Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene miRNA Gene ontology Other IDs Protein Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	9147
Gene name Gene Name - the full gene name approved by the HGNC.	Nuclear export mediator factor
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	NEMF
Synonyms (NCBI Gene) Gene synonyms aliases	IDDSAPN, NY-CO-1, RQC2, SDCCAG1
Disease Acronyms (UniProt) Disease acronyms from UniProt database	IDDSAPN
Chromosome Chromosome number	14
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	14q21.3
Summary Summary of gene provided in NCBI Entrez Gene.	This gene encodes a component of the ribosome quality control complex. The encoded protein facilitates the recognition and ubiquitination of stalled 60S subunits by the ubiquitin ligase listerin. A similar protein in fly functions as a tumor suppressor. [

Show/Hide all(89)

miRTarBase ID	miRNA	Experiments	Reference
MIRT031899	hsa-miR-16-5p	Proteomics	18668040
MIRT1180527	hsa-miR-133a	CLIP-seq
MIRT1180528	hsa-miR-133b	CLIP-seq
MIRT1180529	hsa-miR-3148	CLIP-seq
MIRT1180530	hsa-miR-3153	CLIP-seq
MIRT1180531	hsa-miR-3160-5p	CLIP-seq
MIRT1180532	hsa-miR-374a	CLIP-seq
MIRT1180533	hsa-miR-374b	CLIP-seq
MIRT1180534	hsa-miR-3907	CLIP-seq
MIRT1180535	hsa-miR-4646-5p	CLIP-seq
MIRT1180536	hsa-miR-4668-5p	CLIP-seq
MIRT1180537	hsa-miR-4802-3p	CLIP-seq
MIRT1180538	hsa-miR-548a-3p	CLIP-seq
MIRT1180539	hsa-miR-548e	CLIP-seq
MIRT1180540	hsa-miR-548f	CLIP-seq
MIRT1180541	hsa-miR-579	CLIP-seq
MIRT1180542	hsa-miR-601	CLIP-seq
MIRT1551730	hsa-miR-1238	CLIP-seq
MIRT1551731	hsa-miR-3163	CLIP-seq
MIRT1551732	hsa-miR-410	CLIP-seq
MIRT1180538	hsa-miR-548a-3p	CLIP-seq
MIRT1180539	hsa-miR-548e	CLIP-seq
MIRT1180540	hsa-miR-548f	CLIP-seq
MIRT2052237	hsa-miR-1208	CLIP-seq
MIRT1551730	hsa-miR-1238	CLIP-seq
MIRT2052238	hsa-miR-1305	CLIP-seq
MIRT1551731	hsa-miR-3163	CLIP-seq
MIRT2052239	hsa-miR-3691-3p	CLIP-seq
MIRT1180532	hsa-miR-374a	CLIP-seq
MIRT1180533	hsa-miR-374b	CLIP-seq
MIRT1551732	hsa-miR-410	CLIP-seq
MIRT2052240	hsa-miR-411	CLIP-seq
MIRT2052241	hsa-miR-4328	CLIP-seq
MIRT2052242	hsa-miR-4420	CLIP-seq
MIRT2052243	hsa-miR-4503	CLIP-seq
MIRT2052244	hsa-miR-4708-3p	CLIP-seq
MIRT2052245	hsa-miR-498	CLIP-seq
MIRT2052246	hsa-miR-499-3p	CLIP-seq
MIRT2052247	hsa-miR-499a-3p	CLIP-seq
MIRT1180538	hsa-miR-548a-3p	CLIP-seq
MIRT1180539	hsa-miR-548e	CLIP-seq
MIRT1180540	hsa-miR-548f	CLIP-seq
MIRT1180541	hsa-miR-579	CLIP-seq
MIRT2052248	hsa-miR-936	CLIP-seq
MIRT2281661	hsa-miR-101	CLIP-seq
MIRT2052237	hsa-miR-1208	CLIP-seq
MIRT1551730	hsa-miR-1238	CLIP-seq
MIRT2052238	hsa-miR-1305	CLIP-seq
MIRT2281662	hsa-miR-144	CLIP-seq
MIRT2281663	hsa-miR-203	CLIP-seq
MIRT2281664	hsa-miR-3145-5p	CLIP-seq
MIRT1551731	hsa-miR-3163	CLIP-seq
MIRT2281665	hsa-miR-323b-3p	CLIP-seq
MIRT2281666	hsa-miR-3545-3p	CLIP-seq
MIRT2281667	hsa-miR-3646	CLIP-seq
MIRT2052239	hsa-miR-3691-3p	CLIP-seq
MIRT1551732	hsa-miR-410	CLIP-seq
MIRT2052240	hsa-miR-411	CLIP-seq
MIRT2281668	hsa-miR-4255	CLIP-seq
MIRT2281669	hsa-miR-4282	CLIP-seq
MIRT2052241	hsa-miR-4328	CLIP-seq
MIRT2052242	hsa-miR-4420	CLIP-seq
MIRT2052243	hsa-miR-4503	CLIP-seq
MIRT2281670	hsa-miR-4668-3p	CLIP-seq
MIRT2052244	hsa-miR-4708-3p	CLIP-seq
MIRT2281671	hsa-miR-4719	CLIP-seq
MIRT2052245	hsa-miR-498	CLIP-seq
MIRT2052246	hsa-miR-499-3p	CLIP-seq
MIRT2052247	hsa-miR-499a-3p	CLIP-seq
MIRT1180538	hsa-miR-548a-3p	CLIP-seq
MIRT1180539	hsa-miR-548e	CLIP-seq
MIRT1180540	hsa-miR-548f	CLIP-seq
MIRT2281672	hsa-miR-576-3p	CLIP-seq
MIRT1180541	hsa-miR-579	CLIP-seq
MIRT2052248	hsa-miR-936	CLIP-seq
MIRT1551730	hsa-miR-1238	CLIP-seq
MIRT1551731	hsa-miR-3163	CLIP-seq
MIRT1551732	hsa-miR-410	CLIP-seq
MIRT1180538	hsa-miR-548a-3p	CLIP-seq
MIRT1180539	hsa-miR-548e	CLIP-seq
MIRT1180540	hsa-miR-548f	CLIP-seq
MIRT1180531	hsa-miR-3160-5p	CLIP-seq
MIRT1180534	hsa-miR-3907	CLIP-seq
MIRT1180537	hsa-miR-4802-3p	CLIP-seq
MIRT1180531	hsa-miR-3160-5p	CLIP-seq
MIRT1551731	hsa-miR-3163	CLIP-seq
MIRT2281666	hsa-miR-3545-3p	CLIP-seq
MIRT1180534	hsa-miR-3907	CLIP-seq
MIRT1180537	hsa-miR-4802-3p	CLIP-seq

Show/Hide all(7)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000049	Function	TRNA binding	IBA	21873635
GO:0005634	Component	Nucleus	IEA
GO:0043023	Function	Ribosomal large subunit binding	IBA	21873635
GO:0051168	Process	Nuclear export	IMP	16103875
GO:0072344	Process	Rescue of stalled ribosome	IBA	21873635
GO:1990112	Component	RQC complex	IBA	21873635
GO:1990116	Process	Ribosome-associated ubiquitin-dependent protein catabolic process	IBA	21873635

MIM	HGNC	e!Ensembl
608378	10663	ENSG00000165525

Protein

UniProt ID

O60524

Protein name

Ribosome quality control complex subunit NEMF (Antigen NY-CO-1) (Nuclear export mediator factor) (Serologically defined colon cancer antigen 1)

Protein function

Key component of the ribosome quality control complex (RQC), a ribosome-associated complex that mediates the extraction of incompletely synthesized nascent chains from stalled ribosomes as well as their ubiquitin-mediated proteasomal degradation

PDB

3J92

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF05833	FbpA	6 → 525		Family
PF05670	NFACT-R_1	529 → 639	NFACT protein RNA binding domain	Domain
PF11923	NFACT-C	973 → 1066	NFACT protein C-terminal domain	Domain

Tissue specificity

TISSUE SPECIFICITY: Expressed in brain, heart, liver, lung, spleen, and skeletal muscle. Also expressed at lower levels in stomach and testis. {ECO:0000269|PubMed:16103875, ECO:0000269|PubMed:33048237}.

Sequence

MKSRFSTIDLRAVLAELNASLLGMRVNNVYDVDNKTYLIRLQKPDFKATLLLESGIRIHT
TEFEWPKNMMPSSFAMKCRKHLKSRRLVSAKQLGVDRIVDFQFGSDEAAYHLIIELYDRG
NIVLTDYEYVILNILRFRTDEADDVKFAVRERYPLDHARAAEPLLTLERLTEIVASAPKG
ELLKRVLNPLLPYGPALIEHCLLENGFSGNVKVDEKLETKDIEKVLVSLQKAEDYMKTTS
NFSGKGYIIQKREIKPSLEADKPVEDILTYEEFHPFLFSQHSQCPYIEFESFDKAVDEFY
SKIEGQKIDLKALQQEKQALKKLDNVRKDHENRLEALQQAQEIDKLKGELIEMNLQIVDR
AIQVVRSALANQIDWTEIGLIVKEAQAQGDPVASAIKELKLQTNHVTMLLRNPYLLSEEE
DDDVDGDVNVEKNETEPPKGKKKKQKNKQLQKPQKNKPLLVDVDLSLSAYANAKKYYDHK
RYAAKKTQKTVEAAEKAFKSAEKKTKQTLKEVQTVTSIQKARKVYWFEKFLWFISSENYL
IIGGRDQQQNEIIVKRYLTPGDIYVHADLHGATSCVIKNPTGEPIPPRTLTEAGTMALCY
SAAWDARVITSAWWVYHHQVSKTAPTGEYLTTGSFMIRGKKNFLPPSYLMMGFSFLFKVD
ESCVWRHQGERKVRVQDEDMETLASCTSELISEEMEQLDGGDTSSDEDKEEHETPVEVEL
MTQVDQEDITLQSGRDELNEELIQEESSEDEGEYEEVRKDQDSVGEMKDEGEETLNYPDT
TIDLSHLQPQRSIQKLASKEESSNSSDSKSQSRRHLSAKERREMKKKKLPSDSGDLEALE
GKDKEKESTVHIETHQNTSKNVAAVQPMKRGQKSKMKKMKEKYKDQDEEDRELIMKLLGS
AGSNKEEKGKKGKKGKTKDEPVKKQPQKPRGGQRVSDNIKKETPFLEVITHELQDFAVDD
PHDDKEEQDLDQQGNEENLFDSLTGQPHPEDVLLFAIPICAPYTTMTNYKYKVKLTPGVQ
KKGKAAKTALNSFMHSKEATAREKDLFRSVKDTDLSRNIPGKVKVSAPNLLNVKRK

Sequence length

1076

Interactions

View interactions

Show/Hide Causal Diseases (1)

Disease term	Disease name	dbSNP ID	References
Causal
Autism spectrum disorder	Autism Spectrum Disorders	rs724159978, rs75184679, rs119103221, rs9332964, rs121912562, rs1594344233, rs727504317, rs111033204, rs1801086, rs587784464, rs724159948, rs764659822, rs794727977, rs796052733, rs796052728 View all (51 more)	28191889

Show/Hide Unknown Diseases (1)

Disease term	Disease name	Evidence	References	Source
Unknown
Peripheral Neuropathy	intellectual developmental disorder with speech delay and axonal peripheral neuropathy			GenCC

Show/Hide Text Mining Associations (1)

Disease Name	Relationship Type	References
Associations from Text Mining
Obesity	Associate	30309776

NEMF (nuclear export mediator factor)