Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Pathways
Entrez ID	9088
Gene name	Protein kinase, membrane associated tyrosine/threonine 1
Gene symbol	PKMYT1
Synonyms (NCBI Gene)	MYT1PPP1R126
Chromosome	16
Chromosome location	16p13.3
Summary	This gene encodes a member of the serine/threonine protein kinase family. The encoded protein is a membrane-associated kinase that negatively regulates the G2/M transition of the cell cycle by phosphorylating and inactivating cyclin-dependent kinase 1. Th

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miRTarBase ID	miRNA	Experiments	Reference
MIRT016346	hsa-miR-193b-3p	Microarray	20304954
MIRT050725	hsa-miR-18a-5p	CLASH	23622248
MIRT042806	hsa-miR-339-5p	CLASH	23622248
MIRT439958	hsa-miR-106b-5p	HITS-CLIP	22473208
MIRT439959	hsa-miR-20a-5p	HITS-CLIP	22473208
MIRT439958	hsa-miR-106b-5p	HITS-CLIP	22473208
MIRT726928	hsa-miR-17-5p	HITS-CLIP	22473208
MIRT726929	hsa-miR-20b-5p	HITS-CLIP	22473208
MIRT726927	hsa-miR-93-5p	HITS-CLIP	22473208
MIRT726926	hsa-miR-519d-3p	HITS-CLIP	22473208
MIRT439959	hsa-miR-20a-5p	HITS-CLIP	22473208
MIRT439958	hsa-miR-106b-5p	PAR-CLIP	26701625
MIRT439958	hsa-miR-106b-5p	PAR-CLIP	26701625
MIRT439958	hsa-miR-106b-5p	PAR-CLIP	26701625
MIRT439958	hsa-miR-106b-5p	PAR-CLIP	26701625
MIRT439958	hsa-miR-106b-5p	PAR-CLIP	26701625
MIRT439958	hsa-miR-106b-5p	PAR-CLIP	26701625
MIRT439958	hsa-miR-106b-5p	PAR-CLIP	26701625
MIRT439958	hsa-miR-106b-5p	PAR-CLIP	26701625
MIRT726928	hsa-miR-17-5p	PAR-CLIP	26701625
MIRT726928	hsa-miR-17-5p	PAR-CLIP	26701625
MIRT726928	hsa-miR-17-5p	PAR-CLIP	26701625
MIRT726928	hsa-miR-17-5p	PAR-CLIP	26701625
MIRT726928	hsa-miR-17-5p	PAR-CLIP	26701625
MIRT726928	hsa-miR-17-5p	PAR-CLIP	26701625
MIRT726928	hsa-miR-17-5p	PAR-CLIP	26701625
MIRT726928	hsa-miR-17-5p	PAR-CLIP	26701625
MIRT439959	hsa-miR-20a-5p	PAR-CLIP	26701625
MIRT439959	hsa-miR-20a-5p	PAR-CLIP	26701625
MIRT439959	hsa-miR-20a-5p	PAR-CLIP	26701625
MIRT439959	hsa-miR-20a-5p	PAR-CLIP	26701625
MIRT439959	hsa-miR-20a-5p	PAR-CLIP	26701625
MIRT439959	hsa-miR-20a-5p	PAR-CLIP	26701625
MIRT439959	hsa-miR-20a-5p	PAR-CLIP	26701625
MIRT439959	hsa-miR-20a-5p	PAR-CLIP	26701625
MIRT726929	hsa-miR-20b-5p	PAR-CLIP	26701625
MIRT726929	hsa-miR-20b-5p	PAR-CLIP	26701625
MIRT726929	hsa-miR-20b-5p	PAR-CLIP	26701625
MIRT726929	hsa-miR-20b-5p	PAR-CLIP	26701625
MIRT726929	hsa-miR-20b-5p	PAR-CLIP	26701625
MIRT726929	hsa-miR-20b-5p	PAR-CLIP	26701625
MIRT726929	hsa-miR-20b-5p	PAR-CLIP	26701625
MIRT726929	hsa-miR-20b-5p	PAR-CLIP	26701625
MIRT726926	hsa-miR-519d-3p	PAR-CLIP	26701625
MIRT726926	hsa-miR-519d-3p	PAR-CLIP	26701625
MIRT726926	hsa-miR-519d-3p	PAR-CLIP	26701625
MIRT726926	hsa-miR-519d-3p	PAR-CLIP	26701625
MIRT726926	hsa-miR-519d-3p	PAR-CLIP	26701625
MIRT726926	hsa-miR-519d-3p	PAR-CLIP	26701625
MIRT726926	hsa-miR-519d-3p	PAR-CLIP	26701625
MIRT726926	hsa-miR-519d-3p	PAR-CLIP	26701625
MIRT726927	hsa-miR-93-5p	PAR-CLIP	26701625
MIRT726927	hsa-miR-93-5p	PAR-CLIP	26701625
MIRT726927	hsa-miR-93-5p	PAR-CLIP	26701625
MIRT726927	hsa-miR-93-5p	PAR-CLIP	26701625
MIRT726927	hsa-miR-93-5p	PAR-CLIP	26701625
MIRT726927	hsa-miR-93-5p	PAR-CLIP	26701625
MIRT726927	hsa-miR-93-5p	PAR-CLIP	26701625
MIRT726927	hsa-miR-93-5p	PAR-CLIP	26701625
MIRT1237723	hsa-miR-106a	CLIP-seq
MIRT1237724	hsa-miR-106b	CLIP-seq
MIRT1237725	hsa-miR-1253	CLIP-seq
MIRT1237726	hsa-miR-17	CLIP-seq
MIRT1237727	hsa-miR-185	CLIP-seq
MIRT1237728	hsa-miR-20a	CLIP-seq
MIRT1237729	hsa-miR-20b	CLIP-seq
MIRT1237730	hsa-miR-296-5p	CLIP-seq
MIRT1237731	hsa-miR-3184	CLIP-seq
MIRT1237732	hsa-miR-3919	CLIP-seq
MIRT1237733	hsa-miR-423-5p	CLIP-seq
MIRT1237734	hsa-miR-4306	CLIP-seq
MIRT1237735	hsa-miR-4644	CLIP-seq
MIRT1237736	hsa-miR-4740-3p	CLIP-seq
MIRT1237737	hsa-miR-498	CLIP-seq
MIRT1237738	hsa-miR-519a	CLIP-seq
MIRT1237739	hsa-miR-519d	CLIP-seq
MIRT1237740	hsa-miR-548n	CLIP-seq
MIRT1237741	hsa-miR-548t	CLIP-seq
MIRT1237742	hsa-miR-591	CLIP-seq
MIRT1237743	hsa-miR-93	CLIP-seq
MIRT1237723	hsa-miR-106a	CLIP-seq
MIRT1237724	hsa-miR-106b	CLIP-seq
MIRT1237725	hsa-miR-1253	CLIP-seq
MIRT1237726	hsa-miR-17	CLIP-seq
MIRT1237727	hsa-miR-185	CLIP-seq
MIRT1237728	hsa-miR-20a	CLIP-seq
MIRT1237729	hsa-miR-20b	CLIP-seq
MIRT1237730	hsa-miR-296-5p	CLIP-seq
MIRT1237731	hsa-miR-3184	CLIP-seq
MIRT1237732	hsa-miR-3919	CLIP-seq
MIRT1237733	hsa-miR-423-5p	CLIP-seq
MIRT1237734	hsa-miR-4306	CLIP-seq
MIRT2069887	hsa-miR-4462	CLIP-seq
MIRT2069888	hsa-miR-4514	CLIP-seq
MIRT1237735	hsa-miR-4644	CLIP-seq
MIRT2069889	hsa-miR-4645-5p	CLIP-seq
MIRT2069890	hsa-miR-4673	CLIP-seq
MIRT2069891	hsa-miR-4692	CLIP-seq
MIRT1237736	hsa-miR-4740-3p	CLIP-seq
MIRT2069892	hsa-miR-4755-3p	CLIP-seq
MIRT1237737	hsa-miR-498	CLIP-seq
MIRT1237739	hsa-miR-519d	CLIP-seq
MIRT1237740	hsa-miR-548n	CLIP-seq
MIRT1237741	hsa-miR-548t	CLIP-seq
MIRT1237742	hsa-miR-591	CLIP-seq
MIRT1237743	hsa-miR-93	CLIP-seq
MIRT1237723	hsa-miR-106a	CLIP-seq
MIRT1237724	hsa-miR-106b	CLIP-seq
MIRT1237725	hsa-miR-1253	CLIP-seq
MIRT1237726	hsa-miR-17	CLIP-seq
MIRT1237727	hsa-miR-185	CLIP-seq
MIRT1237728	hsa-miR-20a	CLIP-seq
MIRT1237729	hsa-miR-20b	CLIP-seq
MIRT1237730	hsa-miR-296-5p	CLIP-seq
MIRT1237731	hsa-miR-3184	CLIP-seq
MIRT2297238	hsa-miR-3671	CLIP-seq
MIRT1237732	hsa-miR-3919	CLIP-seq
MIRT1237733	hsa-miR-423-5p	CLIP-seq
MIRT1237734	hsa-miR-4306	CLIP-seq
MIRT2069887	hsa-miR-4462	CLIP-seq
MIRT2069888	hsa-miR-4514	CLIP-seq
MIRT1237735	hsa-miR-4644	CLIP-seq
MIRT2069889	hsa-miR-4645-5p	CLIP-seq
MIRT2069890	hsa-miR-4673	CLIP-seq
MIRT2069891	hsa-miR-4692	CLIP-seq
MIRT1237736	hsa-miR-4740-3p	CLIP-seq
MIRT2069892	hsa-miR-4755-3p	CLIP-seq
MIRT1237737	hsa-miR-498	CLIP-seq
MIRT1237738	hsa-miR-519a	CLIP-seq
MIRT1237739	hsa-miR-519d	CLIP-seq
MIRT1237740	hsa-miR-548n	CLIP-seq
MIRT1237741	hsa-miR-548t	CLIP-seq
MIRT1237742	hsa-miR-591	CLIP-seq
MIRT2297239	hsa-miR-607	CLIP-seq
MIRT1237743	hsa-miR-93	CLIP-seq

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GO ID	Ontology	Definition	Evidence	Reference
GO:0000079	Process	Regulation of cyclin-dependent protein serine/threonine kinase activity	TAS	9001210
GO:0000086	Process	G2/M transition of mitotic cell cycle	TAS
GO:0000139	Component	Golgi membrane	IEA
GO:0000166	Function	Nucleotide binding	IEA
GO:0000278	Process	Mitotic cell cycle	TAS	9001210
GO:0004672	Function	Protein kinase activity	IBA
GO:0004672	Function	Protein kinase activity	IEA
GO:0004672	Function	Protein kinase activity	TAS	9001210
GO:0004674	Function	Protein serine/threonine kinase activity	IDA	9268380
GO:0004674	Function	Protein serine/threonine kinase activity	IEA
GO:0004674	Function	Protein serine/threonine kinase activity	TAS
GO:0005515	Function	Protein binding	IPI	10373560, 23397142, 23602568, 25852190, 26496610, 28514442, 32296183, 32707033, 33961781, 35271311
GO:0005524	Function	ATP binding	IEA
GO:0005634	Component	Nucleus	IBA
GO:0005634	Component	Nucleus	IEA
GO:0005654	Component	Nucleoplasm	IDA
GO:0005654	Component	Nucleoplasm	TAS
GO:0005730	Component	Nucleolus	IDA
GO:0005737	Component	Cytoplasm	IBA
GO:0005737	Component	Cytoplasm	IEA
GO:0005783	Component	Endoplasmic reticulum	IEA
GO:0005783	Component	Endoplasmic reticulum	TAS	9001210
GO:0005789	Component	Endoplasmic reticulum membrane	IEA
GO:0005794	Component	Golgi apparatus	IDA
GO:0005794	Component	Golgi apparatus	IEA
GO:0005794	Component	Golgi apparatus	TAS	9001210
GO:0005829	Component	Cytosol	TAS
GO:0007088	Process	Regulation of mitotic nuclear division	TAS	9001210
GO:0010972	Process	Negative regulation of G2/M transition of mitotic cell cycle	IBA
GO:0010972	Process	Negative regulation of G2/M transition of mitotic cell cycle	IDA	9268380
GO:0016020	Component	Membrane	HDA	19946888
GO:0016020	Component	Membrane	IEA
GO:0016020	Component	Membrane	TAS	9001210
GO:0016301	Function	Kinase activity	IDA	9268380
GO:0016301	Function	Kinase activity	IEA
GO:0016740	Function	Transferase activity	IEA
GO:0046872	Function	Metal ion binding	IEA
GO:0051321	Process	Meiotic cell cycle	IBA
GO:0106310	Function	Protein serine kinase activity	IEA
GO:0110031	Process	Negative regulation of G2/MI transition of meiotic cell cycle	IBA

MIM	HGNC	e!Ensembl
602474	29650	ENSG00000127564

Q99640

Protein name

Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase (EC 2.7.11.1) (Myt1 kinase)

Protein function

Acts as a negative regulator of entry into mitosis (G2 to M transition) by phosphorylation of the CDK1 kinase specifically when CDK1 is complexed to cyclins (PubMed:10373560, PubMed:10504341, PubMed:9001210, PubMed:9268380). Mediates phosphoryla

PDB

3P1A , 5VCV , 5VCW , 5VCX , 5VCY , 5VCZ , 5VD0 , 5VD1 , 5VD3 , 8D6C , 8D6D , 8D6E , 8D6F , 8WJY , 8ZTX , 8ZU2 , 8ZUD , 8ZUL

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00069	Pkinase	110 → 359	Protein kinase domain	Domain

Sequence

MLERPPALAMPMPTEGTPPPLSGTPIPVPAYFRHAEPGFSLKRPRGLSRSLPPPPPAKGS
IPISRLFPPRTPGWHQLQPRRVSFRGEASETLQSPGYDPSRPESFFQQSFQRLSRLGHGS
YGEVFKVRSKEDGRLYAVKRSMSPFRGPKDRARKLAEVGSHEKVGQHPCCVRLEQAWEEG
GILYLQTELCGPSLQQHCEAWGASLPEAQVWGYLRDTLLALAHLHSQGLVHLDVKPANIF
LGPRGRCKLGDFGLLVELGTAGAGEVQEGDPRYMAPELLQGSYGTAADVFSLGLTILEVA
CNMELPHGGEGWQQLRQGYLPPEFTAGLSSELRSVLVMMLEPDPKLRATAEALLALPVLR
QPRAWGVLWCMAAEALSRGWALWQALLALLCWLWHGLAHPASWLQPLGPPATPPGSPPCS
LLLDSSLSSNWDDDSLGPSLSPEAVLARTVGSTSTPRSRCTPRDALDLSDINSEPPRGSF
PSFEPRNLLSLFEDTLDPT

Sequence length

499

Interactions

View interactions

	KEGG		Reactome
	Cell cycle Oocyte meiosis Progesterone-mediated oocyte maturation		Polo-like kinase mediated events Cyclin A/B1/B2 associated events during G2/M transition G2/M DNA replication checkpoint

PKMYT1 (protein kinase, membrane associated tyrosine/threonine 1)