DDX60L (DExD/H-box 60 like)

Gene

• Entrez ID: 91351
• Gene name: DExD/H-box 60 like
• Gene symbol: DDX60L
• Synonyms (NCBI Gene): -
• Chromosome: 4
• Chromosome location: 4q32.3
• Summary: This gene encodes a member of the DExD/H-box helicase family of proteins, a subset of the super family 2 helicases. Members of the DExD/H-box helicase family share a conserved functional core comprised of two RecA-like globular domains. These domains cont

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT931344	hsa-miR-1270	CLIP-seq
MIRT931345	hsa-miR-3145-5p	CLIP-seq
MIRT931346	hsa-miR-3174	CLIP-seq
MIRT931347	hsa-miR-3187-3p	CLIP-seq
MIRT931348	hsa-miR-4434	CLIP-seq
MIRT931349	hsa-miR-4468	CLIP-seq
MIRT931350	hsa-miR-4516	CLIP-seq
MIRT931351	hsa-miR-4529-5p	CLIP-seq
MIRT931352	hsa-miR-4531	CLIP-seq
MIRT931353	hsa-miR-4536	CLIP-seq
MIRT931354	hsa-miR-4652-3p	CLIP-seq
MIRT931355	hsa-miR-4756-3p	CLIP-seq
MIRT931356	hsa-miR-4778-5p	CLIP-seq
MIRT931357	hsa-miR-513a-5p	CLIP-seq
MIRT931358	hsa-miR-620	CLIP-seq
MIRT931359	hsa-miR-921	CLIP-seq
MIRT1975629	hsa-miR-216a	CLIP-seq
MIRT1975630	hsa-miR-216b	CLIP-seq
MIRT1975631	hsa-miR-224	CLIP-seq
MIRT1975632	hsa-miR-23a	CLIP-seq
MIRT1975633	hsa-miR-23b	CLIP-seq
MIRT1975634	hsa-miR-23c	CLIP-seq
MIRT1975635	hsa-miR-3675-3p	CLIP-seq
MIRT1975636	hsa-miR-3691-3p	CLIP-seq
MIRT1975637	hsa-miR-4480	CLIP-seq
MIRT1975638	hsa-miR-4738-3p	CLIP-seq
MIRT1975639	hsa-miR-502-5p	CLIP-seq
MIRT1975640	hsa-miR-518a-5p	CLIP-seq
MIRT1975641	hsa-miR-527	CLIP-seq
MIRT1975642	hsa-miR-579	CLIP-seq
MIRT1975643	hsa-miR-664	CLIP-seq
MIRT2211153	hsa-miR-3612	CLIP-seq
MIRT2211154	hsa-miR-3652	CLIP-seq
MIRT2211155	hsa-miR-3690	CLIP-seq
MIRT2211156	hsa-miR-3977	CLIP-seq
MIRT2211157	hsa-miR-3978	CLIP-seq
MIRT2211158	hsa-miR-4254	CLIP-seq
MIRT2211159	hsa-miR-4430	CLIP-seq
MIRT2211160	hsa-miR-4443	CLIP-seq
MIRT931354	hsa-miR-4652-3p	CLIP-seq
MIRT2211161	hsa-miR-485-5p	CLIP-seq
MIRT2211162	hsa-miR-650	CLIP-seq
MIRT2211163	hsa-miR-875-3p	CLIP-seq
MIRT2448143	hsa-miR-3655	CLIP-seq
MIRT2448144	hsa-miR-593	CLIP-seq
MIRT2515040	hsa-miR-1284	CLIP-seq
MIRT2515041	hsa-miR-27a	CLIP-seq
MIRT2515042	hsa-miR-27b	CLIP-seq
MIRT2515043	hsa-miR-3129-3p	CLIP-seq
MIRT2515044	hsa-miR-323-3p	CLIP-seq
MIRT2515045	hsa-miR-3616-3p	CLIP-seq
MIRT2515046	hsa-miR-4427	CLIP-seq
MIRT2515047	hsa-miR-4436b-3p	CLIP-seq
MIRT2515048	hsa-miR-4452	CLIP-seq
MIRT2515049	hsa-miR-4680-3p	CLIP-seq
MIRT2515050	hsa-miR-4721	CLIP-seq
MIRT2515051	hsa-miR-4735-5p	CLIP-seq
MIRT1975638	hsa-miR-4738-3p	CLIP-seq
MIRT2515052	hsa-miR-4775	CLIP-seq
MIRT931357	hsa-miR-513a-5p	CLIP-seq
MIRT2515053	hsa-miR-548aa	CLIP-seq
MIRT2515054	hsa-miR-548ac	CLIP-seq
MIRT2515055	hsa-miR-548d-3p	CLIP-seq
MIRT2515056	hsa-miR-548z	CLIP-seq
MIRT2515057	hsa-miR-587	CLIP-seq
MIRT2515058	hsa-miR-590-3p	CLIP-seq
MIRT2515059	hsa-miR-606	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000166	Function	Nucleotide binding	IEA
GO:0003676	Function	Nucleic acid binding	IEA
GO:0003723	Function	RNA binding	IEA
GO:0003724	Function	RNA helicase activity	IEA
GO:0003725	Function	Double-stranded RNA binding	IBA
GO:0003727	Function	Single-stranded RNA binding	IBA
GO:0004386	Function	Helicase activity	IEA
GO:0005524	Function	ATP binding	IEA
GO:0005737	Component	Cytoplasm	IBA
GO:0016787	Function	Hydrolase activity	IEA
GO:0016887	Function	ATP hydrolysis activity	IEA
GO:0051607	Process	Defense response to virus	IBA

Other IDs

• MIM: 616725
• HGNC: 26429
• e!Ensembl: ENSG00000181381

Protein

• UniProt ID: Q5H9U9
• Protein name: Probable ATP-dependent RNA helicase DDX60-like (EC 3.6.4.13) (DEAD box protein 60-like)
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00270	DEAD	745 → 908	DEAD/DEAH box helicase	Domain
  PF00271	Helicase_C	1206 → 1314	Helicase conserved C-terminal domain	Family

• Sequence:

  MGSKDHAVFFREMTQLILNEMPKAGYSSILNDFVESNFFVIDGDSLLVTCLGVKSFKWGQ
  NLHFFYLVECYLVDLLSNGGQFTIVFFKDAEYAYFDFPELLSLRTALILHLQHNTNIDVQ
  TEFSGCLSQDWKLFLEQHYPYFLIVSEEGLSDLQTYLFNFLIIHSWGMKVNVVLSSGHES
  DTLRFYAYTMESTDRNQTFSKENETVIQSAYKSLIQHLEEIRVLVLATHFEHLKWNDMME
  EAYQTLFLLQHLWSEGSDIQRVLCVTSCSLSLRMYHRVLVHSNCLSLQEVEDFCRLRCLC
  VAFQLHLPLSQRACSRVITCSWIRNSDSFLKMNKWCEYFILSNLNVFGCWNLNLNHVSDL
  YDEQLLKNIAFYYEFESTQEPHLNLGDSIRRDYEDLWNVVSHLVKEFNVGKSFPLRTTRR
  HFLRQEKSVIQEISLEKMPSVGFIPMTSAVIDEFVGDMMKDLPILKSDDPVVPSLFKQKT
  SDELLHWHAQRLLSDDYDRIKCHVDEQSRDPHVLDFLKKIQDYQQFYGKSLESISTKVIV
  TQTTRPKEDSSGASGEILQNTKPHQITKKSKKKSFLKEDQNKAQQNDDLLFSIEEEMKNN
  LHSGIRKLEDYLTSCASNSVKFGVEMLGLIACFKAWKKHCRGEGKISKDLSIAVQMMKRI
  HSLLERYPEILEAEHHQYIAKCLKYLGFNDLANSLDPTLIGDDKNKKKYSIDIGPARFQL
  QYMGHYLIRDERKDRDPRVQDFIPNAWQQELLDVVDKNESAVIVAPTSSGKTYASYYCME
  KVLRESDVGVVVYVAPAKSLVGQVAATVENRFTKTLPAGRTLCGAFTRDYCHNVLNCQVL
  ITVPECFEILLLAPHRQKWVERIRYVIFDEVHYLGREVGAKFWELLLVIIRCPFLVLSAT
  INNPNLLTKWLQSVKQYWKQADKIMEEKCISEKQADKCLNFLQDHSYKNQSYEVRLVLYG
  ERYNDLEKHICSVKHDDVYFDHFHPCAALTTDIIEKYGFPPDLTLTPQESIQLYDTMAQV
  WETWPRAQELCPEEFILFKNKIVIKKLDARKYEENLKAELTNWIKNGQVKKVKRVLKNLS
  PDSLSSSKDMVKMFPLLVEKLRQMDKLPAIFFLFKNDDVGKRAGSVCTFLEKTETKSHPH
  TECHSYVFAIDEVLEKVRKTQKRITKKNPKKAEKLERKKVYRAEYINFLENLKILEISED
  CTYADVKALHTEITRNKDSTLERVLPRVRFTRHGKELKALAQRGIGYHHSSMYFKEKEFV
  EILFVKGLIRVVTATETLALGIHMPCKSVVFAQDSVYLDALNYRQMSGRAGRRGQDLLGN
  VYFFDIPLPKIKRLLASSVPELRGQFPLSITLVLRLMLLASKGDDPEDAKAKVLSVLKHS
  LLSFKRRRAMETLKLYFLFSLQLLIKEDYLNKKGNPKKFAGLASYLHGHEPSNLVFVNFL
  KRGLFHNLCKPAWKGSQQFSQDVMEKLVLVLANLFGRKYIPAKFQNANLSFSQSKVILAE
  LPEDFKAALYEYNLAVMKDFASFLLIASKSVNMKKEHQLPLSRIKFTGKECEDSQLVSHL
  MSCKKGRVAISPFVCLSGNTDNDLLRPETINQVILRTVGVSGTQAPLLWPWKLDNRGRRM
  PLNAYVLNFYKHNCLTRLDQKNGMRMGQLLKCLKDFAFNIQAISDSLSELCENKRDNVVL
  AFKQLSQTFYEKLQEMQIQMSQNHLE

• Sequence length: 1706

Associated diseases

Unknown
Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession
Gastric cancer	Uncertain significance	rs1050051168	RCV005937432
Prostate cancer	Uncertain significance	rs201155959	RCV000203695

Associations from Text Mining
Disease Name	Relationship Type	References
Aneuploidy	Associate	35347416
Carcinoma Pancreatic Ductal	Associate	34789165
Hepatitis C	Associate	26269178