Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
9057
Gene name Gene Name - the full gene name approved by the HGNC.
Solute carrier family 7 member 6
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
SLC7A6
Synonyms (NCBI Gene) Gene synonyms aliases
LAT-2, LAT3, y+LAT-2
Chromosome Chromosome number
16
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
16q22.1
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT001761 hsa-miR-30a-3p Luciferase reporter assay, qRT-PCR, Western blot 16239240
MIRT004987 hsa-miR-125b-5p Microarray 17891175
MIRT020026 hsa-miR-375 Microarray 20215506
MIRT027832 hsa-miR-98-5p Microarray 19088304
MIRT001761 hsa-miR-30a-3p qRT-PCR 16239240
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0003333 Process Amino acid transmembrane transport IBA 21873635
GO:0003333 Process Amino acid transmembrane transport TAS 9829974
GO:0005515 Function Protein binding IPI 32296183
GO:0005886 Component Plasma membrane IDA
GO:0005886 Component Plasma membrane TAS
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
605641 11064 ENSG00000103064
Protein
UniProt ID Q92536
Protein name Y+L amino acid transporter 2 (Cationic amino acid transporter, y+ system) (Solute carrier family 7 member 6) (y(+)L-type amino acid transporter 2) (Y+LAT2) (y+LAT-2)
Protein function Heterodimer with SLC3A2, that functions as an antiporter which operates as an efflux route by exporting cationic amino acids such as L-arginine from inside the cells in exchange with neutral amino acids like L-leucine, L-glutamine and isoleucine
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF13520 AA_permease_2 45 468 Amino acid permease Family
Tissue specificity TISSUE SPECIFICITY: Expressed in normal fibroblasts and those from LPI patients (PubMed:11078698). Also expressed in HUVECs, monocytes, RPE cells, and various carcinoma cell lines (PubMed:11742806, PubMed:14603368, PubMed:15280038, PubMed:17197568, PubMed
Sequence
Sequence length 515
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  Reactome
    Basigin interactions
Amino acid transport across the plasma membrane
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Causal
Disease term Disease name dbSNP ID References
Schizophrenia Schizophrenia rs13447324, rs387906932, rs387906933, rs863223354, rs863223355, rs776061422, rs863223349, rs748809996, rs759748655, rs863223353, rs863223350, rs863223356, rs781821239, rs863223348, rs863223346
View all (12 more)
28991256, 30285260
Unknown
Disease term Disease name Evidence References Source
Otosclerosis Otosclerosis GWAS
Associations from Text Mining
Disease Name Relationship Type References
Carcinoma Non Small Cell Lung Inhibit 32794418
Carcinoma Renal Cell Associate 24168110
Colorectal Neoplasms Associate 37205704
Drug Related Side Effects and Adverse Reactions Associate 19089452
Lymphatic Metastasis Inhibit 32794418
Lysinuric Protein Intolerance Associate 11078698
Neoplasms Inhibit 24168110, 32794418