Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Associated diseases
Entrez ID	9159
Gene name	Proprotein convertase subtilisin/kexin type 7
Gene symbol	PCSK7
Synonyms (NCBI Gene)	LPCPC7PC8SPC7
Chromosome	11
Chromosome location	11q23.3
Summary	This gene encodes a member of the subtilisin-like proprotein convertase family, which includes proteases that process protein and peptide precursors trafficking through regulated or constitutive branches of the secretory pathway. It encodes a type 1 membr

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miRTarBase ID	miRNA	Experiments	Reference
MIRT039521	hsa-miR-652-3p	CLASH	23622248
MIRT615831	hsa-miR-548c-3p	HITS-CLIP	23824327
MIRT615830	hsa-miR-551b-5p	HITS-CLIP	23824327
MIRT615829	hsa-miR-3664-3p	HITS-CLIP	23824327
MIRT615828	hsa-miR-1266-5p	HITS-CLIP	23824327
MIRT615827	hsa-miR-4518	HITS-CLIP	23824327
MIRT615826	hsa-miR-627-3p	HITS-CLIP	23824327
MIRT615831	hsa-miR-548c-3p	HITS-CLIP	23824327
MIRT615830	hsa-miR-551b-5p	HITS-CLIP	23824327
MIRT615829	hsa-miR-3664-3p	HITS-CLIP	23824327
MIRT615828	hsa-miR-1266-5p	HITS-CLIP	23824327
MIRT615827	hsa-miR-4518	HITS-CLIP	23824327
MIRT615826	hsa-miR-627-3p	HITS-CLIP	23824327
MIRT615831	hsa-miR-548c-3p	HITS-CLIP	23824327
MIRT615830	hsa-miR-551b-5p	HITS-CLIP	23824327
MIRT615829	hsa-miR-3664-3p	HITS-CLIP	23824327
MIRT615828	hsa-miR-1266-5p	HITS-CLIP	23824327
MIRT615827	hsa-miR-4518	HITS-CLIP	23824327
MIRT615826	hsa-miR-627-3p	HITS-CLIP	23824327
MIRT615831	hsa-miR-548c-3p	HITS-CLIP	23824327
MIRT615830	hsa-miR-551b-5p	HITS-CLIP	23824327
MIRT626342	hsa-miR-1972	HITS-CLIP	23824327
MIRT626341	hsa-miR-4650-5p	HITS-CLIP	23824327
MIRT615829	hsa-miR-3664-3p	HITS-CLIP	23824327
MIRT615828	hsa-miR-1266-5p	HITS-CLIP	23824327
MIRT615827	hsa-miR-4518	HITS-CLIP	23824327
MIRT615826	hsa-miR-627-3p	HITS-CLIP	23824327
MIRT615831	hsa-miR-548c-3p	HITS-CLIP	23824327
MIRT615830	hsa-miR-551b-5p	HITS-CLIP	23824327
MIRT615829	hsa-miR-3664-3p	HITS-CLIP	23824327
MIRT615828	hsa-miR-1266-5p	HITS-CLIP	23824327
MIRT615827	hsa-miR-4518	HITS-CLIP	23824327
MIRT615826	hsa-miR-627-3p	HITS-CLIP	23824327
MIRT615831	hsa-miR-548c-3p	HITS-CLIP	23824327
MIRT615830	hsa-miR-551b-5p	HITS-CLIP	23824327
MIRT615829	hsa-miR-3664-3p	HITS-CLIP	23824327
MIRT615828	hsa-miR-1266-5p	HITS-CLIP	23824327
MIRT615827	hsa-miR-4518	HITS-CLIP	23824327
MIRT615826	hsa-miR-627-3p	HITS-CLIP	23824327
MIRT615831	hsa-miR-548c-3p	HITS-CLIP	23824327
MIRT615830	hsa-miR-551b-5p	HITS-CLIP	23824327
MIRT615829	hsa-miR-3664-3p	HITS-CLIP	23824327
MIRT615828	hsa-miR-1266-5p	HITS-CLIP	23824327
MIRT615827	hsa-miR-4518	HITS-CLIP	23824327
MIRT615826	hsa-miR-627-3p	HITS-CLIP	23824327
MIRT615831	hsa-miR-548c-3p	HITS-CLIP	23824327
MIRT615830	hsa-miR-551b-5p	HITS-CLIP	23824327
MIRT615829	hsa-miR-3664-3p	HITS-CLIP	23824327
MIRT615828	hsa-miR-1266-5p	HITS-CLIP	23824327
MIRT615827	hsa-miR-4518	HITS-CLIP	23824327
MIRT615826	hsa-miR-627-3p	HITS-CLIP	23824327
MIRT615831	hsa-miR-548c-3p	HITS-CLIP	23824327
MIRT615830	hsa-miR-551b-5p	HITS-CLIP	23824327
MIRT615829	hsa-miR-3664-3p	HITS-CLIP	23824327
MIRT615828	hsa-miR-1266-5p	HITS-CLIP	23824327
MIRT615827	hsa-miR-4518	HITS-CLIP	23824327
MIRT615826	hsa-miR-627-3p	HITS-CLIP	23824327
MIRT615831	hsa-miR-548c-3p	HITS-CLIP	23824327
MIRT615830	hsa-miR-551b-5p	HITS-CLIP	23824327
MIRT626342	hsa-miR-1972	HITS-CLIP	23824327
MIRT626341	hsa-miR-4650-5p	HITS-CLIP	23824327
MIRT615829	hsa-miR-3664-3p	HITS-CLIP	23824327
MIRT615828	hsa-miR-1266-5p	HITS-CLIP	23824327
MIRT615827	hsa-miR-4518	HITS-CLIP	23824327
MIRT615826	hsa-miR-627-3p	HITS-CLIP	23824327
MIRT615831	hsa-miR-548c-3p	HITS-CLIP	23824327
MIRT615830	hsa-miR-551b-5p	HITS-CLIP	23824327
MIRT615829	hsa-miR-3664-3p	HITS-CLIP	23824327
MIRT615828	hsa-miR-1266-5p	HITS-CLIP	23824327
MIRT615827	hsa-miR-4518	HITS-CLIP	23824327
MIRT615826	hsa-miR-627-3p	HITS-CLIP	23824327
MIRT615831	hsa-miR-548c-3p	HITS-CLIP	23824327
MIRT615830	hsa-miR-551b-5p	HITS-CLIP	23824327
MIRT615829	hsa-miR-3664-3p	HITS-CLIP	23824327
MIRT615828	hsa-miR-1266-5p	HITS-CLIP	23824327
MIRT615827	hsa-miR-4518	HITS-CLIP	23824327
MIRT615826	hsa-miR-627-3p	HITS-CLIP	23824327
MIRT1218563	hsa-miR-1236	CLIP-seq
MIRT1218564	hsa-miR-125a-5p	CLIP-seq
MIRT1218565	hsa-miR-125b	CLIP-seq
MIRT1218566	hsa-miR-2467-3p	CLIP-seq
MIRT1218567	hsa-miR-3125	CLIP-seq
MIRT1218568	hsa-miR-3663-3p	CLIP-seq
MIRT1218569	hsa-miR-3678-3p	CLIP-seq
MIRT1218570	hsa-miR-3909	CLIP-seq
MIRT1218571	hsa-miR-3916	CLIP-seq
MIRT1218572	hsa-miR-4272	CLIP-seq
MIRT1218573	hsa-miR-4319	CLIP-seq
MIRT1218574	hsa-miR-4661-5p	CLIP-seq
MIRT1218575	hsa-miR-4732-3p	CLIP-seq
MIRT1218576	hsa-miR-670	CLIP-seq
MIRT1218577	hsa-miR-7	CLIP-seq
MIRT2063235	hsa-miR-122	CLIP-seq
MIRT2063236	hsa-miR-4269	CLIP-seq
MIRT2063235	hsa-miR-122	CLIP-seq
MIRT1218564	hsa-miR-125a-5p	CLIP-seq
MIRT1218565	hsa-miR-125b	CLIP-seq
MIRT2291623	hsa-miR-34a	CLIP-seq
MIRT2291624	hsa-miR-34c-5p	CLIP-seq
MIRT1218568	hsa-miR-3663-3p	CLIP-seq
MIRT1218573	hsa-miR-4319	CLIP-seq
MIRT2291625	hsa-miR-4446-5p	CLIP-seq
MIRT2291626	hsa-miR-4493	CLIP-seq
MIRT2291627	hsa-miR-449a	CLIP-seq
MIRT2291628	hsa-miR-449b	CLIP-seq
MIRT1218575	hsa-miR-4732-3p	CLIP-seq
MIRT2291629	hsa-miR-4747-5p	CLIP-seq
MIRT2291630	hsa-miR-4753-5p	CLIP-seq
MIRT2291631	hsa-miR-4755-5p	CLIP-seq
MIRT1218576	hsa-miR-670	CLIP-seq
MIRT1218577	hsa-miR-7	CLIP-seq
MIRT2392226	hsa-miR-1289	CLIP-seq
MIRT2392227	hsa-miR-3198	CLIP-seq
MIRT2392228	hsa-miR-4257	CLIP-seq
MIRT2392229	hsa-miR-4294	CLIP-seq
MIRT2392230	hsa-miR-4309	CLIP-seq
MIRT2392231	hsa-miR-4481	CLIP-seq
MIRT2392232	hsa-miR-4658	CLIP-seq
MIRT2392233	hsa-miR-4745-5p	CLIP-seq
MIRT2392234	hsa-miR-4758-5p	CLIP-seq
MIRT2465812	hsa-miR-2392	CLIP-seq
MIRT2465813	hsa-miR-3612	CLIP-seq
MIRT2465814	hsa-miR-3926	CLIP-seq
MIRT2465815	hsa-miR-4443	CLIP-seq
MIRT2465816	hsa-miR-4534	CLIP-seq
MIRT2465817	hsa-miR-4802-5p	CLIP-seq
MIRT2465818	hsa-miR-650	CLIP-seq

Show/Hide all (18)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000139	Component	Golgi membrane	IBA
GO:0000139	Component	Golgi membrane	IDA	9341152
GO:0004252	Function	Serine-type endopeptidase activity	IBA
GO:0004252	Function	Serine-type endopeptidase activity	IEA
GO:0005515	Function	Protein binding	IPI	32814053
GO:0005737	Component	Cytoplasm	IEA
GO:0005794	Component	Golgi apparatus	IEA
GO:0005802	Component	Trans-Golgi network	IBA
GO:0006508	Process	Proteolysis	IEA
GO:0008233	Function	Peptidase activity	IDA	15606899
GO:0008233	Function	Peptidase activity	IEA
GO:0008236	Function	Serine-type peptidase activity	IEA
GO:0012505	Component	Endomembrane system	IEA
GO:0016020	Component	Membrane	IEA
GO:0016485	Process	Protein processing	IBA
GO:0016485	Process	Protein processing	IDA	15606899
GO:0016486	Process	Peptide hormone processing	NAS	9341152
GO:0016787	Function	Hydrolase activity	IEA

MIM	HGNC	e!Ensembl
604872	8748	ENSG00000160613

Q16549

Protein name

Proprotein convertase subtilisin/kexin type 7 (EC 3.4.21.-) (Lymphoma proprotein convertase) (Prohormone convertase 7) (Proprotein convertase 7) (PC7) (Proprotein convertase 8) (PC8) (hPC8) (Subtilisin/kexin-like protease PC7)

Protein function

Serine endoprotease that processes various proproteins by cleavage at paired basic amino acids, recognizing the RXXX[KR]R consensus motif. Likely functions in the constitutive secretory pathway.

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF16470	S8_pro-domain	53 → 141	Peptidase S8 pro-domain	Domain
PF00082	Peptidase_S8	178 → 462	Subtilase family	Domain
PF01483	P_proprotein	525 → 612	Proprotein convertase P-domain	Family

Tissue specificity

TISSUE SPECIFICITY: Expressed in spleen, thymus, prostate, testis, ovary, small intestine, colon and peripheral blood leukocyte.

Sequence

MPKGRQKVPHLDAPLGLPTCLWLELAGLFLLVPWVMGLAGTGGPDGQGTGGPSWAVHLES
LEGDGEEETLEQQADALAQAAGLVNAGRIGELQGHYLFVQPAGHRPALEVEAIRQQVEAV
LAGHEAVRWHSEQRLLRRAKRSVHFNDPKYPQQWHLNNRRSPGRDINVTGVWERNVTGRG
VTVVVVDDGVEHTIQDIAPNYSPEGSYDLNSNDPDPMPHPDVENGNHHGTRCAGEIAAVP
NNSFCAVGVAYGSRIAGIRVLDGPLTDSMEAVAFNKHYQINDIYSCSWGPDDDGKTVDGP
HQLGKAALQHGVIAGRQGFGSIFVVASGNGGQHNDNCNYDGYANSIYTVTIGAVDEEGRM
PFYAEECASMLAVTFSGGDKMLRSIVTTDWDLQKGTGCTEGHTGTSAAAPLAAGMIALML
QVRPCLTWRDVQHIIVFTATRYEDRRAEWVTNEAGFSHSHQHGFGLLNAWRLVNAAKIWT
SVPYLASYVSPVLKENKAIPQSPRSLEVLWNVSRMDLEMSGLKTLEHVAVTVSITHPRRG
SLELKLFCPSGMMSLIGAPRSMDSDPNGFNDWTFSTVRCWGERARGTYRLVIRDVGDESF
QVGILRQWQLTLYGSVWSAVDIRDRQRLLESAMSGKYLHDDFALPCPPGLKIPEEDGYTI
TPNTLKTLVLVGCFTVFWTVYYMLEVYLSQRNVASNQVCRSGPCHWPHRSRKAKEEGTEL
ESVPLCSSKDPDEVETESRGPPTTSDLLAPDLLEQGDWSLSQNKSALDCPHQHLDVPHGK
EEQIC

Sequence length

785

Interactions

View interactions

Show/Hide Unknown Diseases (6)

Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession
Unknown Diseases with uncertain, conflicting, or no pathogenic evidence in ClinVar
EBV-positive nodal T- and NK-cell lymphoma	Likely benign	rs758474960	RCV004557874
Hereditary breast ovarian cancer syndrome	Uncertain significance	rs143209024	RCV001374497
Midline facial cleft	Uncertain significance	rs202038275	RCV001375858
Pericallosal lipoma	Uncertain significance	rs202038275, rs771986131	RCV001375858 RCV001375859
Preauricular skin tag	Uncertain significance	rs771986131	RCV001375859
Skin tags	Uncertain significance	rs202038275, rs771986131	RCV001375858 RCV001375859

Show/Hide Text Mining Associations (15)

Disease Name	Relationship Type	References
Associations from Text MiningDisease associations identified through Pubtator
Acute Coronary Syndrome	Associate	34207761
Breast Neoplasms	Associate	32820145
Carcinoma Hepatocellular	Associate	34866477
Carcinoma Non Small Cell Lung	Associate	33474835
Carcinoma Squamous Cell	Associate	24436242
Cardiovascular Diseases	Associate	25533967
Fibrosis	Associate	24556216
Hemochromatosis	Associate	24556216, 35668470
Insulin Resistance	Associate	25504030
Iron Overload	Associate	35668470
Kidney Failure Chronic	Associate	31464346
Liver Cirrhosis	Associate	24556216
Lung Neoplasms	Associate	23409034, 40649939
Neoplasms	Associate	23409034, 32820145
Weight Loss	Associate	25504030

PCSK7 (proprotein convertase subtilisin/kexin type 7)