Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Pathways
Entrez ID	91689
Gene name	Single-pass membrane protein with aspartate rich tail 1
Gene symbol	SMDT1
Synonyms (NCBI Gene)	C22orf32DDDDEMRE
Chromosome	22
Chromosome location	22q13.2
Summary	This gene encodes a core regulatory component of a calcium channel in the mitochondrial inner membrane. [provided by RefSeq, Apr 2017]

Show/Hide all (39)

miRTarBase ID	miRNA	Experiments	Reference
MIRT040009	hsa-miR-615-3p	CLASH	23622248
MIRT563852	hsa-miR-548e-5p	PAR-CLIP	20371350
MIRT563851	hsa-miR-3173-3p	PAR-CLIP	20371350
MIRT563850	hsa-miR-6891-5p	PAR-CLIP	20371350
MIRT563849	hsa-miR-15a-5p	PAR-CLIP	20371350
MIRT563848	hsa-miR-15b-5p	PAR-CLIP	20371350
MIRT563847	hsa-miR-16-5p	PAR-CLIP	20371350
MIRT563846	hsa-miR-195-5p	PAR-CLIP	20371350
MIRT563845	hsa-miR-424-5p	PAR-CLIP	20371350
MIRT563844	hsa-miR-497-5p	PAR-CLIP	20371350
MIRT563843	hsa-miR-6838-5p	PAR-CLIP	20371350
MIRT563842	hsa-miR-214-3p	PAR-CLIP	20371350
MIRT563840	hsa-miR-3619-5p	PAR-CLIP	20371350
MIRT563841	hsa-miR-761	PAR-CLIP	20371350
MIRT563839	hsa-miR-125a-3p	PAR-CLIP	20371350
MIRT563838	hsa-miR-5681a	PAR-CLIP	20371350
MIRT563837	hsa-miR-6730-5p	PAR-CLIP	20371350
MIRT563836	hsa-miR-3665	PAR-CLIP	20371350
MIRT563835	hsa-miR-6878-5p	PAR-CLIP	20371350
MIRT563834	hsa-miR-488-3p	PAR-CLIP	20371350
MIRT563852	hsa-miR-548e-5p	PAR-CLIP	20371350
MIRT563851	hsa-miR-3173-3p	PAR-CLIP	20371350
MIRT563850	hsa-miR-6891-5p	PAR-CLIP	20371350
MIRT563849	hsa-miR-15a-5p	PAR-CLIP	20371350
MIRT563848	hsa-miR-15b-5p	PAR-CLIP	20371350
MIRT563847	hsa-miR-16-5p	PAR-CLIP	20371350
MIRT563846	hsa-miR-195-5p	PAR-CLIP	20371350
MIRT563845	hsa-miR-424-5p	PAR-CLIP	20371350
MIRT563844	hsa-miR-497-5p	PAR-CLIP	20371350
MIRT563843	hsa-miR-6838-5p	PAR-CLIP	20371350
MIRT563842	hsa-miR-214-3p	PAR-CLIP	20371350
MIRT563840	hsa-miR-3619-5p	PAR-CLIP	20371350
MIRT563841	hsa-miR-761	PAR-CLIP	20371350
MIRT563839	hsa-miR-125a-3p	PAR-CLIP	20371350
MIRT563838	hsa-miR-5681a	PAR-CLIP	20371350
MIRT563837	hsa-miR-6730-5p	PAR-CLIP	20371350
MIRT563836	hsa-miR-3665	PAR-CLIP	20371350
MIRT563835	hsa-miR-6878-5p	PAR-CLIP	20371350
MIRT563834	hsa-miR-488-3p	PAR-CLIP	20371350

Show/Hide all (39)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005515	Function	Protein binding	IPI	27099988, 27184846, 27642048, 28514442, 32494073, 33961781
GO:0005654	Component	Nucleoplasm	IDA
GO:0005739	Component	Mitochondrion	HTP	34800366
GO:0005739	Component	Mitochondrion	IDA
GO:0005739	Component	Mitochondrion	IEA
GO:0005743	Component	Mitochondrial inner membrane	IDA	31080062
GO:0005743	Component	Mitochondrial inner membrane	IDA	24231807, 27099988, 27642048, 32494073
GO:0005743	Component	Mitochondrial inner membrane	IEA
GO:0005743	Component	Mitochondrial inner membrane	NAS	24514027, 31533452, 31862210
GO:0005743	Component	Mitochondrial inner membrane	TAS
GO:0005759	Component	Mitochondrial matrix	TAS
GO:0006811	Process	Monoatomic ion transport	IEA
GO:0006816	Process	Calcium ion transport	IEA
GO:0006851	Process	Mitochondrial calcium ion transmembrane transport	IMP	24231807, 27099988, 27642048
GO:0016020	Component	Membrane	IEA
GO:0030674	Function	Protein-macromolecule adaptor activity	IDA	32494073, 32762847
GO:0036444	Process	Calcium import into the mitochondrion	IBA
GO:0036444	Process	Calcium import into the mitochondrion	IDA	23755363, 29725115
GO:0036444	Process	Calcium import into the mitochondrion	IDA	31080062, 32315830, 32494073, 32762847, 33296646
GO:0036444	Process	Calcium import into the mitochondrion	IEA
GO:0036444	Process	Calcium import into the mitochondrion	IMP	23755363
GO:0036444	Process	Calcium import into the mitochondrion	IMP	27099988, 27642048
GO:0036444	Process	Calcium import into the mitochondrion	NAS	24514027, 31533452, 31862210
GO:0051560	Process	Mitochondrial calcium ion homeostasis	IBA
GO:0051560	Process	Mitochondrial calcium ion homeostasis	IDA	32494073
GO:0051560	Process	Mitochondrial calcium ion homeostasis	IEA
GO:0051560	Process	Mitochondrial calcium ion homeostasis	IMP	24231807, 27099988, 27642048
GO:0051560	Process	Mitochondrial calcium ion homeostasis	NAS	24514027, 31533452, 31862210
GO:0071277	Process	Cellular response to calcium ion	IDA	29725115, 32494073
GO:0072732	Process	Cellular response to calcium ion starvation	IDA	32494073
GO:0072732	Process	Cellular response to calcium ion starvation	IDA	32494073
GO:0072732	Process	Cellular response to calcium ion starvation	IMP	32494073
GO:0099103	Function	Channel activator activity	IDA	31080062, 32315830, 33296646
GO:1990246	Component	Uniplex complex	IBA
GO:1990246	Component	Uniplex complex	IDA	24231807, 27642048, 31080062, 32315830, 32762847, 32862359
GO:1990246	Component	Uniplex complex	IEA
GO:1990246	Component	Uniplex complex	IPI	32494073
GO:1990246	Component	Uniplex complex	ISS
GO:1990246	Component	Uniplex complex	NAS	31533452

MIM	HGNC	e!Ensembl
615588	25055	ENSG00000183172

Q9H4I9

Protein name

Essential MCU regulator, mitochondrial (Single-pass membrane protein with aspartate-rich tail 1, mitochondrial)

Protein function

Essential regulatory subunit of the mitochondrial calcium uniporter complex (uniplex), a complex that mediates calcium uptake into mitochondria (PubMed:24231807, PubMed:26774479, PubMed:27099988, PubMed:30454562, PubMed:31080062, PubMed:32315830

PDB

6K7X , 6K7Y , 6O58 , 6O5B , 6WDN , 6WDO , 6XJV , 6XJX

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF10161	DDDD	32 → 107	Putative mitochondrial precursor protein	Family

Sequence

MASGAARWLVLAPVRSGALRSGPSLRKDGDVSAAWSGSGRSLVPSRSVIVTRSGAILPKP
VKMSFGLLRVFSIVIPFLYVGTLISKNFAALLEEHDIFVPEDDDDDD

Sequence length

107

Interactions

View interactions

	Reactome
			Mitochondrial calcium ion transport Processing of SMDT1

SMDT1 (single-pass membrane protein with aspartate rich tail 1)