Gene Gene information from NCBI Gene database.
Entrez ID 91039
Gene name Dipeptidyl peptidase 9
Gene symbol DPP9
Synonyms (NCBI Gene)
DP9DPLP9DPP IXDPRP-2DPRP2HATISIMD111
Chromosome 19
Chromosome location 19p13.3
Summary This gene encodes a protein that is a member of the S9B family in clan SC of the serine proteases. The protein has been shown to have post-proline dipeptidyl aminopeptidase activity, cleaving Xaa-Pro dipeptides from the N-termini of proteins. Although the
miRNA miRNA information provided by mirtarbase database.
416
miRTarBase ID miRNA Experiments Reference
MIRT020452 hsa-miR-106b-5p Microarray 17242205
MIRT676097 hsa-miR-5582-5p HITS-CLIP 23824327
MIRT676096 hsa-miR-3622a-5p HITS-CLIP 23824327
MIRT676095 hsa-miR-1295b-3p HITS-CLIP 23824327
MIRT676094 hsa-miR-4740-3p HITS-CLIP 23824327
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
25
GO ID Ontology Definition Evidence Reference
GO:0004177 Function Aminopeptidase activity IEA
GO:0005515 Function Protein binding IPI 30291141, 31525884, 32814053, 33731929, 33961781
GO:0005634 Component Nucleus IEA
GO:0005737 Component Cytoplasm IEA
GO:0005829 Component Cytosol IDA 15245913
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
608258 18648 ENSG00000142002
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
Q86TI2
Protein name Dipeptidyl peptidase 9 (DP9) (EC 3.4.14.5) (Dipeptidyl peptidase IV-related protein 2) (DPRP-2) (Dipeptidyl peptidase IX) (DPP IX) (Dipeptidyl peptidase-like protein 9) (DPLP9)
Protein function Dipeptidyl peptidase that cleaves off N-terminal dipeptides from proteins having a Pro or Ala residue at position 2 (PubMed:12662155, PubMed:16475979, PubMed:19667070, PubMed:29382749, PubMed:30291141, PubMed:33731929, PubMed:36112693). Acts as
PDB 6EOQ , 6EOR , 6QZV , 6X6A , 6X6C , 7A3F , 7JKQ , 7JN7 , 7SVL , 7SVN , 7ZXS
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00930 DPPIV_N 146 570 Dipeptidyl peptidase IV (DPP IV) N-terminal region Family
PF00326 Peptidase_S9 658 863 Prolyl oligopeptidase family Domain
Tissue specificity TISSUE SPECIFICITY: Ubiquitously expressed, with highest levels in liver, heart and muscle, and lowest levels in brain. {ECO:0000269|PubMed:12459266, ECO:0000269|PubMed:12662155, ECO:0000269|PubMed:15245913}.
Sequence
MATTGTPTADRGDAAATDDPAARFQVQKHSWDGLRSIIHGSRKYSGLIVNKAPHDFQFVQ
KTDESGPHSHRLYYLGMPYGSRENSLLYSEIPKKVRKEALLLLSWKQMLDHFQATPHHGV
YSREEELLRERKRLGVFGITSYDFHSESGLFLFQASNSLFHCRDGGKNGFMVSPMKPLEI
KTQCSGPRMDPKICPADPAFFSFINNSDLWVANIETGEERRLTFCHQGLSNVLDDPKSAG
VATFVIQEEFDRFTGYWWCPTASWEGSEGLKTLRILYEEVDESEVEVIHVPSPALEERKT
DSYRYPRTGSKNPKIALKLAEFQTDSQGKIVSTQEKELVQPFSSLFPKVEYIARAGWTRD
GKYAWAMFLDRPQQWLQLVLLPPALFIPSTENEEQRLASARAVPRNVQPYVVYEEVTNVW
INVHDIFYPFPQSEGEDELCFLRANECKTGFCHLYKVTAVLKSQGYDWSEPFSPGEDEFK
CPIKEEIALTSGEWEVLARHGSKIWVNEETKLVYFQGTKDTPLEHHLYVVSYEAAGEIVR
LTTPGFSHSCSMSQNFDMFVSHYSSVSTPP
CVHVYKLSGPDDDPLHKQPRFWASMMEAAS
CPPDYVPPEIFHFHTRSDVRLYGMIYKPHALQPGKKHPTVLFVYGGPQVQLVNNSFKGIK
YLRLNTLASLGYAVVVIDGRGSCQRGLRFEGALKNQMGQVEIEDQVEGLQFVAEKYGFID
LSRVAIHGWSYGGFLSLMGLIHKPQVFKVAIAGAPVTVWMAYDTGYTERYMDVPENNQHG
YEAGSVALHVEKLPNEPNRLLILHGFLDENVHFFHTNFLVSQLIRAGKPYQLQIYPNERH
SIRCPESGEHYEVTLLHFLQEYL
Sequence length 863
Interactions View interactions
Associated diseases Disease associations from ClinVar categorized as Causal (Pathogenic/Likely Pathogenic) or Unknown.
10
Causal Diseases associated with Pathogenic or Likely Pathogenic variants in ClinVar
Phenotype Name Clinical Significance dbSNP ID RCV Accession
Hatipoglu immunodeficiency syndrome Pathogenic rs2512344317, rs779854175 RCV003224653
RCV003224654
Unknown Diseases with uncertain, conflicting, or no pathogenic evidence in ClinVar
Phenotype Name Clinical Significance dbSNP ID RCV Accession
Clear cell carcinoma of kidney Uncertain significance rs201281354 RCV005937454
Familial cancer of breast Uncertain significance rs201281354 RCV005937452
Malignant tumor of esophagus Uncertain significance rs981730364 RCV005927288
Malignant tumor of urinary bladder Uncertain significance rs201281354 RCV005937453
Associations from Text MiningDisease associations identified through Pubtator
Disease Name Relationship Type References
Bacterial Infections Associate 34001247
Carcinoma Non Small Cell Lung Associate 27943262
Chronic Kidney Disease Mineral and Bone Disorder Associate 38458339
COVID 19 Associate 33307546, 34001247, 34823125, 35131543, 35212764, 36292769, 37794074, 39344392, 39615159, 39876559
Diabetes Mellitus Type 2 Associate 23519473
Dyskeratosis Congenita Autosomal Dominant Associate 30291141
Heart Diseases Associate 35748249
Hematologic Neoplasms Associate 37048172
Hereditary Autoinflammatory Diseases Associate 30291141, 37544411
Idiopathic Pulmonary Fibrosis Associate 31339356, 34001247, 37794074, 39615159, 39876559