Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	9093
Gene name Gene Name - the full gene name approved by the HGNC.	DnaJ heat shock protein family (Hsp40) member A3
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	DNAJA3
Synonyms (NCBI Gene) Gene synonyms aliases	HCA57, TID1, Tid1-L, Tid1-S, hTID-1
Chromosome Chromosome number	16
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	16p13.3
Summary Summary of gene provided in NCBI Entrez Gene.	This gene encodes a member of the DNAJ/Hsp40 protein family. DNAJ/Hsp40 proteins stimulate the ATPase activity of Hsp70 chaperones and play critical roles in protein folding, degradation, and multimeric complex assembly. The encoded protein is localized t

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miRTarBase ID	miRNA	Experiments	Reference
MIRT029308	hsa-miR-26b-5p	Microarray	19088304
MIRT049135	hsa-miR-92a-3p	CLASH	23622248
MIRT048688	hsa-miR-99a-5p	CLASH	23622248
MIRT045410	hsa-miR-149-5p	CLASH	23622248
MIRT043778	hsa-miR-328-3p	CLASH	23622248
MIRT042039	hsa-miR-484	CLASH	23622248
MIRT041303	hsa-miR-193b-3p	CLASH	23622248
MIRT040500	hsa-miR-550a-3p	CLASH	23622248
MIRT939707	hsa-miR-1233	CLIP-seq
MIRT939708	hsa-miR-1254	CLIP-seq
MIRT939709	hsa-miR-1301	CLIP-seq
MIRT939710	hsa-miR-1324	CLIP-seq
MIRT939711	hsa-miR-181a	CLIP-seq
MIRT939712	hsa-miR-181b	CLIP-seq
MIRT939713	hsa-miR-181c	CLIP-seq
MIRT939714	hsa-miR-181d	CLIP-seq
MIRT939715	hsa-miR-1915	CLIP-seq
MIRT939716	hsa-miR-214	CLIP-seq
MIRT939717	hsa-miR-2278	CLIP-seq
MIRT939718	hsa-miR-24	CLIP-seq
MIRT939719	hsa-miR-298	CLIP-seq
MIRT939720	hsa-miR-3116	CLIP-seq
MIRT939721	hsa-miR-3117-5p	CLIP-seq
MIRT939722	hsa-miR-3121-3p	CLIP-seq
MIRT939723	hsa-miR-3148	CLIP-seq
MIRT939724	hsa-miR-3154	CLIP-seq
MIRT939725	hsa-miR-320e	CLIP-seq
MIRT939726	hsa-miR-326	CLIP-seq
MIRT939727	hsa-miR-330-5p	CLIP-seq
MIRT939728	hsa-miR-3591-5p	CLIP-seq
MIRT939729	hsa-miR-3606	CLIP-seq
MIRT939730	hsa-miR-361-3p	CLIP-seq
MIRT939731	hsa-miR-3619-5p	CLIP-seq
MIRT939732	hsa-miR-374c	CLIP-seq
MIRT939733	hsa-miR-421	CLIP-seq
MIRT939734	hsa-miR-4262	CLIP-seq
MIRT939735	hsa-miR-4263	CLIP-seq
MIRT939736	hsa-miR-4284	CLIP-seq
MIRT939737	hsa-miR-4290	CLIP-seq
MIRT939738	hsa-miR-4291	CLIP-seq
MIRT939739	hsa-miR-4421	CLIP-seq
MIRT939740	hsa-miR-4427	CLIP-seq
MIRT939741	hsa-miR-4436b-3p	CLIP-seq
MIRT939742	hsa-miR-4468	CLIP-seq
MIRT939743	hsa-miR-4474-3p	CLIP-seq
MIRT939744	hsa-miR-4660	CLIP-seq
MIRT939745	hsa-miR-4680-3p	CLIP-seq
MIRT939746	hsa-miR-4687-5p	CLIP-seq
MIRT939747	hsa-miR-4700-3p	CLIP-seq
MIRT939748	hsa-miR-4709-5p	CLIP-seq
MIRT939749	hsa-miR-4720-3p	CLIP-seq
MIRT939750	hsa-miR-4722-5p	CLIP-seq
MIRT939751	hsa-miR-4762-3p	CLIP-seq
MIRT939752	hsa-miR-490-3p	CLIP-seq
MIRT939753	hsa-miR-5047	CLIP-seq
MIRT939754	hsa-miR-505	CLIP-seq
MIRT939755	hsa-miR-520d-5p	CLIP-seq
MIRT939756	hsa-miR-524-5p	CLIP-seq
MIRT939757	hsa-miR-576-3p	CLIP-seq
MIRT939758	hsa-miR-576-5p	CLIP-seq
MIRT939759	hsa-miR-579	CLIP-seq
MIRT939760	hsa-miR-603	CLIP-seq
MIRT939761	hsa-miR-649	CLIP-seq
MIRT939762	hsa-miR-655	CLIP-seq
MIRT939763	hsa-miR-661	CLIP-seq
MIRT939764	hsa-miR-761	CLIP-seq
MIRT939765	hsa-miR-921	CLIP-seq
MIRT939766	hsa-miR-922	CLIP-seq
MIRT1977926	hsa-miR-1207-5p	CLIP-seq
MIRT939707	hsa-miR-1233	CLIP-seq
MIRT939708	hsa-miR-1254	CLIP-seq
MIRT1977927	hsa-miR-1273c	CLIP-seq
MIRT1977928	hsa-miR-128	CLIP-seq
MIRT939710	hsa-miR-1324	CLIP-seq
MIRT1977929	hsa-miR-1587	CLIP-seq
MIRT939711	hsa-miR-181a	CLIP-seq
MIRT939712	hsa-miR-181b	CLIP-seq
MIRT939713	hsa-miR-181c	CLIP-seq
MIRT939714	hsa-miR-181d	CLIP-seq
MIRT1977930	hsa-miR-2110	CLIP-seq
MIRT939716	hsa-miR-214	CLIP-seq
MIRT939718	hsa-miR-24	CLIP-seq
MIRT1977931	hsa-miR-2467-3p	CLIP-seq
MIRT939719	hsa-miR-298	CLIP-seq
MIRT939720	hsa-miR-3116	CLIP-seq
MIRT939721	hsa-miR-3117-5p	CLIP-seq
MIRT939724	hsa-miR-3154	CLIP-seq
MIRT1977932	hsa-miR-3158-3p	CLIP-seq
MIRT1977933	hsa-miR-3176	CLIP-seq
MIRT939731	hsa-miR-3619-5p	CLIP-seq
MIRT1977934	hsa-miR-3683	CLIP-seq
MIRT1977935	hsa-miR-3688-3p	CLIP-seq
MIRT1977936	hsa-miR-3714	CLIP-seq
MIRT939732	hsa-miR-374c	CLIP-seq
MIRT1977937	hsa-miR-3922-3p	CLIP-seq
MIRT1977938	hsa-miR-4261	CLIP-seq
MIRT939734	hsa-miR-4262	CLIP-seq
MIRT1977939	hsa-miR-4270	CLIP-seq
MIRT1977940	hsa-miR-4271	CLIP-seq
MIRT1977941	hsa-miR-4277	CLIP-seq
MIRT939736	hsa-miR-4284	CLIP-seq
MIRT939737	hsa-miR-4290	CLIP-seq
MIRT939738	hsa-miR-4291	CLIP-seq
MIRT1977942	hsa-miR-4420	CLIP-seq
MIRT1977943	hsa-miR-4435	CLIP-seq
MIRT939741	hsa-miR-4436b-3p	CLIP-seq
MIRT1977944	hsa-miR-4441	CLIP-seq
MIRT939743	hsa-miR-4474-3p	CLIP-seq
MIRT1977945	hsa-miR-4492	CLIP-seq
MIRT1977946	hsa-miR-4498	CLIP-seq
MIRT1977947	hsa-miR-4505	CLIP-seq
MIRT1977948	hsa-miR-4530	CLIP-seq
MIRT1977949	hsa-miR-4643	CLIP-seq
MIRT1977950	hsa-miR-4656	CLIP-seq
MIRT1977951	hsa-miR-4667-5p	CLIP-seq
MIRT1977952	hsa-miR-4675	CLIP-seq
MIRT939746	hsa-miR-4687-5p	CLIP-seq
MIRT939747	hsa-miR-4700-3p	CLIP-seq
MIRT1977953	hsa-miR-4700-5p	CLIP-seq
MIRT939748	hsa-miR-4709-5p	CLIP-seq
MIRT1977954	hsa-miR-4717-3p	CLIP-seq
MIRT939750	hsa-miR-4722-5p	CLIP-seq
MIRT1977955	hsa-miR-4725-3p	CLIP-seq
MIRT1977956	hsa-miR-4731-5p	CLIP-seq
MIRT1977957	hsa-miR-4736	CLIP-seq
MIRT1977958	hsa-miR-4738-3p	CLIP-seq
MIRT1977959	hsa-miR-4741	CLIP-seq
MIRT1977960	hsa-miR-4763-3p	CLIP-seq
MIRT1977961	hsa-miR-4790-3p	CLIP-seq
MIRT1977962	hsa-miR-4802-3p	CLIP-seq
MIRT1977963	hsa-miR-485-5p	CLIP-seq
MIRT1977964	hsa-miR-494	CLIP-seq
MIRT1977965	hsa-miR-512-3p	CLIP-seq
MIRT1977966	hsa-miR-634	CLIP-seq
MIRT939762	hsa-miR-655	CLIP-seq
MIRT939763	hsa-miR-661	CLIP-seq
MIRT939764	hsa-miR-761	CLIP-seq
MIRT1977967	hsa-miR-762	CLIP-seq
MIRT1977968	hsa-miR-767-3p	CLIP-seq
MIRT939766	hsa-miR-922	CLIP-seq
MIRT1977927	hsa-miR-1273c	CLIP-seq
MIRT939709	hsa-miR-1301	CLIP-seq
MIRT939710	hsa-miR-1324	CLIP-seq
MIRT939711	hsa-miR-181a	CLIP-seq
MIRT939712	hsa-miR-181b	CLIP-seq
MIRT939713	hsa-miR-181c	CLIP-seq
MIRT939714	hsa-miR-181d	CLIP-seq
MIRT1977930	hsa-miR-2110	CLIP-seq
MIRT939721	hsa-miR-3117-5p	CLIP-seq
MIRT939722	hsa-miR-3121-3p	CLIP-seq
MIRT2213373	hsa-miR-3140-5p	CLIP-seq
MIRT939725	hsa-miR-320e	CLIP-seq
MIRT2213374	hsa-miR-338-5p	CLIP-seq
MIRT2213375	hsa-miR-34b	CLIP-seq
MIRT1977934	hsa-miR-3683	CLIP-seq
MIRT1977935	hsa-miR-3688-3p	CLIP-seq
MIRT939733	hsa-miR-421	CLIP-seq
MIRT1977938	hsa-miR-4261	CLIP-seq
MIRT939734	hsa-miR-4262	CLIP-seq
MIRT939735	hsa-miR-4263	CLIP-seq
MIRT1977940	hsa-miR-4271	CLIP-seq
MIRT1977941	hsa-miR-4277	CLIP-seq
MIRT939739	hsa-miR-4421	CLIP-seq
MIRT1977949	hsa-miR-4643	CLIP-seq
MIRT939744	hsa-miR-4660	CLIP-seq
MIRT2213376	hsa-miR-4671-5p	CLIP-seq
MIRT939748	hsa-miR-4709-5p	CLIP-seq
MIRT1977954	hsa-miR-4717-3p	CLIP-seq
MIRT939749	hsa-miR-4720-3p	CLIP-seq
MIRT1977955	hsa-miR-4725-3p	CLIP-seq
MIRT1977958	hsa-miR-4738-3p	CLIP-seq
MIRT1977962	hsa-miR-4802-3p	CLIP-seq
MIRT939752	hsa-miR-490-3p	CLIP-seq
MIRT2213377	hsa-miR-491-5p	CLIP-seq
MIRT1977964	hsa-miR-494	CLIP-seq
MIRT939753	hsa-miR-5047	CLIP-seq
MIRT939754	hsa-miR-505	CLIP-seq
MIRT939757	hsa-miR-576-3p	CLIP-seq
MIRT939758	hsa-miR-576-5p	CLIP-seq
MIRT939759	hsa-miR-579	CLIP-seq
MIRT939760	hsa-miR-603	CLIP-seq
MIRT1977966	hsa-miR-634	CLIP-seq
MIRT939761	hsa-miR-649	CLIP-seq
MIRT1977958	hsa-miR-4738-3p	CLIP-seq
MIRT939710	hsa-miR-1324	CLIP-seq
MIRT939711	hsa-miR-181a	CLIP-seq
MIRT939712	hsa-miR-181b	CLIP-seq
MIRT939713	hsa-miR-181c	CLIP-seq
MIRT939714	hsa-miR-181d	CLIP-seq
MIRT939721	hsa-miR-3117-5p	CLIP-seq
MIRT939734	hsa-miR-4262	CLIP-seq
MIRT2517147	hsa-miR-1226	CLIP-seq
MIRT2517148	hsa-miR-1263	CLIP-seq
MIRT2517149	hsa-miR-1285	CLIP-seq
MIRT939709	hsa-miR-1301	CLIP-seq
MIRT2517150	hsa-miR-148a	CLIP-seq
MIRT2517151	hsa-miR-148b	CLIP-seq
MIRT2517152	hsa-miR-152	CLIP-seq
MIRT2517153	hsa-miR-185	CLIP-seq
MIRT939715	hsa-miR-1915	CLIP-seq
MIRT2517154	hsa-miR-197	CLIP-seq
MIRT2517155	hsa-miR-198	CLIP-seq
MIRT2517156	hsa-miR-2115	CLIP-seq
MIRT939717	hsa-miR-2278	CLIP-seq
MIRT2517157	hsa-miR-2467-5p	CLIP-seq
MIRT2517158	hsa-miR-2861	CLIP-seq
MIRT2517159	hsa-miR-3184	CLIP-seq
MIRT2517160	hsa-miR-3187-5p	CLIP-seq
MIRT2517161	hsa-miR-3194-3p	CLIP-seq
MIRT2517162	hsa-miR-324-5p	CLIP-seq
MIRT939726	hsa-miR-326	CLIP-seq
MIRT939727	hsa-miR-330-5p	CLIP-seq
MIRT939730	hsa-miR-361-3p	CLIP-seq
MIRT2517163	hsa-miR-3621	CLIP-seq
MIRT2517164	hsa-miR-3656	CLIP-seq
MIRT2517165	hsa-miR-3670	CLIP-seq
MIRT2517166	hsa-miR-378g	CLIP-seq
MIRT2517167	hsa-miR-3922-5p	CLIP-seq
MIRT2517168	hsa-miR-3944-5p	CLIP-seq
MIRT2517169	hsa-miR-423-5p	CLIP-seq
MIRT2517170	hsa-miR-4269	CLIP-seq
MIRT2517171	hsa-miR-4283	CLIP-seq
MIRT2517172	hsa-miR-4300	CLIP-seq
MIRT2517173	hsa-miR-4306	CLIP-seq
MIRT2517174	hsa-miR-432	CLIP-seq
MIRT2517175	hsa-miR-4423-5p	CLIP-seq
MIRT2517176	hsa-miR-4443	CLIP-seq
MIRT939742	hsa-miR-4468	CLIP-seq
MIRT2517177	hsa-miR-4480	CLIP-seq
MIRT2517178	hsa-miR-4486	CLIP-seq
MIRT2517179	hsa-miR-4489	CLIP-seq
MIRT2517180	hsa-miR-4637	CLIP-seq
MIRT2517181	hsa-miR-4644	CLIP-seq
MIRT2517182	hsa-miR-4645-5p	CLIP-seq
MIRT2517183	hsa-miR-4646-3p	CLIP-seq
MIRT939744	hsa-miR-4660	CLIP-seq
MIRT1977951	hsa-miR-4667-5p	CLIP-seq
MIRT2517184	hsa-miR-4673	CLIP-seq
MIRT1977952	hsa-miR-4675	CLIP-seq
MIRT1977953	hsa-miR-4700-5p	CLIP-seq
MIRT2517185	hsa-miR-4715-3p	CLIP-seq
MIRT2517186	hsa-miR-4726-3p	CLIP-seq
MIRT2517187	hsa-miR-4734	CLIP-seq
MIRT1977959	hsa-miR-4741	CLIP-seq
MIRT2517188	hsa-miR-4757-5p	CLIP-seq
MIRT939753	hsa-miR-5047	CLIP-seq
MIRT1977965	hsa-miR-512-3p	CLIP-seq
MIRT2517189	hsa-miR-516a-3p	CLIP-seq
MIRT2517190	hsa-miR-520a-5p	CLIP-seq
MIRT2517191	hsa-miR-525-5p	CLIP-seq
MIRT2517192	hsa-miR-548ac	CLIP-seq
MIRT2517193	hsa-miR-548ae	CLIP-seq
MIRT2517194	hsa-miR-548aj	CLIP-seq
MIRT2517195	hsa-miR-548am	CLIP-seq
MIRT2517196	hsa-miR-548d-3p	CLIP-seq
MIRT2517197	hsa-miR-548x	CLIP-seq
MIRT2517198	hsa-miR-548z	CLIP-seq
MIRT2517199	hsa-miR-612	CLIP-seq
MIRT2517200	hsa-miR-637	CLIP-seq
MIRT2517201	hsa-miR-760	CLIP-seq
MIRT2517202	hsa-miR-920	CLIP-seq
MIRT2517147	hsa-miR-1226	CLIP-seq
MIRT2517148	hsa-miR-1263	CLIP-seq
MIRT1977927	hsa-miR-1273c	CLIP-seq
MIRT2517149	hsa-miR-1285	CLIP-seq
MIRT939709	hsa-miR-1301	CLIP-seq
MIRT2517153	hsa-miR-185	CLIP-seq
MIRT2679312	hsa-miR-1914	CLIP-seq
MIRT939715	hsa-miR-1915	CLIP-seq
MIRT2517154	hsa-miR-197	CLIP-seq
MIRT2517155	hsa-miR-198	CLIP-seq
MIRT1977930	hsa-miR-2110	CLIP-seq
MIRT2517156	hsa-miR-2115	CLIP-seq
MIRT2679313	hsa-miR-218	CLIP-seq
MIRT939717	hsa-miR-2278	CLIP-seq
MIRT1977931	hsa-miR-2467-3p	CLIP-seq
MIRT2517157	hsa-miR-2467-5p	CLIP-seq
MIRT2517158	hsa-miR-2861	CLIP-seq
MIRT2679314	hsa-miR-3124-3p	CLIP-seq
MIRT2679315	hsa-miR-3160-5p	CLIP-seq
MIRT2517159	hsa-miR-3184	CLIP-seq
MIRT2517160	hsa-miR-3187-5p	CLIP-seq
MIRT2517161	hsa-miR-3194-3p	CLIP-seq
MIRT2517162	hsa-miR-324-5p	CLIP-seq
MIRT939726	hsa-miR-326	CLIP-seq
MIRT939727	hsa-miR-330-5p	CLIP-seq
MIRT939730	hsa-miR-361-3p	CLIP-seq
MIRT2517163	hsa-miR-3621	CLIP-seq
MIRT2517164	hsa-miR-3656	CLIP-seq
MIRT2517165	hsa-miR-3670	CLIP-seq
MIRT1977934	hsa-miR-3683	CLIP-seq
MIRT2517166	hsa-miR-378g	CLIP-seq
MIRT2517167	hsa-miR-3922-5p	CLIP-seq
MIRT2517168	hsa-miR-3944-5p	CLIP-seq
MIRT2517169	hsa-miR-423-5p	CLIP-seq
MIRT2517170	hsa-miR-4269	CLIP-seq
MIRT1977940	hsa-miR-4271	CLIP-seq
MIRT2517171	hsa-miR-4283	CLIP-seq
MIRT2679316	hsa-miR-4293	CLIP-seq
MIRT2517172	hsa-miR-4300	CLIP-seq
MIRT2517173	hsa-miR-4306	CLIP-seq
MIRT2517174	hsa-miR-432	CLIP-seq
MIRT1977942	hsa-miR-4420	CLIP-seq
MIRT2517175	hsa-miR-4423-5p	CLIP-seq
MIRT2517176	hsa-miR-4443	CLIP-seq
MIRT939742	hsa-miR-4468	CLIP-seq
MIRT2517177	hsa-miR-4480	CLIP-seq
MIRT2517178	hsa-miR-4486	CLIP-seq
MIRT2517179	hsa-miR-4489	CLIP-seq
MIRT1977947	hsa-miR-4505	CLIP-seq
MIRT1977948	hsa-miR-4530	CLIP-seq
MIRT2517180	hsa-miR-4637	CLIP-seq
MIRT2517181	hsa-miR-4644	CLIP-seq
MIRT2517182	hsa-miR-4645-5p	CLIP-seq
MIRT2517183	hsa-miR-4646-3p	CLIP-seq
MIRT939744	hsa-miR-4660	CLIP-seq
MIRT1977951	hsa-miR-4667-5p	CLIP-seq
MIRT2517184	hsa-miR-4673	CLIP-seq
MIRT1977952	hsa-miR-4675	CLIP-seq
MIRT1977953	hsa-miR-4700-5p	CLIP-seq
MIRT2517185	hsa-miR-4715-3p	CLIP-seq
MIRT1977955	hsa-miR-4725-3p	CLIP-seq
MIRT2517186	hsa-miR-4726-3p	CLIP-seq
MIRT1977956	hsa-miR-4731-5p	CLIP-seq
MIRT2517187	hsa-miR-4734	CLIP-seq
MIRT1977959	hsa-miR-4741	CLIP-seq
MIRT2517188	hsa-miR-4757-5p	CLIP-seq
MIRT1977961	hsa-miR-4790-3p	CLIP-seq
MIRT1977963	hsa-miR-485-5p	CLIP-seq
MIRT2213377	hsa-miR-491-5p	CLIP-seq
MIRT939753	hsa-miR-5047	CLIP-seq
MIRT2517189	hsa-miR-516a-3p	CLIP-seq
MIRT2517190	hsa-miR-520a-5p	CLIP-seq
MIRT2517191	hsa-miR-525-5p	CLIP-seq
MIRT2679317	hsa-miR-541	CLIP-seq
MIRT2517192	hsa-miR-548ac	CLIP-seq
MIRT2517193	hsa-miR-548ae	CLIP-seq
MIRT2517194	hsa-miR-548aj	CLIP-seq
MIRT2517195	hsa-miR-548am	CLIP-seq
MIRT2517196	hsa-miR-548d-3p	CLIP-seq
MIRT2517197	hsa-miR-548x	CLIP-seq
MIRT2517198	hsa-miR-548z	CLIP-seq
MIRT2679318	hsa-miR-596	CLIP-seq
MIRT2517199	hsa-miR-612	CLIP-seq
MIRT1977966	hsa-miR-634	CLIP-seq
MIRT2679319	hsa-miR-636	CLIP-seq
MIRT2517200	hsa-miR-637	CLIP-seq
MIRT2679320	hsa-miR-654-5p	CLIP-seq
MIRT2517201	hsa-miR-760	CLIP-seq
MIRT1977968	hsa-miR-767-3p	CLIP-seq
MIRT2517202	hsa-miR-920	CLIP-seq
MIRT939766	hsa-miR-922	CLIP-seq

Show/Hide all(72)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000122	Process	Negative regulation of transcription by RNA polymerase II	IDA	21106534
GO:0002376	Process	Immune system process	IEA
GO:0002682	Process	Regulation of immune system process	IEA
GO:0005102	Function	Signaling receptor binding	IEA
GO:0005133	Function	Type II interferon receptor binding	IDA	11679576
GO:0005515	Function	Protein binding	IPI	10411904, 15520177, 15601829, 16531398, 16713569, 17230190, 17500595, 17588722, 21106534, 21242965, 23455924, 25416956, 32296183, 32814053, 35384245
GO:0005524	Function	ATP binding	IEA
GO:0005634	Component	Nucleus	IDA	11679576
GO:0005634	Component	Nucleus	IEA
GO:0005737	Component	Cytoplasm	IDA	11679576
GO:0005737	Component	Cytoplasm	IEA
GO:0005739	Component	Mitochondrion	HTP	34800366
GO:0005739	Component	Mitochondrion	IBA
GO:0005739	Component	Mitochondrion	IDA	20053669, 21231916
GO:0005739	Component	Mitochondrion	IEA
GO:0005759	Component	Mitochondrial matrix	IDA	10411904, 11719219
GO:0005759	Component	Mitochondrial matrix	IEA
GO:0005829	Component	Cytosol	IEA
GO:0005829	Component	Cytosol	IMP	16531398
GO:0005884	Component	Actin filament	IDA	17588722
GO:0005886	Component	Plasma membrane	IEA
GO:0006264	Process	Mitochondrial DNA replication	IEA
GO:0006457	Process	Protein folding	IDA	16531398
GO:0006457	Process	Protein folding	IEA
GO:0006915	Process	Apoptotic process	IEA
GO:0006915	Process	Apoptotic process	IEA
GO:0006924	Process	Activation-induced cell death of T cells	IEA
GO:0006950	Process	Response to stress	IEA
GO:0007005	Process	Mitochondrion organization	IBA
GO:0007005	Process	Mitochondrion organization	IEA
GO:0007264	Process	Small GTPase-mediated signal transduction	IEA
GO:0007528	Process	Neuromuscular junction development	IDA	19038220
GO:0007528	Process	Neuromuscular junction development	IEA
GO:0008270	Function	Zinc ion binding	IEA
GO:0008285	Process	Negative regulation of cell population proliferation	IDA	11719219
GO:0009408	Process	Response to heat	IEA
GO:0009898	Component	Cytoplasmic side of plasma membrane	IEA
GO:0009898	Component	Cytoplasmic side of plasma membrane	ISS
GO:0016020	Component	Membrane	IEA
GO:0019901	Function	Protein kinase binding	IBA
GO:0019901	Function	Protein kinase binding	IEA
GO:0019901	Function	Protein kinase binding	IPI	11679576, 15601829
GO:0030544	Function	Hsp70 protein binding	IEA
GO:0030695	Function	GTPase regulator activity	IEA
GO:0031072	Function	Heat shock protein binding	IEA
GO:0031398	Process	Positive regulation of protein ubiquitination	IDA	15520177
GO:0031594	Component	Neuromuscular junction	IEA
GO:0031594	Component	Neuromuscular junction	ISS
GO:0033077	Process	T cell differentiation in thymus	IEA
GO:0034341	Process	Response to type II interferon	IDA	11679576
GO:0042102	Process	Positive regulation of T cell proliferation	IEA
GO:0042127	Process	Regulation of cell population proliferation	IEA
GO:0042645	Component	Mitochondrial nucleoid	IDA	16531398
GO:0043065	Process	Positive regulation of apoptotic process	IDA	10411904
GO:0043066	Process	Negative regulation of apoptotic process	IDA	10411904
GO:0043069	Process	Negative regulation of programmed cell death	IEA
GO:0043069	Process	Negative regulation of programmed cell death	IEA
GO:0043124	Process	Negative regulation of canonical NF-kappaB signal transduction	IDA	11927590
GO:0044877	Function	Protein-containing complex binding	IDA	15601829
GO:0045202	Component	Synapse	IEA
GO:0045211	Component	Postsynaptic membrane	IEA
GO:0045211	Component	Postsynaptic membrane	ISS
GO:0046872	Function	Metal ion binding	IEA
GO:0050821	Process	Protein stabilization	IDA	11927590
GO:0051059	Function	NF-kappaB binding	IPI	15601829
GO:0051082	Function	Unfolded protein binding	IEA
GO:0060336	Process	Negative regulation of type II interferon-mediated signaling pathway	IDA	11679576
GO:0061629	Function	RNA polymerase II-specific DNA-binding transcription factor binding	IPI	16531398
GO:0071340	Process	Skeletal muscle acetylcholine-gated channel clustering	ISS
GO:0090398	Process	Cellular senescence	IEA
GO:0106137	Function	IkappaB kinase complex binding	IDA	15601829
GO:0140297	Function	DNA-binding transcription factor binding	IPI	21106534

MIM	HGNC	e!Ensembl
608382	11808	ENSG00000103423

Protein

UniProt ID

Q96EY1

Protein name

DnaJ homolog subfamily A member 3, mitochondrial (DnaJ protein Tid-1) (hTid-1) (Hepatocellular carcinoma-associated antigen 57) (Tumorous imaginal discs protein Tid56 homolog)

Protein function

Modulates apoptotic signal transduction or effector structures within the mitochondrial matrix. Affect cytochrome C release from the mitochondria and caspase 3 activation, but not caspase 8 activation. Isoform 1 increases apoptosis triggered by

PDB

2CTT , 2DN9 , 6IWS , 7X89

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00226	DnaJ	93 → 155	DnaJ domain	Domain
PF01556	DnaJ_C	209 → 413	DnaJ C terminal domain	Domain
PF00684	DnaJ_CXXCXGXG	236 → 302	DnaJ central domain	Domain

Tissue specificity

TISSUE SPECIFICITY: Widely expressed with highest levels in heart, liver, lung and skeletal muscles (PubMed:9683573). Also expressed in keratinocytes; expression level and distribution is altered in basal cell carcinomas (PubMed:12783860, PubMed:9683573).

Sequence

MAARCSTRWLLVVVGTPRLPAISGRGARPPREGVVGAWLSRKLSVPAFASSLTSCGPRAL
LTLRPGVSLTGTKHNPFICTASFHTSAPLAKEDYYQILGVPRNASQKEIKKAYYQLAKKY
HPDTNKDDPKAKEKFSQLAEAYEVLSDEVKRKQYDAYGSAGFDPGASGSQHSYWKGGPTV
DPEELFRKIFGEFSSSSFGDFQTVFDQPQEYFMELTFNQAAKGVNKEFTVNIMDTCERCN
GKGNEPGTKVQHCHYCGGSGMETINTGPFVMRSTCRRCGGRGSIIISPCVVCRGAGQAKQ
KKRVMIPVPAGVEDGQTVRMPVGKREIFITFRVQKSPVFRRDGADIHSDLFISIAQALLG
GTARAQGLYETINVTIPPGTQTDQKIRMGGKGIPRINSYGYGDHYIHIKIRVPKRLTSRQ
QSLILSYAEDETDVEGTVNGVTLTSSGGSTMDSSAGSKARREAGEDEEGFLSKLKKMFTS

Sequence length

480

Interactions

View interactions

	KEGG
	Viral carcinogenesis

Show/Hide Unknown Diseases (3)

Disease merge term	Disease name	Evidence	References	Source
Unknown Includes: (1) ClinVar NON-pathogenic variants (Uncertain, Benign, Conflicting, VUS), (2) GenCC associations, (3) GWAS associations, (4) CBGDA evidence-based associations. NOTE: Diseases with pathogenic evidence are excluded to avoid conflicts.
Erectile Dysfunction	Erectile dysfunction	N/A	N/A	GWAS
Neurodevelopmental Disorders	complex neurodevelopmental disorder	N/A	N/A	GenCC
Schizophrenia	Schizophrenia	N/A	N/A	GWAS

Show/Hide Text Mining Associations (16)

Disease Name	Relationship Type	References
Associations from Text Mining Disease associations identified through Pubtator
Adenocarcinoma of Lung	Inhibit	11719219
Alzheimer Disease	Associate	26687188, 36776048
Basal Ganglia Diseases	Associate	30770860
Breast Neoplasms	Associate	21311096, 35779338
Carcinogenesis	Associate	26919236
Carcinoma Non Small Cell Lung	Associate	26919236
Cerebral Infarction	Associate	39735968
Developmental Disabilities	Associate	30770860
Head and Neck Neoplasms	Inhibit	26919236
Intellectual Disability	Associate	30770860
Mitochondrial Diseases	Inhibit	26210498
Neoplasms	Associate	21311096, 26919236
Polyneuropathies	Associate	30770860
Sleep Disorders Intrinsic	Stimulate	21311096
Smoke Inhalation Injury	Associate	39735968
Uterine Cervical Neoplasms	Associate	31271297

DNAJA3 (DnaJ heat shock protein family (Hsp40) member A3)