Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
91653
Gene name Gene Name - the full gene name approved by the HGNC.
BOC cell adhesion associated, oncogene regulated
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
BOC
Synonyms (NCBI Gene) Gene synonyms aliases
Boi, CDON2
Chromosome Chromosome number
3
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
3q13.2
Summary Summary of gene provided in NCBI Entrez Gene.
The protein encoded by this gene is a member of the immunoglobulin/fibronectin type III repeat family. It is a component of a cell-surface receptor complex that mediates cell-cell interactions between muscle precursor cells, and promotes myogenic differen
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT021881 hsa-miR-128-3p Microarray 17612493
MIRT030663 hsa-miR-21-5p Microarray 18591254
MIRT539771 hsa-miR-148a-5p PAR-CLIP 21572407
MIRT539770 hsa-miR-148b-5p PAR-CLIP 21572407
MIRT539769 hsa-miR-6874-3p PAR-CLIP 21572407
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0005515 Function Protein binding IPI 11782431, 20519495, 21802063
GO:0005886 Component Plasma membrane TAS
GO:0005887 Component Integral component of plasma membrane IEA
GO:0007155 Process Cell adhesion IEA
GO:0007224 Process Smoothened signaling pathway IEA
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
608708 17173 ENSG00000144857
Protein
UniProt ID Q9BWV1
Protein name Brother of CDO (Protein BOC)
Protein function Component of a cell-surface receptor complex that mediates cell-cell interactions between muscle precursor cells. Promotes differentiation of myogenic cells.
PDB 3N1G , 3N1M , 3N1P
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF13927 Ig_3 35 109 Domain
PF00047 ig 134 213 Immunoglobulin domain Domain
PF13927 Ig_3 230 303 Domain
PF07679 I-set 323 408 Immunoglobulin I-set domain Domain
PF16625 ISET-FN3_linker 409 473 Disordered
PF00041 fn3 477 561 Fibronectin type III domain Domain
PF00041 fn3 607 693 Fibronectin type III domain Domain
PF00041 fn3 716 802 Fibronectin type III domain Domain
Tissue specificity TISSUE SPECIFICITY: Detected in skeletal muscle, heart, thymus, kidney and small intestine. Detected at lower levels in brain, placenta, lung and colon mucosa. {ECO:0000269|PubMed:11782431}.
Sequence
MLRGTMTAWRGMRPEVTLACLLLATAGCFADLNEVPQVTVQPASTVQKPGGTVILGCVVE
PPRMNVTWRLNGKELNGSDDALGVLITHGTLVITALNNHTVGRYQCVAR
MPAGAVASVPA
TVTLANLQDFKLDVQHVIEVDEGNTAVIACHLPESHPKAQVRYSVKQEWLEASRGNYLIM
PSGNLQIVNASQEDEGMYKCAAYNPVTQEVKTS
GSSDRLRVRRSTAEAARIIYPPEAQTI
IVTKGQSLILECVASGIPPPRVTWAKDGSSVTGYNKTRFLLSNLLIDTTSEEDSGTYRCM
ADN
GVGQPGAAVILYNVQVFEPPEVTMELSQLVIPWGQSAKLTCEVRGNPPPSVLWLRNA
VPLISSQRLRLSRRALRVLSMGPEDEGVYQCMAENEVGSAHAVVQLRT
SRPSITPRLWQD
AELATGTPPVSPSKLGNPEQMLRGQPALPRPPTSVGPASPQCPGEKGQGAPAE
APIILSS
PRTSKTDSYELVWRPRHEGSGRAPILYYVVKHRKVTNSSDDWTISGIPANQHRLTLTRLD
PGSLYEVEMAAYNCAGEGQTA
MVTFRTGRRPKPEIMASKEQQIQRDDPGASPQSSSQPDH
GRLSPPEAPDRPTISTASETSVYVTWIPRGNGGFPIQSFRVEYKKLKKVGDWILATSAIP
PSRLSVEITGLEKGTSYKFRVRALNMLGESEPS
APSRPYVVSGYSGRVYERPVAGPYITF
TDAVNETTIMLKWMYIPASNNNTPIHGFYIYYRPTDSDNDSDYKKDMVEGDKYWHSISHL
QPETSYDIKMQCFNEGGESEFS
NVMICETKARKSSGQPGRLPPPTLAPPQPPLPETIERP
VGTGAMVARSSDLPYLIVGVVLGSIVLIIVTFIPFCLWRAWSKQKHTTDLGFPRSALPPS
CPYTMVPLGGLPGHQASGQPYLSGISGRACANGIHMNRGCPSAAVGYPGMKPQQHCPGEL
QQQSDTSSLLRQTHLGNGYDPQSHQITRGPKSSPDEGSFLYTLPDDSTHQLLQPHHDCCQ
RQEQPAAVGQSGVRRAPDSPVLEAVWDPPFHSGPPCCLGLVPVEEVDSPDSCQVSGGDWC
PQHPVGAYVGQEPGMQLSPGPLVRVSFETPPLTI
Sequence length 1114
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG   Reactome
  Hedgehog signaling pathway
Axon guidance
  Myogenesis
Activation of SMO
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Causal
Disease term Disease name dbSNP ID References
Breast cancer Malignant neoplasm of breast rs587776547, rs1137887, rs137853007, rs587776650, rs80359351, rs80359714, rs121917783, rs104886456, rs121964878, rs80359874, rs80357868, rs80357508, rs387906843, rs80357569, rs80358158
View all (309 more)
Colonic neoplasms Malignant tumor of colon rs267607789, rs774277300, rs781222233, rs1060502734, rs1060503333, rs1339238483 30510241
Colorectal cancer Colorectal Carcinoma, Adenocarcinoma of large intestine rs137854568, rs137854573, rs137854575, rs387906234, rs121908380, rs121908702, rs267606674, rs794729661, rs121909055, rs281865417, rs267606884, rs28934575, rs587776769, rs104893815, rs587776800
View all (467 more)
30510241
Colorectal neoplasms Colorectal Neoplasms, Malignant neoplasm of large intestine rs28929483, rs63751108, rs28929484, rs63749831, rs63750047, rs63751207, rs63749811, rs1553350126, rs63750875, rs63750955, rs587776706, rs63750871, rs587776715, rs63751466, rs63750049
View all (1682 more)
30510241
Unknown
Disease term Disease name Evidence References Source
Asthma Childhood asthma 23829686 ClinVar
Dental caries Dental caries GWAS
Colorectal Cancer Colorectal Cancer In summary, our data strongly demonstrated that upregulation of GRB7 conferred MEKi resistance in CRC cells with KRAS mutations by mediating RTK signaling through the recruitment of PLK1. GWAS, CBGDA
Diabetes Diabetes GWAS
Associations from Text Mining
Disease Name Relationship Type References
Basal Cell Nevus Syndrome Associate 28915250
Neoplasms Inhibit 33811245
Squamous Cell Carcinoma of Head and Neck Associate 33892811
Stomach Neoplasms Associate 33811245