Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
90780
Gene name Gene Name - the full gene name approved by the HGNC.
Pygopus family PHD finger 2
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
PYGO2
Synonyms (NCBI Gene) Gene synonyms aliases
1190004M21Rik
Chromosome Chromosome number
1
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
1q21.3
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT044810 hsa-miR-320a CLASH 23622248
MIRT717545 hsa-miR-5002-5p HITS-CLIP 19536157
MIRT717544 hsa-miR-3155a HITS-CLIP 19536157
MIRT717543 hsa-miR-3155b HITS-CLIP 19536157
MIRT717542 hsa-miR-484 HITS-CLIP 19536157
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0001822 Process Kidney development IBA
GO:0001822 Process Kidney development IEA
GO:0002088 Process Lens development in camera-type eye IEA
GO:0003682 Function Chromatin binding IEA
GO:0005515 Function Protein binding IPI 17113272, 21399610, 24981860, 32296183
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
606903 30257 ENSG00000163348
Protein
UniProt ID Q9BRQ0
Protein name Pygopus homolog 2
Protein function Involved in signal transduction through the Wnt pathway.
PDB 2XB1 , 4UP0 , 4UP5 , 8HIB
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00628 PHD 329 385 PHD-finger Domain
Sequence
MAASAPPPPDKLEGGGGPAPPPAPPSTGRKQGKAGLQMKSPEKKRRKSNTQGPAYSHLTE
FAPPPTPMVDHLVASNPFEDDFGAPKVGVAAPPFLGSPVPFGGFRVQGGMAGQVPPGYST
GGGGGPQPLRRQPPPFPPNPMGPAFNMPPQGPGYPPPGNMNFPSQPFNQPLGQNFSPPSG
QMMPGPVGGFGPMISPTMGQPPRAELGPPSLSQRFAQPGAPFGPSPLQRPGQGLPSLPPN
TSPFPGPDPGFPGPGGEDGGKPLNPPASTAFPQEPHSGSPAAAVNGNQPSFPPNSSGRGG
GTPDANSLAPPGKAGGGSGPQPPPGLVYPCGACRSEVNDDQDAILCEASCQKWFHRECTG
MTESAYGLLTTEASAVWACDLCLKT
KEIQSVYIREGMGQLVAANDG
Sequence length 406
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  Reactome
    Formation of the beta-catenin:TCF transactivating complex
Deactivation of the beta-catenin transactivating complex
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Associated diseases Disease associations categorized as Causal (pathogenic variants), Unknown (uncertain genetic evidence), or Text Mining (literature-based associations)
Unknown Includes: (1) ClinVar NON-pathogenic variants (Uncertain, Benign, Conflicting, VUS), (2) GenCC associations, (3) GWAS associations, (4) CBGDA evidence-based associations. NOTE: Diseases with pathogenic evidence are excluded to avoid conflicts.
Disease merge term Disease name Evidence References Source
Crohn Disease Crohn's disease N/A N/A GWAS
Inflammatory Bowel Disease Inflammatory bowel disease N/A N/A GWAS
Ulcerative colitis Ulcerative colitis N/A N/A GWAS
Associations from Text Mining Disease associations identified through Pubtator
Disease Name Relationship Type References
Adenoma Liver Cell Associate 18277965
Azoospermia Associate 36688188
Breast Neoplasms Stimulate 18314487
Breast Neoplasms Associate 28055972, 31273950
Carcinoma Hepatocellular Associate 18277965, 36404439
Carcinoma Non Small Cell Lung Associate 23865714
Glioma Stimulate 26902498
Glioma Associate 28427190
Glioma of Brain Familial Stimulate 26902498
Glioma of Brain Familial Associate 28427190