Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene miRNA Gene ontology Other IDs Protein Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	9079
Gene name Gene Name - the full gene name approved by the HGNC.	LIM domain binding 2
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	LDB2
Synonyms (NCBI Gene) Gene synonyms aliases	CLIM1, LDB-2, LDB1
Chromosome Chromosome number	4
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	4p15.32
Summary Summary of gene provided in NCBI Entrez Gene.	The protein encoded by this gene belongs to the LIM-domain binding family. Members of this family are characterized by a conserved nuclear localization sequence, an amino-terminal homodimerization domain and a carboxy-terminal LIM interaction domain. Thes

Show/Hide all(134)

miRTarBase ID	miRNA	Experiments	Reference
MIRT030241	hsa-miR-26b-5p	Microarray	19088304
MIRT609694	hsa-miR-3169	HITS-CLIP	23824327
MIRT609693	hsa-miR-4515	HITS-CLIP	23824327
MIRT609692	hsa-miR-7154-3p	HITS-CLIP	23824327
MIRT609694	hsa-miR-3169	HITS-CLIP	23824327
MIRT609693	hsa-miR-4515	HITS-CLIP	23824327
MIRT609692	hsa-miR-7154-3p	HITS-CLIP	23824327
MIRT609694	hsa-miR-3169	HITS-CLIP	23824327
MIRT609693	hsa-miR-4515	HITS-CLIP	23824327
MIRT609692	hsa-miR-7154-3p	HITS-CLIP	23824327
MIRT609694	hsa-miR-3169	HITS-CLIP	23824327
MIRT609693	hsa-miR-4515	HITS-CLIP	23824327
MIRT609692	hsa-miR-7154-3p	HITS-CLIP	23824327
MIRT609694	hsa-miR-3169	HITS-CLIP	23824327
MIRT609693	hsa-miR-4515	HITS-CLIP	23824327
MIRT609692	hsa-miR-7154-3p	HITS-CLIP	23824327
MIRT609694	hsa-miR-3169	HITS-CLIP	23824327
MIRT609693	hsa-miR-4515	HITS-CLIP	23824327
MIRT609692	hsa-miR-7154-3p	HITS-CLIP	23824327
MIRT609694	hsa-miR-3169	HITS-CLIP	23824327
MIRT609693	hsa-miR-4515	HITS-CLIP	23824327
MIRT609692	hsa-miR-7154-3p	HITS-CLIP	23824327
MIRT609694	hsa-miR-3169	HITS-CLIP	23824327
MIRT609693	hsa-miR-4515	HITS-CLIP	23824327
MIRT609692	hsa-miR-7154-3p	HITS-CLIP	23824327
MIRT609694	hsa-miR-3169	HITS-CLIP	23824327
MIRT609693	hsa-miR-4515	HITS-CLIP	23824327
MIRT609692	hsa-miR-7154-3p	HITS-CLIP	23824327
MIRT609694	hsa-miR-3169	HITS-CLIP	23824327
MIRT609693	hsa-miR-4515	HITS-CLIP	23824327
MIRT609692	hsa-miR-7154-3p	HITS-CLIP	23824327
MIRT609694	hsa-miR-3169	HITS-CLIP	23824327
MIRT609693	hsa-miR-4515	HITS-CLIP	23824327
MIRT609692	hsa-miR-7154-3p	HITS-CLIP	23824327
MIRT609694	hsa-miR-3169	HITS-CLIP	23824327
MIRT609693	hsa-miR-4515	HITS-CLIP	23824327
MIRT609692	hsa-miR-7154-3p	HITS-CLIP	23824327
MIRT609694	hsa-miR-3169	HITS-CLIP	23824327
MIRT609693	hsa-miR-4515	HITS-CLIP	23824327
MIRT609692	hsa-miR-7154-3p	HITS-CLIP	23824327
MIRT609694	hsa-miR-3169	HITS-CLIP	23824327
MIRT609693	hsa-miR-4515	HITS-CLIP	23824327
MIRT609692	hsa-miR-7154-3p	HITS-CLIP	23824327
MIRT609694	hsa-miR-3169	HITS-CLIP	23824327
MIRT609693	hsa-miR-4515	HITS-CLIP	23824327
MIRT609692	hsa-miR-7154-3p	HITS-CLIP	23824327
MIRT609694	hsa-miR-3169	HITS-CLIP	23824327
MIRT609693	hsa-miR-4515	HITS-CLIP	23824327
MIRT609692	hsa-miR-7154-3p	HITS-CLIP	23824327
MIRT609694	hsa-miR-3169	HITS-CLIP	23824327
MIRT609693	hsa-miR-4515	HITS-CLIP	23824327
MIRT609692	hsa-miR-7154-3p	HITS-CLIP	23824327
MIRT609694	hsa-miR-3169	HITS-CLIP	23824327
MIRT609693	hsa-miR-4515	HITS-CLIP	23824327
MIRT609692	hsa-miR-7154-3p	HITS-CLIP	23824327
MIRT609694	hsa-miR-3169	HITS-CLIP	23824327
MIRT609693	hsa-miR-4515	HITS-CLIP	23824327
MIRT609692	hsa-miR-7154-3p	HITS-CLIP	23824327
MIRT609694	hsa-miR-3169	HITS-CLIP	23824327
MIRT609693	hsa-miR-4515	HITS-CLIP	23824327
MIRT609692	hsa-miR-7154-3p	HITS-CLIP	23824327
MIRT609694	hsa-miR-3169	HITS-CLIP	23824327
MIRT609693	hsa-miR-4515	HITS-CLIP	23824327
MIRT609692	hsa-miR-7154-3p	HITS-CLIP	23824327
MIRT609694	hsa-miR-3169	HITS-CLIP	23824327
MIRT609693	hsa-miR-4515	HITS-CLIP	23824327
MIRT609692	hsa-miR-7154-3p	HITS-CLIP	23824327
MIRT609694	hsa-miR-3169	HITS-CLIP	23824327
MIRT609693	hsa-miR-4515	HITS-CLIP	23824327
MIRT609692	hsa-miR-7154-3p	HITS-CLIP	23824327
MIRT609694	hsa-miR-3169	HITS-CLIP	23824327
MIRT609693	hsa-miR-4515	HITS-CLIP	23824327
MIRT609692	hsa-miR-7154-3p	HITS-CLIP	23824327
MIRT609694	hsa-miR-3169	HITS-CLIP	23824327
MIRT609693	hsa-miR-4515	HITS-CLIP	23824327
MIRT609692	hsa-miR-7154-3p	HITS-CLIP	23824327
MIRT609694	hsa-miR-3169	HITS-CLIP	23824327
MIRT609693	hsa-miR-4515	HITS-CLIP	23824327
MIRT609692	hsa-miR-7154-3p	HITS-CLIP	23824327
MIRT609694	hsa-miR-3169	HITS-CLIP	23824327
MIRT609693	hsa-miR-4515	HITS-CLIP	23824327
MIRT609692	hsa-miR-7154-3p	HITS-CLIP	23824327
MIRT609694	hsa-miR-3169	HITS-CLIP	23824327
MIRT609693	hsa-miR-4515	HITS-CLIP	23824327
MIRT609692	hsa-miR-7154-3p	HITS-CLIP	23824327
MIRT609694	hsa-miR-3169	HITS-CLIP	23824327
MIRT609693	hsa-miR-4515	HITS-CLIP	23824327
MIRT609692	hsa-miR-7154-3p	HITS-CLIP	23824327
MIRT609694	hsa-miR-3169	HITS-CLIP	23824327
MIRT609693	hsa-miR-4515	HITS-CLIP	23824327
MIRT609692	hsa-miR-7154-3p	HITS-CLIP	23824327
MIRT609694	hsa-miR-3169	HITS-CLIP	23824327
MIRT609693	hsa-miR-4515	HITS-CLIP	23824327
MIRT609692	hsa-miR-7154-3p	HITS-CLIP	23824327
MIRT609694	hsa-miR-3169	HITS-CLIP	23824327
MIRT609693	hsa-miR-4515	HITS-CLIP	23824327
MIRT609692	hsa-miR-7154-3p	HITS-CLIP	23824327
MIRT609694	hsa-miR-3169	HITS-CLIP	23824327
MIRT609693	hsa-miR-4515	HITS-CLIP	23824327
MIRT609692	hsa-miR-7154-3p	HITS-CLIP	23824327
MIRT609694	hsa-miR-3169	HITS-CLIP	23824327
MIRT609693	hsa-miR-4515	HITS-CLIP	23824327
MIRT609692	hsa-miR-7154-3p	HITS-CLIP	23824327
MIRT1106236	hsa-miR-1246	CLIP-seq
MIRT1106237	hsa-miR-3127-5p	CLIP-seq
MIRT1106238	hsa-miR-3148	CLIP-seq
MIRT1106239	hsa-miR-3150b-3p	CLIP-seq
MIRT1106240	hsa-miR-3688-3p	CLIP-seq
MIRT1106241	hsa-miR-3918	CLIP-seq
MIRT1106242	hsa-miR-3921	CLIP-seq
MIRT1106243	hsa-miR-3928	CLIP-seq
MIRT1106244	hsa-miR-4517	CLIP-seq
MIRT1106245	hsa-miR-4649-3p	CLIP-seq
MIRT1106246	hsa-miR-4653-5p	CLIP-seq
MIRT1106247	hsa-miR-4689	CLIP-seq
MIRT1106248	hsa-miR-4694-3p	CLIP-seq
MIRT1106249	hsa-miR-4784	CLIP-seq
MIRT1106250	hsa-miR-548aa	CLIP-seq
MIRT1106251	hsa-miR-548g	CLIP-seq
MIRT1106252	hsa-miR-889	CLIP-seq
MIRT2029398	hsa-miR-511	CLIP-seq
MIRT2029399	hsa-miR-561	CLIP-seq
MIRT2260262	hsa-miR-3611	CLIP-seq
MIRT2260263	hsa-miR-421	CLIP-seq
MIRT2260264	hsa-miR-4493	CLIP-seq
MIRT2260262	hsa-miR-3611	CLIP-seq
MIRT2260264	hsa-miR-4493	CLIP-seq
MIRT2452900	hsa-miR-4742-3p	CLIP-seq
MIRT2452901	hsa-miR-556-3p	CLIP-seq
MIRT2560431	hsa-miR-338-5p	CLIP-seq
MIRT2260262	hsa-miR-3611	CLIP-seq
MIRT2260264	hsa-miR-4493	CLIP-seq
MIRT2452900	hsa-miR-4742-3p	CLIP-seq
MIRT2452901	hsa-miR-556-3p	CLIP-seq

Show/Hide all(22)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000122	Process	Negative regulation of transcription by RNA polymerase II	IBA	21873635
GO:0001102	Function	RNA polymerase II activating transcription factor binding	IBA	21873635
GO:0001942	Process	Hair follicle development	IEA
GO:0003712	Function	Transcription coregulator activity	IEA
GO:0005515	Function	Protein binding	IPI	15231748, 18330356, 32296183
GO:0005634	Component	Nucleus	IBA	21873635
GO:0005634	Component	Nucleus	IDA	9853615
GO:0005654	Component	Nucleoplasm	IDA
GO:0005667	Component	Transcription regulator complex	IBA	21873635
GO:0005730	Component	Nucleolus	IDA
GO:0005886	Component	Plasma membrane	IDA
GO:0007399	Process	Nervous system development	IBA	21873635
GO:0010669	Process	Epithelial structure maintenance	IEA
GO:0019899	Function	Enzyme binding	IEA
GO:0030274	Function	LIM domain binding	IBA	21873635
GO:0030274	Function	LIM domain binding	ISS
GO:0030334	Process	Regulation of cell migration	ISS
GO:0031252	Component	Cell leading edge	ISS
GO:0035019	Process	Somatic stem cell population maintenance	IEA
GO:0043549	Process	Regulation of kinase activity	ISS
GO:0044089	Process	Positive regulation of cellular component biogenesis	IEA
GO:0045944	Process	Positive regulation of transcription by RNA polymerase II	IBA	21873635

MIM	HGNC	e!Ensembl
603450	6533	ENSG00000169744

Protein

UniProt ID

O43679

Protein name

LIM domain-binding protein 2 (LDB-2) (Carboxyl-terminal LIM domain-binding protein 1) (CLIM-1) (LIM domain-binding factor CLIM1)

Protein function

Transcription cofactor. Binds to the LIM domain of a wide variety of LIM domain-containing transcription factors.

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF01803	LIM_bind	30 → 186	LIM-domain binding protein	Family
PF01803	LIM_bind	175 → 232	LIM-domain binding protein	Family
PF17916	LID	298 → 326	LIM interaction domain (LID)	Domain

Sequence

MSSTPHDPFYSSPFGPFYRRHTPYMVQPEYRIYEMNKRLQSRTEDSDNLWWDAFATEFFE
DDATLTLSFCLEDGPKRYTIGRTLIPRYFSTVFEGGVTDLYYILKHSKESYHNSSITVDC
DQCTMVTQHGKPMFTKVCTEGRLILEFTFDDLMRIKTWHFTIRQYRELVPRSILAMHAQD
PQVLDQLSKNITRMGLTNFTLNYLRLCVILEPMQELMSRHKTYNLSPRDCLKTCLFQKWQ
RMVAPPAEPTRQPTTKRRKRKNSTSSTSNSSAGNNANSTGSKKKTTAANLSLSSQVPDVM
VVGEPTLMGGEFGDEDERLITRLENTQYDAANGMDDEEDFNNSPALGNNSPWNSKPPATQ
ETKSENPPPQASQ

Sequence length

373

Interactions

View interactions

Show/Hide Causal Diseases (1)

Disease term	Disease name	dbSNP ID	References
Causal
Lung adenocarcinoma	Adenocarcinoma of lung (disorder)	rs28934576, rs121913530, rs397516975, rs587776805, rs121913469, rs121913364, rs121913351, rs121913366, rs397516896, rs397516977, rs397516981, rs397517127, rs121913344, rs727504233, rs121913370 View all (5 more)	19836008

Show/Hide Unknown Diseases (5)

Disease term	Disease name	Evidence	Source
Unknown
Rhegmatogenous retinal detachment	Rhegmatogenous retinal detachment		GWAS
Metabolic Syndrome	Metabolic Syndrome		GWAS
Breast Cancer	Breast Cancer	Importantly, breast cancer patients bearing PRC2 LOF mutations displayed significantly worse prognosis compared with PRC2 wild-type patients	GWAS, CBGDA
Oligodendroglioma	Oligodendroglioma		GWAS
Insomnia	Insomnia		GWAS

Show/Hide Text Mining Associations (9)

Disease Name	Relationship Type	References
Associations from Text Mining
Adenocarcinoma of Lung	Associate	32196072
Adenoma	Associate	37794510
Colorectal Neoplasms	Associate	37794510
Glaucoma	Associate	33114701
Hand Foot and Mouth Disease	Associate	32634583
Lung Neoplasms	Inhibit	36473369
Neoplasm Metastasis	Stimulate	36473369
Neoplasms	Associate	15967107
Small Cell Lung Carcinoma	Associate	35845940

LDB2 (LIM domain binding 2)