Gene Gene information from NCBI Gene database.
Entrez ID 91584
Gene name Plexin A4
Gene symbol PLXNA4
Synonyms (NCBI Gene)
FAYV2820PLEXA4PLXNA4APLXNA4BPRO34003
Chromosome 7
Chromosome location 7q32.3
miRNA miRNA information provided by mirtarbase database.
512
miRTarBase ID miRNA Experiments Reference
MIRT017313 hsa-miR-335-5p Microarray 18185580
MIRT023616 hsa-miR-1-3p Microarray 18668037
MIRT029049 hsa-miR-26b-5p Microarray 19088304
MIRT612694 hsa-miR-8485 HITS-CLIP 19536157
MIRT612693 hsa-miR-4789-3p HITS-CLIP 19536157
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
49
GO ID Ontology Definition Evidence Reference
GO:0002116 Component Semaphorin receptor complex IBA
GO:0002116 Component Semaphorin receptor complex TAS 19909241
GO:0005515 Function Protein binding IPI 32814053, 33961781
GO:0005886 Component Plasma membrane IBA
GO:0005886 Component Plasma membrane IEA
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
604280 9102 ENSG00000221866
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
Q9HCM2
Protein name Plexin-A4
Protein function Coreceptor for SEMA3A. Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance in the developing nervous system. Class 3 semaphorins bind to a complex composed of a neuropilin a
PDB 4E74
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF01403 Sema 53 488 Sema domain Family
PF01437 PSI 509 559 Plexin repeat Family
PF17960 TIG_plexin 564 654 TIG domain Domain
PF01437 PSI 655 702 Plexin repeat Family
PF18020 TIG_2 708 802 TIG domain found in plexin Domain
PF01833 TIG 858 951 IPT/TIG domain Domain
PF01833 TIG 954 1036 IPT/TIG domain Domain
PF01833 TIG 1040 1138 IPT/TIG domain Domain
PF01833 TIG 1142 1227 IPT/TIG domain Domain
PF08337 Plexin_cytopl 1311 1864 Plexin cytoplasmic RasGAP domain Family
Sequence
MKAMPWNWTCLLSHLLMVGMGSSTLLTRQPAPLSQKQRSFVTFRGEPAEGFNHLVVDERT
GHIYLGAVNRIYKLSSDLKVLVTHETGPDEDNPKCYPPRIVQTCNEPLTTTNNVNKMLLI
DYKENRLIACGSLYQGICKLLRLEDLFKLGEPYHKKEHYLSGVNESGSVFGVIVSYSNLD
DKLFIATAVDGKPEYFPTISSRKLTKNSEADGMFAYVFHDEFVASMIKIPSDTFTIIPDF
DIYYVYGFSSGNFVYFLTLQPEMVSPPGSTTKEQVYTSKLVRLCKEDTAFNSYVEVPIGC
ERSGVEYRLLQAAYLSKAGAVLGRTLGVHPDDDLLFTVFSKGQKRKMKSLDESALCIFIL
KQINDRIKERLQSCYRGEGTLDLAWLKVKDIPCSSALLTIDDNFCGLDMNAPLGVSDMVR
GIPVFTEDRDRMTSVIAYVYKNHSLAFVGTKSGKLKKIRVDGPRGNALQYETVQVVDPGP
VLRDMAFS
KDHEQLYIMSERQLTRVPVESCGQYQSCGECLGSGDPHCGWCVLHNTCTRKE
RCERSKEPRRFASEMKQCV
RLTVHPNNISVSQYNVLLVLETYNVPELSAGVNCTFEDLSE
MDGLVVGNQIQCYSPAAKEVPRIITENGDHHVVQLQLKSKETGMTFASTSFVFY
NCSVHN
SCLSCVESPYRCHWCKYRHVCTHDPKTCSFQEGRVKLPEDCP
QLLRVDKILVPVEVIKPI
TLKAKNLPQPQSGQRGYECILNIQGSEQRVPALRFNSSSVQCQNTSYSYEGMEINNLPVE
LTVVWNGHFNIDNPAQNKVHLY
KCGAMRESCGLCLKADPDFACGWCQGPGQCTLRQHCPA
QESQWLELSGAKSKCTNPRITEIIPVTGPREGGTKVTIRGENLGLEFRDIASHVKVAGVE
CSPLVDGYIPAEQIVCEMGEAKPSQHAGFVEICVAVCRPEFMARSSQLYYF
MTLTLSDLK
PSRGPMSGGTQVTITGTNLNAGSNVVVMFGKQPCLFHRRSPSYIVCNTTSSDEVLEMKVS
VQVDRAKIHQDLVFQY
VEDPTIVRIEPEWSIVSGNTPIAVWGTHLDLIQNPQIRAKHGGK
EHINICEVLNATEMTCQAPALALGPDHQSDLTERPEEFGFILDNVQSLLILNKTNFTY
YP
NPVFEAFGPSGILELKPGTPIILKGKNLIPPVAGGNVKLNYTVLVGEKPCTVTVSDVQLL
CESPNLIGRHKVMARVGGMEYSPGMVY
IAPDSPLSLPAIVSIAVAGGLLIIFIVAVLIAY
KRKSRESDLTLKRLQMQMDNLESRVALECKEAFAELQTDIHELTSDLDGAGIPFLDYRTY
TMRVLFPGIEDHPVLRDLEVPGYRQERVEKGLKLFAQLINNKVFLLSFIRTLESQRSFSM
RDRGNVASLIMTVLQSKLEYATDVLKQLLADLIDKNLESKNHPKLLLRRTESVAEKMLTN
WFTFLLYKFLKECAGEPLFSLFCAIKQQMEKGPIDAITGEARYSLSEDKLIRQQIDYKTL
VLSCVSPDNANSPEVPVKILNCDTITQVKEKILDAIFKNVPCSHRPKAADMDLEWRQGSG
ARMILQDEDITTKIENDWKRLNTLAHYQVPDGSVVALVSKQVTAYNAVNNSTVSRTSASK
YENMIRYTGSPDSLRSRTPMITPDLESGVKMWHLVKNHEHGDQKEGDRGSKMVSEIYLTR
LLATKGTLQKFVDDLFETIFSTAHRGSALPLAIKYMFDFLDEQADKHGIHDPHVRHTWKS
NCLPLRFWVNMIKNPQFVFDIHKNSITDACLSVVAQTFMDSCSTSEHRLGKDSPSNKLLY
AKDIPSYKNWVERYYSDIGKMPAISDQDMNAYLAEQSRMHMNEFNTMSALSEIFSYVGKY
SEEI
LGPLDHDDQCGKQKLAYKLEQVITLMSLDS
Sequence length 1894
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG  Reactome
  Axon guidance   Sema3A PAK dependent Axon repulsion
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion
CRMPs in Sema3A signaling
Associated diseases Disease associations from ClinVar categorized as Causal (Pathogenic/Likely Pathogenic) or Unknown.
302
Unknown Diseases with uncertain, conflicting, or no pathogenic evidence in ClinVar
Phenotype Name Clinical Significance dbSNP ID RCV Accession
Lung cancer Likely benign rs749115824 RCV005933496
PLXNA4-related disorder Uncertain significance; Likely benign; Benign rs778856713, rs199571283, rs200493064, rs771852886, rs150905373, rs767272765, rs199914956, rs867001202, rs1460318926, rs201337636, rs542202891, rs564051494, rs200301458, rs371929100, rs766893062
View all (279 more)
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RCV003939601
RCV003951755
RCV003943855
RCV003949615
RCV003949685
RCV003949866
RCV003959294
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RCV003937198
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Sarcoma Benign rs76286420 RCV005937249
Associations from Text MiningDisease associations identified through Pubtator
Disease Name Relationship Type References
Acute Lung Injury Associate 34234248
Carcinoma Squamous Cell Associate 37856813
Cholangiocarcinoma Associate 40593068
COVID 19 Associate 34234248
Hypercholesterolemia Associate 40428410
Idiopathic Pulmonary Fibrosis Associate 34872285
Melanoma Associate 19462467
Neoplasms Associate 19462467, 21832283
Obesity Associate 39743445, 40428410
Parkinson Disease Associate 24244438