Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways
Entrez ID	9112
Gene name	Metastasis associated 1
Gene symbol	MTA1
Synonyms (NCBI Gene)	-
Chromosome	14
Chromosome location	14q32.33
Summary	This gene encodes a protein that was identified in a screen for genes expressed in metastatic cells, specifically, mammary adenocarcinoma cell lines. Expression of this gene has been correlated with the metastatic potential of at least two types of carcin

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miRTarBase ID	miRNA	Experiments	Reference
MIRT000033	hsa-miR-661	Review	20026422
MIRT000033	hsa-miR-661	Luciferase reporter assayWestern blot	19584269
MIRT004442	hsa-miR-559	Luciferase reporter assayWestern blot	19584269
MIRT052954	hsa-miR-30c-5p	5.0	22139444
MIRT052954	hsa-miR-30c-5p	5.0	22139444
MIRT052954	hsa-miR-30c-5p	Luciferase reporter assayqRT-PCRWestern blot	22139444
MIRT052954	hsa-miR-30c-5p	qRT-PCRWestern blot	24595016
MIRT052954	hsa-miR-30c-5p	ImmunohistochemistryLuciferase reporter assayqRT-PCRWestern blot	23988701
MIRT052954	hsa-miR-30c-5p	ImmunohistochemistryLuciferase reporter assayqRT-PCRWestern blot	23988701
MIRT694397	hsa-miR-3141	HITS-CLIP	23313552
MIRT694396	hsa-miR-4999-3p	HITS-CLIP	23313552
MIRT069482	hsa-miR-125a-3p	HITS-CLIP	23313552
MIRT694395	hsa-miR-6728-3p	HITS-CLIP	23313552
MIRT694394	hsa-miR-3158-5p	HITS-CLIP	23313552
MIRT694393	hsa-miR-1184	HITS-CLIP	23313552
MIRT694392	hsa-miR-1205	HITS-CLIP	23313552
MIRT694391	hsa-miR-17-3p	HITS-CLIP	23313552
MIRT694390	hsa-miR-3616-3p	HITS-CLIP	23313552
MIRT694389	hsa-miR-4721	HITS-CLIP	23313552
MIRT694388	hsa-miR-3184-5p	HITS-CLIP	23313552
MIRT694387	hsa-miR-423-5p	HITS-CLIP	23313552
MIRT694386	hsa-miR-1914-3p	HITS-CLIP	23313552
MIRT694385	hsa-miR-5194	HITS-CLIP	23313552
MIRT694384	hsa-miR-6738-5p	HITS-CLIP	23313552
MIRT694383	hsa-miR-6134	HITS-CLIP	23313552
MIRT694382	hsa-miR-3665	HITS-CLIP	23313552
MIRT694381	hsa-miR-657	HITS-CLIP	23313552
MIRT694380	hsa-miR-3689d	HITS-CLIP	23313552
MIRT694379	hsa-miR-6851-5p	HITS-CLIP	23313552
MIRT694378	hsa-miR-6799-5p	HITS-CLIP	23313552
MIRT694377	hsa-miR-486-3p	HITS-CLIP	23313552
MIRT694376	hsa-miR-4710	HITS-CLIP	23313552
MIRT694375	hsa-miR-92a-2-5p	HITS-CLIP	23313552
MIRT694374	hsa-miR-3151-5p	HITS-CLIP	23313552
MIRT694373	hsa-miR-3191-5p	HITS-CLIP	23313552
MIRT694372	hsa-miR-1226-5p	HITS-CLIP	23313552
MIRT694371	hsa-miR-6734-5p	HITS-CLIP	23313552
MIRT694370	hsa-miR-4768-5p	HITS-CLIP	23313552
MIRT694369	hsa-miR-6833-3p	HITS-CLIP	23313552
MIRT694368	hsa-miR-6809-3p	HITS-CLIP	23313552
MIRT694367	hsa-miR-1323	HITS-CLIP	23313552
MIRT069484	hsa-miR-543	ImmunohistochemistryLuciferase reporter assayqRT-PCRWestern blot	26968810
MIRT069484	hsa-miR-543	ImmunohistochemistryLuciferase reporter assayqRT-PCRWestern blot	26968810
MIRT069482	hsa-miR-125a-3p	Luciferase reporter assayqRT-PCRWestern blot	25998575
MIRT069482	hsa-miR-125a-3p	Luciferase reporter assayqRT-PCRWestern blot	28088556
MIRT694367	hsa-miR-1323	PAR-CLIP	26701625
MIRT694386	hsa-miR-1914-3p	PAR-CLIP	26701625
MIRT694374	hsa-miR-3151-5p	PAR-CLIP	26701625
MIRT694388	hsa-miR-3184-5p	PAR-CLIP	26701625
MIRT694387	hsa-miR-423-5p	PAR-CLIP	26701625
MIRT694377	hsa-miR-486-3p	PAR-CLIP	26701625
MIRT694396	hsa-miR-4999-3p	PAR-CLIP	26701625
MIRT694385	hsa-miR-5194	PAR-CLIP	26701625
MIRT694371	hsa-miR-6734-5p	PAR-CLIP	26701625
MIRT694384	hsa-miR-6738-5p	PAR-CLIP	26701625
MIRT694375	hsa-miR-92a-2-5p	PAR-CLIP	26701625
MIRT694397	hsa-miR-3141	HITS-CLIP	23313552
MIRT694396	hsa-miR-4999-3p	HITS-CLIP	23313552
MIRT069482	hsa-miR-125a-3p	HITS-CLIP	23313552
MIRT694395	hsa-miR-6728-3p	HITS-CLIP	23313552
MIRT694394	hsa-miR-3158-5p	HITS-CLIP	23313552
MIRT694393	hsa-miR-1184	HITS-CLIP	23313552
MIRT694392	hsa-miR-1205	HITS-CLIP	23313552
MIRT694391	hsa-miR-17-3p	HITS-CLIP	23313552
MIRT694390	hsa-miR-3616-3p	HITS-CLIP	23313552
MIRT694389	hsa-miR-4721	HITS-CLIP	23313552
MIRT694388	hsa-miR-3184-5p	HITS-CLIP	23313552
MIRT694387	hsa-miR-423-5p	HITS-CLIP	23313552
MIRT694386	hsa-miR-1914-3p	HITS-CLIP	23313552
MIRT694385	hsa-miR-5194	HITS-CLIP	23313552
MIRT694384	hsa-miR-6738-5p	HITS-CLIP	23313552
MIRT694383	hsa-miR-6134	HITS-CLIP	23313552
MIRT694382	hsa-miR-3665	HITS-CLIP	23313552
MIRT694381	hsa-miR-657	HITS-CLIP	23313552
MIRT694380	hsa-miR-3689d	HITS-CLIP	23313552
MIRT694379	hsa-miR-6851-5p	HITS-CLIP	23313552
MIRT694378	hsa-miR-6799-5p	HITS-CLIP	23313552
MIRT694377	hsa-miR-486-3p	HITS-CLIP	23313552
MIRT694376	hsa-miR-4710	HITS-CLIP	23313552
MIRT694375	hsa-miR-92a-2-5p	HITS-CLIP	23313552
MIRT694374	hsa-miR-3151-5p	HITS-CLIP	23313552
MIRT694373	hsa-miR-3191-5p	HITS-CLIP	23313552
MIRT694372	hsa-miR-1226-5p	HITS-CLIP	23313552
MIRT694371	hsa-miR-6734-5p	HITS-CLIP	23313552
MIRT694370	hsa-miR-4768-5p	HITS-CLIP	23313552
MIRT694369	hsa-miR-6833-3p	HITS-CLIP	23313552
MIRT694368	hsa-miR-6809-3p	HITS-CLIP	23313552
MIRT694367	hsa-miR-1323	HITS-CLIP	23313552
MIRT1162166	hsa-miR-1283	CLIP-seq
MIRT1162167	hsa-miR-199a-5p	CLIP-seq
MIRT1162168	hsa-miR-199b-5p	CLIP-seq
MIRT1162169	hsa-miR-3143	CLIP-seq
MIRT1162170	hsa-miR-3151	CLIP-seq
MIRT1162171	hsa-miR-3183	CLIP-seq
MIRT1162172	hsa-miR-361-3p	CLIP-seq
MIRT1162173	hsa-miR-3648	CLIP-seq
MIRT1162174	hsa-miR-3670	CLIP-seq
MIRT1162175	hsa-miR-3934	CLIP-seq
MIRT1162176	hsa-miR-4279	CLIP-seq
MIRT1162177	hsa-miR-4669	CLIP-seq
MIRT1162178	hsa-miR-4723-3p	CLIP-seq
MIRT1162179	hsa-miR-4778-3p	CLIP-seq
MIRT1162180	hsa-miR-4797-5p	CLIP-seq
MIRT2046467	hsa-miR-1296	CLIP-seq
MIRT2046468	hsa-miR-1538	CLIP-seq
MIRT2046469	hsa-miR-2909	CLIP-seq
MIRT2046470	hsa-miR-3065-5p	CLIP-seq
MIRT1162169	hsa-miR-3143	CLIP-seq
MIRT1162175	hsa-miR-3934	CLIP-seq
MIRT2046471	hsa-miR-421	CLIP-seq
MIRT2046472	hsa-miR-4258	CLIP-seq
MIRT2046473	hsa-miR-4512	CLIP-seq
MIRT2046474	hsa-miR-4514	CLIP-seq
MIRT2046475	hsa-miR-4645-5p	CLIP-seq
MIRT2046476	hsa-miR-4651	CLIP-seq
MIRT2046477	hsa-miR-4660	CLIP-seq
MIRT2046478	hsa-miR-4665-3p	CLIP-seq
MIRT2046479	hsa-miR-4673	CLIP-seq
MIRT2046480	hsa-miR-4688	CLIP-seq
MIRT2046481	hsa-miR-4692	CLIP-seq
MIRT2046482	hsa-miR-4709-5p	CLIP-seq
MIRT2046483	hsa-miR-4745-3p	CLIP-seq
MIRT2046484	hsa-miR-4749-3p	CLIP-seq
MIRT2046485	hsa-miR-4755-3p	CLIP-seq
MIRT1162180	hsa-miR-4797-5p	CLIP-seq
MIRT2046486	hsa-miR-564	CLIP-seq
MIRT2046487	hsa-miR-608	CLIP-seq
MIRT2046488	hsa-miR-663b	CLIP-seq
MIRT2275575	hsa-miR-183	CLIP-seq
MIRT1162167	hsa-miR-199a-5p	CLIP-seq
MIRT1162168	hsa-miR-199b-5p	CLIP-seq
MIRT2046470	hsa-miR-3065-5p	CLIP-seq
MIRT2275576	hsa-miR-30a	CLIP-seq
MIRT2275577	hsa-miR-30b	CLIP-seq
MIRT2275578	hsa-miR-30c	CLIP-seq
MIRT2275579	hsa-miR-30d	CLIP-seq
MIRT2275580	hsa-miR-30e	CLIP-seq
MIRT1162169	hsa-miR-3143	CLIP-seq
MIRT1162171	hsa-miR-3183	CLIP-seq
MIRT1162172	hsa-miR-361-3p	CLIP-seq
MIRT2275581	hsa-miR-3662	CLIP-seq
MIRT2275582	hsa-miR-3669	CLIP-seq
MIRT2275583	hsa-miR-3917	CLIP-seq
MIRT1162175	hsa-miR-3934	CLIP-seq
MIRT2046471	hsa-miR-421	CLIP-seq
MIRT1162176	hsa-miR-4279	CLIP-seq
MIRT1162177	hsa-miR-4669	CLIP-seq
MIRT2046482	hsa-miR-4709-5p	CLIP-seq
MIRT1162178	hsa-miR-4723-3p	CLIP-seq
MIRT1162179	hsa-miR-4778-3p	CLIP-seq
MIRT1162180	hsa-miR-4797-5p	CLIP-seq
MIRT2275584	hsa-miR-548a-5p	CLIP-seq
MIRT2275585	hsa-miR-548ab	CLIP-seq
MIRT2275586	hsa-miR-548ak	CLIP-seq
MIRT2275587	hsa-miR-548b-5p	CLIP-seq
MIRT2275588	hsa-miR-548c-5p	CLIP-seq
MIRT2275589	hsa-miR-548d-5p	CLIP-seq
MIRT2275590	hsa-miR-548h	CLIP-seq
MIRT2275591	hsa-miR-548i	CLIP-seq
MIRT2275592	hsa-miR-548j	CLIP-seq
MIRT2275593	hsa-miR-548n	CLIP-seq
MIRT2275594	hsa-miR-548w	CLIP-seq
MIRT2275595	hsa-miR-548y	CLIP-seq
MIRT2275596	hsa-miR-572	CLIP-seq
MIRT2275597	hsa-miR-766	CLIP-seq
MIRT1162171	hsa-miR-3183	CLIP-seq
MIRT1162176	hsa-miR-4279	CLIP-seq
MIRT1162178	hsa-miR-4723-3p	CLIP-seq
MIRT1162179	hsa-miR-4778-3p	CLIP-seq

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Transcription factor	Regulation	Reference
LMO4	Unknown	16288053
SP1	Activation	21555589

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GO ID	Ontology	Definition	Evidence	Reference
GO:0000122	Process	Negative regulation of transcription by RNA polymerase II	IBA
GO:0000978	Function	RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA	21965678, 24413532
GO:0000978	Function	RNA polymerase II cis-regulatory region sequence-specific DNA binding	ISS
GO:0003677	Function	DNA binding	IEA
GO:0003682	Function	Chromatin binding	IEA
GO:0003713	Function	Transcription coactivator activity	IBA
GO:0003713	Function	Transcription coactivator activity	IMP	21965678
GO:0003714	Function	Transcription corepressor activity	IBA
GO:0003714	Function	Transcription corepressor activity	IMP	21965678
GO:0005515	Function	Protein binding	IPI	16511565, 18451879, 19805145, 20651739, 21258344, 21555589, 21965678, 23752268, 24413532, 24920672, 24970816, 24981860, 25416956, 25609649, 26028330, 26496610, 26949739, 27705803, 29997244, 30327463, 31515488, 32296183, 33961781, 35271311
GO:0005634	Component	Nucleus	IDA	21965678, 24413532, 24970816, 28977666, 33283408
GO:0005634	Component	Nucleus	IEA
GO:0005635	Component	Nuclear envelope	IDA	24970816
GO:0005635	Component	Nuclear envelope	IEA
GO:0005654	Component	Nucleoplasm	IBA
GO:0005654	Component	Nucleoplasm	IDA
GO:0005654	Component	Nucleoplasm	TAS
GO:0005737	Component	Cytoplasm	IDA	24970816
GO:0005737	Component	Cytoplasm	IEA
GO:0005829	Component	Cytosol	IDA
GO:0005856	Component	Cytoskeleton	IEA
GO:0005874	Component	Microtubule	IDA	24970816
GO:0006302	Process	Double-strand break repair	IBA
GO:0006302	Process	Double-strand break repair	IMP	19805145
GO:0006338	Process	Chromatin remodeling	IDA	9790534
GO:0006338	Process	Chromatin remodeling	IEA
GO:0006355	Process	Regulation of DNA-templated transcription	IEA
GO:0007165	Process	Signal transduction	TAS	8083195
GO:0008270	Function	Zinc ion binding	IEA
GO:0010212	Process	Response to ionizing radiation	IBA
GO:0010212	Process	Response to ionizing radiation	IDA	19805145
GO:0016581	Component	NuRD complex	IBA
GO:0016581	Component	NuRD complex	IDA	22926524, 33283408
GO:0016581	Component	NuRD complex	IEA
GO:0016581	Component	NuRD complex	NAS	16428440
GO:0032922	Process	Circadian regulation of gene expression	ISS
GO:0042659	Process	Regulation of cell fate specification	NAS	22560079
GO:0042826	Function	Histone deacetylase binding	IBA
GO:0043153	Process	Entrainment of circadian clock by photoperiod	ISS
GO:0043161	Process	Proteasome-mediated ubiquitin-dependent protein catabolic process	IMP	19805145
GO:0043565	Function	Sequence-specific DNA binding	IEA
GO:0045475	Process	Locomotor rhythm	ISS
GO:0045814	Process	Negative regulation of gene expression, epigenetic	IMP	24413532
GO:0045892	Process	Negative regulation of DNA-templated transcription	NAS	22560079
GO:0045893	Process	Positive regulation of DNA-templated transcription	NAS	19927129
GO:0046872	Function	Metal ion binding	IEA
GO:0048511	Process	Rhythmic process	IEA
GO:0061629	Function	RNA polymerase II-specific DNA-binding transcription factor binding	IEA
GO:0061629	Function	RNA polymerase II-specific DNA-binding transcription factor binding	IPI	22926524
GO:1902499	Process	Positive regulation of protein autoubiquitination	IDA	19805145
GO:2000736	Process	Regulation of stem cell differentiation	NAS	22560079

MIM	HGNC	e!Ensembl
603526	7410	ENSG00000182979

Q13330

Protein name

Metastasis-associated protein MTA1

Protein function

Transcriptional coregulator which can act as both a transcriptional corepressor and coactivator (PubMed:16617102, PubMed:17671180, PubMed:17922032, PubMed:21965678, PubMed:24413532). Acts as a component of the histone deacetylase NuRD complex wh

PDB

4BKX , 4PBY , 4PBZ , 4PC0 , 5FXY , 5ICN , 6G16 , 6ZRC , 6ZRD , 7AO8 , 7AO9 , 7AOA

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF01426	BAH	4 → 164	BAH domain	Domain
PF01448	ELM2	167 → 219	ELM2 domain	Family
PF00249	Myb_DNA-binding	285 → 331	Myb-like DNA-binding domain	Domain
PF00320	GATA	393 → 430	GATA zinc finger	Domain
PF17226	MTA_R1	464 → 541	MTA R1 domain	Domain
PF17226	MTA_R1	656 → 695	MTA R1 domain	Domain

Tissue specificity

TISSUE SPECIFICITY: Widely expressed. High expression in brain, liver, kidney, and cardiac muscle, ovaries, adrenal glands and virgin mammary glands. Higher in tumors than in adjacent normal tissue from the same individual. Up-regulated in a wide variety

Sequence

MAANMYRVGDYVYFENSSSNPYLIRRIEELNKTANGNVEAKVVCFYRRRDISSTLIALAD
KHATLSVCYKAGPGADNGEEGEIEEEMENPEMVDLPEKLKHQLRHRELFLSRQLESLPAT
HIRGKCSVTLLNETESLKSYLEREDFFFYSLVYDPQQKTLLADKGEIRVGNRYQADITDL
LKEGEEDGRDQSRLETQVWEAHNPLTDKQIDQFLVVARSVGTFARALDCSSSVRQPSLHM
SAAAASRDITLFHAMDTLHKNIYDISKAISALVPQGGPVLCRDEMEEWSASEANLFEEAL
EKYGKDFTDIQQDFLPWKSLTSIIEYYYMWKTTDRYVQQKRLKAAEAESKLKQVYIPNYN
KPNPNQISVNNVKAGVVNGTGAPGQSPGAGRACESCYTTQSYQWYSWGPPNMQCRLCASC
WTYWKKYGGLKMPTRLDGERPGPNRSNMSPHGLPARSSGSPKFAMKTRQAFYLHTTKLTR
IARRLCREILRPWHAARHPYLPINSAAIKAECTARLPEASQSPLVLKQAVRKPLEAVLRY
LETHPRPPKPDPVKSVSSVLSSLTPAKVAPVINNGSPTILGKRSYEQHNGVDGNMKKRLL
MPSRGLANHGQARHMGPSRNLLLNGKSYPTKVRLIRGGSLPPVKRRRMNWIDAPDDVFYM
ATEETRKIRKLLSSSETKRAARRPYKPIALRQSQALPPRPPPPAPVNDEPIVIED

Sequence length

715

Interactions

View interactions

	KEGG		Reactome
	ATP-dependent chromatin remodeling		HDACs deacetylate histones SUMOylation of transcription factors RNA Polymerase I Transcription Initiation Regulation of PTEN gene transcription

MTA1 (metastasis associated 1)