	hsa-miR-3117-5p	CLIP-seq
MIRT2686193	hsa-miR-3124-3p	CLIP-seq
MIRT2579831	hsa-miR-3125	CLIP-seq
MIRT2686194	hsa-miR-3127-5p	CLIP-seq
MIRT2281573	hsa-miR-3135	CLIP-seq
MIRT2579832	hsa-miR-3150b-3p	CLIP-seq
MIRT2281576	hsa-miR-3161	CLIP-seq
MIRT2579834	hsa-miR-3183	CLIP-seq
MIRT2579835	hsa-miR-3185	CLIP-seq
MIRT2579836	hsa-miR-3189-5p	CLIP-seq
MIRT2281577	hsa-miR-32	CLIP-seq
MIRT2281578	hsa-miR-320a	CLIP-seq
MIRT2281579	hsa-miR-320b	CLIP-seq
MIRT2281580	hsa-miR-320c	CLIP-seq
MIRT2281581	hsa-miR-320d	CLIP-seq
MIRT2281584	hsa-miR-33a	CLIP-seq
MIRT2281585	hsa-miR-33b	CLIP-seq
MIRT2579837	hsa-miR-3545-3p	CLIP-seq
MIRT2052213	hsa-miR-3591-3p	CLIP-seq
MIRT2579838	hsa-miR-3605-5p	CLIP-seq
MIRT2281588	hsa-miR-3620	CLIP-seq
MIRT2281589	hsa-miR-363	CLIP-seq
MIRT2579839	hsa-miR-3664-3p	CLIP-seq
MIRT2281590	hsa-miR-367	CLIP-seq
MIRT2281591	hsa-miR-3671	CLIP-seq
MIRT2579841	hsa-miR-3679-5p	CLIP-seq
MIRT2686195	hsa-miR-3690	CLIP-seq
MIRT2579842	hsa-miR-370	CLIP-seq
MIRT2686196	hsa-miR-378	CLIP-seq
MIRT2686197	hsa-miR-378b	CLIP-seq
MIRT2686198	hsa-miR-378c	CLIP-seq
MIRT2686199	hsa-miR-378d	CLIP-seq
MIRT2686200	hsa-miR-378e	CLIP-seq
MIRT2686201	hsa-miR-378f	CLIP-seq
MIRT2686202	hsa-miR-378h	CLIP-seq
MIRT2686203	hsa-miR-378i	CLIP-seq
MIRT2579843	hsa-miR-3916	CLIP-seq
MIRT2686204	hsa-miR-3918	CLIP-seq
MIRT2281595	hsa-miR-3919	CLIP-seq
MIRT2579844	hsa-miR-3921	CLIP-seq
MIRT2281596	hsa-miR-3973	CLIP-seq
MIRT2281597	hsa-miR-409-3p	CLIP-seq
MIRT2686205	hsa-miR-422a	CLIP-seq
MIRT2579845	hsa-miR-4251	CLIP-seq
MIRT2686206	hsa-miR-4254	CLIP-seq
MIRT2579846	hsa-miR-4257	CLIP-seq
MIRT2281600	hsa-miR-4282	CLIP-seq
MIRT2579847	hsa-miR-4293	CLIP-seq
MIRT2052214	hsa-miR-4328	CLIP-seq
MIRT2281602	hsa-miR-4329	CLIP-seq
MIRT2052215	hsa-miR-4420	CLIP-seq
MIRT2686207	hsa-miR-4422	CLIP-seq
MIRT2281603	hsa-miR-4429	CLIP-seq
MIRT2052216	hsa-miR-4434	CLIP-seq
MIRT2281604	hsa-miR-4453	CLIP-seq
MIRT2281605	hsa-miR-4470	CLIP-seq
MIRT2281608	hsa-miR-4496	CLIP-seq
MIRT2052217	hsa-miR-4516	CLIP-seq
MIRT2579850	hsa-miR-4518	CLIP-seq
MIRT2052218	hsa-miR-4531	CLIP-seq
MIRT2281612	hsa-miR-4538	CLIP-seq
MIRT2579852	hsa-miR-4650-5p	CLIP-seq
MIRT2579854	hsa-miR-4653-5p	CLIP-seq
MIRT2579855	hsa-miR-4662a-3p	CLIP-seq
MIRT2579856	hsa-miR-4663	CLIP-seq
MIRT2579857	hsa-miR-4666-5p	CLIP-seq
MIRT2579858	hsa-miR-4684-5p	CLIP-seq
MIRT2579859	hsa-miR-4687-5p	CLIP-seq
MIRT2579860	hsa-miR-4689	CLIP-seq
MIRT2686208	hsa-miR-4691-5p	CLIP-seq
MIRT2579861	hsa-miR-4705	CLIP-seq
MIRT2579862	hsa-miR-4708-5p	CLIP-seq
MIRT2579863	hsa-miR-4714-3p	CLIP-seq
MIRT2052221	hsa-miR-4715-3p	CLIP-seq
MIRT2579864	hsa-miR-4723-3p	CLIP-seq
MIRT2579865	hsa-miR-4728-3p	CLIP-seq
MIRT2579866	hsa-miR-4746-5p	CLIP-seq
MIRT2281623	hsa-miR-4753-3p	CLIP-seq
MIRT2281624	hsa-miR-4756-3p	CLIP-seq
MIRT2579867	hsa-miR-4758-3p	CLIP-seq
MIRT2281626	hsa-miR-4768-5p	CLIP-seq
MIRT2579868	hsa-miR-4770	CLIP-seq
MIRT2281627	hsa-miR-4774-3p	CLIP-seq
MIRT2579869	hsa-miR-4779	CLIP-seq
MIRT2579870	hsa-miR-4784	CLIP-seq
MIRT2281628	hsa-miR-494	CLIP-seq
MIRT2686209	hsa-miR-510	CLIP-seq
MIRT2281630	hsa-miR-513a-3p	CLIP-seq
MIRT2579872	hsa-miR-520d-5p	CLIP-seq
MIRT2281631	hsa-miR-520g	CLIP-seq
MIRT2281632	hsa-miR-520h	CLIP-seq
MIRT2579873	hsa-miR-524-5p	CLIP-seq
MIRT2281633	hsa-miR-532-3p	CLIP-seq
MIRT2281634	hsa-miR-539	CLIP-seq
MIRT2281639	hsa-miR-587	CLIP-seq
MIRT2281641	hsa-miR-605	CLIP-seq
MIRT2052225	hsa-miR-620	CLIP-seq
MIRT2579876	hsa-miR-624	CLIP-seq
MIRT2579877	hsa-miR-642b	CLIP-seq
MIRT2579878	hsa-miR-873	CLIP-seq
MIRT1180465	hsa-miR-9	CLIP-seq
MIRT2281646	hsa-miR-92a	CLIP-seq
MIRT2281647	hsa-miR-92b	CLIP-seq
MIRT2579879	hsa-miR-938	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000166	Function	Nucleotide binding	IEA
GO:0000278	Process	Mitotic cell cycle	IDA	12840024, 19941817
GO:0004672	Function	Protein kinase activity	IEA
GO:0004674	Function	Protein serine/threonine kinase activity	IDA	12840024, 19941817
GO:0004674	Function	Protein serine/threonine kinase activity	IEA
GO:0005515	Function	Protein binding	IPI	20562859, 21642957, 22939624, 25852190, 26496610, 27173435, 28514442, 32707033, 33961781, 35044719, 35271311, 36931259
GO:0005524	Function	ATP binding	IEA
GO:0005634	Component	Nucleus	IEA
GO:0005737	Component	Cytoplasm	IEA
GO:0005813	Component	Centrosome	IBA
GO:0005813	Component	Centrosome	IDA	20873783
GO:0005829	Component	Cytosol	TAS
GO:0007346	Process	Regulation of mitotic cell cycle	IDA	19941817
GO:0007346	Process	Regulation of mitotic cell cycle	IDA	19941817
GO:0016301	Function	Kinase activity	IEA
GO:0016740	Function	Transferase activity	IEA
GO:0019901	Function	Protein kinase binding	IBA
GO:0019901	Function	Protein kinase binding	IPI	19001501
GO:0030295	Function	Protein kinase activator activity	IDA	12840024
GO:0046872	Function	Metal ion binding	IEA
GO:0051301	Process	Cell division	IEA
GO:0106310	Function	Protein serine kinase activity	IEA
GO:1900227	Process	Positive regulation of NLRP3 inflammasome complex assembly	IDA	31189953

Other IDs

• MIM: 609798
• HGNC: 18591
• e!Ensembl: ENSG00000119638

Protein

• UniProt ID: Q8TD19
• Protein name: Serine/threonine-protein kinase Nek9 (EC 2.7.11.1) (Nercc1 kinase) (Never in mitosis A-related kinase 9) (NimA-related protein kinase 9) (NimA-related kinase 8) (Nek8)
• Protein function: Pleiotropic regulator of mitotic progression, participating in the control of spindle dynamics and chromosome separation (PubMed:12101123, PubMed:12840024, PubMed:14660563, PubMed:19941817). Phosphorylates different histones, myelin basic protei
• PDB: 3ZKE, 3ZKF
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00069	Pkinase	52 → 308	Protein kinase domain	Domain
  PF00415	RCC1	389 → 441	Regulator of chromosome condensation (RCC1) repeat	Repeat
  PF00415	RCC1	444 → 495	Regulator of chromosome condensation (RCC1) repeat	Repeat
  PF00415	RCC1	499 → 547	Regulator of chromosome condensation (RCC1) repeat	Repeat
  PF00415	RCC1	615 → 665	Regulator of chromosome condensation (RCC1) repeat	Repeat

• Tissue specificity: TISSUE SPECIFICITY: Most abundant in heart, liver, kidney and testis. Also expressed in smooth muscle cells and fibroblasts. {ECO:0000269|PubMed:11864968}.
• Sequence:

  MSVLGEYERHCDSINSDFGSESGGCGDSSPGPSASQGPRAGGGAAEQEELHYIPIRVLGR
  GAFGEATLYRRTEDDSLVVWKEVDLTRLSEKERRDALNEIVILALLQHDNIIAYYNHFMD
  NTTLLIELEYCNGGNLYDKILRQKDKLFEEEMVVWYLFQIVSAVSCIHKAGILHRDIKTL
  NIFLTKANLIKLGDYGLAKKLNSEYSMAETLVGTPYYMSPELCQGVKYNFKSDIWAVGCV
  IFELLTLKRTFDATNPLNLCVKIVQGIRAMEVDSSQYSLELIQMVHSCLDQDPEQRPTAD
  ELLDRPLLRKRRREMEEKVTLLNAPTKRPRSSTVTEAPIAVVTSRTSEVYVWGGGKSTPQ
  KLDVIKSGCSARQVCAGNTHFAVVTVEKELYTWVNMQGGTKLHGQLGHGDKASYRQPKHV
  EKLQGKAIRQVSCGDDFTVCVTDEGQLYAFGSDYYGCMGVDKVAGPEVLEPMQLNFFLSN
  PVEQVSCGDNHVVVLTRNKEVYSWGCGEYGRLGLDSEEDYYTPQKVDVPKALIIVAVQCG
  CDGTFLLTQSGKVLACGLNEFNKLGLNQCMSGIINHEAYHEVPYTTSFTLAKQLSFYKIR
  TIAPGKTHTAAIDERGRLLTFGCNKCGQLGVGNYKKRLGINLLGGPLGGKQVIRVSCGDE
  FTIAATDDNHIFAWGNGGNGRLAMTPTERPHGSDICTSWPRPIFGSLHHVPDLSCRGWHT
  ILIVEKVLNSKTIRSNSSGLSIGTVFQSSSPGGGGGGGGGEEEDSQQESETPDPSGGFRG
  TMEADRGMEGLISPTEAMGNSNGASSSCPGWLRKELENAEFIPMPDSPSPLSAAFSESEK
  DTLPYEELQGLKVASEAPLEHKPQVEASSPRLNPAVTCAGKGTPLTPPACACSSLQVEVE
  RLQGLVLKCLAEQQKLQQENLQIFTQLQKLNKKLEGGQQVGMHSKGTQTAKEEMEMDPKP
  DLDSDSWCLLGTDSCRPSL

• Sequence length: 979

Pathways

Reactome:

Activation of NIMA Kinases NEK9, NEK6, NEK7
Nuclear Pore Complex (NPC) Disassembly
EML4 and NUDC in mitotic spindle formation

Associated diseases

Causal
Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession
Arthrogryposis, Perthes disease, and upward gaze palsy	Likely pathogenic	rs1327520738, rs1362564667, rs2503501853	RCV001332756 RCV003494516 RCV003494518
Goldberg-Shprintzen syndrome	Likely pathogenic	rs2139820216, rs1402196530	RCV001730015 RCV001730016
NEK9-related lethal skeletal dysplasia	Pathogenic; Likely pathogenic	rs757011098, rs1362564667, rs2503501853	RCV000234925 RCV003494516 RCV003494518
Nevus comedonicus syndrome	Pathogenic	rs1555352529, rs879253775	RCV000234968 RCV000240653

Unknown
Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession
-	no classification for the single variant	rs886037839, rs886037838	-
Cleft palate	Likely benign	rs534245464	RCV000845273
Congenital contracture	Uncertain significance	rs1167437528	RCV002244254
Congenital omphalocele	Uncertain significance	rs1167437528	RCV002244254
Lung cancer	Conflicting classifications of pathogenicity	rs146787666	RCV005928703
Malignant tumor of urinary bladder	Conflicting classifications of pathogenicity	rs146787666	RCV005928702
NEK9-related disorder	Conflicting classifications of pathogenicity; Uncertain significance; Likely benign; Benign	rs146787666, rs150013785, rs377136228, rs375873968, rs143703209, rs1566663876, rs375063665, rs143529818, rs200445076, rs36014869, rs143597394, rs202006653, rs562180803	RCV003943518 RCV004757570 RCV004757581 RCV003946472 RCV003954139 RCV003896581 RCV003896332 RCV003974173 RCV003955842 RCV004757315 RCV003923046 RCV003910745 RCV003933072
Ovarian serous cystadenocarcinoma	Uncertain significance	rs201574563	RCV005939330
Prostate cancer	Uncertain significance	rs193920844	RCV000149323
Retinal disorder	Likely benign	rs534245464	RCV000845273
Uterine corpus endometrial carcinoma	Uncertain significance	rs111316318	RCV005911101

Associations from Text Mining
Disease Name	Relationship Type	References
Airway Remodeling	Associate	31961058
Allan Herndon Dudley syndrome	Associate	36611072
Breast Neoplasms	Associate	35935324
Colorectal Neoplasms	Associate	36611072
Glioblastoma	Associate	26956052
Leukemia Myeloid Acute	Associate	34051812
Lymphatic Metastasis	Associate	35935324
Melanoma	Associate	29112787, 37558831
Meningioma	Associate	30594554
Neoplasm Metastasis	Associate	36611072, 37443302
Neoplasms	Stimulate	26956052
Neoplasms	Associate	29112787, 37443302, 37558831, 39241280
Stomach Neoplasms	Associate	37443302
Syndrome	Associate	26633546