IDI2 (isopentenyl-diphosphate delta isomerase 2)

Gene

• Entrez ID: 91734
• Gene name: Isopentenyl-diphosphate delta isomerase 2
• Gene symbol: IDI2
• Synonyms (NCBI Gene): IPPI2
• Chromosome: 10
• Chromosome location: 10p15.3
• Summary: The protein encoded by this gene catalyzes the conversion of isopentenyl diphosphate to dimethylallyl diphosphate, which is a precursor for the synthesis of cholesterol and other isoprenoids. This gene, which is a product of an ancestral gene duplication

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT1059488	hsa-miR-1261	CLIP-seq
MIRT1059489	hsa-miR-3150a-3p	CLIP-seq
MIRT1059490	hsa-miR-3151	CLIP-seq
MIRT1059491	hsa-miR-3175	CLIP-seq
MIRT1059492	hsa-miR-320a	CLIP-seq
MIRT1059493	hsa-miR-320b	CLIP-seq
MIRT1059494	hsa-miR-320c	CLIP-seq
MIRT1059495	hsa-miR-320d	CLIP-seq
MIRT1059496	hsa-miR-4429	CLIP-seq
MIRT1059497	hsa-miR-4447	CLIP-seq
MIRT1059498	hsa-miR-4472	CLIP-seq
MIRT1059499	hsa-miR-491-5p	CLIP-seq
MIRT1059500	hsa-miR-939	CLIP-seq
MIRT2013856	hsa-miR-1207-3p	CLIP-seq
MIRT2451581	hsa-miR-146b-3p	CLIP-seq
MIRT2451582	hsa-miR-3157-3p	CLIP-seq
MIRT2451583	hsa-miR-3173-5p	CLIP-seq
MIRT2451584	hsa-miR-371b-3p	CLIP-seq
MIRT2451585	hsa-miR-4749-3p	CLIP-seq
MIRT2451586	hsa-miR-4789-5p	CLIP-seq
MIRT2451587	hsa-miR-874	CLIP-seq
MIRT2549169	hsa-miR-105	CLIP-seq
MIRT1059488	hsa-miR-1261	CLIP-seq
MIRT2549170	hsa-miR-1265	CLIP-seq
MIRT2549171	hsa-miR-2392	CLIP-seq
MIRT2549172	hsa-miR-346	CLIP-seq
MIRT2549173	hsa-miR-3614-5p	CLIP-seq
MIRT2549174	hsa-miR-3616-3p	CLIP-seq
MIRT2549175	hsa-miR-3646	CLIP-seq
MIRT2549176	hsa-miR-3678-5p	CLIP-seq
MIRT2549177	hsa-miR-3681	CLIP-seq
MIRT2549178	hsa-miR-4329	CLIP-seq
MIRT2549179	hsa-miR-4466	CLIP-seq
MIRT2549180	hsa-miR-4696	CLIP-seq
MIRT2549181	hsa-miR-4721	CLIP-seq
MIRT2549182	hsa-miR-4763-5p	CLIP-seq
MIRT2549183	hsa-miR-4786-5p	CLIP-seq
MIRT2549184	hsa-miR-4793-3p	CLIP-seq
MIRT2549185	hsa-miR-4795-5p	CLIP-seq
MIRT2549186	hsa-miR-643	CLIP-seq
MIRT2549187	hsa-miR-647	CLIP-seq
MIRT2549188	hsa-miR-651	CLIP-seq
MIRT2549189	hsa-miR-675	CLIP-seq
MIRT2549190	hsa-miR-769-5p	CLIP-seq
MIRT2549172	hsa-miR-346	CLIP-seq
MIRT2549174	hsa-miR-3616-3p	CLIP-seq
MIRT2549179	hsa-miR-4466	CLIP-seq
MIRT2549181	hsa-miR-4721	CLIP-seq
MIRT2549182	hsa-miR-4763-5p	CLIP-seq
MIRT2549184	hsa-miR-4793-3p	CLIP-seq
MIRT2549189	hsa-miR-675	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0004452	Function	Isopentenyl-diphosphate delta-isomerase activity	IBA
GO:0004452	Function	Isopentenyl-diphosphate delta-isomerase activity	IDA	17202134
GO:0004452	Function	Isopentenyl-diphosphate delta-isomerase activity	IEA
GO:0005515	Function	Protein binding	IPI	28514442, 32296183
GO:0005737	Component	Cytoplasm	IBA
GO:0005777	Component	Peroxisome	IDA	17202134
GO:0005777	Component	Peroxisome	IEA
GO:0005829	Component	Cytosol	TAS
GO:0006629	Process	Lipid metabolic process	IEA
GO:0006694	Process	Steroid biosynthetic process	IEA
GO:0006695	Process	Cholesterol biosynthetic process	IEA
GO:0008202	Process	Steroid metabolic process	IEA
GO:0008203	Process	Cholesterol metabolic process	IEA
GO:0008299	Process	Isoprenoid biosynthetic process	IDA	17202134
GO:0008299	Process	Isoprenoid biosynthetic process	IEA
GO:0009240	Process	Isopentenyl diphosphate biosynthetic process	IBA
GO:0016126	Process	Sterol biosynthetic process	IEA
GO:0016853	Function	Isomerase activity	IEA
GO:0016860	Function	Intramolecular oxidoreductase activity	IEA
GO:0046490	Process	Isopentenyl diphosphate metabolic process	IDA	17202134
GO:0046872	Function	Metal ion binding	IEA
GO:0050992	Process	Dimethylallyl diphosphate biosynthetic process	IEA

Other IDs

• MIM: 615389
• HGNC: 23487
• e!Ensembl: ENSG00000148377

Protein

• UniProt ID: Q9BXS1
• Protein name: Isopentenyl-diphosphate delta-isomerase 2 (EC 5.3.3.2) (Isopentenyl pyrophosphate isomerase 2) (IPP isomerase 2) (IPPI2)
• Protein function: Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP).
• PDB: 2PNY
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00293	NUDIX	49 → 197	NUDIX domain	Domain

• Tissue specificity: TISSUE SPECIFICITY: Muscle-specific expression. {ECO:0000269|PubMed:17202134}.
• Sequence:

  MSDINLDWVDRRQLQRLEEMLIVVDENDKVIGADTKRNCHLNENIEKGLLHRAFSVVLFN
  TKNRILIQQRSDTKVTFPGYFTDSCSSHPLYNPAELEEKDAIGVRRAAQRRLQAELGIPG
  EQISPEDIVFMTIYHHKAKSDRIWGEHEICYLLLVRKNVTLNPDPSETKSILYLSQEELW
  ELLEREARGEVKVTPWLRTIAERFLYRWWPHLDDVTPFVELHKIHRV

• Sequence length: 227

Pathways

KEGG:

Terpenoid backbone biosynthesis
Metabolic pathways

Reactome:

Cholesterol biosynthesis