Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Associated diseases
Entrez ID	90987
Gene name	Zinc finger protein 251
Gene symbol	ZNF251
Synonyms (NCBI Gene)	-
Chromosome	8
Chromosome location	8q24.3

Show/Hide all (88)

miRTarBase ID	miRNA	Experiments	Reference
MIRT017209	hsa-miR-335-5p	Microarray	18185580
MIRT1519256	hsa-miR-1305	CLIP-seq
MIRT1519257	hsa-miR-361-5p	CLIP-seq
MIRT1519258	hsa-miR-3684	CLIP-seq
MIRT1519259	hsa-miR-3977	CLIP-seq
MIRT1519260	hsa-miR-4282	CLIP-seq
MIRT1519261	hsa-miR-4528	CLIP-seq
MIRT1519262	hsa-miR-4633-5p	CLIP-seq
MIRT1519263	hsa-miR-576-5p	CLIP-seq
MIRT2156727	hsa-miR-4293	CLIP-seq
MIRT2376424	hsa-miR-1200	CLIP-seq
MIRT2376425	hsa-miR-1202	CLIP-seq
MIRT2376426	hsa-miR-1265	CLIP-seq
MIRT2376427	hsa-miR-1324	CLIP-seq
MIRT2376428	hsa-miR-29a	CLIP-seq
MIRT2376429	hsa-miR-29b	CLIP-seq
MIRT2376430	hsa-miR-29c	CLIP-seq
MIRT2376431	hsa-miR-3065-3p	CLIP-seq
MIRT2376432	hsa-miR-3120-3p	CLIP-seq
MIRT2376433	hsa-miR-3132	CLIP-seq
MIRT2376434	hsa-miR-3202	CLIP-seq
MIRT2376435	hsa-miR-3529	CLIP-seq
MIRT2376436	hsa-miR-3663-3p	CLIP-seq
MIRT2376437	hsa-miR-3713	CLIP-seq
MIRT2376438	hsa-miR-379	CLIP-seq
MIRT2376439	hsa-miR-3941	CLIP-seq
MIRT2376440	hsa-miR-3972	CLIP-seq
MIRT2376441	hsa-miR-4324	CLIP-seq
MIRT2376442	hsa-miR-4533	CLIP-seq
MIRT2376443	hsa-miR-466	CLIP-seq
MIRT2376444	hsa-miR-4672	CLIP-seq
MIRT2376445	hsa-miR-4776-3p	CLIP-seq
MIRT2376446	hsa-miR-496	CLIP-seq
MIRT2376447	hsa-miR-5096	CLIP-seq
MIRT2376448	hsa-miR-541	CLIP-seq
MIRT2376449	hsa-miR-544b	CLIP-seq
MIRT2668698	hsa-miR-1254	CLIP-seq
MIRT2376426	hsa-miR-1265	CLIP-seq
MIRT2668699	hsa-miR-1912	CLIP-seq
MIRT2668700	hsa-miR-2117	CLIP-seq
MIRT2668701	hsa-miR-2861	CLIP-seq
MIRT2668702	hsa-miR-3116	CLIP-seq
MIRT2376433	hsa-miR-3132	CLIP-seq
MIRT2668703	hsa-miR-3157-5p	CLIP-seq
MIRT2376434	hsa-miR-3202	CLIP-seq
MIRT2376435	hsa-miR-3529	CLIP-seq
MIRT2668704	hsa-miR-3681	CLIP-seq
MIRT2668705	hsa-miR-3691-5p	CLIP-seq
MIRT2376438	hsa-miR-379	CLIP-seq
MIRT2668706	hsa-miR-4261	CLIP-seq
MIRT2668707	hsa-miR-4273	CLIP-seq
MIRT2668708	hsa-miR-4432	CLIP-seq
MIRT2668709	hsa-miR-4463	CLIP-seq
MIRT2668710	hsa-miR-4496	CLIP-seq
MIRT2376442	hsa-miR-4533	CLIP-seq
MIRT2668711	hsa-miR-4691-3p	CLIP-seq
MIRT2668712	hsa-miR-4764-5p	CLIP-seq
MIRT2668713	hsa-miR-4796-3p	CLIP-seq
MIRT2668714	hsa-miR-499-5p	CLIP-seq
MIRT2668715	hsa-miR-661	CLIP-seq
MIRT2668698	hsa-miR-1254	CLIP-seq
MIRT2376426	hsa-miR-1265	CLIP-seq
MIRT2668699	hsa-miR-1912	CLIP-seq
MIRT2668700	hsa-miR-2117	CLIP-seq
MIRT2668701	hsa-miR-2861	CLIP-seq
MIRT2376428	hsa-miR-29a	CLIP-seq
MIRT2376429	hsa-miR-29b	CLIP-seq
MIRT2376430	hsa-miR-29c	CLIP-seq
MIRT2668702	hsa-miR-3116	CLIP-seq
MIRT2376433	hsa-miR-3132	CLIP-seq
MIRT2668703	hsa-miR-3157-5p	CLIP-seq
MIRT2376434	hsa-miR-3202	CLIP-seq
MIRT2376435	hsa-miR-3529	CLIP-seq
MIRT2376436	hsa-miR-3663-3p	CLIP-seq
MIRT2668704	hsa-miR-3681	CLIP-seq
MIRT2668705	hsa-miR-3691-5p	CLIP-seq
MIRT2376438	hsa-miR-379	CLIP-seq
MIRT2668706	hsa-miR-4261	CLIP-seq
MIRT2668707	hsa-miR-4273	CLIP-seq
MIRT2668708	hsa-miR-4432	CLIP-seq
MIRT2668709	hsa-miR-4463	CLIP-seq
MIRT2668710	hsa-miR-4496	CLIP-seq
MIRT2376442	hsa-miR-4533	CLIP-seq
MIRT2668711	hsa-miR-4691-3p	CLIP-seq
MIRT2668712	hsa-miR-4764-5p	CLIP-seq
MIRT2668713	hsa-miR-4796-3p	CLIP-seq
MIRT2668714	hsa-miR-499-5p	CLIP-seq
MIRT2668715	hsa-miR-661	CLIP-seq

Show/Hide all (12)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000978	Function	RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA
GO:0000981	Function	DNA-binding transcription factor activity, RNA polymerase II-specific	IBA
GO:0003677	Function	DNA binding	IEA
GO:0005515	Function	Protein binding	IPI	32296183
GO:0005634	Component	Nucleus	IBA
GO:0005634	Component	Nucleus	IEA
GO:0006355	Process	Regulation of DNA-templated transcription	IEA
GO:0006357	Process	Regulation of transcription by RNA polymerase II	IBA
GO:0008270	Function	Zinc ion binding	IEA
GO:0046872	Function	Metal ion binding	IEA
GO:0061484	Process	Hematopoietic stem cell homeostasis	IEA
GO:1990837	Function	Sequence-specific double-stranded DNA binding	IEA

MIM	HGNC	e!Ensembl
HGNC	N/A	HGNC

Q9BRH9

Protein name

Zinc finger protein 251

Protein function

May be involved in transcriptional regulation.

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF01352	KRAB	14 → 55	KRAB box	Family
PF00096	zf-C2H2	209 → 231	Zinc finger, C2H2 type	Domain
PF00096	zf-C2H2	237 → 259	Zinc finger, C2H2 type	Domain
PF00096	zf-C2H2	265 → 287	Zinc finger, C2H2 type	Domain
PF00096	zf-C2H2	293 → 315	Zinc finger, C2H2 type	Domain
PF00096	zf-C2H2	321 → 343	Zinc finger, C2H2 type	Domain
PF00096	zf-C2H2	349 → 371	Zinc finger, C2H2 type	Domain
PF00096	zf-C2H2	377 → 399	Zinc finger, C2H2 type	Domain
PF00096	zf-C2H2	405 → 427	Zinc finger, C2H2 type	Domain
PF00096	zf-C2H2	433 → 455	Zinc finger, C2H2 type	Domain
PF00096	zf-C2H2	461 → 483	Zinc finger, C2H2 type	Domain
PF00096	zf-C2H2	489 → 511	Zinc finger, C2H2 type	Domain
PF00096	zf-C2H2	594 → 616	Zinc finger, C2H2 type	Domain

Sequence

MAATFQLPGHQEMPLTFQDVAVYFSQAEGRQLGPQQRALYRDVMLENYGNVASLGFPVPK
PELISQLEQGKELWVLNLLGAEEPDILKSCQKDSEVGTKKELSILNQKFSEEVKTPEFVS
RRLLRDNAQAAEFREAWGREGKLKERVGNSAGQSLNKPNIHKRVLTEATVGRERSLGERT
QECSAFDRNLNLDQNVVRLQRNKTGERVFKCDICSKTFKYNSDLSRHQRSHTGEKPYECG
RCGRAFTHSSNLVLHHHIHTGNKPFKCDECGKTFGLNSHLRLHRRIHTGEKPFGCGECGK
AFSRSSTLIQHRIIHTGEKPYKCNECGRGFSQSPQLTQHQRIHTGEKPHECSHCGKAFSR
SSSLIQHERIHTGEKPHKCNQCGKAFSQSSSLFLHHRVHTGEKPYVCNECGRAFGFNSHL
TEHVRIHTGEKPYVCNECGKAFRRSSTLVQHRRVHTGEKPYQCVECGKAFSQSSQLTLHQ
RVHTGEKPYDCGDCGKAFSRRSTLIQHQKVHSGETRKCRKHGPAFVHGSSLTADGQIPTG
EKHGRAFNHGANLILRWTVHTGEKSFGCNEYGKAFSPTSRPTEDQIMHAGEKPYKCQECG
NAFSGKSTLIQHQVTHTGQKPCHCSVYGKAFSQSSQLTPPQQTRVGEKPALNDGSKRYFI
HIKKIFQERHF

Sequence length

671

Interactions

View interactions

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (1)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
TYPE 2 DIABETES MELLITUS	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (3)

Disease Name	Relationship Type	References	Evidence Score
Associations from Text MiningDisease associations identified through Pubtator
Attention Deficit Disorder with Hyperactivity	Associate	30610198	★★★★★ ★☆☆☆☆ Found in Text Mining only
Hereditary Breast and Ovarian Cancer Syndrome	Associate	39892701	★★★★★ ★☆☆☆☆ Found in Text Mining only
Neoplasms	Associate	39892701	★★★★★ ★☆☆☆☆ Found in Text Mining only

ZNF251 (zinc finger protein 251)