FIBP (FGF1 intracellular binding protein)

Gene

• Entrez ID: 9158
• Gene name: FGF1 intracellular binding protein
• Gene symbol: FIBP
• Synonyms (NCBI Gene): FGFIBP, FIBP-1, TROFAS
• Chromosome: 11
• Chromosome location: 11q13.1
• Summary: Acidic fibroblast growth factor is mitogenic for a variety of different cell types and acts by stimulating mitogenesis or inducing morphological changes and differentiation. The FIBP protein is an intracellular protein that binds selectively to acidic fib

SNPs

SNP ID	Visualize variation	Clinical significance	Consequence
rs786204849	G>A	Pathogenic, likely-pathogenic	Stop gained, non coding transcript variant, coding sequence variant
rs886037928	->TTA	Pathogenic	Inframe indel, non coding transcript variant, coding sequence variant, 5 prime UTR variant

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT044999	hsa-miR-186-5p	CLASH	23622248
MIRT043668	hsa-miR-342-3p	CLASH	23622248
MIRT1995573	hsa-miR-4733-3p	CLIP-seq
MIRT1995574	hsa-miR-764	CLIP-seq
MIRT2229543	hsa-miR-3907	CLIP-seq
MIRT2229544	hsa-miR-3919	CLIP-seq
MIRT2229545	hsa-miR-4252	CLIP-seq
MIRT2229546	hsa-miR-4269	CLIP-seq
MIRT2229547	hsa-miR-4643	CLIP-seq
MIRT2229548	hsa-miR-466	CLIP-seq
MIRT1995573	hsa-miR-4733-3p	CLIP-seq
MIRT2229549	hsa-miR-4756-3p	CLIP-seq
MIRT2229550	hsa-miR-4789-3p	CLIP-seq
MIRT1995574	hsa-miR-764	CLIP-seq
MIRT2229551	hsa-miR-891b	CLIP-seq
MIRT2533523	hsa-miR-1203	CLIP-seq
MIRT2533524	hsa-miR-3130-3p	CLIP-seq
MIRT2533525	hsa-miR-3131	CLIP-seq
MIRT2229546	hsa-miR-4269	CLIP-seq
MIRT2533526	hsa-miR-4286	CLIP-seq
MIRT2533527	hsa-miR-4707-5p	CLIP-seq
MIRT2533528	hsa-miR-4751	CLIP-seq
MIRT2533529	hsa-miR-4793-3p	CLIP-seq
MIRT2533530	hsa-miR-515-5p	CLIP-seq
MIRT2533531	hsa-miR-611	CLIP-seq
MIRT2229551	hsa-miR-891b	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005634	Component	Nucleus	IBA
GO:0005634	Component	Nucleus	IDA	9806903
GO:0005634	Component	Nucleus	IEA
GO:0005634	Component	Nucleus	TAS	9806903
GO:0005739	Component	Mitochondrion	TAS	9806903
GO:0008543	Process	Fibroblast growth factor receptor signaling pathway	TAS	9806903
GO:0012505	Component	Endomembrane system	IEA
GO:0016020	Component	Membrane	IDA	9806903
GO:0016020	Component	Membrane	IEA
GO:0016020	Component	Membrane	TAS	9806903
GO:0016607	Component	Nuclear speck	IDA
GO:0017134	Function	Fibroblast growth factor binding	IBA
GO:0017134	Function	Fibroblast growth factor binding	IPI	9806903
GO:0070527	Process	Platelet aggregation	HMP	23382103

Other IDs

• MIM: 608296
• HGNC: 3705
• e!Ensembl: ENSG00000172500

Protein

• UniProt ID: O43427
• Protein name: Acidic fibroblast growth factor intracellular-binding protein (aFGF intracellular-binding protein) (FGF-1 intracellular-binding protein)
• Protein function: May be involved in mitogenic function of FGF1. May mediate with IER2 FGF-signaling in the establishment of laterality in the embryo (By similarity).
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF05427	FIBP	3 → 363	Acidic fibroblast growth factor binding (FIBP)	Family

• Tissue specificity: TISSUE SPECIFICITY: Highly expressed in heart, skeletal muscle and pancreas. Expressed at lower levels in brain. Also found in placenta, liver and kidney.
• Sequence:

  MTSELDIFVGNTTLIDEDVYRLWLDGYSVTDAVALRVRSGILEQTGATAAVLQSDTMDHY
  RTFHMLERLLHAPPKLLHQLIFQIPPSRQALLIERYYAFDEAFVREVLGKKLSKGTKKDL
  DDISTKTGITLKSCRRQFDNFKRVFKVVEEMRGSLVDNIQQHFLLSDRLARDYAAIVFFA
  NNRFETGKKKLQYLSFGDFAFCAELMIQNWTLGAVGEAPTDPDSQMDDMDMDLDKEFLQD
  LKELKVLVADKDLLDLHKSLVCTALRGKLGVFSEMEANFKNLSRGLVNVAAKLTHNKDVR
  DLFVDLVEKFVEPCRSDHWPLSDVRFFLNQYSASVHSLDGFRHQALWDRYMGTLRGCLLR
  LYHD

• Sequence length: 364

Associated diseases

Causal
Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession
Tall stature-intellectual disability-renal anomalies syndrome	Likely pathogenic; Pathogenic	rs786204849, rs886037928, rs2495607710, rs2495606218	RCV000240847 RCV000240848 RCV003989255 RCV003989356

Unknown
Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession
FIBP-related disorder	Likely benign; Benign	rs370619260, rs116455583, rs137950249	RCV003951868 RCV003897946 RCV003940395

Associations from Text Mining
Disease Name	Relationship Type	References
Adenocarcinoma of Lung	Associate	37564211
Alzheimer Disease	Associate	35931864
Aortic Aneurysm Abdominal	Associate	27157464
Breast Neoplasms	Associate	25096995
Lung Neoplasms	Associate	37564211