Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	9055
Gene name Gene Name - the full gene name approved by the HGNC.	Protein regulator of cytokinesis 1
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	PRC1
Synonyms (NCBI Gene) Gene synonyms aliases	ASE1, MAP65
Chromosome Chromosome number	15
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	15q26.1
Summary Summary of gene provided in NCBI Entrez Gene.	This gene encodes a protein that is involved in cytokinesis. The protein is present at high levels during the S and G2/M phases of mitosis but its levels drop dramatically when the cell exits mitosis and enters the G1 phase. It is located in the nucleus d

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miRTarBase ID	miRNA	Experiments	Reference
MIRT002532	hsa-miR-373-3p	Microarray	15685193
MIRT016238	hsa-miR-548b-3p	Sequencing	20371350
MIRT002532	hsa-miR-373-3p	Microarray;Other	15685193
MIRT049644	hsa-miR-92a-3p	CLASH	23622248
MIRT045708	hsa-miR-125a-5p	CLASH	23622248
MIRT040993	hsa-miR-505-3p	CLASH	23622248
MIRT052746	hsa-miR-1260b	CLASH	23622248
MIRT052746	hsa-miR-1260b	CLASH	23622248
MIRT574524	hsa-miR-302c-3p	PAR-CLIP	20371350
MIRT574523	hsa-miR-520f-3p	PAR-CLIP	20371350
MIRT574522	hsa-miR-5692a	PAR-CLIP	20371350
MIRT574521	hsa-miR-6507-5p	PAR-CLIP	20371350
MIRT574520	hsa-miR-512-3p	PAR-CLIP	20371350
MIRT574519	hsa-miR-1324	PAR-CLIP	20371350
MIRT574518	hsa-miR-2277-3p	PAR-CLIP	20371350
MIRT574516	hsa-miR-3166	PAR-CLIP	20371350
MIRT574517	hsa-miR-633	PAR-CLIP	20371350
MIRT574515	hsa-miR-4473	PAR-CLIP	20371350
MIRT574514	hsa-miR-3977	PAR-CLIP	20371350
MIRT574524	hsa-miR-302c-3p	PAR-CLIP	20371350
MIRT574523	hsa-miR-520f-3p	PAR-CLIP	20371350
MIRT574522	hsa-miR-5692a	PAR-CLIP	20371350
MIRT574521	hsa-miR-6507-5p	PAR-CLIP	20371350
MIRT574520	hsa-miR-512-3p	PAR-CLIP	20371350
MIRT574519	hsa-miR-1324	PAR-CLIP	20371350
MIRT574518	hsa-miR-2277-3p	PAR-CLIP	20371350
MIRT574516	hsa-miR-3166	PAR-CLIP	20371350
MIRT574517	hsa-miR-633	PAR-CLIP	20371350
MIRT574515	hsa-miR-4473	PAR-CLIP	20371350
MIRT574514	hsa-miR-3977	PAR-CLIP	20371350
MIRT1259679	hsa-miR-1205	CLIP-seq
MIRT1259680	hsa-miR-1207-3p	CLIP-seq
MIRT1259681	hsa-miR-1273d	CLIP-seq
MIRT1259682	hsa-miR-1278	CLIP-seq
MIRT1259683	hsa-miR-146a	CLIP-seq
MIRT1259684	hsa-miR-146b-5p	CLIP-seq
MIRT1259685	hsa-miR-150	CLIP-seq
MIRT1259686	hsa-miR-199a-3p	CLIP-seq
MIRT1259687	hsa-miR-199b-3p	CLIP-seq
MIRT1259688	hsa-miR-224	CLIP-seq
MIRT1259689	hsa-miR-3128	CLIP-seq
MIRT1259690	hsa-miR-3129-5p	CLIP-seq
MIRT1259691	hsa-miR-3136-5p	CLIP-seq
MIRT1259692	hsa-miR-3140-3p	CLIP-seq
MIRT1259693	hsa-miR-3185	CLIP-seq
MIRT1259694	hsa-miR-320e	CLIP-seq
MIRT1259695	hsa-miR-3591-3p	CLIP-seq
MIRT1259696	hsa-miR-3652	CLIP-seq
MIRT1259697	hsa-miR-3691-3p	CLIP-seq
MIRT1259698	hsa-miR-383	CLIP-seq
MIRT1259699	hsa-miR-4430	CLIP-seq
MIRT1259700	hsa-miR-4439	CLIP-seq
MIRT1259701	hsa-miR-4474-3p	CLIP-seq
MIRT1259702	hsa-miR-4490	CLIP-seq
MIRT1259703	hsa-miR-4505	CLIP-seq
MIRT1259704	hsa-miR-4513	CLIP-seq
MIRT1259705	hsa-miR-4514	CLIP-seq
MIRT1259706	hsa-miR-4645-3p	CLIP-seq
MIRT1259707	hsa-miR-4692	CLIP-seq
MIRT1259708	hsa-miR-4704-5p	CLIP-seq
MIRT1259709	hsa-miR-4772-5p	CLIP-seq
MIRT1259710	hsa-miR-4786-3p	CLIP-seq
MIRT1259711	hsa-miR-495	CLIP-seq
MIRT1259712	hsa-miR-498	CLIP-seq
MIRT1259713	hsa-miR-520f	CLIP-seq
MIRT1259714	hsa-miR-548ae	CLIP-seq
MIRT1259715	hsa-miR-548aj	CLIP-seq
MIRT1259716	hsa-miR-548am	CLIP-seq
MIRT1259717	hsa-miR-548x	CLIP-seq
MIRT1259718	hsa-miR-563	CLIP-seq
MIRT1259719	hsa-miR-580	CLIP-seq
MIRT1259720	hsa-miR-589	CLIP-seq
MIRT1259721	hsa-miR-660	CLIP-seq
MIRT1259722	hsa-miR-671-5p	CLIP-seq
MIRT1259723	hsa-miR-943	CLIP-seq
MIRT1259679	hsa-miR-1205	CLIP-seq
MIRT1259724	hsa-miR-1206	CLIP-seq
MIRT1259725	hsa-miR-1245	CLIP-seq
MIRT1259682	hsa-miR-1278	CLIP-seq
MIRT1259683	hsa-miR-146a	CLIP-seq
MIRT1259684	hsa-miR-146b-5p	CLIP-seq
MIRT1259686	hsa-miR-199a-3p	CLIP-seq
MIRT1259687	hsa-miR-199b-3p	CLIP-seq
MIRT1259726	hsa-miR-19a	CLIP-seq
MIRT1259727	hsa-miR-19b	CLIP-seq
MIRT1259728	hsa-miR-2355-5p	CLIP-seq
MIRT1259729	hsa-miR-3065-5p	CLIP-seq
MIRT1259690	hsa-miR-3129-5p	CLIP-seq
MIRT1259692	hsa-miR-3140-3p	CLIP-seq
MIRT1259730	hsa-miR-3180-5p	CLIP-seq
MIRT1259695	hsa-miR-3591-3p	CLIP-seq
MIRT1259697	hsa-miR-3691-3p	CLIP-seq
MIRT1259731	hsa-miR-3973	CLIP-seq
MIRT1259732	hsa-miR-4269	CLIP-seq
MIRT1259733	hsa-miR-4461	CLIP-seq
MIRT1259702	hsa-miR-4490	CLIP-seq
MIRT1259734	hsa-miR-4511	CLIP-seq
MIRT1259705	hsa-miR-4514	CLIP-seq
MIRT1259735	hsa-miR-4640-3p	CLIP-seq
MIRT1259706	hsa-miR-4645-3p	CLIP-seq
MIRT1259736	hsa-miR-4650-3p	CLIP-seq
MIRT1259707	hsa-miR-4692	CLIP-seq
MIRT1259708	hsa-miR-4704-5p	CLIP-seq
MIRT1259737	hsa-miR-4742-5p	CLIP-seq
MIRT1259738	hsa-miR-4781-3p	CLIP-seq
MIRT1259739	hsa-miR-485-3p	CLIP-seq
MIRT1259740	hsa-miR-510	CLIP-seq
MIRT1259741	hsa-miR-518a-5p	CLIP-seq
MIRT1259742	hsa-miR-520a-5p	CLIP-seq
MIRT1259713	hsa-miR-520f	CLIP-seq
MIRT1259743	hsa-miR-525-5p	CLIP-seq
MIRT1259744	hsa-miR-527	CLIP-seq
MIRT1259719	hsa-miR-580	CLIP-seq
MIRT1259720	hsa-miR-589	CLIP-seq
MIRT1259681	hsa-miR-1273d	CLIP-seq
MIRT1259745	hsa-miR-1275	CLIP-seq
MIRT1259746	hsa-miR-1323	CLIP-seq
MIRT1259747	hsa-miR-143	CLIP-seq
MIRT1259685	hsa-miR-150	CLIP-seq
MIRT1259748	hsa-miR-1915	CLIP-seq
MIRT1259686	hsa-miR-199a-3p	CLIP-seq
MIRT1259687	hsa-miR-199b-3p	CLIP-seq
MIRT1259726	hsa-miR-19a	CLIP-seq
MIRT1259727	hsa-miR-19b	CLIP-seq
MIRT1259749	hsa-miR-2053	CLIP-seq
MIRT1259688	hsa-miR-224	CLIP-seq
MIRT1259689	hsa-miR-3128	CLIP-seq
MIRT1259690	hsa-miR-3129-5p	CLIP-seq
MIRT1259750	hsa-miR-3132	CLIP-seq
MIRT1259751	hsa-miR-3175	CLIP-seq
MIRT1259730	hsa-miR-3180-5p	CLIP-seq
MIRT1259752	hsa-miR-361-3p	CLIP-seq
MIRT1259753	hsa-miR-3622a-5p	CLIP-seq
MIRT1259696	hsa-miR-3652	CLIP-seq
MIRT1259697	hsa-miR-3691-3p	CLIP-seq
MIRT1259754	hsa-miR-3923	CLIP-seq
MIRT1259755	hsa-miR-3945	CLIP-seq
MIRT1259731	hsa-miR-3973	CLIP-seq
MIRT1259756	hsa-miR-410	CLIP-seq
MIRT1259757	hsa-miR-4253	CLIP-seq
MIRT1259732	hsa-miR-4269	CLIP-seq
MIRT1259758	hsa-miR-4423-3p	CLIP-seq
MIRT1259699	hsa-miR-4430	CLIP-seq
MIRT1259701	hsa-miR-4474-3p	CLIP-seq
MIRT1259703	hsa-miR-4505	CLIP-seq
MIRT1259734	hsa-miR-4511	CLIP-seq
MIRT1259705	hsa-miR-4514	CLIP-seq
MIRT1259759	hsa-miR-4525	CLIP-seq
MIRT1259735	hsa-miR-4640-3p	CLIP-seq
MIRT1259736	hsa-miR-4650-3p	CLIP-seq
MIRT1259760	hsa-miR-4665-5p	CLIP-seq
MIRT1259707	hsa-miR-4692	CLIP-seq
MIRT1259761	hsa-miR-4706	CLIP-seq
MIRT1259762	hsa-miR-4712-3p	CLIP-seq
MIRT1259763	hsa-miR-4723-5p	CLIP-seq
MIRT1259764	hsa-miR-4734	CLIP-seq
MIRT1259737	hsa-miR-4742-5p	CLIP-seq
MIRT1259765	hsa-miR-4749-5p	CLIP-seq
MIRT1259766	hsa-miR-4770	CLIP-seq
MIRT1259767	hsa-miR-4787-5p	CLIP-seq
MIRT1259711	hsa-miR-495	CLIP-seq
MIRT1259768	hsa-miR-5095	CLIP-seq
MIRT1259740	hsa-miR-510	CLIP-seq
MIRT1259741	hsa-miR-518a-5p	CLIP-seq
MIRT1259742	hsa-miR-520a-5p	CLIP-seq
MIRT1259713	hsa-miR-520f	CLIP-seq
MIRT1259743	hsa-miR-525-5p	CLIP-seq
MIRT1259744	hsa-miR-527	CLIP-seq
MIRT1259769	hsa-miR-548aa	CLIP-seq
MIRT1259770	hsa-miR-548o	CLIP-seq
MIRT1259771	hsa-miR-552	CLIP-seq
MIRT1259772	hsa-miR-569	CLIP-seq
MIRT1259773	hsa-miR-625	CLIP-seq
MIRT1259721	hsa-miR-660	CLIP-seq
MIRT1259774	hsa-miR-744	CLIP-seq
MIRT2076508	hsa-miR-1183	CLIP-seq
MIRT2076509	hsa-miR-1185	CLIP-seq
MIRT1259679	hsa-miR-1205	CLIP-seq
MIRT1259680	hsa-miR-1207-3p	CLIP-seq
MIRT1259725	hsa-miR-1245	CLIP-seq
MIRT2076510	hsa-miR-1271	CLIP-seq
MIRT1259745	hsa-miR-1275	CLIP-seq
MIRT1259682	hsa-miR-1278	CLIP-seq
MIRT1259747	hsa-miR-143	CLIP-seq
MIRT2076511	hsa-miR-182	CLIP-seq
MIRT2076512	hsa-miR-1972	CLIP-seq
MIRT1259686	hsa-miR-199a-3p	CLIP-seq
MIRT1259687	hsa-miR-199b-3p	CLIP-seq
MIRT1259726	hsa-miR-19a	CLIP-seq
MIRT1259727	hsa-miR-19b	CLIP-seq
MIRT1259688	hsa-miR-224	CLIP-seq
MIRT1259728	hsa-miR-2355-5p	CLIP-seq
MIRT2076513	hsa-miR-299-3p	CLIP-seq
MIRT2076514	hsa-miR-30a	CLIP-seq
MIRT2076515	hsa-miR-30b	CLIP-seq
MIRT2076516	hsa-miR-30c	CLIP-seq
MIRT2076517	hsa-miR-30d	CLIP-seq
MIRT2076518	hsa-miR-30e	CLIP-seq
MIRT2076519	hsa-miR-3123	CLIP-seq
MIRT1259689	hsa-miR-3128	CLIP-seq
MIRT1259690	hsa-miR-3129-5p	CLIP-seq
MIRT1259750	hsa-miR-3132	CLIP-seq
MIRT1259691	hsa-miR-3136-5p	CLIP-seq
MIRT1259751	hsa-miR-3175	CLIP-seq
MIRT1259730	hsa-miR-3180-5p	CLIP-seq
MIRT2076520	hsa-miR-320a	CLIP-seq
MIRT2076521	hsa-miR-320b	CLIP-seq
MIRT2076522	hsa-miR-320c	CLIP-seq
MIRT2076523	hsa-miR-320d	CLIP-seq
MIRT2076524	hsa-miR-34a	CLIP-seq
MIRT2076525	hsa-miR-34c-5p	CLIP-seq
MIRT2076526	hsa-miR-3529	CLIP-seq
MIRT1259695	hsa-miR-3591-3p	CLIP-seq
MIRT2076527	hsa-miR-3614-3p	CLIP-seq
MIRT2076528	hsa-miR-3617	CLIP-seq
MIRT1259753	hsa-miR-3622a-5p	CLIP-seq
MIRT1259696	hsa-miR-3652	CLIP-seq
MIRT2076529	hsa-miR-3667-3p	CLIP-seq
MIRT2076530	hsa-miR-3679-5p	CLIP-seq
MIRT1259697	hsa-miR-3691-3p	CLIP-seq
MIRT2076531	hsa-miR-379	CLIP-seq
MIRT2076532	hsa-miR-3925-5p	CLIP-seq
MIRT1259731	hsa-miR-3973	CLIP-seq
MIRT1259756	hsa-miR-410	CLIP-seq
MIRT1259732	hsa-miR-4269	CLIP-seq
MIRT2076533	hsa-miR-4282	CLIP-seq
MIRT2076534	hsa-miR-4297	CLIP-seq
MIRT2076535	hsa-miR-4325	CLIP-seq
MIRT2076536	hsa-miR-4421	CLIP-seq
MIRT1259758	hsa-miR-4423-3p	CLIP-seq
MIRT2076537	hsa-miR-4429	CLIP-seq
MIRT1259699	hsa-miR-4430	CLIP-seq
MIRT2076538	hsa-miR-4436b-3p	CLIP-seq
MIRT1259700	hsa-miR-4439	CLIP-seq
MIRT2076539	hsa-miR-4451	CLIP-seq
MIRT1259733	hsa-miR-4461	CLIP-seq
MIRT2076540	hsa-miR-4475	CLIP-seq
MIRT2076541	hsa-miR-4491	CLIP-seq
MIRT2076542	hsa-miR-449a	CLIP-seq
MIRT2076543	hsa-miR-449b	CLIP-seq
MIRT1259703	hsa-miR-4505	CLIP-seq
MIRT1259734	hsa-miR-4511	CLIP-seq
MIRT1259704	hsa-miR-4513	CLIP-seq
MIRT1259705	hsa-miR-4514	CLIP-seq
MIRT1259759	hsa-miR-4525	CLIP-seq
MIRT2076544	hsa-miR-4529-5p	CLIP-seq
MIRT2076545	hsa-miR-4536	CLIP-seq
MIRT1259706	hsa-miR-4645-3p	CLIP-seq
MIRT1259736	hsa-miR-4650-3p	CLIP-seq
MIRT2076546	hsa-miR-4650-5p	CLIP-seq
MIRT2076547	hsa-miR-4657	CLIP-seq
MIRT2076548	hsa-miR-4659a-5p	CLIP-seq
MIRT2076549	hsa-miR-4659b-5p	CLIP-seq
MIRT1259760	hsa-miR-4665-5p	CLIP-seq
MIRT1259707	hsa-miR-4692	CLIP-seq
MIRT1259761	hsa-miR-4706	CLIP-seq
MIRT1259762	hsa-miR-4712-3p	CLIP-seq
MIRT1259763	hsa-miR-4723-5p	CLIP-seq
MIRT1259764	hsa-miR-4734	CLIP-seq
MIRT1259737	hsa-miR-4742-5p	CLIP-seq
MIRT1259765	hsa-miR-4749-5p	CLIP-seq
MIRT2076550	hsa-miR-4761-3p	CLIP-seq
MIRT1259766	hsa-miR-4770	CLIP-seq
MIRT2076551	hsa-miR-4776-3p	CLIP-seq
MIRT1259738	hsa-miR-4781-3p	CLIP-seq
MIRT1259710	hsa-miR-4786-3p	CLIP-seq
MIRT1259767	hsa-miR-4787-5p	CLIP-seq
MIRT1259711	hsa-miR-495	CLIP-seq
MIRT2076552	hsa-miR-507	CLIP-seq
MIRT1259740	hsa-miR-510	CLIP-seq
MIRT1259741	hsa-miR-518a-5p	CLIP-seq
MIRT1259742	hsa-miR-520a-5p	CLIP-seq
MIRT1259713	hsa-miR-520f	CLIP-seq
MIRT1259743	hsa-miR-525-5p	CLIP-seq
MIRT1259744	hsa-miR-527	CLIP-seq
MIRT1259714	hsa-miR-548ae	CLIP-seq
MIRT1259715	hsa-miR-548aj	CLIP-seq
MIRT1259716	hsa-miR-548am	CLIP-seq
MIRT1259717	hsa-miR-548x	CLIP-seq
MIRT2076553	hsa-miR-557	CLIP-seq
MIRT1259718	hsa-miR-563	CLIP-seq
MIRT1259773	hsa-miR-625	CLIP-seq
MIRT2076554	hsa-miR-641	CLIP-seq
MIRT2076555	hsa-miR-645	CLIP-seq
MIRT1259722	hsa-miR-671-5p	CLIP-seq
MIRT1259774	hsa-miR-744	CLIP-seq
MIRT2076556	hsa-miR-9	CLIP-seq
MIRT1259723	hsa-miR-943	CLIP-seq
MIRT2076557	hsa-miR-96	CLIP-seq
MIRT2076509	hsa-miR-1185	CLIP-seq
MIRT1259681	hsa-miR-1273d	CLIP-seq
MIRT2303147	hsa-miR-1276	CLIP-seq
MIRT1259685	hsa-miR-150	CLIP-seq
MIRT2076513	hsa-miR-299-3p	CLIP-seq
MIRT2303148	hsa-miR-3146	CLIP-seq
MIRT2303149	hsa-miR-3189-5p	CLIP-seq
MIRT1259696	hsa-miR-3652	CLIP-seq
MIRT2076530	hsa-miR-3679-5p	CLIP-seq
MIRT2076533	hsa-miR-4282	CLIP-seq
MIRT2303150	hsa-miR-4291	CLIP-seq
MIRT2303151	hsa-miR-4311	CLIP-seq
MIRT2076535	hsa-miR-4325	CLIP-seq
MIRT1259699	hsa-miR-4430	CLIP-seq
MIRT1259701	hsa-miR-4474-3p	CLIP-seq
MIRT2076540	hsa-miR-4475	CLIP-seq
MIRT2076541	hsa-miR-4491	CLIP-seq
MIRT1259703	hsa-miR-4505	CLIP-seq
MIRT2076547	hsa-miR-4657	CLIP-seq
MIRT2076548	hsa-miR-4659a-5p	CLIP-seq
MIRT2076549	hsa-miR-4659b-5p	CLIP-seq
MIRT2076551	hsa-miR-4776-3p	CLIP-seq
MIRT1259738	hsa-miR-4781-3p	CLIP-seq
MIRT2076552	hsa-miR-507	CLIP-seq
MIRT2303152	hsa-miR-545	CLIP-seq
MIRT2076553	hsa-miR-557	CLIP-seq
MIRT2303153	hsa-miR-583	CLIP-seq
MIRT1259721	hsa-miR-660	CLIP-seq
MIRT2392940	hsa-miR-147	CLIP-seq
MIRT2392941	hsa-miR-1914	CLIP-seq
MIRT2392942	hsa-miR-194	CLIP-seq
MIRT2392943	hsa-miR-3144-5p	CLIP-seq
MIRT2392944	hsa-miR-3191	CLIP-seq
MIRT2392945	hsa-miR-3911	CLIP-seq
MIRT2392946	hsa-miR-4652-5p	CLIP-seq
MIRT2392947	hsa-miR-491-5p	CLIP-seq
MIRT1259741	hsa-miR-518a-5p	CLIP-seq
MIRT1259744	hsa-miR-527	CLIP-seq
MIRT2392948	hsa-miR-541	CLIP-seq
MIRT2392949	hsa-miR-644	CLIP-seq
MIRT2392950	hsa-miR-654-5p	CLIP-seq
MIRT1259722	hsa-miR-671-5p	CLIP-seq
MIRT2465897	hsa-miR-139-5p	CLIP-seq
MIRT2465898	hsa-miR-3685	CLIP-seq
MIRT2465899	hsa-miR-384	CLIP-seq
MIRT2465900	hsa-miR-4705	CLIP-seq

Transcription factors

Show/Hide all(1)

Transcription factor	Regulation	Reference
TP53	Repression	12889596

Show/Hide all(26)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000022	Process	Mitotic spindle elongation	TAS	9885575
GO:0000226	Process	Microtubule cytoskeleton organization	IBA	21873635
GO:0000922	Component	Spindle pole	IEA
GO:0001578	Process	Microtubule bundle formation	IEA
GO:0005515	Function	Protein binding	IPI	14744859, 16189514, 16431929, 17409436, 19447967, 19468300, 23036704, 32296183
GO:0005634	Component	Nucleus	IDA	17409436
GO:0005654	Component	Nucleoplasm	IDA
GO:0005694	Component	Chromosome	IEA
GO:0005737	Component	Cytoplasm	IBA	21873635
GO:0005819	Component	Spindle	IBA	21873635
GO:0005819	Component	Spindle	IDA	17351640
GO:0005829	Component	Cytosol	TAS
GO:0005876	Component	Spindle microtubule	TAS	9885575
GO:0005886	Component	Plasma membrane	IDA
GO:0008017	Function	Microtubule binding	IBA	21873635
GO:0008284	Process	Positive regulation of cell population proliferation	IMP	17409436
GO:0015630	Component	Microtubule cytoskeleton	IDA
GO:0019894	Function	Kinesin binding	IPI	16431929
GO:0019901	Function	Protein kinase binding	IPI	17351640
GO:0030496	Component	Midbody	IDA	17409436
GO:0032465	Process	Regulation of cytokinesis	IDA	17351640
GO:0045171	Component	Intercellular bridge	IDA
GO:0051256	Process	Mitotic spindle midzone assembly	IBA	21873635
GO:0051301	Process	Cell division	IEA
GO:0070938	Component	Contractile ring	IDA	17409436
GO:1990023	Component	Mitotic spindle midzone	IBA	21873635

MIM	HGNC	e!Ensembl
603484	9341	ENSG00000198901

Protein

UniProt ID

O43663

Protein name

Protein regulator of cytokinesis 1

Protein function

Key regulator of cytokinesis that cross-links antiparrallel microtubules at an average distance of 35 nM. Essential for controlling the spatiotemporal formation of the midzone and successful cytokinesis. Required for KIF14 localization to the ce

PDB

3NRX , 3NRY , 4L3I , 4L6Y , 5KMG , 7VBG

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF03999	MAP65_ASE1	35 → 615		Family

Tissue specificity

TISSUE SPECIFICITY: Overexpressed in bladder cancer cells (PubMed:17409436). {ECO:0000269|PubMed:17409436}.

Sequence

MRRSEVLAEESIVCLQKALNHLREIWELIGIPEDQRLQRTEVVKKHIKELLDMMIAEEES
LKERLIKSISVCQKELNTLCSELHVEPFQEEGETTILQLEKDLRTQVELMRKQKKERKQE
LKLLQEQDQELCEILCMPHYDIDSASVPSLEELNQFRQHVTTLRETKASRREEFVSIKRQ
IILCMEALDHTPDTSFERDVVCEDEDAFCLSLENIATLQKLLRQLEMQKSQNEAVCEGLR
TQIRELWDRLQIPEEEREAVATIMSGSKAKVRKALQLEVDRLEELKMQNMKKVIEAIRVE
LVQYWDQCFYSQEQRQAFAPFCAEDYTESLLQLHDAEIVRLKNYYEVHKELFEGVQKWEE
TWRLFLEFERKASDPNRFTNRGGNLLKEEKQRAKLQKMLPKLEEELKARIELWEQEHSKA
FMVNGQKFMEYVAEQWEMHRLEKERAKQERQLKNKKQTETEMLYGSAPRTPSKRRGLAPN
TPGKARKLNTTTMSNATANSSIRPIFGGTVYHSPVSRLPPSGSKPVAASTCSGKKTPRTG
RHGANKENLELNGSILSGGYPGSAPLQRNFSINSVASTYSEFAKDPSLSDSSTVGLQREL
SKASKSDATSGILNSTNIQS

Sequence length

620

Interactions

View interactions

	Reactome
			RHO GTPases activate CIT

Show/Hide Causal Diseases (6)

Disease term	Disease name	dbSNP ID	References
Causal
Breast cancer	Malignant neoplasm of breast	rs587776547, rs1137887, rs137853007, rs587776650, rs80359351, rs80359714, rs121917783, rs104886456, rs121964878, rs80359874, rs80357868, rs80357508, rs387906843, rs80357569, rs80358158 View all (309 more)	25038754
Breast carcinoma	Breast Carcinoma	rs80359671, rs11540652, rs28934575, rs28897672, rs137886232, rs193922376, rs80357783, rs80359306, rs80359405, rs80359507, rs80359598, rs80358429, rs397507683, rs397515636, rs80359451 View all (71 more)	29059683, 25038754
Diabetes mellitus	Diabetes Mellitus, Non-Insulin-Dependent	rs587776515, rs61730328, rs606231121, rs606231122, rs79020217, rs77625743, rs78378398, rs606231123, rs1362648752, rs104893649, rs80356624, rs80356616, rs80356625, rs80356611, rs104894237 View all (293 more)	20581827, 22885922, 30054458, 23300278, 30718926, 28869590, 21647700
Glomerulonephritis	IGA Glomerulonephritis	rs778043831	25133636
Marfan syndrome	Mammary Carcinoma, Human	rs137854456, rs137854457, rs267606796, rs137854458, rs137854459, rs137854460, rs137854470, rs137854471, rs267606797, rs137854461, rs137854462, rs137854463, rs869025419, rs137854464, rs137854465 View all (942 more)	25038754
Ovarian cancer	Malignant neoplasm of ovary	rs34424986, rs137853060, rs28934575, rs79658334, rs121913021, rs62625308, rs80356898, rs80357579, rs41293497, rs80356904, rs80357471, rs80357522, rs80357234, rs80357912, rs80357828 View all (31 more)	31043753

Show/Hide Unknown Diseases (2)

Disease term	Disease name	Evidence	Source
Unknown
Diabetes	Diabetes		GWAS
Breast Cancer	Breast Cancer	Importantly, breast cancer patients bearing PRC2 LOF mutations displayed significantly worse prognosis compared with PRC2 wild-type patients	GWAS, CBGDA

Show/Hide Text Mining Associations (54)

Disease Name	Relationship Type	References
Associations from Text Mining
Acute Kidney Injury	Associate	33863396
Adenocarcinoma of Lung	Associate	30587197, 33126397, 35982906, 36311801, 36524512
Adenoma	Associate	16817948
Aneuploidy	Associate	36524512
Arthritis Rheumatoid	Associate	33407587
Blast Crisis	Inhibit	32157296
Breast Neoplasms	Associate	18289367, 18587273, 23648477, 25038754, 27053251, 28061449, 34384030, 37713876
Carcinogenesis	Associate	28190297, 31922238, 33706578, 36524512
Carcinoma Hepatocellular	Associate	30702595, 31043166, 31746405, 31811111, 31822116, 32685988, 33946043, 34737790, 34746301, 36553600, 36566204, 36882493, 39596041
Carcinoma Hepatocellular	Stimulate	35983074
Carcinoma Intraductal Noninfiltrating	Associate	14965441
Carcinoma Non Small Cell Lung	Associate	23357979, 39914199
Carcinoma Renal Cell	Stimulate	40093809
Carcinoma Squamous Cell	Associate	35872842
Cell Transformation Viral	Associate	19451220
Cholangiocarcinoma	Associate	31545466, 33706578
Colorectal Neoplasms	Associate	34120619
COVID 19	Associate	37278873
Dermatitis Contact	Associate	33318199
Diabetes Mellitus Type 2	Associate	25273842, 26290879, 27053251, 37738238
Drug Hypersensitivity	Associate	33318199
Ectodermal Dysplasia	Stimulate	37563591
Fatty Liver Alcoholic	Associate	32685988
Fibrosis	Associate	31811111
Hypoxia	Associate	36524512
Infections	Associate	27606464
Leukemia	Associate	35015684, 35650206
Leukemia Myeloid	Associate	19451220
Light Fixation Seizure Syndrome	Associate	26894859
Liposarcoma	Associate	21693658
Lung Neoplasms	Associate	18289367, 31789390, 36135961
Lymphatic Metastasis	Stimulate	29752448, 33706578
Lymphoma B Cell	Associate	14742259
Lymphoma Non Hodgkin	Associate	37828118
Muscular Dystrophy Facioscapulohumeral	Associate	38451221
Nasopharyngeal Carcinoma	Associate	37647439
Neoplasm Invasiveness	Associate	14965441, 32228488
Neoplasm Metastasis	Associate	31922238
Neoplasm Metastasis	Stimulate	33706578
Neoplasms	Associate	18587273, 19602592, 23357979, 26894859, 28190297, 28329686, 29752448, 31792072, 31922238, 32035007, 32685988, 34746301, 35983074, 36135961, 36524512 View all (4 more)
Neoplasms	Stimulate	23542236, 33706578
Neoplasms	Inhibit	32157296
Osteosarcoma	Associate	33176597
Ovarian Neoplasms	Associate	23542236, 31043753
Ovarian Neoplasms	Stimulate	31922238
Prostatic Neoplasms	Associate	21840484, 35513262
Sarcoma Synovial	Associate	32747783
Shock Septic	Associate	33863396
Silicosis	Associate	37278873
Small Cell Lung Carcinoma	Associate	35194152
Squamous Cell Carcinoma of Head and Neck	Associate	29752448, 32228488
Stomach Neoplasms	Associate	28190297
Triple Negative Breast Neoplasms	Associate	31792072
Uterine Cervical Neoplasms	Associate	23405241

PRC1 (protein regulator of cytokinesis 1)