Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Associated diseases
Entrez ID	9147
Gene name	Nuclear export mediator factor
Gene symbol	NEMF
Synonyms (NCBI Gene)	IDDSAPNNY-CO-1RQC2SDCCAG1
Chromosome	14
Chromosome location	14q21.3
Summary	This gene encodes a component of the ribosome quality control complex. The encoded protein facilitates the recognition and ubiquitination of stalled 60S subunits by the ubiquitin ligase listerin. A similar protein in fly functions as a tumor suppressor. [

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miRTarBase ID	miRNA	Experiments	Reference
MIRT031899	hsa-miR-16-5p	Proteomics	18668040
MIRT1180527	hsa-miR-133a	CLIP-seq
MIRT1180528	hsa-miR-133b	CLIP-seq
MIRT1180529	hsa-miR-3148	CLIP-seq
MIRT1180530	hsa-miR-3153	CLIP-seq
MIRT1180531	hsa-miR-3160-5p	CLIP-seq
MIRT1180532	hsa-miR-374a	CLIP-seq
MIRT1180533	hsa-miR-374b	CLIP-seq
MIRT1180534	hsa-miR-3907	CLIP-seq
MIRT1180535	hsa-miR-4646-5p	CLIP-seq
MIRT1180536	hsa-miR-4668-5p	CLIP-seq
MIRT1180537	hsa-miR-4802-3p	CLIP-seq
MIRT1180538	hsa-miR-548a-3p	CLIP-seq
MIRT1180539	hsa-miR-548e	CLIP-seq
MIRT1180540	hsa-miR-548f	CLIP-seq
MIRT1180541	hsa-miR-579	CLIP-seq
MIRT1180542	hsa-miR-601	CLIP-seq
MIRT1551730	hsa-miR-1238	CLIP-seq
MIRT1551731	hsa-miR-3163	CLIP-seq
MIRT1551732	hsa-miR-410	CLIP-seq
MIRT1180538	hsa-miR-548a-3p	CLIP-seq
MIRT1180539	hsa-miR-548e	CLIP-seq
MIRT1180540	hsa-miR-548f	CLIP-seq
MIRT2052237	hsa-miR-1208	CLIP-seq
MIRT1551730	hsa-miR-1238	CLIP-seq
MIRT2052238	hsa-miR-1305	CLIP-seq
MIRT1551731	hsa-miR-3163	CLIP-seq
MIRT2052239	hsa-miR-3691-3p	CLIP-seq
MIRT1180532	hsa-miR-374a	CLIP-seq
MIRT1180533	hsa-miR-374b	CLIP-seq
MIRT1551732	hsa-miR-410	CLIP-seq
MIRT2052240	hsa-miR-411	CLIP-seq
MIRT2052241	hsa-miR-4328	CLIP-seq
MIRT2052242	hsa-miR-4420	CLIP-seq
MIRT2052243	hsa-miR-4503	CLIP-seq
MIRT2052244	hsa-miR-4708-3p	CLIP-seq
MIRT2052245	hsa-miR-498	CLIP-seq
MIRT2052246	hsa-miR-499-3p	CLIP-seq
MIRT2052247	hsa-miR-499a-3p	CLIP-seq
MIRT1180538	hsa-miR-548a-3p	CLIP-seq
MIRT1180539	hsa-miR-548e	CLIP-seq
MIRT1180540	hsa-miR-548f	CLIP-seq
MIRT1180541	hsa-miR-579	CLIP-seq
MIRT2052248	hsa-miR-936	CLIP-seq
MIRT2281661	hsa-miR-101	CLIP-seq
MIRT2052237	hsa-miR-1208	CLIP-seq
MIRT1551730	hsa-miR-1238	CLIP-seq
MIRT2052238	hsa-miR-1305	CLIP-seq
MIRT2281662	hsa-miR-144	CLIP-seq
MIRT2281663	hsa-miR-203	CLIP-seq
MIRT2281664	hsa-miR-3145-5p	CLIP-seq
MIRT1551731	hsa-miR-3163	CLIP-seq
MIRT2281665	hsa-miR-323b-3p	CLIP-seq
MIRT2281666	hsa-miR-3545-3p	CLIP-seq
MIRT2281667	hsa-miR-3646	CLIP-seq
MIRT2052239	hsa-miR-3691-3p	CLIP-seq
MIRT1551732	hsa-miR-410	CLIP-seq
MIRT2052240	hsa-miR-411	CLIP-seq
MIRT2281668	hsa-miR-4255	CLIP-seq
MIRT2281669	hsa-miR-4282	CLIP-seq
MIRT2052241	hsa-miR-4328	CLIP-seq
MIRT2052242	hsa-miR-4420	CLIP-seq
MIRT2052243	hsa-miR-4503	CLIP-seq
MIRT2281670	hsa-miR-4668-3p	CLIP-seq
MIRT2052244	hsa-miR-4708-3p	CLIP-seq
MIRT2281671	hsa-miR-4719	CLIP-seq
MIRT2052245	hsa-miR-498	CLIP-seq
MIRT2052246	hsa-miR-499-3p	CLIP-seq
MIRT2052247	hsa-miR-499a-3p	CLIP-seq
MIRT1180538	hsa-miR-548a-3p	CLIP-seq
MIRT1180539	hsa-miR-548e	CLIP-seq
MIRT1180540	hsa-miR-548f	CLIP-seq
MIRT2281672	hsa-miR-576-3p	CLIP-seq
MIRT1180541	hsa-miR-579	CLIP-seq
MIRT2052248	hsa-miR-936	CLIP-seq
MIRT1551730	hsa-miR-1238	CLIP-seq
MIRT1551731	hsa-miR-3163	CLIP-seq
MIRT1551732	hsa-miR-410	CLIP-seq
MIRT1180538	hsa-miR-548a-3p	CLIP-seq
MIRT1180539	hsa-miR-548e	CLIP-seq
MIRT1180540	hsa-miR-548f	CLIP-seq
MIRT1180531	hsa-miR-3160-5p	CLIP-seq
MIRT1180534	hsa-miR-3907	CLIP-seq
MIRT1180537	hsa-miR-4802-3p	CLIP-seq
MIRT1180531	hsa-miR-3160-5p	CLIP-seq
MIRT1551731	hsa-miR-3163	CLIP-seq
MIRT2281666	hsa-miR-3545-3p	CLIP-seq
MIRT1180534	hsa-miR-3907	CLIP-seq
MIRT1180537	hsa-miR-4802-3p	CLIP-seq

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GO ID	Ontology	Definition	Evidence	Reference
GO:0000049	Function	TRNA binding	IBA
GO:0001680	Process	TRNA 3'-terminal CCA addition	IDA	32075755
GO:0005634	Component	Nucleus	IEA
GO:0005737	Component	Cytoplasm	IEA
GO:0005829	Component	Cytosol	IDA	25578875
GO:0005829	Component	Cytosol	IEA
GO:0022626	Component	Cytosolic ribosome	IDA	25578875, 33909987
GO:0042780	Process	TRNA 3'-end processing	IDA	32075755
GO:0043023	Function	Ribosomal large subunit binding	IBA
GO:0043023	Function	Ribosomal large subunit binding	IDA	25578875
GO:0051168	Process	Nuclear export	IMP	16103875
GO:0065003	Process	Protein-containing complex assembly	IMP	25578875
GO:0072344	Process	Rescue of stalled ribosome	IBA
GO:0072344	Process	Rescue of stalled ribosome	IDA	25578875, 31011209, 32075755, 33909987
GO:0072344	Process	Rescue of stalled ribosome	IDA	25578875
GO:0140627	Process	Ubiquitin-dependent protein catabolic process via the C-end degron rule pathway	IDA	33909987
GO:0140708	Process	CAT tailing	IDA	33406423, 33909987
GO:0140708	Process	CAT tailing	IEA
GO:1904678	Function	Alpha-aminoacyl-tRNA binding	IDA	33406423, 33909987
GO:1990112	Component	RQC complex	IBA
GO:1990112	Component	RQC complex	IDA	25578875, 33909987
GO:1990116	Process	Ribosome-associated ubiquitin-dependent protein catabolic process	IBA
GO:1990116	Process	Ribosome-associated ubiquitin-dependent protein catabolic process	IDA	25578875, 33406423, 33909987
GO:1990116	Process	Ribosome-associated ubiquitin-dependent protein catabolic process	IEA

MIM	HGNC	e!Ensembl
608378	10663	ENSG00000165525

O60524

Protein name

Ribosome quality control complex subunit NEMF (Antigen NY-CO-1) (Nuclear export mediator factor) (Serologically defined colon cancer antigen 1)

Protein function

Key component of the ribosome quality control complex (RQC), a ribosome-associated complex that mediates the extraction of incompletely synthesized nascent chains from stalled ribosomes as well as their ubiquitin-mediated proteasomal degradation

PDB

3J92

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF05833	FbpA	6 → 525		Family
PF05670	NFACT-R_1	529 → 639	NFACT protein RNA binding domain	Domain
PF11923	NFACT-C	973 → 1066	NFACT protein C-terminal domain	Domain

Tissue specificity

TISSUE SPECIFICITY: Expressed in brain, heart, liver, lung, spleen, and skeletal muscle. Also expressed at lower levels in stomach and testis. {ECO:0000269|PubMed:16103875, ECO:0000269|PubMed:33048237}.

Sequence

MKSRFSTIDLRAVLAELNASLLGMRVNNVYDVDNKTYLIRLQKPDFKATLLLESGIRIHT
TEFEWPKNMMPSSFAMKCRKHLKSRRLVSAKQLGVDRIVDFQFGSDEAAYHLIIELYDRG
NIVLTDYEYVILNILRFRTDEADDVKFAVRERYPLDHARAAEPLLTLERLTEIVASAPKG
ELLKRVLNPLLPYGPALIEHCLLENGFSGNVKVDEKLETKDIEKVLVSLQKAEDYMKTTS
NFSGKGYIIQKREIKPSLEADKPVEDILTYEEFHPFLFSQHSQCPYIEFESFDKAVDEFY
SKIEGQKIDLKALQQEKQALKKLDNVRKDHENRLEALQQAQEIDKLKGELIEMNLQIVDR
AIQVVRSALANQIDWTEIGLIVKEAQAQGDPVASAIKELKLQTNHVTMLLRNPYLLSEEE
DDDVDGDVNVEKNETEPPKGKKKKQKNKQLQKPQKNKPLLVDVDLSLSAYANAKKYYDHK
RYAAKKTQKTVEAAEKAFKSAEKKTKQTLKEVQTVTSIQKARKVYWFEKFLWFISSENYL
IIGGRDQQQNEIIVKRYLTPGDIYVHADLHGATSCVIKNPTGEPIPPRTLTEAGTMALCY
SAAWDARVITSAWWVYHHQVSKTAPTGEYLTTGSFMIRGKKNFLPPSYLMMGFSFLFKVD
ESCVWRHQGERKVRVQDEDMETLASCTSELISEEMEQLDGGDTSSDEDKEEHETPVEVEL
MTQVDQEDITLQSGRDELNEELIQEESSEDEGEYEEVRKDQDSVGEMKDEGEETLNYPDT
TIDLSHLQPQRSIQKLASKEESSNSSDSKSQSRRHLSAKERREMKKKKLPSDSGDLEALE
GKDKEKESTVHIETHQNTSKNVAAVQPMKRGQKSKMKKMKEKYKDQDEEDRELIMKLLGS
AGSNKEEKGKKGKKGKTKDEPVKKQPQKPRGGQRVSDNIKKETPFLEVITHELQDFAVDD
PHDDKEEQDLDQQGNEENLFDSLTGQPHPEDVLLFAIPICAPYTTMTNYKYKVKLTPGVQ
KKGKAAKTALNSFMHSKEATAREKDLFRSVKDTDLSRNIPGKVKVSAPNLLNVKRK

Sequence length

1076

Interactions

View interactions

Show/Hide Causal Diseases (3)

Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession
Causal Diseases associated with Pathogenic or Likely Pathogenic variants in ClinVar
Intellectual developmental disorder with speech delay and axonal peripheral neuropathy	Likely pathogenic; Pathogenic	rs2139857246, rs371405135, rs2503091962, rs2503270978, rs1892669150, rs765802022, rs766931948, rs1891004545, rs1890324880, rs1890664852, rs1892495985, rs1892495588, rs1892998702	RCV001814944 RCV005406565 RCV003131043 RCV003988280 RCV001267817 RCV005232221 RCV001267813 RCV001267814 RCV001267815 RCV001267816 RCV001267818 RCV001281347 RCV001283802
NEMF-related disorder	Likely pathogenic	rs2503266718	RCV003402446
See cases	Likely pathogenic; Pathogenic	rs1892669150, rs1890324880	RCV001198080 RCV003313206

Show/Hide Unknown Diseases (5)

Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession
Unknown Diseases with uncertain, conflicting, or no pathogenic evidence in ClinVar
Acute myeloid leukemia	Likely benign	rs184927855	RCV005929297
Familial cancer of breast	Likely benign	rs148593806	RCV005933196
Hereditary breast ovarian cancer syndrome	Uncertain significance	rs2168538	RCV001374555
Lung cancer	Likely benign	rs184927855	RCV005929298
Prostate cancer	Uncertain significance	rs864622015	RCV000204354

Show/Hide Text Mining Associations (1)

Disease Name	Relationship Type	References
Associations from Text MiningDisease associations identified through Pubtator
Obesity	Associate	30309776

NEMF (nuclear export mediator factor)