Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
91039
Gene name Gene Name - the full gene name approved by the HGNC.
Dipeptidyl peptidase 9
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
DPP9
Synonyms (NCBI Gene) Gene synonyms aliases
DP9, DPLP9, DPP IX, DPRP-2, DPRP2, HATIS, IMD111
Disease Acronyms (UniProt) Disease acronyms from UniProt database
HATIS
Chromosome Chromosome number
19
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
19p13.3
Summary Summary of gene provided in NCBI Entrez Gene.
This gene encodes a protein that is a member of the S9B family in clan SC of the serine proteases. The protein has been shown to have post-proline dipeptidyl aminopeptidase activity, cleaving Xaa-Pro dipeptides from the N-termini of proteins. Although the
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT020452 hsa-miR-106b-5p Microarray 17242205
MIRT676097 hsa-miR-5582-5p HITS-CLIP 23824327
MIRT676096 hsa-miR-3622a-5p HITS-CLIP 23824327
MIRT676095 hsa-miR-1295b-3p HITS-CLIP 23824327
MIRT676094 hsa-miR-4740-3p HITS-CLIP 23824327
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0004177 Function Aminopeptidase activity IEA
GO:0005634 Component Nucleus IEA
GO:0005829 Component Cytosol IDA
GO:0005874 Component Microtubule IDA 25486458
GO:0006508 Process Proteolysis IEA
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
608258 18648 ENSG00000142002
Protein
UniProt ID Q86TI2
Protein name Dipeptidyl peptidase 9 (DP9) (EC 3.4.14.5) (Dipeptidyl peptidase IV-related protein 2) (DPRP-2) (Dipeptidyl peptidase IX) (DPP IX) (Dipeptidyl peptidase-like protein 9) (DPLP9)
Protein function Dipeptidyl peptidase that cleaves off N-terminal dipeptides from proteins having a Pro or Ala residue at position 2 (PubMed:12662155, PubMed:16475979, PubMed:19667070, PubMed:29382749, PubMed:30291141, PubMed:33731929, PubMed:36112693). Acts as
PDB 6EOQ , 6EOR , 6QZV , 6X6A , 6X6C , 7A3F , 7JKQ , 7JN7 , 7SVL , 7SVN , 7ZXS
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00930 DPPIV_N 146 570 Dipeptidyl peptidase IV (DPP IV) N-terminal region Family
PF00326 Peptidase_S9 658 863 Prolyl oligopeptidase family Domain
Tissue specificity TISSUE SPECIFICITY: Ubiquitously expressed, with highest levels in liver, heart and muscle, and lowest levels in brain. {ECO:0000269|PubMed:12459266, ECO:0000269|PubMed:12662155, ECO:0000269|PubMed:15245913}.
Sequence
MATTGTPTADRGDAAATDDPAARFQVQKHSWDGLRSIIHGSRKYSGLIVNKAPHDFQFVQ
KTDESGPHSHRLYYLGMPYGSRENSLLYSEIPKKVRKEALLLLSWKQMLDHFQATPHHGV
YSREEELLRERKRLGVFGITSYDFHSESGLFLFQASNSLFHCRDGGKNGFMVSPMKPLEI
KTQCSGPRMDPKICPADPAFFSFINNSDLWVANIETGEERRLTFCHQGLSNVLDDPKSAG
VATFVIQEEFDRFTGYWWCPTASWEGSEGLKTLRILYEEVDESEVEVIHVPSPALEERKT
DSYRYPRTGSKNPKIALKLAEFQTDSQGKIVSTQEKELVQPFSSLFPKVEYIARAGWTRD
GKYAWAMFLDRPQQWLQLVLLPPALFIPSTENEEQRLASARAVPRNVQPYVVYEEVTNVW
INVHDIFYPFPQSEGEDELCFLRANECKTGFCHLYKVTAVLKSQGYDWSEPFSPGEDEFK
CPIKEEIALTSGEWEVLARHGSKIWVNEETKLVYFQGTKDTPLEHHLYVVSYEAAGEIVR
LTTPGFSHSCSMSQNFDMFVSHYSSVSTPP
CVHVYKLSGPDDDPLHKQPRFWASMMEAAS
CPPDYVPPEIFHFHTRSDVRLYGMIYKPHALQPGKKHPTVLFVYGGPQVQLVNNSFKGIK
YLRLNTLASLGYAVVVIDGRGSCQRGLRFEGALKNQMGQVEIEDQVEGLQFVAEKYGFID
LSRVAIHGWSYGGFLSLMGLIHKPQVFKVAIAGAPVTVWMAYDTGYTERYMDVPENNQHG
YEAGSVALHVEKLPNEPNRLLILHGFLDENVHFFHTNFLVSQLIRAGKPYQLQIYPNERH
SIRCPESGEHYEVTLLHFLQEYL
Sequence length 863
Interactions View interactions
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Causal
Disease term Disease name dbSNP ID References
Bronchiectasis Bronchiectasis rs121908758, rs121908811, rs76649725, rs267606722, rs121909008, rs387906360, rs387906361, rs80034486, rs74767530, rs121908776, rs121909012, rs77646904, rs121908754, rs121909015, rs121909016
View all (214 more)
Pulmonary fibrosis Pulmonary Fibrosis, Idiopathic Pulmonary Fibrosis, Familial Idiopathic Pulmonary Fibrosis, Idiopathic pulmonary fibrosis rs121918666, rs199422300, rs121917834, rs199422294, rs201159197, rs199422297, rs199422305, rs751381953, rs876661305, rs878853260, rs1555811762, rs1060502990, rs1555903332, rs1554038539, rs1554042899
View all (1 more)
23583980
Unknown
Disease term Disease name Evidence References Source
Pulmonary Fibrosis Pulmonary Fibrosis GWAS
Associations from Text Mining
Disease Name Relationship Type References
Bacterial Infections Associate 34001247
Carcinoma Non Small Cell Lung Associate 27943262
Chronic Kidney Disease Mineral and Bone Disorder Associate 38458339
COVID 19 Associate 33307546, 34001247, 34823125, 35131543, 35212764, 36292769, 37794074, 39344392, 39615159, 39876559
Diabetes Mellitus Type 2 Associate 23519473
Dyskeratosis Congenita Autosomal Dominant Associate 30291141
Heart Diseases Associate 35748249
Hematologic Neoplasms Associate 37048172
Hereditary Autoinflammatory Diseases Associate 30291141, 37544411
Idiopathic Pulmonary Fibrosis Associate 31339356, 34001247, 37794074, 39615159, 39876559