Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene SNPs miRNA Gene ontology Other IDs Protein Pathways
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	9070
Gene name Gene Name - the full gene name approved by the HGNC.	ASH2 like, histone lysine methyltransferase complex subunit
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	ASH2L
Synonyms (NCBI Gene) Gene synonyms aliases	ASH2, ASH2L1, ASH2L2, Bre2
Chromosome Chromosome number	8
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	8p11.23

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SNP ID	Visualize variation	Clinical significance	Consequence
rs1060499744	A>G	Likely-pathogenic	Missense variant, coding sequence variant

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miRTarBase ID	miRNA	Experiments	Reference
MIRT001383	hsa-miR-1-3p	pSILAC	18668040
MIRT001383	hsa-miR-1-3p	Proteomics;Other	18668040
MIRT038629	hsa-miR-125b-2-3p	CLASH	23622248
MIRT036952	hsa-miR-877-3p	CLASH	23622248
MIRT628737	hsa-miR-1253	HITS-CLIP	23824327
MIRT628736	hsa-miR-6770-5p	HITS-CLIP	23824327
MIRT628735	hsa-miR-580-3p	HITS-CLIP	23824327
MIRT628737	hsa-miR-1253	HITS-CLIP	23824327
MIRT628736	hsa-miR-6770-5p	HITS-CLIP	23824327
MIRT628735	hsa-miR-580-3p	HITS-CLIP	23824327
MIRT509391	hsa-miR-449b-3p	PAR-CLIP	20371350
MIRT509390	hsa-miR-8063	PAR-CLIP	20371350
MIRT509389	hsa-miR-4698	PAR-CLIP	20371350
MIRT509388	hsa-miR-371b-5p	PAR-CLIP	20371350
MIRT509387	hsa-miR-373-5p	PAR-CLIP	20371350
MIRT509386	hsa-miR-616-5p	PAR-CLIP	20371350
MIRT509385	hsa-miR-371a-5p	PAR-CLIP	20371350
MIRT509384	hsa-miR-372-5p	PAR-CLIP	20371350
MIRT509383	hsa-miR-619-5p	PAR-CLIP	20371350
MIRT509382	hsa-miR-6506-5p	PAR-CLIP	20371350
MIRT509381	hsa-miR-4731-5p	PAR-CLIP	20371350
MIRT509380	hsa-miR-5589-5p	PAR-CLIP	20371350
MIRT509379	hsa-miR-6807-5p	PAR-CLIP	20371350
MIRT509378	hsa-miR-5089-5p	PAR-CLIP	20371350
MIRT509391	hsa-miR-449b-3p	PAR-CLIP	20371350
MIRT509390	hsa-miR-8063	PAR-CLIP	20371350
MIRT509389	hsa-miR-4698	PAR-CLIP	20371350
MIRT509388	hsa-miR-371b-5p	PAR-CLIP	20371350
MIRT509387	hsa-miR-373-5p	PAR-CLIP	20371350
MIRT509386	hsa-miR-616-5p	PAR-CLIP	20371350
MIRT509385	hsa-miR-371a-5p	PAR-CLIP	20371350
MIRT509384	hsa-miR-372-5p	PAR-CLIP	20371350
MIRT509383	hsa-miR-619-5p	PAR-CLIP	20371350
MIRT509382	hsa-miR-6506-5p	PAR-CLIP	20371350
MIRT509381	hsa-miR-4731-5p	PAR-CLIP	20371350
MIRT509380	hsa-miR-5589-5p	PAR-CLIP	20371350
MIRT509379	hsa-miR-6807-5p	PAR-CLIP	20371350
MIRT509378	hsa-miR-5089-5p	PAR-CLIP	20371350
MIRT509391	hsa-miR-449b-3p	PAR-CLIP	21572407
MIRT509390	hsa-miR-8063	PAR-CLIP	21572407
MIRT509389	hsa-miR-4698	PAR-CLIP	21572407
MIRT509388	hsa-miR-371b-5p	PAR-CLIP	21572407
MIRT509387	hsa-miR-373-5p	PAR-CLIP	21572407
MIRT509386	hsa-miR-616-5p	PAR-CLIP	21572407
MIRT509385	hsa-miR-371a-5p	PAR-CLIP	21572407
MIRT509384	hsa-miR-372-5p	PAR-CLIP	21572407
MIRT509383	hsa-miR-619-5p	PAR-CLIP	21572407
MIRT509382	hsa-miR-6506-5p	PAR-CLIP	21572407
MIRT509381	hsa-miR-4731-5p	PAR-CLIP	21572407
MIRT509380	hsa-miR-5589-5p	PAR-CLIP	21572407
MIRT509379	hsa-miR-6807-5p	PAR-CLIP	21572407
MIRT509378	hsa-miR-5089-5p	PAR-CLIP	21572407
MIRT509391	hsa-miR-449b-3p	PAR-CLIP	23446348
MIRT509390	hsa-miR-8063	PAR-CLIP	23446348
MIRT509389	hsa-miR-4698	PAR-CLIP	23446348
MIRT509388	hsa-miR-371b-5p	PAR-CLIP	23446348
MIRT509387	hsa-miR-373-5p	PAR-CLIP	23446348
MIRT509386	hsa-miR-616-5p	PAR-CLIP	23446348
MIRT509385	hsa-miR-371a-5p	PAR-CLIP	23446348
MIRT509384	hsa-miR-372-5p	PAR-CLIP	23446348
MIRT509383	hsa-miR-619-5p	PAR-CLIP	23446348
MIRT509382	hsa-miR-6506-5p	PAR-CLIP	23446348
MIRT509381	hsa-miR-4731-5p	PAR-CLIP	23446348
MIRT509380	hsa-miR-5589-5p	PAR-CLIP	23446348
MIRT509379	hsa-miR-6807-5p	PAR-CLIP	23446348
MIRT509378	hsa-miR-5089-5p	PAR-CLIP	23446348
MIRT509391	hsa-miR-449b-3p	PAR-CLIP	23446348
MIRT509390	hsa-miR-8063	PAR-CLIP	23446348
MIRT509389	hsa-miR-4698	PAR-CLIP	23446348
MIRT509388	hsa-miR-371b-5p	PAR-CLIP	23446348
MIRT509387	hsa-miR-373-5p	PAR-CLIP	23446348
MIRT509386	hsa-miR-616-5p	PAR-CLIP	23446348
MIRT509385	hsa-miR-371a-5p	PAR-CLIP	23446348
MIRT509384	hsa-miR-372-5p	PAR-CLIP	23446348
MIRT509383	hsa-miR-619-5p	PAR-CLIP	23446348
MIRT509382	hsa-miR-6506-5p	PAR-CLIP	23446348
MIRT509381	hsa-miR-4731-5p	PAR-CLIP	23446348
MIRT509380	hsa-miR-5589-5p	PAR-CLIP	23446348
MIRT509379	hsa-miR-6807-5p	PAR-CLIP	23446348
MIRT509378	hsa-miR-5089-5p	PAR-CLIP	23446348
MIRT628737	hsa-miR-1253	HITS-CLIP	23824327
MIRT628736	hsa-miR-6770-5p	HITS-CLIP	23824327
MIRT628735	hsa-miR-580-3p	HITS-CLIP	23824327
MIRT628737	hsa-miR-1253	HITS-CLIP	23824327
MIRT628736	hsa-miR-6770-5p	HITS-CLIP	23824327
MIRT628735	hsa-miR-580-3p	HITS-CLIP	23824327
MIRT509391	hsa-miR-449b-3p	PAR-CLIP	20371350
MIRT509390	hsa-miR-8063	PAR-CLIP	20371350
MIRT509389	hsa-miR-4698	PAR-CLIP	20371350
MIRT509388	hsa-miR-371b-5p	PAR-CLIP	20371350
MIRT509387	hsa-miR-373-5p	PAR-CLIP	20371350
MIRT509386	hsa-miR-616-5p	PAR-CLIP	20371350
MIRT509385	hsa-miR-371a-5p	PAR-CLIP	20371350
MIRT509384	hsa-miR-372-5p	PAR-CLIP	20371350
MIRT509383	hsa-miR-619-5p	PAR-CLIP	20371350
MIRT509382	hsa-miR-6506-5p	PAR-CLIP	20371350
MIRT509381	hsa-miR-4731-5p	PAR-CLIP	20371350
MIRT509380	hsa-miR-5589-5p	PAR-CLIP	20371350
MIRT509379	hsa-miR-6807-5p	PAR-CLIP	20371350
MIRT509378	hsa-miR-5089-5p	PAR-CLIP	20371350
MIRT509391	hsa-miR-449b-3p	PAR-CLIP	20371350
MIRT509390	hsa-miR-8063	PAR-CLIP	20371350
MIRT509389	hsa-miR-4698	PAR-CLIP	20371350
MIRT509388	hsa-miR-371b-5p	PAR-CLIP	20371350
MIRT509387	hsa-miR-373-5p	PAR-CLIP	20371350
MIRT509386	hsa-miR-616-5p	PAR-CLIP	20371350
MIRT509385	hsa-miR-371a-5p	PAR-CLIP	20371350
MIRT509384	hsa-miR-372-5p	PAR-CLIP	20371350
MIRT509383	hsa-miR-619-5p	PAR-CLIP	20371350
MIRT509382	hsa-miR-6506-5p	PAR-CLIP	20371350
MIRT509381	hsa-miR-4731-5p	PAR-CLIP	20371350
MIRT509380	hsa-miR-5589-5p	PAR-CLIP	20371350
MIRT509379	hsa-miR-6807-5p	PAR-CLIP	20371350
MIRT509378	hsa-miR-5089-5p	PAR-CLIP	20371350
MIRT509391	hsa-miR-449b-3p	PAR-CLIP	21572407
MIRT509390	hsa-miR-8063	PAR-CLIP	21572407
MIRT509389	hsa-miR-4698	PAR-CLIP	21572407
MIRT509388	hsa-miR-371b-5p	PAR-CLIP	21572407
MIRT509387	hsa-miR-373-5p	PAR-CLIP	21572407
MIRT509386	hsa-miR-616-5p	PAR-CLIP	21572407
MIRT509385	hsa-miR-371a-5p	PAR-CLIP	21572407
MIRT509384	hsa-miR-372-5p	PAR-CLIP	21572407
MIRT509383	hsa-miR-619-5p	PAR-CLIP	21572407
MIRT509382	hsa-miR-6506-5p	PAR-CLIP	21572407
MIRT509381	hsa-miR-4731-5p	PAR-CLIP	21572407
MIRT509380	hsa-miR-5589-5p	PAR-CLIP	21572407
MIRT509379	hsa-miR-6807-5p	PAR-CLIP	21572407
MIRT509378	hsa-miR-5089-5p	PAR-CLIP	21572407
MIRT509391	hsa-miR-449b-3p	PAR-CLIP	23446348
MIRT509390	hsa-miR-8063	PAR-CLIP	23446348
MIRT509389	hsa-miR-4698	PAR-CLIP	23446348
MIRT509388	hsa-miR-371b-5p	PAR-CLIP	23446348
MIRT509387	hsa-miR-373-5p	PAR-CLIP	23446348
MIRT509386	hsa-miR-616-5p	PAR-CLIP	23446348
MIRT509385	hsa-miR-371a-5p	PAR-CLIP	23446348
MIRT509384	hsa-miR-372-5p	PAR-CLIP	23446348
MIRT509383	hsa-miR-619-5p	PAR-CLIP	23446348
MIRT509382	hsa-miR-6506-5p	PAR-CLIP	23446348
MIRT509381	hsa-miR-4731-5p	PAR-CLIP	23446348
MIRT509380	hsa-miR-5589-5p	PAR-CLIP	23446348
MIRT509379	hsa-miR-6807-5p	PAR-CLIP	23446348
MIRT509378	hsa-miR-5089-5p	PAR-CLIP	23446348
MIRT509391	hsa-miR-449b-3p	PAR-CLIP	23446348
MIRT509390	hsa-miR-8063	PAR-CLIP	23446348
MIRT509389	hsa-miR-4698	PAR-CLIP	23446348
MIRT509388	hsa-miR-371b-5p	PAR-CLIP	23446348
MIRT509387	hsa-miR-373-5p	PAR-CLIP	23446348
MIRT509386	hsa-miR-616-5p	PAR-CLIP	23446348
MIRT509385	hsa-miR-371a-5p	PAR-CLIP	23446348
MIRT509384	hsa-miR-372-5p	PAR-CLIP	23446348
MIRT509383	hsa-miR-619-5p	PAR-CLIP	23446348
MIRT509382	hsa-miR-6506-5p	PAR-CLIP	23446348
MIRT509381	hsa-miR-4731-5p	PAR-CLIP	23446348
MIRT509380	hsa-miR-5589-5p	PAR-CLIP	23446348
MIRT509379	hsa-miR-6807-5p	PAR-CLIP	23446348
MIRT509378	hsa-miR-5089-5p	PAR-CLIP	23446348
MIRT802968	hsa-miR-1	CLIP-seq
MIRT802969	hsa-miR-1207-3p	CLIP-seq
MIRT802970	hsa-miR-1207-5p	CLIP-seq
MIRT802971	hsa-miR-1323	CLIP-seq
MIRT802972	hsa-miR-206	CLIP-seq
MIRT802973	hsa-miR-224	CLIP-seq
MIRT802974	hsa-miR-2278	CLIP-seq
MIRT802975	hsa-miR-27a	CLIP-seq
MIRT802976	hsa-miR-27b	CLIP-seq
MIRT802977	hsa-miR-3065-3p	CLIP-seq
MIRT802978	hsa-miR-3120-3p	CLIP-seq
MIRT802979	hsa-miR-3150a-3p	CLIP-seq
MIRT802980	hsa-miR-3175	CLIP-seq
MIRT802981	hsa-miR-361-3p	CLIP-seq
MIRT802982	hsa-miR-3651	CLIP-seq
MIRT802983	hsa-miR-3673	CLIP-seq
MIRT802984	hsa-miR-3938	CLIP-seq
MIRT802985	hsa-miR-4274	CLIP-seq
MIRT802986	hsa-miR-4704-3p	CLIP-seq
MIRT802987	hsa-miR-4736	CLIP-seq
MIRT802988	hsa-miR-4760-5p	CLIP-seq
MIRT802989	hsa-miR-4763-3p	CLIP-seq
MIRT802990	hsa-miR-4795-3p	CLIP-seq
MIRT802991	hsa-miR-4795-5p	CLIP-seq
MIRT802992	hsa-miR-491-5p	CLIP-seq
MIRT802993	hsa-miR-509-3p	CLIP-seq
MIRT802994	hsa-miR-513a-5p	CLIP-seq
MIRT802995	hsa-miR-522	CLIP-seq
MIRT802996	hsa-miR-548o	CLIP-seq
MIRT802997	hsa-miR-613	CLIP-seq
MIRT802998	hsa-miR-939	CLIP-seq
MIRT802969	hsa-miR-1207-3p	CLIP-seq
MIRT802970	hsa-miR-1207-5p	CLIP-seq
MIRT1937162	hsa-miR-1252	CLIP-seq
MIRT1937163	hsa-miR-1289	CLIP-seq
MIRT802973	hsa-miR-224	CLIP-seq
MIRT1937164	hsa-miR-2682	CLIP-seq
MIRT1937165	hsa-miR-3198	CLIP-seq
MIRT1937166	hsa-miR-365	CLIP-seq
MIRT1937167	hsa-miR-3690	CLIP-seq
MIRT1937168	hsa-miR-3714	CLIP-seq
MIRT1937169	hsa-miR-4254	CLIP-seq
MIRT1937170	hsa-miR-4294	CLIP-seq
MIRT1937171	hsa-miR-4309	CLIP-seq
MIRT1937172	hsa-miR-449c	CLIP-seq
MIRT1937173	hsa-miR-4514	CLIP-seq
MIRT1937174	hsa-miR-4654	CLIP-seq
MIRT1937175	hsa-miR-4692	CLIP-seq
MIRT802987	hsa-miR-4736	CLIP-seq
MIRT802989	hsa-miR-4763-3p	CLIP-seq
MIRT1937176	hsa-miR-4769-5p	CLIP-seq
MIRT1937177	hsa-miR-488	CLIP-seq
MIRT1937178	hsa-miR-511	CLIP-seq
MIRT1937179	hsa-miR-548an	CLIP-seq
MIRT1937180	hsa-miR-940	CLIP-seq
MIRT802969	hsa-miR-1207-3p	CLIP-seq
MIRT802970	hsa-miR-1207-5p	CLIP-seq
MIRT802973	hsa-miR-224	CLIP-seq
MIRT802975	hsa-miR-27a	CLIP-seq
MIRT802976	hsa-miR-27b	CLIP-seq
MIRT802977	hsa-miR-3065-3p	CLIP-seq
MIRT802978	hsa-miR-3120-3p	CLIP-seq
MIRT802987	hsa-miR-4736	CLIP-seq
MIRT802989	hsa-miR-4763-3p	CLIP-seq
MIRT802994	hsa-miR-513a-5p	CLIP-seq

Show/Hide all(29)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000976	Function	Transcription cis-regulatory region binding	IBA
GO:0000976	Function	Transcription cis-regulatory region binding	IDA	16603732
GO:0003677	Function	DNA binding	IEA
GO:0005515	Function	Protein binding	IPI	12482968, 12670868, 14992727, 16189514, 16603732, 16892064, 17178841, 17500065, 17925232, 17998332, 19047629, 19131338, 19187761, 19433796, 19556245, 20085832, 21220120, 21516116, 22722839, 23414517, 23870121, 23995757, 24981860, 25416956, 25456412, 26886794, 31485071, 31515488, 322
GO:0005634	Component	Nucleus	IDA	15199122, 17500065, 18245475
GO:0005634	Component	Nucleus	IEA
GO:0005634	Component	Nucleus	IMP	22723415
GO:0005654	Component	Nucleoplasm	TAS
GO:0006325	Process	Chromatin organization	IEA
GO:0006974	Process	DNA damage response	IDA	17500065
GO:0008013	Function	Beta-catenin binding	IPI	22723415
GO:0008270	Function	Zinc ion binding	IEA
GO:0008284	Process	Positive regulation of cell population proliferation	IMP	18245475
GO:0010468	Process	Regulation of gene expression	IEA
GO:0010557	Process	Positive regulation of macromolecule biosynthetic process	IEA
GO:0030097	Process	Hemopoiesis	NAS	11466562
GO:0035097	Component	Histone methyltransferase complex	IDA	17355966, 17500065, 19556245
GO:0043627	Process	Response to estrogen	IDA	16603732
GO:0044665	Component	MLL1/2 complex	IPI	23508102
GO:0044666	Component	MLL3/4 complex	IDA	17500065
GO:0044666	Component	MLL3/4 complex	IPI	23508102
GO:0045815	Process	Transcription initiation-coupled chromatin remodeling	IDA	19556245
GO:0046872	Function	Metal ion binding	IEA
GO:0048188	Component	Set1C/COMPASS complex	IBA
GO:0048188	Component	Set1C/COMPASS complex	IDA	17998332, 18838538
GO:0048188	Component	Set1C/COMPASS complex	IEA
GO:0048188	Component	Set1C/COMPASS complex	IPI	23508102
GO:0071339	Component	MLL1 complex	IEA
GO:0071339	Component	MLL1 complex	IPI	23508102

MIM	HGNC	e!Ensembl
604782	744	ENSG00000129691

Protein

UniProt ID

Q9UBL3

Protein name

Set1/Ash2 histone methyltransferase complex subunit ASH2 (ASH2-like protein)

Protein function

Transcriptional regulator (PubMed:12670868). Component or associated component of some histone methyltransferase complexes which regulates transcription through recruitment of those complexes to gene promoters (PubMed:19131338). Component of the

PDB

3RSN , 3S32 , 3TOJ , 4RIQ , 4X8N , 4X8P , 5F6K , 5F6L , 6E2H , 6KIU , 6KIV , 6KIW , 6KIX , 6KIZ , 6PWV , 6W5I , 6W5M , 6W5N , 7BRE , 7MBM , 7MBN , 7UD5 , 7W67 , 7W6A , 7W6I , 7W6J , 7W6L

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00622	SPRY	420 → 498	SPRY domain	Family

Tissue specificity

TISSUE SPECIFICITY: Ubiquitously expressed. Predominantly expressed in adult heart and testis and fetal lung and liver, with barely detectable expression in adult lung, liver, kidney, prostate, and peripheral leukocytes. {ECO:0000269|PubMed:10393421}.

Sequence

MAAAGAGPGQEAGAGPGPGAVANATGAEEGEMKPVAAGAAAPPGEGISAAPTVEPSSGEA
EGGEANLVDVSGGLETESSNGKDTLEGAGDTSEVMDTQAGSVDEENGRQLGEVELQCGIC
TKWFTADTFGIDTSSCLPFMTNYSFHCNVCHHSGNTYFLRKQANLKEMCLSALANLTWQS
RTQDEHPKTMFSKDKDIIPFIDKYWECMTTRQRPGKMTWPNNIVKTMSKERDVFLVKEHP
DPGSKDPEEDYPKFGLLDQDLSNIGPAYDNQKQSSAVSTSGNLNGGIAAGSSGKGRGAKR
KQQDGGTTGTTKKARSDPLFSAQRLPPHGYPLEHPFNKDGYRYILAEPDPHAPDPEKLEL
DCWAGKPIPGDLYRACLYERVLLALHDRAPQLKISDDRLTVVGEKGYSMVRASHGVRKGA
WYFEITVDEMPPDTAARLGWSQPLGNLQAPLGYDKFSYSWRSKKGTKFHQSIGKHYSSGY
GQGDVLGFYINLPEDTETAKSLPDTYKDKALIKFKSYLYFEEKDFVDKAEKSLKQTPHSE
IIFYKNGVNQGVAYKDIFEGVYFPAISLYKSCTVSINFGPCFKYPPKDLTYRPMSDMGWG
AVVEHTLADVLYHVETEVDGRRSPPWEP

Sequence length

628

Interactions

View interactions

	KEGG		Reactome
	Cushing syndrome		Formation of the beta-catenin:TCF transactivating complex PKMTs methylate histone lysines Deactivation of the beta-catenin transactivating complex RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function

ASH2L (ASH2 like, histone lysine methyltransferase complex subunit)