Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	91734
Gene name Gene Name - the full gene name approved by the HGNC.	Isopentenyl-diphosphate delta isomerase 2
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	IDI2
Synonyms (NCBI Gene) Gene synonyms aliases	IPPI2
Chromosome Chromosome number	10
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	10p15.3
Summary Summary of gene provided in NCBI Entrez Gene.	The protein encoded by this gene catalyzes the conversion of isopentenyl diphosphate to dimethylallyl diphosphate, which is a precursor for the synthesis of cholesterol and other isoprenoids. This gene, which is a product of an ancestral gene duplication

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miRTarBase ID	miRNA	Experiments
MIRT1059488	hsa-miR-1261	CLIP-seq
MIRT1059489	hsa-miR-3150a-3p	CLIP-seq
MIRT1059490	hsa-miR-3151	CLIP-seq
MIRT1059491	hsa-miR-3175	CLIP-seq
MIRT1059492	hsa-miR-320a	CLIP-seq
MIRT1059493	hsa-miR-320b	CLIP-seq
MIRT1059494	hsa-miR-320c	CLIP-seq
MIRT1059495	hsa-miR-320d	CLIP-seq
MIRT1059496	hsa-miR-4429	CLIP-seq
MIRT1059497	hsa-miR-4447	CLIP-seq
MIRT1059498	hsa-miR-4472	CLIP-seq
MIRT1059499	hsa-miR-491-5p	CLIP-seq
MIRT1059500	hsa-miR-939	CLIP-seq
MIRT2013856	hsa-miR-1207-3p	CLIP-seq
MIRT2451581	hsa-miR-146b-3p	CLIP-seq
MIRT2451582	hsa-miR-3157-3p	CLIP-seq
MIRT2451583	hsa-miR-3173-5p	CLIP-seq
MIRT2451584	hsa-miR-371b-3p	CLIP-seq
MIRT2451585	hsa-miR-4749-3p	CLIP-seq
MIRT2451586	hsa-miR-4789-5p	CLIP-seq
MIRT2451587	hsa-miR-874	CLIP-seq
MIRT2549169	hsa-miR-105	CLIP-seq
MIRT1059488	hsa-miR-1261	CLIP-seq
MIRT2549170	hsa-miR-1265	CLIP-seq
MIRT2549171	hsa-miR-2392	CLIP-seq
MIRT2549172	hsa-miR-346	CLIP-seq
MIRT2549173	hsa-miR-3614-5p	CLIP-seq
MIRT2549174	hsa-miR-3616-3p	CLIP-seq
MIRT2549175	hsa-miR-3646	CLIP-seq
MIRT2549176	hsa-miR-3678-5p	CLIP-seq
MIRT2549177	hsa-miR-3681	CLIP-seq
MIRT2549178	hsa-miR-4329	CLIP-seq
MIRT2549179	hsa-miR-4466	CLIP-seq
MIRT2549180	hsa-miR-4696	CLIP-seq
MIRT2549181	hsa-miR-4721	CLIP-seq
MIRT2549182	hsa-miR-4763-5p	CLIP-seq
MIRT2549183	hsa-miR-4786-5p	CLIP-seq
MIRT2549184	hsa-miR-4793-3p	CLIP-seq
MIRT2549185	hsa-miR-4795-5p	CLIP-seq
MIRT2549186	hsa-miR-643	CLIP-seq
MIRT2549187	hsa-miR-647	CLIP-seq
MIRT2549188	hsa-miR-651	CLIP-seq
MIRT2549189	hsa-miR-675	CLIP-seq
MIRT2549190	hsa-miR-769-5p	CLIP-seq
MIRT2549172	hsa-miR-346	CLIP-seq
MIRT2549174	hsa-miR-3616-3p	CLIP-seq
MIRT2549179	hsa-miR-4466	CLIP-seq
MIRT2549181	hsa-miR-4721	CLIP-seq
MIRT2549182	hsa-miR-4763-5p	CLIP-seq
MIRT2549184	hsa-miR-4793-3p	CLIP-seq
MIRT2549189	hsa-miR-675	CLIP-seq

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GO ID	Ontology	Definition	Evidence	Reference
GO:0004452	Function	Isopentenyl-diphosphate delta-isomerase activity	IBA	21873635
GO:0004452	Function	Isopentenyl-diphosphate delta-isomerase activity	IDA	17202134
GO:0005515	Function	Protein binding	IPI	28514442, 32296183
GO:0005737	Component	Cytoplasm	IBA	21873635
GO:0005777	Component	Peroxisome	IDA	17202134
GO:0005829	Component	Cytosol	TAS
GO:0006695	Process	Cholesterol biosynthetic process	TAS
GO:0008299	Process	Isoprenoid biosynthetic process	IDA	17202134
GO:0009240	Process	Isopentenyl diphosphate biosynthetic process	IBA	21873635
GO:0016787	Function	Hydrolase activity	IEA
GO:0043231	Component	Intracellular membrane-bounded organelle	IDA
GO:0046490	Process	Isopentenyl diphosphate metabolic process	IDA	17202134
GO:0046872	Function	Metal ion binding	IEA
GO:0050992	Process	Dimethylallyl diphosphate biosynthetic process	IEA

MIM	HGNC	e!Ensembl
615389	23487	ENSG00000148377

Protein

UniProt ID

Q9BXS1

Protein name

Isopentenyl-diphosphate delta-isomerase 2 (EC 5.3.3.2) (Isopentenyl pyrophosphate isomerase 2) (IPP isomerase 2) (IPPI2)

Protein function

Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP).

PDB

2PNY

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00293	NUDIX	49 → 197	NUDIX domain	Domain

Tissue specificity

TISSUE SPECIFICITY: Muscle-specific expression. {ECO:0000269|PubMed:17202134}.

Sequence

MSDINLDWVDRRQLQRLEEMLIVVDENDKVIGADTKRNCHLNENIEKGLLHRAFSVVLFN
TKNRILIQQRSDTKVTFPGYFTDSCSSHPLYNPAELEEKDAIGVRRAAQRRLQAELGIPG
EQISPEDIVFMTIYHHKAKSDRIWGEHEICYLLLVRKNVTLNPDPSETKSILYLSQEELW
ELLEREARGEVKVTPWLRTIAERFLYRWWPHLDDVTPFVELHKIHRV

Sequence length

227

Interactions

View interactions

	KEGG		Reactome
	Terpenoid backbone biosynthesis Metabolic pathways		Cholesterol biosynthesis

Show/Hide Unknown Diseases (1)

Disease term	Disease name	Evidence	References	Source
Unknown
Kidney Disease	Kidney Disease			GWAS

Show/Hide Text Mining Associations (4)

Disease Name	Relationship Type	References
Associations from Text Mining
Cardiomyopathy Dilated	Associate	32727980
Death	Stimulate	36267302
Neoplasms	Associate	37671354
Thyroid Neoplasms	Associate	37671354

IDI2 (isopentenyl-diphosphate delta isomerase 2)